Nanotechnology May Find Disease Before It = Starts

From: Subject: Nanotechnology May Find Disease Before It Starts Date: Fri, 28 Apr 2006 09:56:13 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_00F7_01C66AA9.FC2B9610" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2869 This is a multi-part message in MIME format. ------=_NextPart_000_00F7_01C66AA9.FC2B9610 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://researchnews.osu.edu/archive/nanobitz.htm Nanotechnology May Find Disease Before It = Starts

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OSU News = Research=20 Archive Search an archive of past research = stories.=20
Coverage of OSU = Research=20
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(Last updated 4/24/06) =

Previous stories = pertaining to=20 Professor Rosol's research:

"New = Model Of=20 Prostate Cancer Helps Identify Promising Pain Treatment," = 12/1/05.=20

NANOTECHNOLOGY MAY FIND DISEASE BEFORE IT = STARTS

COLUMBUS , Ohio =96 Nanotechnology may one day help physicians = detect the=20 very earliest stages of serious diseases like cancer, a new study=20 suggests.

It would do so by improving the quality of images produced by = one of=20 the most common diagnostic tools used in doctors' offices =96 the = ultrasound=20 machine.

Thomas J.=20 Rosol

In laboratory experiments on mice, scientists found that = nano-sized=20 particles injected into the animals improved the resulting images. = This=20 study is one of the first reports showing that ultrasound can = detect these=20 tiny particles when they are inside the body, said Thomas = Rosol, a=20 study co-author and dean of the college of veterinary = medicine at=20 Ohio State University.

=93Given their tiny size, nobody thought it would be possible = for=20 ultrasound to detect nanoparticles,=94 he said.

It turns out that not only can ultrasound waves sense = nanoparticles,=20 but the particles can brighten the resulting image. One day, those = bright=20 spots may indicate that a few cells in the area may be on the = verge of=20 mutating and growing out of control.

=93The long-term goal is to use this technology to improve our = ability to=20 identify very early cancers and other diseases,=94 said Jun Liu, = a study=20 co-author and an assistant professor of biomedical = engineering at=20 Ohio State University. =93We ultimately want to identify = disease at its=20 cellular level, at its very earliest stage.=94

The study is in the current issue of the journal Physics in Medicine and = Biology.

The researchers injected a solution of silica nanoparticles = into the=20 tail vein of each mouse. They then anesthetized the animals and = placed=20 them on their backs on a warm imaging table.

=93These = nanoparticles may=20 make it possible for physicians to screen for tumors very = quickly,=20 and perhaps lessen the need for a biopsy in many cases,=94 = Liu said.=20 Nanoparticles are smaller than any cell in the human body, = so they=20 may pass through the walls of the leaky blood vessels, or=20 capillaries, of tumor tissue and actually infiltrate the=20 tumor.

Rosol said that Liu and her team are working on creating = biodegradable=20 nanoparticles. For the purposes of this study, however, the = researchers=20 wanted to use a hard substance, silica, to see if their idea would = work.=20 The strongest ultrasound signals are those produced by sound waves = bounce=20 off a hard surface. While not biodegradable, the nanoparticles = used in the=20 study were biologically inert.

The researchers took ultrasound images of the animals' livers = every=20 five minutes for 90 minutes after the injection. The nanoparticles = had=20 accumulated in the animals' livers. Another future step for this = work is=20 to label nanoparticles with a molecular road map of sorts, which = would=20 direct the particles to go to specific locations in the body.

=93The liver takes up foreign substances in the body, so it's = not=20 surprising that that's where we saw the particles,=94 Rosol said. = =93But we=20 ultimately want to be able to make these particles to go to the = mammary=20 glands or other tissues we're interested in.=94

The ultrasound images grew brighter over the 90-minute period. = The=20 researchers compared these images to those from a group of control = mice=20 injected with a saline solution. There was no change in ultrasound = image=20 brightness in the control mice after that injection.

While this research is still in its infancy, Rosol and his = colleagues=20 foresee a day when nanotechnology can alert a physician to the = beginnings=20 of cancer or heart disease, perhaps in a woman who = has a=20 family history of breast cancer:

=93Her doctor could inject the breast with nanoparticles and = the=20 resulting ultrasound image would alert the doctor to any = suspicious areas=20 in the tissue, even at the cellular level,=94 Rosol said.

The hope is that combining ultrasound and nanotechnology may = provide a=20 definitive diagnosis in lieu of an invasive procedure like a = biopsy.

=93These nanoparticles may make it possible for physicians to = screen for=20 tumors very quickly, and perhaps lessen the need for a biopsy in = many=20 cases,=94 Liu said.

Nanoparticles are smaller than any cell in the human body, so = they may=20 pass through the walls of the leaky blood vessels, or capillaries, = of=20 tumor tissue and actually infiltrate the tumor.

=93Until now, nobody knew what these particles would do in the = blood,=94=20 Rosol said. =93But they made it into the liver.

And despite their miniscule size, nanoparticles are still big = enough to=20 carry a payload of medicine, Rosol said.

=93That the particles made it into the liver suggests that they = could be=20 used to deliver toxic chemotherapeutic drugs that would act = locally on a=20 tissue, at the site of a tumor, and not have such a pronounced = affect on=20 the rest of the body,=94 Rosol said. =93The problem with = chemotherapy is that=20 the drug affects the whole body, causing a host of problems such = as hair=20 loss, diarrhea and anemia.=94

Rosol and Liu conducted the study with colleagues from various = academic=20 departments at Ohio State : Andrea Levine and Mamoru Yamaguchi , = both with=20 veterinary=20 biosciences; John Mattoon , with veterinary = clinical=20 sciences; Robert Lee , with pharmacy; and=20 Xueliang Pan, with statistics.

This work was supported by the Susan=20 G. Komen Breast Cancer Foundation, the National Cancer Institute, the = National Center for Research = Resources=20 and the National Science = Foundation.

Contact: Thomas Rosol , (614) 688-8749;

Rosol.1@rf.ohio-state.edu =

Jun Liu, (614) 247-8904; liu.314@osu.edu

Written by Holly Wagner , (614) 292-8310; Wagner.235@osu.edu

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