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	=?Windows-1252?Q?_for_patients_with_high-grade_malignant_glioma?=
Date: Mon, 15 May 2006 12:09:29 +0200
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<HTML><HEAD><TITLE>Gliadel=AE Wafer demonstrates long-term survival =
benefit for patients with high-grade malignant glioma</TITLE>
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<META=20
content=3D"MGI PHARMA, INC.  today announced the publication of =
long-term (56 month) follow-up data showing that Gliadel=AE Wafer =
provides a durable long-term survival benefit for patients with =
high-grade malignant glioma.&#13;&#10;&#13;&#10;Gliadel Wafer is =
approved by the FDA for treatment of patients with newly-diagnosed =
high-grade malignant glioma as an adjunct to surgery and radiation.  =
Gliadel Wafer is also indicated to treat recurrent glioblastoma =
multiforme (GBM) in addition to surgery.  "=20
name=3Ddescription>
<META content=3D"Medicine/Health Cancer Clinical Trials Neurobiology"=20
name=3Dkeywords>
<META content=3D"Wed, 08 Mar 2006 05:00:00 GMT" name=3Ddate>
<META content=3D"MGI Pharma" name=3Dfunder>
<META content=3D"European Journal of Neurosurgery, Acta Neurochirurgica" =

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release date:=20
8-Mar-2006</STRONG><BR>[
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 ]<BR><BR>Contact: Jennifer Davis<BR><A=20
href=3D"mailto:IR@mgipharma.com">IR@mgipharma.com</A><BR>212-332-4381<BR>=
<SPAN=20
class=3Drelinst><A href=3D"http://www.edelman.com/">Edelman Public=20
Relations</A></SPAN> <BR>
<H1 class=3Dtitle>Gliadel=AE Wafer demonstrates long-term survival =
benefit for=20
patients with high-grade malignant glioma</H1>
<H2 class=3Dsubtitle></H2>MGI PHARMA, INC. (Nasdaq: MOGN) today =
announced the=20
publication of long-term (56 month) follow-up data showing that =
Gliadel=AE Wafer=20
provides a durable long-term survival benefit for patients with =
high-grade=20
malignant glioma.=20
<P>Gliadel Wafer is approved by the FDA for treatment of patients with=20
newly-diagnosed high-grade malignant glioma as an adjunct to surgery and =

radiation. Gliadel Wafer is also indicated to treat recurrent =
glioblastoma=20
multiforme (GBM) in addition to surgery. The approval was based on =
clinical=20
trial results showing the median survival of patients with high-grade =
malignant=20
gliomas increased to 13.9 months from 11.6 months, and the median =
survival of=20
patients with recurrent GBM increased to 6.4 months from 4.6 months.=20
<P>The newly-published data in the March edition of The European Journal =
of=20
Neurosurgery, Acta Neurochirurgica, reports long-term survival results =
from a=20
previously published 240-patient, randomized, multi-center, =
placebo-controlled=20
study. This study demonstrated that patients treated with Gliadel Wafer =
in=20
combination with radiation therapy had a significant survival advantage =
at three=20
years compared with placebo (9.2% vs. 1.7%; P=3D0.01). Of the 59 =
patients=20
available for long-term follow-up, 11 were alive at 56 months (4.7 =
years). Of=20
those 11 patients, nine had received Gliadel Wafer and two had received =
placebo=20
wafers. Two of the nine remaining patients had GBM. Treatment with =
Gliadel Wafer=20
in patients with high grade malignant glioma was associated with a 27% =
reduction=20
in risk of death over the study period (P=3D0.018, log-rank statistic).=20
<P>"We feel that the publication of this important data contributes=20
significantly to the result of the randomized, placebo-controlled study, =
showing=20
that patients with high-grade malignant gliomas have a better chance of=20
long-term survival when treated with Gliadel Wafer," said Manfred =
Westphal, M.D.=20
of the University Hospital Eppendorf in Hamburg, Germany and lead =
investigator=20
of the study.=20
<P>"MGI PHARMA is committed to advancing the treatment of high-grade =
malignant=20
brain tumors and will continue to investigate ways in which our products =
can=20
provide greater benefit to more cancer patients," said Mary Lynne =
Hedley, Ph.D.,=20
Senior Vice President and Chief Scientific Officer of MGI PHARMA.=20
<P>
<DIV align=3Dcenter>###</DIV>
<P><B>About Gliadel=AE Wafer</B> <BR>Gliadel Wafer (polifeprosan 20 with =

