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Contents
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Cancer
Research |
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Banerjee S, Li Y, Wang Z, Sarkar FH.
Multi-targeted
therapy of cancer by genistein.
Cancer Lett. 2008 Oct
8;269(2):226-42. Epub 2008 May 19.
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Davis
JN, Kucuk O, Djuric Z, Sarkar FH
Soy
isoflavone supplementation in healthy men prevents NF-kappa B activation by
TNF-alpha in blood lymphocytes
Free
Radic Biol Med 2001 Jun 1;30(11):1293-302
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Fazlul
H. Sarkar, Yiwei Li
Mechanisms of Cancer Chemoprevention by Soy Isoflavone
Genistein
Cancer and Metastasis Reviews 21
(3-4): 265-280, December 2002
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Glioblastoma |
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Laboratory
Investigations
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Das
A, Banik NL, Ray SK.
Flavonoids activated caspases for apoptosis in human glioblastoma T98G
and U87MG cells but not in human normal astrocytes.
Cancer. 2010 Jan 1;116(1):164-76. Epub 2009 Nov 5.
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Khoshyomn
S, Nathan D, Manske GC, Osler TM, Penar PL
Synergistic
effect of genistein and BCNU on growth inhibition and cytotoxicity of
glioblastoma cells.
J
Neurooncol 2002 May;57(3):193-200
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Penar PL, Khoshyomn S, Bhushan A, Tritton TR.
Inhibition of epidermal growth factor receptor-associated tyrosine kinase
blocks glioblastoma invasion of the brain.
Neurosurgery. 1997 Jan;40(1):141-51.
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Puli S, Lai JC, Bhushan A.
Inhibition of matrix degrading enzymes and invasion in human glioblastoma
(U87MG) cells by isoflavones.
J Neurooncol.
2006 Sep;79(2):135-42. Epub 2006 Apr 6.
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Regenbrecht CR, Jung M, Lehrach H, Adjaye J.
The molecular basis of phytoestrogen Genistein induced mitotic arrest and
exit of self-renewal in embryonal carcinoma and primary cancer cell lines
BMC Med Genomics. 2008 Oct 10;1(1):49. [Epub ahead of print]
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Gliomas |
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Laboratory
Investigations
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Baltuch GH, Yong VW.
Signal transduction for proliferation of glioma cells in vitro occurs
predominantly through a protein kinase C-mediated pathway.
Brain Res. 1996 Feb
26;710(1-2):143-9.
Abstract |
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Oude Weernink PA, Verheul E, Kerkhof E, van Veelen CW, Rijksen G.
Inhibitors of protein tyrosine phosphorylation reduce the proliferation
of two human glioma cell lines.
Neurosurgery. 1996 Jan;38(1):108-13;
discussion 113-4.
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Schmidt F, Knobbe CB, Frank B, Wolburg H, Weller M.
The topoisomerase II inhibitor, genistein, induces G2/M arrest and
apoptosis in human malignant glioma cell lines.
Oncol Rep. 2008 Apr;19(4):1061-6.
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Siegelin MD, Siegelin Y, Habel A, Gaiser T.
Genistein enhances proteasomal degradation of the short isoform of FLIP
in malignant glioma cells and thereby augments TRAIL-mediated apoptosis.
Neurosci Lett. 2009
Apr 3;453(2):92-7. Epub 2009 Feb 13.
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Yakisich JS, Ohlsson Lindblom I, Siden A, Cruz MH.
Rapid inhibition of ongoing DNA synthesis in human glioma tissue by
genistein.
Oncol Rep. 2009 Sep;22(3):569-74.
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Medulloblastoma |
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Khoshyomn S, Manske GC, Lew SM, Wald SL, Penar PL
Synergistic
action of genistein and cisplatin on growth inhibition and cytotoxicity of human
medulloblastoma cells
Pediatr Neurosurg 2000 Sep;33(3):123-31
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Monograph |
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Barrie Cassileth
and K. Simon Yeung
Soy (Glycine Max)
12/24/2002
Memorial Sloar-Kettering Cancer Center (Full Text)
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Non-CNS Tumors |
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Bhatia N, Agarwal R
Detrimental effect of cancer preventive phytochemicals
silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in
human prostate carcinoma DU145 cells
Prostate 2001 Feb 1;46(2):98-107
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Chang WH,
Liu JJ, Chen CH, Huang TS, Lu FJ
Growth
inhibition and induction of apoptosis in MCF-7 breast cancer cells by fermented
soy milk
Nutr Cancer 2002;43(2):214-26
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S
Fan, Q Meng, K Auborn, T Carter and E M Rosen
BRCA1
and BRCA2 as molecular targets for phytochemicals indole-3-carbinol
and genistein in breast and prostate cancer cells
British Journal of Cancer
(2006) 94, 407-426.
Published online 24 January 2006
Abstract
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Li
D, Yee JA, McGuire MH, Murphy PA, Yan L
Soybean
isoflavones reduce experimental metastasis in mice
J Nutr 1999
May;129(5):1075-8 (PDF Full Text)
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Frank M. Sacks MD, Alice
Lichtenstein DSc, Linda Van Horn PhD, RD, William Harris PhD, Penny Kris-Etherton
PhD, Mary Winston EdD, for the American Heart Association Nutrition
Committee
Soy Protein, Isoflavones, and Cardiovascular
Health. An American Heart Association Science Advisory for Professionals
From the Nutrition Committee
Circulation 2006: published online before
print January 17, 2006
Abstract
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News
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Shen F,
Weber G
Synergistic
action of quercetin and genistein in human ovarian carcinoma cells
Oncol Res 1997;9(11-12):597-602
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Zhou
JR, Gugger ET,
Tanaka T, Guo Y, Blackburn GL, Clinton SK
Soybean
phytochemicals inhibit the growth of transplantable human prostate carcinoma and
tumor angiogenesis in mice
J Nutr 1999 Sep;129(9):1628-35
(PDF Full Text)
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Products
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Life
Extension Foundation
Mega Soy Extract
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Treatment Related Pathology
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Jefferson W,
Newbold R, Padilla-Banks E, Pepling M
Neonatal genistein
treatment alters ovarian differentiation in the mouse: inhibition of
oocyte nest breakdown and increased oocyte survival
Biol Reprod. 2006
Jan;74(1):161-8. Epub 2005 Sep 28
Abstract
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