| 1: AJNR
Am J Neuroradiol. 2006 Jun-Jul;27(6):1362-9. |
|
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Apparent diffusion coefficients for differentiation of
cerebellar tumors in children.
Rumboldt Z, Camacho DL, Lake D, Welsh CT, Castillo
M.
Department of Radiology, Medical University of South Carolina, 169 Ashley
Avenue, Charleston, SC 29425, USA.
BACKGROUND AND PURPOSE: Diffusion-weighted imaging (DWI) and apparent
diffusion coefficient (ADC) maps provide information at MR imaging that may
reflect cell attenuation and integrity. We hypothesized that cerebellar
tumors in children can be differentiated by their ADC values. METHODS: Brain
MR imaging studies that included ADC maps were retrospectively reviewed in
32 patients with histologically proved cerebellar neoplasm. There were 17
juvenile pilocytic astrocytomas (JPA), 8 medulloblastomas, 5 ependymomas,
and 2 rhabdoid (atypical teratoid/rhabdoid tumor [AT/RT]) tumors. Absolute
ADC values of contrast-enhancing solid tumor regions and ADC ratios (ADC of
solid tumor to ADC of normal-appearing white matter) were compared with the
histologic diagnosis. ADC values and ratios of JPAs, medulloblastomas, and
ependymomas were compared by using a 2-tailed t test and one-way analysis of
variance (ANOVA). RESULTS: ADC values were significantly higher in pilocytic
astrocytomas (1.65 +/- 0.27) (mean +/- SD) than in ependymomas (1.10 +/-
0.11) (P = .0003) and medulloblastomas (0.66 +/- 0.15) (P < .0001).
Ependymomas demonstrated significantly higher ADC values than
medulloblastomas (P = .0005). The observed differences were statistically
significant on ANOVA (P < .001). ADC ratios were also significantly
different among these 3 tumor types. AT/RT ADC values were similar to
medulloblastoma. The range of ADC values and ratios within JPAs and
ependymomas did not overlap with that of medulloblastomas. CONCLUSION:
Assessment of ADC values of enhancing solid tumor is a simple and reliable
technique for preoperative differentiation of cerebellar tumors in pediatric
patients. Our cutoff values of >1.4 x 10(3) mm(2)/s for JPA and <0.9 x
10(3) mm(2)/s for medulloblastoma were 100% specific.
PMID: 16775298 [PubMed - indexed for MEDLINE]
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| 2: AJNR
Am J Neuroradiol. 2006 Jun-Jul;27(6):1307-11. |
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Focal T2 hyperintensity in the dorsal brain stem in
patients with vestibular schwannoma.
Okamoto K, Furusawa T, Ishikawa K, Sasai K, Tokiguchi
S.
Center for Integrated Human Brain Science, Brain Research Institute, Niigata
University, 1-757 Asahimachi-dori, Niigata 951-8585, Japan.
BACKGROUND AND PURPOSE: The vestibular nucleus cannot be visualized on MR
imaging, but some patients with vestibular schwannoma show a tiny area of
hyperintensity in the dorsal brain stem on T2-weighted images. The aim of
this study was to determine whether this tiny area is characteristic of
vestibular schwannoma. METHODS: We retrospectively reviewed the
postoperative MR images of 53 patients with cerebellopontine angle tumor. MR
images were obtained with a 1.5T scanner. Spin-echo pre- and postcontrast
3-mm-thick T1-weighted axial images, 3-mm-thick fast spin-echo (FSE)
T2-weighted axial images, and 0.8-mm-thick constructive interference in
steady state (CISS) axial images were acquired. Surgical and histopathologic
diagnosis was vestibular schwannoma (41/53 = 77%), meningioma (7/53 = 13%),
epidermoid cyst (3/53 = 6%), glioma with exophytic growth (1/53 = 2%), and
chordoma (1/53 = 2%). RESULTS: A tiny area of hyperintensity was observed at
the lateral angle of the fourth ventricle floor in 6 patients (3 men, 3
women; age range, 24-54 years; mean age, 43 years) with vestibular
schwannoma larger than 2 cm in maximal diameter on both FSE T2-weighted and
CISS images. Preoperative MR images with the same pulse sequences showed the
same area of hyperintensity in all these patients. CONCLUSION: Because the
location of the area of hyperintensity is coincident with the vestibular
nucleus, the hyperintensity may represent degeneration of the nucleus. This
hyperintensity should not be confused with a postoperative lesion or a small
infarction. If such hyperintensity is seen in a patient with a large
cerebellopontine angle tumor, a diagnosis of vestibular schwannoma is
suggested.