carmustine implant) is a biodegradable wafer containing the chemotherapy =
agent=20
carmustine, or BCNU, and is indicated in newly diagnosed patients with=20
high-grade malignant glioma as an adjunct to surgery and radiation. =
Gliadel=20
Wafer is also indicated in recurrent glioblastoma multiforme patients as =
an=20
adjunct to surgery. Gliadel Wafer provides localized delivery of =
chemotherapy=20
directly to the site of the tumor and is the only FDA approved brain =
cancer=20
treatment capable of doing so. Up to eight Gliadel wafers can be =
implanted in=20
the brain after tumors are surgically removed. As a Gliadel wafer =
dissolves,=20
BCNU is delivered directly to the site once occupied by the tumor, =
providing=20
site-specific chemotherapy to target any remaining tumor cells. Side =
effects=20
that have been reported in patients receiving Gliadel Wafer include =
seizures,=20
intracranial infections, abnormal wound healing, and brain edema =
(swelling).=20
Although these events may result as a consequence of brain surgery =
(craniotomy)=20
without Gliadel Wafer, they may occur more frequently when Gliadel Wafer =
is=20
used. In clinical studies, the most common side effects that occurred =
more often=20
in patients receiving Gliadel Wafer than in patients receiving placebo, =
included=20
pain and abnormal wound healing. Certain side effects reported with =
intravenous=20
delivery of BCNU have not been seen after implantation of Gliadel Wafer. =

<P><B>About MGI PHARMA</B> <BR>MGI PHARMA, INC. is an oncology- and =
acute=20
care-focused biopharmaceutical company that acquires, researches, =
develops and=20
commercializes proprietary products that address the unmet needs of =
patients.=20
MGI PHARMA markets Aloxi=AE (palonosetron hydrochloride) Injection and =
Gliadel=AE=20
Wafer (polifeprosan 20 with carmustine implant) in the United States. =
The=20
Company directly markets its products in the U.S. and collaborates with =
partners=20
to reach international markets. International distribution partners for =
Gliadel=20
Wafer include: Link Pharmaceuticals Ltd. in the United Kingdom and the =
Republic=20
of Ireland, Link Pharmaceuticals EU Ltd. in France and Germany, Dompe=20
Farmaceutici s.p.a. in Italy, Laboratorios del Dr. Esteve S.A. in Spain =
and=20
Portugal, Genesis Pharma S.A. in Greece, BioPro Pharmaceuticals Ltd. in =
South=20
East Asia, PharmaPlan Pty Ltd. in South Africa and Medison Pharma Ltd. =
in=20
Israel.=20
<P>For more information about MGI PHARMA, please visit <A=20
href=3D"http://www.mgipharma.com/">http://www.mgipharma.com/</A>.=20
<P>This news release contains certain "forward-looking" statements =
within the=20
meaning of the Private Securities Litigation Reform Act of 1995. These=20
statements are typically preceded by words such as "believes," =
"expects,"=20
"anticipates," "intends," "will," "may," "should," or similar =
expressions. These=20
forward-looking statements are not guarantees of MGI PHARMA's future =
performance=20
and involve a number of risks and uncertainties that may cause actual =
results to=20
differ materially from the results discussed in these statements. =
Factors that=20
might cause MGI PHARMA's results to differ materially from those =
expressed or=20
implied by such forward-looking statements include, but are not limited =
to, the=20
ability of MGI PHARMA's product candidates to be proven safe and =
effective in=20
humans, to receive marketing authorization from regulatory authorities, =
and to=20
ultimately compete successfully with other therapies; continued sales of =
MGI=20
PHARMA's marketed products; development or acquisition of additional =
products;=20
reliance on contract manufacturing; changes in strategic alliances; =
continued=20
access to capital; ability of MGI PHARMA to successfully complete the=20
integration of Guilford with its existing operations; the risk that the=20
perceived advantages of the Guilford transaction may not be achieved; =
and other=20
risks and uncertainties detailed from time to time in MGI PHARMA's =
filings with=20
the Securities and Exchange Commission including its most recently filed =
Form=20
10-Q or 10-K. MGI PHARMA undertakes no duty to update any of these=20
forward-looking statements to conform them to actual results.=20
<P><BR clear=3Dboth>
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