Growth Factor-promoting Angiogenesis Expressed In = Tumor Cells And Normal Neurons

Scientists have discovered that a stem cell factor = overexpressed=20 both in brain tumor cells and in neurons following brain injury promotes = tumor=20 survival by inducing angiogenesis. The research study, published in the = April=20 issue of Cancer Cell, examines the interaction between tumor cells and=20 surrounding tissues and may have substantial significance for design of = more=20 effective therapeutics for one of the most lethal types of tumor, = malignant=20 gliomas.

Stem cell factor (SCF) is an important growth factor for multiple = cell types.=20 Research has shown that SCF is expressed in glioma cells and as a result = of=20 various types of brain injury, but its significance is not fully = understood. Dr.=20 Howard A. Fine from the National Cancer Institute/National Institute of=20 Neurological Disorders and Stroke at the National Institutes of Health = and=20 colleagues designed a study to investigate whether, as a result of = tumor-induced=20 brain injury, brain cell-mediated SCF expression contributes to tumor = growth by=20 setting up an environment that supports angiogenesis and tumor = progression.

The researchers demonstrate that decreased SCF expression in vivo = results in=20 decreased angiogenesis and improved survival in mouse glioma models, = whereas=20 overexpression of SCF is associated with a worse prognosis and shorter = survival=20 in patients with glioblastomas. SCF expression is not directly linked to = tumor=20 cell proliferation but instead encourages the growth of blood vessels = needed to=20 support the expanding tumor. Importantly, these findings provide = definitive=20 evidence that factors promoting tumor progression extend beyond the = tumor itself=20 and involve a complex interaction between the cancer cells and the = normal cells=20 that are perturbed by expanding tumor.

These results suggest that SCF is a potent glioma-associated = angiogenic=20 factor that plays a prominent role in pathological angiogenesis both = through=20 direct tumor cell expression of SCF and by normal neurons that are = damaged by=20 the growing tumor. The researchers point out that the clinical = significance of=20 these findings extends beyond identification of SCF as a rational target = for=20 gliomas. "Normal neuronal expression of SCF in response to traumatic = brain=20 injury also raises the disturbing possibility that standard invasive = procedures=20 such as surgical biopsies or partial tumor resections may be inducing a=20 proangiogenic response, or trigger, within the brain," cautions Dr. = Fine.

Lixin Sun, Ai-Min Hui, Qin Su, Yuri Kotliarov, Sandra Pastorino, = Jennifer=20 Walling, Rolando Bailey, and Howard A. Fine of the National Cancer=20 Institute/National Institute of Neurological Disorders and Stroke, = National=20 Institutes of Health in Bethesda, MD; Alexander Vortmeyer of the = National=20 Institute of Neurological Disorders and Stroke, National Institutes of = Health in=20 Bethesda, MD; Antonino Passaniti of the University of Maryland School of = Medicine in Baltimore, MD; Jayant Menon of the National Institute of=20 Neurological Disorders and Stroke, National Institutes of Health in = Bethesda, MD=20 and Howard Hughes Medical Institute-National Institutes of Health = Research=20 Scholars Program in Bethesda, MA; Marc Rosenblum and Tom Mikkelsen of = Henry Ford=20 Hospital in Detroit, MI. J.M. was a 2004 HHMI-NIH Research Scholar.

Sun et al.: "Neuronal and Glioma-Derived Stem Cell Factor Induces=20 Angiogenesis within the Brain." Publishing in Cancer Cell 9, 287-300, = APRIL=20 2006. DOI 10.1016/j.ccr.2006.03.003 http://www.cancercell.org/