PMID: 16775286 [PubMed - indexed for MEDLINE]
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| 3: AJNR
Am J Neuroradiol. 2006 Jun-Jul;27(6):1204-10. |
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Two patients with intraspinal germinoma associated with
Klinefelter syndrome: case report and review of the literature.
Nakata Y, Yagishita A, Arai N.
Department of Neuroradiology, Tokyo Metropolitan Neurological Hospital,
2-6-1 Musashi-dai, Fuchu, Tokyo 183-0042, Japan.
We report 2 cases of intraspinal germinoma associated with Klinefelter
syndrome. In one patient, spinal cord atrophy was observed at the upper and
lower ends of the intraspinal tumor. Brain atrophy was observed in both
cases. Germinoma should be included in the differential diagnosis if an
intraspinal tumor is observed in a patient with Klinefelter syndrome.
Publication Types:
PMID: 16775265 [PubMed - indexed for MEDLINE]
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| 4: Eur
J Cancer. 2006 Jun;42(9):1298-308. Epub 2006 May 12. |
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Neural stem cells as novel cancer therapeutic vehicles.
Yip S, Sabetrasekh R, Sidman RL, Snyder EY.
Department of Pathology & Laboratory Medicine, Vancouver General
Hospital, University of British Columbia, Vancouver, BC, Canada.
The startling resemblance of many of the behaviours of brain tumours to the
intrinsic properties of the neural stem/progenitor cell has triggered a
recent dual interest in arming stem cells to track and help eradicate
tumours and in viewing stem cell biology as somehow integral to the
emergence and/or propagation of the neoplasm itself. These aspects are
reviewed and discussed here.
Publication Types:
PMID: 16697638 [PubMed - indexed for MEDLINE]4
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| 5: Eur
J Cancer. 2006 Jun;42(9):1237-42. Epub 2006 May 2. |
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Brain cancer stem-like cells.
Kondo T.
Centre for Brain Repair, University of Cambridge, Cambridge CB2 2PY, UK.
tkondo@cdb.riken.jp
Both stem cells and cancer cells are thought to be capable of unlimited
proliferation. Moreover, many tumours and cancer cell lines express stem
cell markers, including adenosine triphosphate (ATP)-binding cassette
transporters, by which the cells pump out specific fluorescent dyes as well
as anti-cancer drugs, suggesting either that cancer cells resemble stem
cells or that cancers contain stem-like cells. Using the common
characteristics of brain tumour cells and neural stem cells, several
research groups have succeeded in identifying stem-like cells (cancer
stem-like cells) in brain tumours and brain cancer cell lines. The purified
cancer stem-like cells, but not the other cancer cells, self-renew and form
tumours when transplanted in vivo. Thus, cancer stem-like cells in brain
tumours might be a crucial target for anti-brain tumour therapy.
Publication Types:
PMID: 16632342 [PubMed - indexed for MEDLINE]4
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| 6: Int
J Cancer. 2006 Sep 1;119(5):1136-44. |
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Brain cancer mortality and potential occupational
exposure to lead: findings from the National Longitudinal Mortality Study,
1979-1989.
van Wijngaarden E, Dosemeci M.
