From: Subject: Secret to long life in lifestyle not genes Date: Tue, 13 May 2008 17:05:44 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C8B51B.948619E0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5512 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C8B51B.948619E0 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.news-medical.net/print_article.asp?id=38037 Secret to long life in lifestyle not genes

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Secret to long life in lifestyle not = genes

Published: Monday, 5-May-2008 =

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Medical Research News

A research on the bone health of one of the oldest = persons=20 in the world, who recently died at the age of 114, = reveals=20 that there were no genetic modifications which could = have=20 contributed to this longevity.

The research team, directed by Universitat Aut?a de Barcelona = professor=20 Adolfo D? P=E9rez, pointed out a healthy lifestyle, a=20 Mediterranean diet, a temperate climate and regular = physical=20 activity as the reasons for his excellent health.

The research team studied the bone mass and = analysed the=20 genetics of a man with enviable health who at the time = of the=20 study was 113 years old. The research was carried out = with=20 four other members of his family: a 101-year-old = brother, two=20 daughters aged 81 and 77, and a nephew aged 85, all of = them=20 born and still living in a small town of the island of = Menorca. The research findings were recently published = in the=20 Journal of Gerontology and reported that the man's = bones were=20 in excellent conditions: his bone mass was normal, = there were=20 no anomalous curvatures and he had never sustained a=20 fracture.

With regard to the genetical analyses, researchers = were=20 unsuccessful in finding any mutations in the KLOTHO = gene,=20 which is generally related to a good level of mineral = density=20 and therefore healthy bones. Neither did they find any = mutations in the LRP5 gene, which is associated with=20 longevity. None of the members of the family who = participated=20 in the study presented any mutations in this gene.

The results of the research do not rule out the = possibility=20 that other genetic mutations could positively = influence=20 longevity. However, researchers do point out the fact = that the=20 excellent health of this family, and of the = 113-year-old man=20 in particular, is probably due to a Mediterranean = diet, the=20 temperate climate of the island, a lack of stress and = regular=20 physical activity. The article underlines the fact = that until=20 the age of 102, the man cycled every day and looked = after the=20 family orchard.

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