------=_NextPart_000_0047_01C65EF4.40AC6970 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.sciencedaily.com/images/logo-print.gif R0lGODlhEwFaAPcAAP///////5kAAOvr6x5cmZmZmWuUvHWbwKS91nqfw4ysy5azzwEBAYSmx0p8 raYgIKMZGSlknjJrordLS52402KNuJGvzbNBQa/F2/b29yNgm73P4cRra7PI3ZwICDhvpXGYv60y MlWDsp8QEMXV5UJ2qd3m8F2JtbjL36WlpTxxp6oqKtTU1LpTU7S0tFiGsxAQEH6ixb1aWi5ooJq2 0ezOzjIyMjo6OqvC2d7e3iAgIAgICNbh7c3Nzefn5ysrK6nB2Impyc7c6cXFxRgYGD90qLlQUKC6 1IWFhUtLS+ju9K84OFCBsMBiYlpaWmtra2aQuu7V1UJCQr29vc6EhJSUlHp6euG0tPD0+N6srNec nPz4+Pju7tCLi/bo6GRkZNSUlK2trdulpejFxcJmZqgmJoyMjLE8PNnj7lNTU8d0dPf5+/r7/WWQ ufLd3eS9vXR0dKETE8t9fcHS4y1noOzx9kV4q8l4eMvZ509/r+rLy9KOjvPh4eO4uNLe6nedwoep yXidwePr8sDR49mhobYDFar3B4gDFc32B3EDFT72B3EDFf31B3EDFav1B4QDFW71B6kDFUb1B88D FR31B/wDFQn1BzAEFQn1B8wEFQn1B5YFFWf1B40GFST2B9kHFRv3B+YIFWf4B7MJFQj6B4AKFan7 B+YKFVj9B+YKFRb/B+YKFTYCCMUJFdQECIEHFe8GCD4FFQoJCBUCFRcKCAf+FBcKCJX6FBcKCKn3 FGMJCEP1FPwHCN3yFJQGCA/xFJoECNjvFA0CCKHuFID/BwbuFNn8BwbuFBb6BwbuFGj3B7PuFPf0 Bw7wFMPyB2nxFJDwB0/zFPXuB8L1FPPtBzX4FPDsBwL7FG7sByn+FG7sBzMBFW7sB9ADFdvsB/8F FbPtBy8IFYzuB/IJFdDvB0gLFYHxB6r2FFj5B6r2FLv3B/72FIr2B6X3FMf1B034FAT1Bx35FKL0 BxT6FKL0B836FKL0B3z7FND0Bx78FCv1B5r8FGz1BxT9FNL1B4z9FCH5BAEAAAAALAAAAAATAVoA AAj/AAMIHEiwoMGDCBMqXMiwocOHECNKnEixosWLD01g3Mixo8ePIEOKjChkwYEKKNtAOaAABZaR A5XwmElzDcybOA1uqcGzp8+eXHIajNLTy0A3PaPcFJIgJRQDUKMaAIGADUwEDbJq1Si068gaRoxM GEu27IQLEzhk2dL1AYS3Yga2GEFXxlUDT6XqnQoihpKRQBQIHszVq2GPWVooDivWbNkLLd7k9PL2 7ZiBS+iOkDOSxl6pIEIfGH0gwd+QOAYrsGCh8OHXF8HIUEy7RVjHZcHgHOP2bVCBEOLQjRsSxWe+ pJMnSNBAJA7WC6IvcA27ukQqMrLPrm27seMuN7U8/xi/4ujbOHEug6yzV3Ty0svjJwASEoP06DSo W9/fUI32/9x159gVMMkx3gMTDNRHZRD89tECUbmnnHzLxWBhA3WAhAENFHTYoX78hYgQB000IQMZ VKSoYop3NCEgWS04CFITB3IwEBiVPRBSBgcg9x6FCVgYg1YN0PcRBh4egQACIIropEBclFgiZwlx AcaLE4AnEgdkaTGQHJUlCFIHEpKWgAU4dIDDAkISmZUCYy4pJ5NP1llQDWRIqdtCUcx2WwtGdSVD