Division of Epidemiology, Department of Community and Preventive Medicine,
University of Rochester School of Medicine and Dentistry, NY 14642, USA.
edwin_van_wijngaarden@urmc.rochester.edu
We evaluated the association between potential occupational lead exposure
and the risk of brain cancer mortality in the National Longitudinal
Mortality Study (NLMS), which is a prospective census-based cohort study of
mortality among the noninstitutionalized United States population
(1979-1989). The present study was limited to individuals for whom
occupation and industry were available (n = 317,968). Estimates of
probability and intensity of lead exposure were assigned using a
job-exposure matrix (JEM). Risk estimates for the impact of lead on brain
cancer mortality were computed using standardized mortality ratio (SMR) and
proportional hazards and Poisson regression techniques, adjusting for the
effects of age, gender and several other covariates. Brain cancer mortality
rates were greater among individuals in jobs potentially involving lead
exposure as compared to those unexposed (age- and gender-adjusted hazard
ratio (HR) = 1.5; 95% confidence interval (CI) = 0.9-2.3) with indications
of an exposure-response trend (probability: low HR = 0.7 (95% CI = 0.2-2.2),
medium HR = 1.4 (95% CI = 0.8-2.5), high HR = 2.2 (95% CI = 1.2-4.0);
intensity: low HR = 1.2 (95% CI = 0.7-2.1), medium/high HR = 1.9 (95% CI =
1.0-3.4)). Brain cancer risk was greatest among individuals with the highest
levels of probability and intensity (HR = 2.3; 95% CI = 1.3-4.2). These
findings provide further support for an association between occupational
lead exposure and brain cancer mortality, but need to be interpreted
cautiously due to the consideration of brain cancer as one disease entity
and the absence of biological measures of lead exposure. Copyright 2006
Wiley-Liss, Inc.
PMID: 16570286 [PubMed - indexed for MEDLINE]4
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| 7: J
Clin Oncol. 2006 Aug 20;24(24):4037; author reply 4037-8. |
|
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Influence of whole-brain radiotherapy on remission of
brain metastases.
Nieder C.
Publication Types:
PMID: 16921062 [PubMed - in process]3
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| 8: J
Clin Oncol. 2006 Aug 20;24(24):3871-9. |
|
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Phase III trial of carmustine and cisplatin compared with
carmustine alone and standard radiation therapy or accelerated radiation
therapy in patients with glioblastoma multiforme: North Central Cancer
Treatment Group 93-72-52 and Southwest Oncology Group 9503 Trials.
Buckner JC, Ballman KV, Michalak JC, Burton GV, Cascino
TL, Schomberg PJ, Hawkins RB, Scheithauer BW, Sandler
HM, Marks RS, O'Fallon JR; North Central Cancer
Treatment Group 93-72-52; Southwest Oncology Group 9503 Trials.
Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA. buckner.jan@mayo.edu
PURPOSE: In patients with newly diagnosed glioblastoma multiforme, to
determine whether cisplatin plus carmustine (BCNU) administered before and
concurrently with radiation therapy (RT) improves survival compared with
BCNU and RT and whether survival using accelerated RT (ART) is equivalent to
survival using standard RT (SRT). PATIENTS AND METHODS: After surgery,
patients were stratified by age, performance score, extent of surgical
resection, and histology (glioblastoma v gliosarcoma) and then randomly
assigned to arm A (BCNU plus SRT), arm B (BCNU plus ART), arm C (cisplatin
plus BCNU plus SRT), or arm D (cisplatin plus BCNU plus ART). RESULTS: Four
hundred fifty-one patients were randomly assigned, and 401 were eligible.
