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Contents
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Cancer
Research |
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Arimura T, Kojima-Yuasa A, Kennedy DO, Matsui-Yuasa I.
Reactive oxygen species-independent G1 arrest induced by evening primrose
extract in Ehrlich ascites tumor cells.
Cancer Lett. 2004 Apr
15;207(1):19-25.
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Arimura
T, Kojima-Yuasa A, Suzuki M, Kennedy DO, Matsui-Yuasa I.
Caspase-independent
apoptosis induced by evening primrose extract in Ehrlich ascites tumor cells.
Cancer Lett. 2003 Nov
10;201(1):9-16.
Abstract |
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Cai
J, Jiang WG, Mansel RE
Inhibition
of angiogenic factor- and tumour-induced angiogenesis by gamma linolenic acid.
Prostaglandins
Leukot Essent Fatty Acids 1999 Jan;60(1):21-9
Abstract |
Related articles
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Das UN, Madhavi N.
Effect of polyunsaturated fatty acids on drug-sensitive and resistant
tumor cells in vitro.
Lipids Health Dis.
2011 Sep 14;10:159.
Abstract |
Reprint |
Related articles
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Das UN.
Tumoricidal and anti-angiogenic actions of gamma-linolenic acid and its
derivatives.
Curr Pharm
Biotechnol. 2006 Dec;7(6):457-66.
Abstract |
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Das
UN.
Tumoricidal action of cis-unsaturated fatty acids and their relationship
to free radicals and lipid peroxidation.
Cancer Lett. 1991
Mar;56(3):235-43.
Abstract |
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Das UN.
Gamma-linolenic acid, arachidonic acid, and eicosapentaenoic acid as
potential anticancer drugs.
Nutrition.
1990 Nov-Dec;6(6):429-34.
Abstract |
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Das UN, Begin ME, Ells G, Huang YS, Horrobin DF.
Polyunsaturated fatty acids augment free radical generation in tumor
cells in vitro.
Biochem
Biophys Res Commun. 1987 May 29;145(1):15-24.
Abstract |
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Fearon
KC, Falconer JS, Ross JA, Carter DC, Hunter JO, Reynolds PD, Tuffnell Q
An
open-label phase I/II dose escalation study of the treatment of pancreatic
cancer using lithium gammalinolenate.
Anticancer Res 1996 Mar-Apr;16(2):867-74
Abstract |
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Kenny
FS, Gee JM, Nicholson RI, Ellis IO, Morris TM, Watson SA, Bryce RP,
Robertson JF
Effect of dietary GLA+/-tamoxifen on the growth, ER
expression and fatty acid profile of ER positive human breast cancer
xenografts.
Int J Cancer 2001 May 1;92(3):342-7. Epub 2001 Mar 1.
Abstract |
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Kenny
FS, Pinder SE, Ellis IO, Gee JM, Nicholson RI, Bryce RP, Robertson JF.
Gamma linolenic
acid with tamoxifen as primary therapy in breast cancer.
Int J Cancer 2000 Mar 1;85(5):643-8
Abstract |
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Vartak S, Robbins ME, Spector AA.
The selective cytotoxicity of gamma-linolenic acid (GLA) is associated
with increased oxidative stress.
Adv
Exp Med Biol. 1999;469:493-8.
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Astrocytomas |
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Vartak S, McCaw R, Davis CS, Robbins ME, Spector AA.
Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat
astrocytoma cells but not to 'normal' rat astrocytes.
Br J Cancer.
1998 May;77(10):1612-20.
Abstract |
Reprint |
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Vartak S, Robbins ME, Spector AA.
Polyunsaturated fatty acids increase the sensitivity of 36B10 rat
astrocytoma cells to radiation-induced cell kill.
Lipids. 1997 Mar;32(3):283-92.
Abstract |
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Brain
Tumors |
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Arachidonic
acid (AA) |
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Paoletti P, Chiabrando C, Gaetani P, Castelli MG, Butti G,
Martelli L, Rolli M.
Prostaglandins in human brain tumors.
J Neurosurg Sci 1989 Jan-Mar;33(1):65-9
Abstract |
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Williams JR,
Leaver HA, Ironside JW, Miller EP, Whittle IR, Gregor A.
Apoptosis
in human primary brain tumours: actions of arachidonic acid.
Prostaglandins Leukot Essent Fatty Acids. 1998 Mar;58(3):193-200.