bzaCZMF7pVHwEkFYLODmm358tMGcSzZpJ39ZcMBBnlk0NMZiYnnZ1QXjQUBFSIjOl5AFRA6GwaWw 4v8Ehqab1uDQHqA24dWBDxDnERY/NpeQCVqpRkOsyIpEBa0cyKgQF9uF5YZQbvCqnkc8TLjAQqyq tlqy4Hp0B7MQyUGbEZ3m9Aavzm4khJnLHbEQBt5+G+69F6lB6x0QvXHuqTmJR15I744W37YKCVEv nAqRgECSSpKQkEw0zWQTQiZ00MEcJJCAwgaWBqAEGiST7JoSKKDQMQodCPEQFiggAAQOOACBQAch E7QGCjRExxoFEjfEBbNaOsRFbbomNEYXTVzgtAwcXMFWQkTxFGgAdxyYIBc+OVR1DUoVZAK8QWag EBYKcEgBBilbdRAPFKjdoZJyumxQBxjkjYHGILL/0cEGgHPccccdmH0QCkIknjgKA20w+OBzzIGB 4Qn5rTcGNANhs8yUI0TCfQuwJjoPDNXArKgPuaiYXQe5wYHTsF9wxhlLTCAZQiGsoHu6AQw6no01 MNiuThB4IIAAahhUB9kJIIwRCgvQIPfcczJeEN6X42xQBhgA7n3kj6NwWkEqhy9Q+ZDP4X3hCWEB xOU017z5kuPfDXrorA22wUJXMEsgRGoAVbvGcJbYOW12S0gg6gjiBt3pzlYCIdV4wEOZyoRNIVrw gPEEcEGC/IF5FqjfRKCHn+lRgG5LCtpA1HQ5DFCHDThImfdmuIHIzcElBkEf4QLgOBJEjobee9VB /9bwPr1lbn5yOkLnBkLC+4jOWyo8iBaY1cGGUAFUVaxBAQ2IwAQmkHcDeYMDV+CgMhwoXb2BwO0U MoENLgEhCphQhY6QoYnw4H7S8xD1EHCE+nVgZjTLG3U01oGUGfJjQBQiQf42ww7wAIiAO2TKSGeQ IsZPc5SilEHu6MQn1stSy6LV8BRypdtcKwBHM+ABu5jAEJzhagLRggNDcBReQTAElfEVQtygweMt kCAI+JF8YmCBKDoEf3g0Id0WuSTNzcw1JsgbIacpSUPub5E0zFs1DTlNvBmEBJdEIqWO4CFKDgR0 nqxXAyyQEH3RSiJauM0E+kAQKmzxAjLQQk+0IP8DL4YgBAD7kgONEEZ2CWQCldnDQqiwwREscSBj SxWFGkABcy4EBasRXTJNWJgOZNI1CGhh9rqpMQxcTCAkTSkhRWokYIpznHr0EEFIKDoLLEwwWjHm QGhFhuRFRAze4V0NDLinguxhCf8MwQUKIgPdlaFQARDYA8ojkCZUxqcJecAGkwbHMhmMQjFQwDUV 4q2aLoACoMsjBVqKARRWaiA8kJkz43czDBSxhWMNAPZEmre6hhRz4XSNwzL5MAogQG7S69kCxoc/ m6pGZjZ9FDsN4oVN5SmgDxFDWXh3h9gV1SAcSGoIYHmBFZShDEVTQ6nEFAAwBYd1CHnDBgVwSoP/ CAEqXoXPMAGh04GQYGEWQMNA0HC/6AwESXo8QmEIiwC7BWANcnWmzQgC2PjJj04CyQBz85pEPSKA cmu6nxDx4FjVUGCmj/KLQcYgpSb8siFa2KxAvBA72B5kDKK91hZMOx7eDeotUNUCekbA2oO04HgC oKpCIIRbECBKt/GhgNsKQoNiDaaOENWodOy2ocR+SCBrSJKc5lAQ6GZyUQHAAHOpowTCKhILMZUe AgyCAJ9pVCAUqJfzBoKVBggpATgwSBba+z+IgKEs9AyAGGK3xoNw4Z+6K3IUzDgeCAZgCZUp2hU0 