From: Subject: Infections could contribute to adult brain tumours Date: Tue, 16 May 2006 08:19:11 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C678C1.68DD6980" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2869 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C678C1.68DD6980 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.eurekalert.org/pub_releases/2006-01/uonu-icc012306.php Infections could contribute to adult brain = tumours

Public = release date:=20 23-Jan-2006
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Contact: Dr Richard McNally
richard.mcnally@ncl.ac.uk44-191-202-3029
University of = Newcastle upon=20 Tyne

Infections could contribute to adult brain = tumours

Infections could play a key role in triggering = certain=20 types of adult brain cancer, according to results from a new statistical = analysis of the disease.=20

The international study, led by Dr Richard McNally at the University = of=20 Newcastle upon Tyne, was funded by Cancer Research UK, the Dutch Cancer = Society,=20 and the Christie Hospital Research Endowment Fund.=20

The British and Dutch team* analysed a database of adult brain = tumours=20 diagnosed in patients from the North Brabant province of the Netherlands = between=20 1983 and 2001. They found clusters of cases of glioma tumours, which = make up=20 about half of all brain tumours, at different time intervals in = different=20 geographical locations.=20

This 'space-time clustering' of cases is a pattern typical of = diseases caused=20 by infections, adding weight to the theory that outbreaks of viruses are = a=20 potential contributory cause of brain tumours. Diseases caused by more = constant=20 environmental factors, such as pollution, produce clusters of cases in = one place=20 over a much longer time period.=20

However, the research team stresses it is too early to say exactly = which=20 infections could be the cause, and say that more research is needed to = pinpoint=20 what they are.=20

The findings, published in the European Journal of Cancer, may = potentially be=20 a step towards developing better preventative measures for cancer and = may also=20 result in better treatment.=20

Dr Richard McNally, of Newcastle University's School of Clinical = Medical=20 Sciences (Child Health), said: "Very little is known about the cause of = brain=20 tumours and we think our research brings us closer to understanding more = about=20 this disease.=20

"We only found clustering of cases in the East of the province we=20 investigated, and we think it could be something to do with the way = infections=20 spread in less densely populated areas."=20

However, the researchers stress that people cannot 'catch cancer'. = Infections=20 are only likely to trigger cancer in a very small number of individuals = who are=20 already genetically susceptible to the disease.=20

The team looked at data from the Eindhoven Cancer Registry. They = analysed=20 results for the East and West of the 5000 square-kilometre province = separately.=20 They found an irregular pattern where many cases occurred at the same = time in=20 men and women over 15-years old in the East but not in the West. Around = seven=20 per cent more cases of brain tumours were observed to occur in = 'clusters' than=20 would be expected by chance.=20

This is the first study to carry out this sophisticated form of = statistical=20 analysis known as 'clustering' in brain tumours in adults.=20

The results of this work are consistent with earlier research led by = Dr=20 McNally into childhood cancer in North West England. This discovered = patterns in=20 the diagnosis of two types of cancer - leukaemia and brain tumours - in = that=20 they tended to occur together at similar times and geographical = locations.=20

Dr McNally, who also works with Newcastle University's School of = Population=20 and Health Sciences, added: "Future research should try to identify = specific=20 infections which could potentially be a trigger. If these are found, it = could=20 lead to future preventative measures."=20

Professor John Toy, Cancer Research UK's medical director, said: = "Brain=20 cancer is rare, accounting for less than two per cent of all new adult = cancers=20 diagnosed in the UK each year. These findings suggest a possible link = between=20 infection and this type of the disease but by no means provide proof."=20

*The team included UK and Dutch researchers. In the UK, they came = from the=20 University of Newcastle upon Tyne and The University of = Manchester/Central=20 Manchester and Manchester Children's University Hospitals NHS Trust. In = Holland=20 the researchers came from St Elisabeth Hospital, Tilburg, Erasmus MC, = Rotterdam,=20 and Comprehensive Cancer Centre South, Eindhoven.=20

###

MEDIA INFORMATION

Interviews: Dr Richard McNally Tel: + 44 (0) 191 202 3029 Email: Richard.McNally@newcastle= .ac.uk
For=20 Professor John Toy at Cancer Research UK, contact Michael Regnier in the = Press=20 Office on: +44 (0)20 7061 8309 or email: michael.regnier@cancer.org.= uk=20

Background information - brain cancer (source, Cancer Research UK): =
Brain=20 cancer is not very common and, unlike many other cancers, does not = usually=20 spread to other parts of the body. Each year, in the UK, there are 2,500 = new=20 cases of brain cancer in men, and almost 1,800 cases in women.=20

Brain cancers are abnormal growths of tissue found inside the skull. = The=20 brain is a soft spongy mass of nerve cells and supporting tissue. It = controls=20 every physiological system in the body and is responsible for our = thoughts,=20 language and emotions. In the brain, any abnormal growth puts pressure = on=20 sensitive structures and may impair their function.=20

For more information about brain cancer diagnosis and treatment for = patients=20 and their families, visit Cancer Research UK's patient information = website http://www.cancerhelp.co.uk/.=20

END OF PRESS RELEASE: Issued by Newcastle University Press Office. = Contact=20 Claire Jordan, tel. + 44 (0) 191 222 6067/7850 or email press.office@ncl.ac.uk. = Website: http://www.ncl.ac.uk/press.off= ice

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