Abstract |
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Glioblastoma |
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Ilc K, Ferrero JM, Fischel JL, Formento P, Bryce R,
Etienne MC, Milano G
Cytotoxic
effects of two gamma linoleic salts (lithium gammalinolenate or meglumine
gammalinolenate) alone or associated with a nitrosourea: an experimental study
on human glioblastoma cell lines
Anticancer Drugs
1999 Apr;10(4):413-7
Abstract |
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Gliomas |
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Laboratory
Investigations
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Bell
HS, Wharton SB, Leaver HA, Whittle IR
Effects
of N-6 essential fatty acids on glioma invasion and growth: experimental studies
with glioma spheroids in collagen gels.
J Neurosurg 1999 Dec;91(6):989-96
Abstract |
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Benadiba M, Miyake JA, Colquhoun A.
Gamma-linolenic acid alters Ku80, E2F1, and bax expression and induces
micronucleus formation in C6 glioma cells in vitro.
IUBMB Life. 2009
Mar;61(3):244-51.
Abstract |
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Farago N, Feher LZ, Kitajka K, Das UN, Puskas LG.
MicroRNA profile of polyunsaturated fatty acid treated glioma cells
reveal apoptosis-specific expression changes.
Lipids Health Dis.
2011 Sep 30;10(1):173. [Epub ahead of print]
Abstract |
Reprint |
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Higuchi Y, Tanii H, Koriyama Y, Mizukami Y, Yoshimoto T.
Arachidonic acid promotes glutamate-induced cell
death associated with necrosis by 12- lipoxygenase
activation in glioma cells.
Life Sci. 2007 Apr
24;80(20):1856-64. Epub 2007 Mar 1.
Abstract |
Related articles
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Higuchi Y.
Glutathione depletion-induced chromosomal DNA fragmentation
associated with apoptosis and necrosis.
J Cell
Mol Med. 2004 Oct-Dec;8(4):455-64.
Abstract |
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Higuchi Y, Yoshimoto T.
Promoting effects of polyunsaturated fatty acids on chromosomal giant DNA
fragmentation associated with cell death induced by glutathione depletion.
Free Radic Res. 2004
Jun;38(6):649-58.
Abstract |
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Higuchi Y.
Polyunsaturated fatty acids promote 8-hydroxy-2-deoxyguanosine formation
through lipid peroxidation under the glutamate-induced GSH depletion in rat
glioma cells.
Arch
Biochem Biophys. 2001 Aug 1;392(1):65-70.
Abstract |
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Leaver HA, Williams JR, Smith C, Whittle IR.
Intracellular oxidation by human glioma cell populations: effect of
arachidonic acid.
Prostaglandins
Leukot Essent Fatty Acids. 2004 May;70(5):449-53.
Abstract |
Related articles
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Leaver HA, Wharton SB, Bell HS, Leaver-Yap IM, Whittle IR.
Highly unsaturated fatty acid induced tumour regression in glioma
pharmacodynamics and bioavailability of gamma linolenic acid in an
implantation glioma model: effects on tumour biomass, apoptosis and neuronal
tissue histology.
Prostaglandins
Leukot Essent Fatty Acids. 2002 Nov;67(5):283-92.
Abstract |
Related articles
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Leaver HA, Bell HS, Rizzo MT, Ironside JW, Gregor A, Wharton SB, Whittle IR.
Antitumour and pro-apoptotic actions of highly unsaturated fatty acids in
glioma.
Prostaglandins
Leukot Essent Fatty Acids. 2002 Jan;66(1):19-29.
Abstract |
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Leaver HA, Williams JR, Ironside JW, Miller EP, Gregor A, Su BH, Prescott RJ,
Whittle IR.
Dynamics of reactive oxygen intermediate production in human glioma: n-6
essential fatty acid effects.
Eur J
Clin Invest. 1999 Mar;29(3):220-31.
Abstract |
Related articles
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Miyake JA, Benadiba M, Colquhoun A.
Gamma-linolenic acid inhibits both tumour cell cycle progression and
angiogenesis in the orthotopic C6 glioma model through changes in VEGF,
Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression.
Lipids Health Dis.
2009 Mar 17;8:8.
Abstract |
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Nasrollahzadeh J, Siassi F, Doosti M, Eshraghian MR, Shokri F, Modarressi
MH, Mohammadi-Asl J, Abdi K, Nikmanesh A, Karimian SM.
The influence of feeding linoleic, gamma-linolenic and docosahexaenoic
acid rich oils on rat brain tumor fatty acids composition and fatty acid
binding protein 7 mRNA expression.
Lipids Health Dis.