o2CDcGG2RUtIBhKgl9xCWAEnHcijGmC9ghxh/zCiE6J9QMcVIahVpt+E2BHG2tYj+PnPigRmTA3b OMXeZ8IDwUL+VPMS1WzFIGzwsXwYRhAwmCg7VWzIHsbitNu9TnYFxp0Di3wFXhluC2kUqmZGkBAw INgDsEzI8j5j5uVQWiAmuBCRED0QhXlrxgF4Tk1bI5Dw3ievBEms2oAd7EHTAMUE2YChoyMvgdRY OqwJNEEWUC8eEMtNk6WxfEpjEOxo56EMoULsIJgFMMhBBgpViBfGeC0wHIiWAokCg6zMBc3AGncI bsHLFHCcBiMq0CiIj5B2rLM3HYEEKE6Nt7hCg2FbANrAvN9AgFBchJTExhY4lkDwpxqLUjcrFv8A QqR4SCQLaXsgeEAUdTigHa4CMHbTikgUnFqGC6p2PAQVyBUqE4fOFU+DmQ5ADRAsgCI7ZAMHyEvB Q+PgA2AYAUDqQEJIIEJrN2DiAllYQjpgcR5bnNli0/FAxI4xEvAaAT9ejnMLAqzRhMYAg2AqbaAK ERmscmoQycJpx+Og/0IAqzgSTpcDEAINesDpO0UwBCjSgQOoROoFr3YADvUePEikx0TSSKTfJJhw f7Nep0FAvV4uECWoXWSPunVDFkChA3R9ID2SCtq9ACrMPkR2CQx1QzLAgQN1GctvSa1mQt1GDb53 CyNAMJUo4gcLGMApmI/KAdRM9arn7CBwb1P/AzTybSKZviBCeBQlQa+VNtNdsgLhQewj0gBEYdgg uY/KjglIls86xA1etAT2hRBcUwNi0AVNxStLJRBbwCC8YwSaYXMBQAYb5HtKxnQ5ZxFssAENgBIe eHlRETR/sBcY1xBYRyEawQNBIiRDclM45SZBw35ZgWyJxoIWMlkkACQMxxAJcABUBxU2GAPyARVQ AAVtUAGAQBCaRRZg5BBZgFT/NH0EcQVqMAFLMHi8wisQAFv6FhwjYGUrMAIa5HtUgGB8F0EItoAc oQQW4IFuiBLVBgJ7gW4LEUzvoRE5CCR6uIcJYD0nKB+9JRBAwjAbEB+kIXIPkX8FV4RH+IYV/xAD BNEFnHYBVvYQciBauqRkZ8BfWaiFlTF9W6YZpyaGGtSEWoBgoeYGTJeJG2ECBnACsHgCHigs15cS KjERCNB9DoaHD9aLvShEdpgcc1cQiEKI7wECO7gQelGERuiIbxiL27dTsUOHCnEBULYCF7QFNNKJ B8IgDOIrXaAZZTAQUeB4HlCJAfAGCIZvA1GGxzMCgOcRSlABL/ACsXgCBiAQzjgRR7AXeEhruhiQ 3QdsR0AaVDeMBNF9UEGIe5GMClGLzuiB9xiL9fgC+TgQfjc7wscQO+dAZ0AQvpOF3rgCZJB4wnEt HOB4angFs7VEUSB5BfEAZugQJgBOCpAAWv/HEDQgAjwpAvV4Avo4kSdAjQlBAcwYFcJFAgW3lLqH Y3uBkAOxF8JiHHpxfgwBkUIJixW5lT0pAhcZQV40gA3RBaZlRli1B54IASHQAmqgBW+Qc2Kwag5y AY4HVV0AkwWxBUxHEOqIYElXEAhQAiVgBw5QmMKyEDzABEzQlSJgFRXAk1t5ewtBAY4oXELwhm2Q mcy4mZvZlAFAAU+ZEMyYmW0gLBvgiLJ3lVq5lRXJmF2pmEzwlV4gWvwSERI0Hv/jBWXAIGVABRlY EFRAFx4weQOhVcZTNGSQhgcBAQh2NTKAYG/EEDhQBIJZnV+pEHVQmIWZB4r5EgawmF0pXBH/QQFC KVw8gJoTQZlvCJX6+IbCQgIocY+QCBEGwJgvQBH4lVT+xxDrYnxT0wUMcgGjJBAyoJIDoZcIVmQX