Frequent toxicities included myelosuppression, vomiting, sensory neuropathy,
and ototoxicity and were worse with cisplatin. There was no difference in
toxicity between SRT and ART. Median survival times and 2-year survival
rates for patients who received BCNU plus RT (arms A and B) compared with
cisplatin, BCNU, and RT (arms C and D) were 10.1 v 11.5 months,
respectively, and 11.5% v 13.7%, respectively (P = .19). Median survival
times and 2-year survival rates for patients who received SRT (arms A and C)
compared with ART (arms B and D) were 11.2 v 10.5 months, respectively, and
13.8% v 11.4%, respectively (P = .33). CONCLUSION: Cisplatin administered
concurrently with BCNU and RT resulted in more toxicity but provided no
significant improvement in survival. SRT and ART produced similar toxicity
and survival.
PMID: 16921039 [PubMed - in process]3
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| 9: J Neurochem.
2006 Sep;98(5):1497-506. |
|
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RNA interference targeting protein tyrosine phosphatase
zeta/receptor-type protein tyrosine phosphatase beta suppresses glioblastoma
growth in vitro and in vivo.
Ulbricht U, Eckerich C, Fillbrandt R, Westphal M,
Lamszus K.
Department of Neurosurgery, University Medical Center Hamburg-Eppendorf,
Hamburg, Germany.
The protein tyrosine phosphatase zeta/receptor-type protein tyrosine
phosphatase beta (PTPzeta/RPTPbeta) and its ligand pleiotrophin (PTN) are
overexpressed in human glioblastomas. Both molecules are involved in
neuronal cell migration during CNS development. In addition, PTN can induce
glioma cell migration which is at least in part mediated through binding to
PTPzeta/RPTPbeta. To study the relevance of this ligand-receptor pair for
glioma growth in vitro and in vivo, we transfected the human glioblastoma
cell line U251-MG with small interfering RNA (siRNA) directed against
PTPzeta/RPTPbeta. Stable siRNA transfection resulted in strong
down-regulation of PTPzeta/RPTPbeta expression. When injected subcutaneously
into nude mice, clones that expressed normal levels of PTPzeta/RPTPbeta (PTPzeta
+ clones) formed exponentially growing tumours, whereas tumour growth was
almost completely abrogated for clones that expressed reduced PTPzeta/RPTPbeta
levels (PTPzeta - clones). Similar results were obtained using an orthotopic
intracerebral model. Proliferation of PTPzeta - cells in vitro was
significantly reduced compared with that of control clones.
Matrix-immobilized PTN stimulated the proliferation of PTPzeta + cells but
not of PTPzeta - cells. Haptotactic migration induced by PTN was reduced for
PTPzeta - clones compared with control clones. Our findings suggest that
antagonization of PTPzeta/RPTPbeta expression can inhibit glioma growth in
vivo and may thus represent a potentially promising treatment strategy.
PMID: 16923162 [PubMed - in process]
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| 10: J
Neurol Neurosurg Psychiatry. 2006 Sep;77(9):1099-100. |
|
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Misoplegia: a review of the literature and a case without
hemiplegia.
Loetscher T, Regard M, Brugger P.
Publication Types:
PMID: 16914766 [PubMed - indexed for MEDLINE]
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| 11: J
Neurol Neurosurg Psychiatry. 2006 Sep;77(9):1097. |
|
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Neurogenic pulmonary oedema in a patient with
leptomeningeal carcinomatosis.
Dammers R, van den Bent MJ.
Publication Types:
PMID: 16914765 [PubMed - indexed for MEDLINE]
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| 12: J
Neurol Neurosurg Psychiatry. 2006 Sep;77(9):1078. |
|
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Neurological picture. Torcular Erdheim-Chester disease.
Gazzeri R, Galarza M, Amoroso R, De Bonis C, D'Angelo
V.
Department of Neurosurgery, San Giovanni Addolorata Hospital, Rome, Italy.
robertogazzeri@gmail.com
Publication Types:
PMID: 16914757 [PubMed - indexed for MEDLINE]
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| 13: J Neurooncol.
