Integrative Medicine > Omega-6 Fats


Astrocytoma

Vartak S, McCaw R, Davis CS, Robbins ME, Spector AA
Gamma-linolenic acid (GLA) is cytotoxic to 36B10 malignant rat astrocytoma cells but not to 'normal' rat astrocytes
Br J Cancer 1998 May;77(10):1612-20 (Cell Culture Study, Abstract)


Brain Tumors

Paoletti P, Chiabrando C, Gaetani P, Castelli MG, Butti G, Martelli L, Rolli M
Prostaglandins in human brain tumors
J Neurosurg Sci 1989 Jan-Mar;33(1):65-9 (Cell Culture Study, Abstract)

Williams JR, Leaver HA, Ironside JW, Miller EP, Whittle IR, Gregor A
Apoptosis in human primary brain tumours: actions of arachidonic acid
Prostaglandins Leukot Essent Fatty Acids. 1998 Mar;58(3):193-200
(Cell Culture Study, Abstract)


Cancer Research

Cai J, Jiang WG, Mansel RE
Inhibition of angiogenic factor- and tumour-induced angiogenesis by gamma linolenic acid
Prostaglandins Leukot Essent Fatty Acids 1999 Jan;60(1):21-9 (Cell Culture Study, Abstract)


Glioblastoma

Ilc K, Ferrero JM, Fischel JL, Formento P, Bryce R, Etienne MC, Milano G
Cytotoxic effects of two gamma linoleic salts (lithium gammalinolenate or meglumine gammalinolenate) alone or associated with a nitrosourea: an experimental study on human glioblastoma cell lines
Anticancer Drugs 1999 Apr;10(4):413-7 (Cell Culture Study, Abstract)


Gliomas

Bakshi A, Mukherjee D, Bakshi A, Banerji AK, Das UN
gamma-linolenic acid therapy of human gliomas
Nutrition. 2003 Apr;19(4):305-9
(Clinical Study, Abstract)

Bell HS, Wharton SB, Leaver HA, Whittle IR
Effects of N-6 essential fatty acids on glioma invasion and growth: experimental studies with glioma spheroids in collagen gels
J Neurosurg 1999 Dec;91(6):989-96 (Cell Culture Study, Abstract)

Das UN.
Gamma-linolenic acid therapy of human glioma-a review of in vitro, in vivo, and clinical studies.
Med Sci Monit. 2007 Jul;13(7):RA119-131.
PMID: 17599036 [PubMed - in process]

Das U
A radical approach to cancer
Med Sci Monit 2002 Apr;8(4):RA79-92 (Review Article, Abstract & PDF Full Text)

Das UN, Prasad VV, Reddy DR
Local application of gamma-linolenic acid in the treatment of human gliomas
Cancer Lett 1995 Aug 1;94(2):147-55 (Clinical Study, Abstract)

Leaver HA, Wharton SB, Bell HS, Leaver-Yap IM, Whittle IR
Highly unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and bioavailability of gamma linolenic acid in an implantation glioma model: effects on tumour biomass, apoptosis and neuronal tissue histology
Prostaglandins Leukot Essent Fatty Acids. 2002 Nov;67(5):283-92 (Animal Study, Abstract)

Naidu MR, Das UN, Kishan A
Intratumoral gamma-linoleic acid therapy of human gliomas
Prostaglandins Leukot Essent Fatty Acids 1992 Mar;45(3):181-4 (Clinical Study, Abstract)


Monographs

Barrie Cassileth and K. Simon Yeung
Borage (Borago officinalis)
11/01/2002 Memorial Sloar-Kettering Cancer Center (Monograph, HTML Full Text)

www.bioriginal.com
Pyrrolizidine Alkaloids and Borage Oil
Bioriginal Food & Science Corp. © 1999 (Monograph, HTML Full Text)


Non-Neoplastic Diseases

Zurier RB, Rossetti RG, Jacobson EW, DeMarco DM, Liu NY, Temming JE, White BM, Laposata M
gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial
Arthritis Rheum 1996 Nov;39(11):1808-17 (Clinical Study, Abstract)


Non-Nervous Sustem Tumors

Fearon KC, Falconer JS, Ross JA, Carter DC, Hunter JO, Reynolds PD, Tuffnell Q
An open-label phase I/II dose escalation study of the treatment of pancreatic cancer using lithium gammalinolenate
Anticancer Res 1996 Mar-Apr;16(2):867-74 (Clinical Study, Abstract)

Kenny FS, Pinder SE, Ellis IO, Gee JM, Nicholson RI, Bryce RP, Robertson JF
Gamma linolenic acid with tamoxifen as primary therapy in breast cancer
Int J Cancer 2000 Mar 1;85(5):643-8 (Clinical Study, Abstract)

Kenny FS, Gee JM, Nicholson RI, Ellis IO, Morris TM, Watson SA, Bryce RP, Robertson JF
Effect of dietary GLA+/-tamoxifen on the growth, ER expression and fatty acid profile of ER positive human breast cancer xenografts

Int J Cancer 2001 May 1;92(3):342-7 (Animal Study, Abstract)

Tsutomu Arimura, Akiko Kojima-Yuasa, Mayu Suzuki, David Opare Kennedy and Isao Matsui-Yuasa
Caspase-independent apoptosis induced by evening primrose extract in Ehrlich ascites tumor cells
Cancer Letters, Volume 201, Issue 1, 10 November 2003, Pages 9-16 (Cell Culture Study, Abstract)

 

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