gGBkcBAh4JdQMlvvdRBzoAIWWgQYWgJEKRDZqZ3a+RIHoJ3cyQSBGADedhA0wJovIFxK8JOxeJgQ QQNCyZ4BIJTzaQIqep3fhHEgAJuwmWYPIUujFhEywCBQdQYD9gCxZhAr0EtQ9ZIQKhAyeTxhNhAT gGC342rH4wEDShAm8AFgaqEWSoObJJiEqZ0C0QAeWphoVxANwAQnEAPYFQAL4Jri+QKMCQITsQAq SqOumQDZ5ZovwGsxoZgGYAEb8BJquqbf/3cQVHBaZvSXCNGF5wFBXrBqUngQXsB0WsZ0U4Ogx9OE AsEBCEYcD3o8EqgQRSABrAqmH6CjB0EBGEqdgikCOGam2jmfB1EBa/oCNrEAIpoHeSCeUOCjTHCf ElGnjEmjxsoEgCoQJwCbwpoHJudba+oAZ3WtZMoQ2zge8cgQLSAcdPGRAiFbjoeOQsZ0RXaXx0Oc AQClx4OuAcCuAqAb8EpbD1EBrLqvrEqjAcAGDiCmYnqRJDCr1ekACKEE1wqUdHqt4pkA18qePUgD JACkwLqmNHqt0RgAIbqm53UQF1uYdmAHCIAC1VmdqYlSIsBmXUcqb8GODZEFq+YBvCMG5v/4rQbx nFE6gcopdEyHbmKAYPxCqsezeAuxABEQAXQwA0wrAUxAjQrgqlLLMFhQBAJroe7HYycrmM+6ACc7 suJ5BNeasmsgAh5qAAtwMSGrnRm7pht7sSNrByVgqwfxAieLoUKgBLNqtSqAsAcRA1LrAAkgngHA IBu5S0enQTCrpQLAagqRAdGHYIC3oMfToAJBr+5aEGOAYE0AfQhWpYiZtKIruidwezTAr/w6Vi8g tWDqABiXASJwtSoAbBawtxgqnjywtSXgAPd3PrpLt5unuzSquxsrBIJpuzvYAbJbAjbxAirAukFW EBlQAqgrAXbjBuI6AmeYELPpeMfjdKf/uKULwbgCkLnMSaUDkZzHo4YFoYrHMwFZwHRLuhAOoAH2 qwGjKwEKgAdKkAFxxQRJSwdL27QSQDkLUL0SUAEotgYHwLpgehoWILuEG7BXq6NscAK2WwSHWbu2 S6Oye50UfLXRG3924MDR2ADVqwLUccASwLQzQAcqEEb+BroHsXNMJwChFr/NKWbnezzRGQAZoK4D QbkCYLkHAZ1XejxBBxFHQABO7MT3G8X4O7pUHAGB4KUt7ML7qsE15gAIzLABoACo+wGEG7UObACn gQUG4MAfoEJmLLU0esYE0QCuironQANAkAAfgMA5yQP86sIloEIIQAdV/KxRZY6QR1lq/zBb7xhr m4tgE0qgN8xaS7ezPUzDwPGOQhwRGSABT/zJoEwAUizFJmcAVXzKAuzCMzDCYoy65mQCCMyq9agC CAy8YVy9NFq91wnLsbyvqvzCdFAEJ/UCpxwBdsAEKiC6pDwQasB0meYFNZAFd7AEN4xgogqqCYaz rVXNsBW0kptdm3wQ1HzDmQsRCBDK6JzOBACrPBABUlzMo1sCE6YAVWxRBiDAqfzL+sy0ORl2+kyj v0wHOtoA8AzPO4YC7jzKUgzKFUAQSVzNEB3RmTrETCeB0ALRXOWOAqAj+ebMCaGzTDfRD/EC6lzS BDADtxcD6KzQ9xto9EzFFgXLBV3FyP+6dlXseQhRxW1QEEogAVXM0varAktE0ib9yRrgGisQ0Up9 w9s7EOGLYCvQBWIwRZG70acqALClvjg8EFfgqe1Uzb8ZEUrwAUWNztu6Bg5Q1k6sowpg1BpgcggA 