2006 May;78(1):41-6. Epub 2006 Mar 31. |
|
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Predicting which children are at risk for ependymoma
relapse.
Sowar K, Straessle J, Donson AM, Handler M, Foreman
NK.
University of Colorado at Denver and Health Sciences Center (UCDHSC) and
Denver Children's Hospital, Denver, Colorado 80045, USA.
Ependymomas account for 6-12% of all pediatric intracranial tumors. Despite
complete resection and radiation, about 50% of patients relapse and have
subsequent dismal prognoses. As no clinical findings reliably forecast tumor
recurrence, we sought to determine if gene expression profiling could be
used to distinguish patients at high risk for relapse at initial diagnosis,
and thereby make them candidates for innovative treatments at an early
stage. We extracted RNA from 13 ependymoma specimens: 7 from patients who
experienced tumor recurrence, and 6 from patients who have not recurred. RNA
was applied to Affymetrix HG-U133 plus 2.0 microarray chips, and microarrays
were analyzed with GeneSpring 7.0 and Prediction Analysis of Microarrays
(PAM) software. The 3-gene subset of PLEK (pleckstrin), NF-kappaB2 (nuclear
factor kappa beta-2), and LOC374491 (TPTE and PTEN homologous inositol
phosphatase pseudogene) was identified as the minimal subset capable of
accurately distinguishing tumors according to recurrence. In summary, gene
expression profiling may be valuable, perhaps in combination with clinical
findings identified in some studies, for identifying children at high risk
for ependymoma relapse.
PMID: 16575538 [PubMed - indexed for MEDLINE]3
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| 14: J Neurooncol.
2006 May;78(1):59-62. |
|
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Development of contrast enhancement after long-term
observation of a dysembryoplastic neuroepithelial tumor.
Jensen RL, Caamano E, Jensen EM, Couldwell WT.
Department of Neurosurgery, University of Utah, Salt Lake City, Utah
84132-2303, USA. randy.jensen@hsc.utah.edu
Dysembryoplastic neuroepithelial tumors (DNET) are usually benign lesions
that arise in cortical regions and are discovered after new onset of
seizure. These lesions have many different imaging characteristics. We
report a patient with a presumed low-grade medial temporal lobe lesion that
was followed for many years without any change in size or imaging
characteristics. This previously non-enhancing tumor evolved to become
contrast enhanced on routine imaging without apparent tumor growth. The
patient underwent surgery, and the pathology was confirmed as a DNET with no
atypical changes. This case demonstrates the potential that DNETs may
exhibit a changing MRI pattern over time. Natural history, imaging
characteristics, and management are reviewed.
PMID: 16314940 [PubMed - indexed for MEDLINE]
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| 15: J Neurooncol.
2006 May;78(1):63-9. Epub 2005 Nov 29. |
|
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Hypofractionated radiotherapy boost for dose escalation
as a treatment option for high-grade spinal cord astrocytic tumor.
Katoh N, Shirato H, Aoyama H, Onimaru R, Suzuki
K, Hida K, Miyasaka K, Iwasaki Y.
Department of Radiology, Hokkaido University School of Medicine, Sapporo,
Japan. noriwo@radi.med.hokudai.ac.jp
PURPOSE: To retrospectively analyze the outcome of post-operative
radiotherapy for spinal cord glioma with the emphasis on the
hypofractionated radiotherapy boost for dose escalation as a treatment
option for high-grade spinal cord astrocytic tumors. MATERIALS AND METHODS:
Forty-one patients with spinal cord glioma received post-operative
radiotherapy between 1979 and 2003. The median age was 34 years (range,
10-66 years). Median follow-up was 49 months (range, 5-291 months). There
were 12 low-grade astrocytic tumors, 11 high-grade astrocytic tumors, 16
low-grade ependymal tumors and 2 high-grade ependymal tumors. Among 11
patients with high-grade astrocytic tumors, 5 with anaplastic astrocytoma
and 1 with glioblastoma received hypofractionated radiotherapy boost for
dose escalation. The median total dose of the conventional radiotherapy was
45.5 Gy in 19 fractions (range, 30.0-60.0 Gy). The median normalized total
dose (using daily dose of 2.0 Gy and an alpha/ per thousandbeta ratio of
2.0) of the hypofractionated radiotherapy boost was 131 Gy2 (range, 85-249).
