From: Subject: =?iso-8859-1?Q?Exercise=92s_chemo_benefits_studied?= Date: Wed, 29 Mar 2006 18:39:28 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0024_01C65360.1C4FB770" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2180 This is a multi-part message in MIME format. ------=_NextPart_000_0024_01C65360.1C4FB770 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.mc.vanderbilt.edu/reporter/index.html?ID=4611 Exercise=92s chemo benefits studied =
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Exercise=92s chemo=20 benefits studied

March 24, 2006

Charles Matthews, = Ph.D., is=20 studying whether regular exercise can help alleviate the = cognitive=20 impairment experienced by many people following = chemotherapy. Photo=20 by Dana Johnson

Heather L. Hall=20

Researchers at the Vanderbilt-Ingram Cancer Center are = studying=20 whether exercise can help curb memory and cognitive problems = experienced by many cancer survivors following chemotherapy. =

Charles Matthews, Ph.D., Laurel Brown, Ph.D., and a team = of=20 researchers at Vanderbilt-Ingram are taking a closer look at = the=20 chemotherapy side effect commonly referred to as =93chemo = brain=94 or=20 =93chemo fog=94 to determine whether starting an exercise = program can=20 help patients experiencing these problems. The study is = being done=20 with the help of funding from the foundation established by=20 well-known cancer survivor and athlete, Lance Armstrong. =

=93A substantial number of cancer survivors who receive=20 chemotherapy report mild to moderate cognitive impairment = that=20 persists following treatment. These impairments have been = reported=20 across a range of cancer types and chemotherapy agents,=94 = said Brown.=20

It's something Robert Carver Bone, M.D., a surgeon and = physician=20 who has been in general practice in Lebanon, Tenn., since = 1964 and=20 is on the clinical faculty at Vanderbilt, never dreamed he'd = have to=20 deal with as a patient himself.

Bone was diagnosed with stage four squamous cell = carcinoma of his=20 right tonsil that metastasized to his neck in 2001. He beat = the=20 cancer with chemotherapy once a week for three weeks and = radiation=20 for seven weeks, but he's still dealing with lingering = problems that=20 affect his daily life.

=93I had problems with walking after chemotherapy. I had = trouble=20 finding my way in the dark, and for a while I had problems = with my=20 hands,=94 said Bone. =93I do think I have some short-term = memory loss.=20 I'm 69; I thought it was just my age,=94 he added.

Bone has been undergoing regular occupational and = physical=20 therapy at Vanderbilt to help him overcome the problems and = get back=20 to practicing medicine full-time and helping other patients. =

=93I feel very good. Every day I feel stronger and = stronger. I'm=20 doing everything I know to help with it,=94 he said. He's = now=20 considering enrolling in the study being conducted by = Matthews and=20 Brown.

Participants in the study will be asked to make three = visits to=20 VUMC over six months, and will be placed into either a = walking=20 exercise group or a control group.

Study members in the exercise group will receive a = personalized=20 walking program that they can do at home, counseling to help = them=20 reach their exercise goals and techniques to help with = memory=20 problems.

Those enrolled in the control group will immediately = receive=20 counseling and techniques to help with memory problems, but = will=20 only be given the exercise program at the end of the = six-month study=20 period.

All participants will be asked to complete questionnaires = assessing memory and cognitive function, physical activity = and=20 fitness, and to provide urine and blood samples. Anyone aged = 18 and=20 older who has received chemotherapy in the last five years,=20 experienced persistent memory or cognitive problems since=20 chemotherapy, does not already exercise regularly, and has = no=20 history of brain cancer, heart disease, or a serious medical = condition that could be worsened by exercise, is eligible = for the=20 study.

Matthews said exercise at levels most adults can perform, = such as=20 brisk walking for 30 to 45 minutes, four to five days a = week, has=20 been shown to improve cognitive function in older adults. =

=93A wealth of research now indicates that exercise = participation=20 preserves cognition function as we age,=94 said Matthews. = =93In=20 addition, sedentary older adults without cancer that = completed six=20 months of exercise have been shown to improve their = cognitive=20 function. We want to see if exercise might help cancer = survivors in=20 the same way.=94

Researchers said this exercise intervention study is the = first of=20 its kind for cancer survivors.

=93To our knowledge this study would be the first to = examine the=20 influence of regular exercise on cancer survivors who = experienced=20 cognitive difficulties following chemotherapy,=94 said = Matthews.

Vanderbilt was one of 21 institutions across the country = and in=20 Rome, Italy, to receive cancer survivorship and testicular = cancer=20 research grants from the Lance Armstrong Foundation.

To find out more about the study, call Cara Hanby at = 936-0997.=20

Return=20 to Issue

Also in this issue:
  • Aware= ness=20 efforts focus on cost benefits, efficacy of = generics
  • Calen= dar=20 of Events - March 24-31, 2006
  • Child= =20 champs
  • Claus= s=20 takes on Comprehensive Regional Pediatric Center = duties
  • Harri= s=20 lauded for dedication to equality
  • Hecke= rs=20 highlights latest advances, obstacles in schizophrenia=20 research
  • Lectu= res=20 set for World Health Week
  • LifeF= light=92s=20 Bland named EMT of Year
  • Londo= n=20 meet to focus on Down Syndrome
  • Magne= t=20 bound
  • New=20 awards honor patient care initiatives
  • Perso= nalized=20 health focus of new post
  • Proce= dure=20 straightens scoliosis curves
  • Resea= rch=20 nurse career pathway outlined
  • Satis= faction=20 rates on rise in adult = ED

[ VUMC Home |=20 About = Us |=20 Key = Sites |=20 Finders | Intranet | = Search = | Help | Eskind Library | = Eskind Digital = Library | VU ]

Copyright =A9 2006, Vanderbilt University = Medical=20 Center
For More=20 Information: <http://www.mc.vanderbilt.edu/cgi-bin/mail?reporter@www.mc.Vander= bilt.Edu>
Editorial=20 tool created by the Eskind Biomedical Library Web Team
Last = modified:=20 Wednesday, 02 February 2005 = <http://www.m= c.vanderbilt.edu/cgi-bin/mail?webmaster>=20


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