1KMsAdShAKOM0wcxyg1dEBtgv2qN1zExA2pNAAzHyEsN0RZIEKh22OXbJ6hI0cdjlwjG0QhBvgLA vhNhAiow2KLczwcx1mXNBBjX1qBcrQ1Q1hpAg6T9yYBdEKG814Cp1m3aaxFQ1nrKQIwd0StQWwfR 1UsNAbZCtAk2ED1cVFqN2QWhw6WKEXXQBmpdAtVqEErABCZdAUAaxqEc3TSgASU9A73/tdpP3NoE 8doIgQG1rc4RwHpwtdklnZq+ndtpyIoJQa/VvAI5R68eAM4JCtlFrBCV/I7aPBGXWdIiMMImSNah 7ADbKraMijEGwN2gHAEx0LsDweAeGt0Cca0wKjYHAOGfHAG2xxAZYAGeHMoiAJVZIFoqLlpLQAZ3 IAbzuxBZ0MPvSAWAl5//FBRuIFoZOAFJFcnzxXRNbRFYIG3yYQHiQxFCcATLQQM4IJkUUeS0lwAI sAGE2hUwc5MNUOVXrhB4cIIWgAFQ3hVXQAUuLjU48d4CIK/40uZu/uYEYQTrCOd0Xudu7gWztZ92 vud8LiL43aV9HuiCnhNTKgCpOuiI/57oIqHc+Krojv7oHbHYRQvplF7pFHEHTAfklr7plT4rWqAF RFy+Ac7ppP7own3DiQ0RA7DqrN7qrv7qsB7rsj7rtF7rtn7ruJ7rur7rvN7rvh7r6QvREGA2ul4Q YVAAyJ7syr7szN7szv7s0B7t0j7t1F7t1n7t2J7t2r7tzB4GGAnRxOEC1j4ABPHr5n7u6J7u6r7u 7N7urm6l1WzExV7q9A7noY489Z7vlu4F2DEBasDm+h7wAj/wBF/wBn/wCJ/wCr/wDN/wDv/wEC8U GdADPRDxg54BOmADBYEEO8ACgT4AOsAAOyARPVAAAnEDVjARMJACCpECQyARKTAFsP/yA0jwJEPA ADUvECywA2Yg6C7AADkwEUnwBCef8hKx8grBAC4gEQzA8pdC83XyBB0vEDYgBQPBAlMQ9ALhAxW/ 9R4fAD0w8VpPED4wBWFP9mZPED1A7gKx9gGQAz7gA0NgODkwBGMPxEMwBGxP9kjAAD3gAwKRA2mf XRVv9wSRAzeQBhWP8hkwBF0/EGX/+AWB9Dpv9obTAwxQBVo/8VOw9wEQ+ZeP83cfACwwACzw+D0w BYA/EI0/BKtP+KpfEKl/9gFg+o2/+nL/+DQ/AINfEKZP+rGv9sGfA19P+qs/8Vvv+ESJ8TcQAEgA A0HvA1KwAzbAAElgNlUAAwNRBTr/UPsMkAYi7/kcbwNEQARdz/E/AAM6UPEDoPQC0f5L7wRJsAMM UAADMP82sANOIBBhoP46AAMAESbAwIEFdDCwUSDAEwY/dvzIESAHAycMYBBcCIOIlAA3pMCw0XDA QCsNYUDEOBBGigA+bIAkAqNHgJA6rAQYQoSIjh0KAxTYYUMHDBcBpDCwmVJHRQYscvw4yQDOwCEn HVahqvPqQBY6iLwkEjHFjxsMkgRA8pDIDx8BfnwMeSNDyhRE0sDgyTJAD68Ozfy8GGAAxYEpdAQw E3TokJQphzBI7DMJW4lEngSoEhjz4cE2fLDAOHjKQClOAqRgUDSDEyIZBhcVnDpA/0UXPgY80RGR xY4UPnbcRLwjIkbUAxPPzCDlh0QGUgaAxpjkckcYoHP0PL2DcYYkNxqvDPDFxtwMP74MlD0AxnTU oMGH9x6AgV6MXlmAtiFl7hDeRqdi3iGADIg4L4AwGGAsCY5aIuIm1ODwIYcpGBAogxvScIsI0FiY