RESULTS: The Kaplan-Meier survival rates at 10 years from the date of the
first surgery were 64% for the entire group, 47% for the astrocytic tumors
and 84% for the ependymal tumors, respectively (P=0.009). Among 11 patients
with high-grade astrocytic tumors, the actuarial survival rate at 10 years
was 35%. The actuarial survival rates at 10 years were 67% for those who
received hypofractionated radiotherapy boost for dose escalation, and 20%
for those who did not (P=0.47). DISCUSSION: The results for ependymal tumors
and low-grade astrocytic tumors were comparable to those reported in the
literature. Hypofractionated radiotherapy boost for dose escalation may help
to prolong the survival of patients with high-grade astrocytic tumors.
PMID: 16314938 [PubMed - indexed for MEDLINE]3
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| 16: J Neurosurg.
2006 Aug;105(2):159-60; author reply 160. |
|
Craniopharyngioma.
Fraioli MF, Contratti F.
Publication Types:
PMID: 16922083 [PubMed - in process]
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| 17: J Neurosurg.
2006 Aug;105(2):134-9. |
|
Intracranial aneurysm following radiation therapy during
childhood for a brain tumor. Case report and review of the literature.
Sciubba DM, Gallia GL, Recinos P, Garonzik IM, Clatterbuck
RE.
Department of Neurosurgery, The Johns Hopkins School of Medicine, Baltimore,
Maryland 21287, USA.
Ionizing radiation therapy is associated with pathological vascular changes
in intracranial vessels, most commonly in the form of vessel thrombosis and
occlusion. The development of an intracranial aneurysm following such
therapy, however, is far less common. In this report the authors describe a
24-year-old man in whom a distal middle cerebral artery aneurysm developed
15 years after radiotherapy, which was given as adjuvant treatment following
resection of a medulloblastoma. The patient underwent a craniotomy for
microsurgical trapping of the aneurysm and was discharged without any
neurological deficit. This case serves to remind clinicians of the
possibility, albeit rare, that intracranial aneurysms may form following
cranial radiotherapy.
PMID: 16922075 [PubMed - in process]3
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| 18: J Neurosurg.
2006 May;104(5 Suppl):362-5. |
|
Basicranial diplomyelia: an extension of the split cord
malformation theory. Case report.
Rustamzadeh E, Graupman PC, Lam CH.
Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota
55455, USA.
Basicranial diastematomyelia is an extremely rare congenital disorder. A
review of the literature indicates only one reported case of basicranial
diastematomyelia in which an osseous peg divided the brainstem in two. The
authors present the first reported case of basicranial diplomyelia split by
a fibrous band and correlate its pathogenesis with that of split cord
malformation (SCM). The patient described in the present report had a
fibrous stalk dividing the brainstem, and therefore the condition was
categorized as a diplomyelia, or SCM Type II. Because the occipital
dermatomes behave similarly to the spinal dermatomes early in development,
they may be subject to the same embryonic error that results in SCM. The
authors propose that the mechanism leading to SCM is the same as that found
in basicranial split malformations and that the theory explaining it be
modified to include the posterior fossa.
Publication Types:
PMID: 16848097 [PubMed - indexed for MEDLINE]
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| 19: J Neurosurg.
2006 May;104(5 Suppl):348-51. |
|
Navigated laser-assisted endoscopic fenestration of a
suprasellar arachnoid cyst in a 2-year-old child with bobble-head doll
syndrome. Case report.