2008 Nov 16;7:45.
Abstract |
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Preuss M, Girnun GD, Darby CJ, Khoo N, Spector AA, Robbins ME.
Role of antioxidant enzyme expression in the selective cytotoxic response
of glioma cells to gamma-linolenic acid supplementation.
Free Radic
Biol Med. 2000 Apr 1;28(7):1143-56.
Abstract |
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Ramos KL, Colquhoun A.
Protective role of glucose-6-phosphate dehydrogenase activity in the
metabolic response of C6 rat glioma cells to polyunsaturated fatty acid
exposure.
Glia. 2003 Aug;43(2):149-66.
Abstract |
Related articles
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Ribeiro G, Benadiba M, de Oliveira Silva D, Colquhoun A.
The novel ruthenium-gamma-linolenic complex [Ru(2)(aGLA)(4)Cl] inhibits
C6 rat glioma cell proliferation and induces changes in mitochondrial
membrane potential, increased reactive oxygen species generation and
apoptosis in vitro.
Cell Biochem Funct.
2010 Jan;28(1):15-23. Epub 2009 Nov 19.
Abstract |
Related articles
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Scheim DE.
Cytotoxicity of unsaturated fatty acids in fresh human tumor explants:
concentration thresholds and implications for clinical efficacy.
Lipids Health Dis.
2009 Dec 15;8:54.
Abstract |
Reprint |
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Clinical
Investigations
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Bakshi A, Mukherjee D, Bakshi A, Banerji AK, Das UN.
Gamma-linolenic acid therapy of human gliomas.
Nutrition.
2003 Apr;19(4):305-9.
Abstract |
Related articles
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Das UN.
Gamma-linolenic acid therapy of human glioma-a review of in vitro, in
vivo, and clinical studies.
Med
Sci Monit. 2007 Jul;13(7):RA119-31.
Abstract |
Reprint |
Related articles
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Das UN.
From bench to the clinic: gamma-linolenic acid therapy of human gliomas.
Prostaglandins
Leukot Essent Fatty Acids. 2004 Jun;70(6):539-52.
Abstract |
Related articles
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Das U.
A radical
approach to cancer.
Med Sci Monit 2002 Apr;8(4):RA79-92.
Abstract |
Reprint |
Related articles
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Das UN, Prasad VV, Reddy DR.
Local application of gamma-linolenic acid in the treatment of human
gliomas.
Cancer Lett. 1995 Aug
1;94(2):147-55.
Abstract |
Related articles
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Kyritsis
AP, Bondy ML, Levin VA.
Modulation of Glioma Risk and Progression by Dietary Nutrients and
Antiinflammatory Agents.
Nutr Cancer. 2011 Feb 6;63(2):174-84.. [Epub ahead of print]
Abstract |
Related articles
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Naidu MR, Das UN, Kishan A.
Intratumoral gamma-linoleic acid therapy of human gliomas.
Prostaglandins
Leukot Essent Fatty Acids. 1992 Mar;45(3):181-4.
Abstract |
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Monographs |
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Borage (Borago officinalis)
Memorial Sloar-Kettering Cancer Center. 2011 Feb 9.
Abstract |
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Full
text
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As a matter of fact, the German legislation has indicated that the
ingestion of 10g of borage oil per day does not present any health risk.
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www.bioriginal.com
Pyrrolizidine
Alkaloids and Borage Oil
Bioriginal
Food & Science Corp., 1999
(HTML Full Text)
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Based on this analysis, there is no likelihood
of toxicity from pyrrolizidine alkaloids from borage
oil ingestion.
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Kapoor R, Nair H.
Gamma Linolenic Acid Oils. (In: Bailey's
Industrial Oil and Fat Products)
Wiley, DOI: 10.1002/047167849X.bio026. Published Online: 15 Jul 2005.
Abstract |
Reprint
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Non-Neoplastic
Diseases |
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Das UN.
Essential fatty acids and their metabolites could function as endogenous
HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic,
anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective,
and cardioprotective molecules.
Lipids Health Dis.
2008 Oct 15;7:37.
Abstract |
Reprint |
Related articles
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Kapoor R, Huang YS.
Gamma linolenic acid: an antiinflammatory omega-6 fatty acid.
Curr Pharm
Biotechnol. 2006 Dec;7(6):531-4.
Abstract
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Related
articles
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Zurier
RB, Rossetti RG, Jacobson EW, DeMarco DM, Liu NY, Temming JE, White BM,
Laposata M
gamma-Linolenic
acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial.
Arthritis
Rheum 1996 Nov;39(11):1808-17
Abstract |
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