jy6pBnLisACWmmvCKQZjzIUdiADxiQx2gC2JsxrDiCEMY6MPiYsyI6gKzhjAKqXBnJiJIBkJ8iG1 1wZa0gkbCIIBCYKGyMEMzQIgIkiCiqNpOpwY6GEi+qKb7oYCabpJihv3aiol8HJoS7Aj5SsKtbkG +uEmIpJgDKMOlZqOwz5nO0s5F//uNJCBkQayYSoW4vThhstQi/OJ+AK4zy0vf5CSOAbiLG7C4Yw6 74abnmDIvUN3SGNQGjESlCswCTpwAB4H8jE22OgiggHLIvrhv4F2qGJJXWe7MQMKU2KIAWedFbYw BlTS8rWJikxJuoFMJYjbg551djSMwMsAiRuI2AGGGWVDAlxnTZviIBicgO7P+oJ0wd2GMA1phyRG M0NfDAew4gYY0p00QNJMS4lTghz2lKB8f9KXI3NHdOGHKqqay4VeCYTuVUwRlHXQAqa9dbNjXx3C ip06OlPZAoxtkmFl6cshAziWE/m0abHslLkpJgqZzG2B6+imYHsOALw0dKhiJif/1i3KDBZfZQEJ qOaylyCoB8p31JRyqKKsHqpQOKUbfkhhJikm1SyJNQdoC2K3gpZW4mntbIzDHnbIwIo04GCYKiS8 QpTGWAdqkKA0nkwBcBB/3JWgHm5Y1E7c7swXNAZ8mrAoJwq34UxT22Pyhsp9Hqi7HhUlmkZtk+72 pi90uHMKGxaFkiXIHqY6ABMHSq43G6Droc3+lApyAGIJciJNgQSc7zHYkisgSb0ygOG8FDRDorWB Dr/7YbxZB3taDulL4q8RpfDOBbxYysGG4SaME2uScWXAijAYKkqS0lCAJ7zMWBjJgA6kEIYw2OAs OdhIGKzEsCRAzQwOEV3h8gUH/xd8AQYRuYEOCuCCEPIub3vZgRPCkJabxK4xIZISt44mEXWFoQAE +g5LbGCDKUwhCTCITwQDkIQsuUAKRGjL2lJgRJ4R4QbT85qWrLADJHRQO+HJ0hScAIO2pIEIZnAB ESOiwCGQEAYY+h5BBrARF0SmfHg6H5cCMLHwwACMd4FOSaT0oh0siiwMvMGlXuWDL4gtjDZoFUGm IIVGtUxAXygaQXLwhB1a4U45EM8NtERIB7LACqApgE8G4kMb0It4BbPBE/I3pTOxwElS0MsAvrBK grBAQRkwAxRzyZVMmiFxA3kCY3LwyhQMYTphuMFUynWDVA7HB3DYoSoHgsxoBWfACuIqCCPTUKRl lhI6uGRmIbnyuCS4wAVTMSZGMJmf6VWRIO7EyBBaeaYqMNKUvIQOEtzXEko2yoRMA2hABTpQghbU oAdFaEIVulCGNtShD4VoRCU6UYpW1KIXxWhGNbpRjnYUoQEBADs= ------=_NextPart_000_0047_01C65EF4.40AC6970 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://216.139.227.236/pan/adview.php?what=zone:1&n=a9c24d0f R0lGODlhAQABAIAAAAQCBAAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw== ------=_NextPart_000_0047_01C65EF4.40AC6970 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.sciencedaily.com/scripts/google-topics.js function google_ad_request_done(google_ads) { =20 if (google_ads.length > 0) { var ad_unit =3D '