Van Beijnum J, Hanlo PW, Han KS, Ludo Van der Pol W,
Verdaasdonk RM, Van Nieuwenhuizen O.
Department of Neurosurgery, University Medical Center, Utrecht, The
Netherlands. J.vanBeijnum@umcutrecht.nl
The authors present the case of a 2-year-old boy with bobble-head doll
syndrome (BHDS) associated with a large suprasellar arachnoid cyst and
enlarged ventricles, who was successfully treated with neuronavigated
laser-assisted endoscopic ventriculocystocisternostomy. The clinical
history, surgical treatment, and clinical follow up of the patient are
described. A navigated laser-assisted endoscopic
ventriculocystocisternostomy of the suprasellar arachnoid cyst led to
cessation of the head bobbing, and notable reduction of the cyst and
ventricles was visible on the postoperative magnetic resonance images.
Caused by a suprasellar arachnoid cyst, BHDS can be successfully treated
with navigated laser-assisted endoscopic ventriculocystocisternostomy. The
advantages of this procedure are minimal invasiveness and facilitated
guidance of the neuronavigation system to the target area when normal
anatomical landmarks are not visible.
Publication Types:
PMID: 16848093 [PubMed - indexed for MEDLINE]
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| 20: Radiology. 2006
Sep;240(3):803-10. |
|
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Gliomas: histopathologic evaluation of changes in
directionality and magnitude of water diffusion at diffusion-tensor MR
imaging.
Stadlbauer A, Ganslandt O, Buslei R, Hammen T, Gruber
S, Moser E, Buchfelder M, Salomonowitz E, Nimsky
C.
Department of Neurosurgery, Neurocenter, Departments of Neuropathology and
Neurology, University of Erlangen-Nuremberg, Erlangen, Germany.
PURPOSE: To retrospectively correlate changes in fractional anisotropy (FA)
and mean diffusivity in gliomas at diffusion-tensor magnetic resonance (MR)
imaging with the degree of tumor cell infiltration determined histologically.
MATERIALS AND METHODS: The institutional review board required neither
ethics committee approval nor patient informed consent for this study.
Twenty patients (eight women, 12 men; age range, 18-53 years) with glioma
(seven World Health Organization grade II and 13 grade III tumors) underwent
diffusion-tensor MR imaging at 1.5 T. Diffusion-tensor data were obtained
with an echo-planar imaging sequence with six diffusion directions (b = 1000
sec/mm(2)), isotropic 1.9-mm voxels, and five averages. FA and mean
diffusivity values were calculated from diffusion-tensor data.
Coregistration with a three-dimensional MR imaging data set (used for
stereotactic brain biopsies) enabled correlation of FA and mean diffusivity
values with the histopathologic findings total cell number (CN), tumor CN,
and percentage tumor infiltration (TI) by using linear, exponential, and
logarithmic models. Student t and Mann-Whitney U tests were performed.
RESULTS: Histopathologic findings of 77 MR image-guided stereotactic
biopsies in all 20 patients were correlated with FA and mean diffusivity
values at the biopsy locus. For FA and mean diffusivity, a logarithmic model
showed strongest correlation with tumor CN and total CN; a linear model
showed strongest correlation with percentage TI. For FA there were negative
logarithmic (R = -0.802, P < .001) and linear (R = -0.796, P < .001)
correlations with tumor CN and percentage TI, respectively. For mean
diffusivity there were positive logarithmic (R = 0.557, P < .001) and
linear correlations (R = 0.521, P < .001) with tumor CN and percentage
TI, respectively. Differences between correlations for FA and mean
diffusivity versus tumor CN (P < .001) and percentage TI (P < .001)
were significant. CONCLUSION: FA is better than mean diffusivity for
assessment and delineation of different degrees of pathologic changes (ie,
TI) in glioma. (c) RSNA, 2006.
PMID: 16926329 [PubMed - in process]
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|
Volume 5, Number 35 - 28 August 2006