'; if (google_info.feedback_url) { ad_unit +=3D 'Ads by Google'; } else { ad_unit +=3D 'Ads by Google'; } ad_unit +=3D '

Advertise on this = site

'; if (google_ads[0].type =3D=3D 'text') { for (var i =3D 0; i < google_ads.length; ++i) { ad_unit +=3D '

' + google_ads[i].line1 + = '
' + = google_ads[i].line2 + ' ' + google_ads[i].line3 + '
' + google_ads[i].visible_url + = '

'; } } if (google_ads[0].type =3D=3D 'image') { ad_unit +=3D '

'; } ad_unit +=3D '

'; } document.getElementById("google-rectangle").innerHTML +=3D ad_unit; } google_ad_client =3D "pub-1787672658759074"; google_ad_output =3D "js"; google_max_num_ads =3D "5"; google_feedback =3D "on"; google_ad_width =3D 300; google_ad_height =3D 250; google_ad_format =3D "300x250_as"; google_ad_type =3D "text_image"; google_ad_channel =3D "7225681903"; ------=_NextPart_000_0047_01C65EF4.40AC6970 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://pagead2.googlesyndication.com/pagead/show_ads.js (function(){=0A= function m(b){return b!=3Dnull?'"'+b+'"':'""'}=0A= function B(b){if(typeof encodeURIComponent=3D=3D"function"){return = encodeURIComponent(b)}else{return escape(b)}}=0A= function c(b,a){if(a){window.google_ad_url+=3D"&"+b+"=3D"+a}}=0A= function g(b,a){if(a){c(b,B(a))}}=0A= function l(b,a,d){if(a&&typeof = a=3D=3D"object"){a=3Da[d%a.length]}c("color_"+b,a)}=0A= function D(b,a){var d=3Db.screen;var f=3Dnavigator.javaEnabled();var = e=3D-a.getTimezoneOffset();if(d){c("u_h",d.height);c("u_w",d.width);c("u_= ah",d.availHeight);c("u_aw",d.availWidth);c("u_cd",d.colorDepth)}c("u_tz"= ,e);c("u_his",history.length);c("u_java",f);if(navigator.plugins){c("u_np= lug",navigator.plugins.length)}if(navigator.mimeTypes){c("u_nmime",naviga= tor.mimeTypes.length)}}=0A= function = y(b){b=3Db.toLowerCase();if(b.substring(0,3)!=3D"ca-"){b=3D"ca-"+b}return= b}=0A= function = G(b,a,d){d=3Dd.substring(0,1000);d=3Dd.replace(/%\w?$/,"");if(b.google_ad= _output=3D=3D"js"&&(b.google_ad_request_done||b.google_radlink_request_do= ne)){a.write('

Growth Factor-promoting Angiogenesis Expressed In Tumor Cells And = Normal=20 Neurons