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| BRAINLIFE NEWSLETTER | |
Volume 5, Supplement 5 -
31 May 2006 |
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31 May 2006 |
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Jim Dryden
Calorie restriction appears better than exercise at slowing primary aging EurekAlert!, 31 may 2006 
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| Integrative Medicine > Dietary Restriction | |
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Luigi Fontana, Samuel Klein, John O. Holloszy,
and Bhartur N. Premachandra
Effect of Long-term Calorie Restriction with Adequate Protein and Micronutrients on Thyroid Hormones Journal of Clinical Endocrinology & Metabolism 2006, 10.1210/jc.2006-0328; Published online ahead of print May 23, 2006 
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30 May 2006 |
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New Protein Target for Antiviral Drug
Development
Newswise, 30 May 2006 News
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| Treatment > Targeted Therapy | |
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Atilio I. Anzellotti, Qin Liu, Marieke J. Bloemink,
J. Neel Scarsdale and Nicholas Farrell Targeting Retroviral Zn Finger-DNA Interactions: A Small-Molecule Approach Using the Electrophilic Nature of trans-Platinum-Nucleobase Compounds Chemistry & Biology, Volume 13, Issue 5, May 2006, Pages 539-548, doi:10.1016/j.chembiol.2006.04.004; Available online 30 May 2006 Abstract
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22 May 2006 |
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Darrell E. Ward
Research reveals control of potent immune regulator Ohio State University, Research News, 22 May 2006
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| Etiology and Pathogenesis > Inflammation | |
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Pro- and Antiinflammatory Cytokine Signaling: Reciprocal Antagonism Regulates Interferon-gamma Production by Human Natural Killer Cells Immunity, Volume 24, Issue 5 , May 2006, Pages 575-590; Available online 23 May 2006; doi:10.1016/j.immuni.2006.03.016
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21 May 2006 |
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Mark Shwartz Researchers uncover new mechanism of tumor suppressor EurekAlert!, 21 May 2006
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| Etiology and Pathogenesis > Tumor Suppressor Genes | |
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Pedro V. Peña, Foteini Davrazou, Xiaobing Shi, Kay
L. Walter, Vladislav V. Verkhusha, Or Gozani, Rui Zhao and Tatiana G.
Kutateladze
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2 Nature, Advance online publication 21 May 2006; doi:10.1038/nature04814
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| Etiology and Pathogenesis > Tumor Suppressor Genes | |
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Xiaobing Shi, Tao Hong, Kay L. Walter, Mark
Ewalt, Eriko Michishita, Tiffany Hung, Dylan Carney, Pedro Peña, Fei Lan,
Mohan R. Kaadige, Nicolas Lacoste, Christelle Cayrou, Foteini Davrazou,
Anjanabha Saha, Bradley R. Cairns, Donald E. Ayer, Tatiana G. Kutateladze,
Yang Shi, Jacques Côté, Katrin F. Chua and Or Gozani
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression Nature, Advance online publication 21 May 2006; doi:10.1038/nature04835
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18 May 2006 |
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Patti Jacobs
Schepens scientists are first to discover angiogenesis switch inside blood vessel cells EurekAlert!, 18 May 2006 News
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| Etiology and Pathogenesis > Angiogenesis | |
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Eunok Im, Andrius Kazlauskas
Regulating angiogenesis at the level of PtdIns-4,5-P2 The EMBO Journal (May 17, 2006) 25, 20752082; Published online 20 April 2006; doi:10.1038/sj.emboj.7601100
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Reuters Health
Cholesterol inhibitors block proliferation of medulloblastoma cells OncoLink, 18 May 2006 News
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| Treatment > Inhibition of Cell Signalling Channels | |
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Ryan B. Corcoran and Matthew
P.
Scott
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells Proc. Natl. Acad. Sci. USA, Published online before print May 17, 2006; DOI: 10.1073/pnas.0602852103
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17 May 2006 |
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Joseph Blumberg
Broccoli, cauliflower and genetic cancer EurekAlert!, 17 May 2006 News
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| Integrative Medicine > Cruciferous Vegetables - Prevention | |
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Rong Hu, Tin Oo Khor, Guoxiang Shen, Woo-Sik
Jeong, Vidya Hebbar, Chi Chen, Changjiang Xu, Bandaru Reddy, Kiran Chada,
and Ah-Ng Tony Kong
Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable Carcinogenesis, Advance Access published online on May 4, 2006; doi:10.1093/carcin/bgl049
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Kim Carlyle
'Pinball protons' created by ultraviolet rays and other causes can lead to DNA damage EurekAlert!, 17 May 2006 News
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| Etiology and Pathogenesis > Ultraviolet Rays | |
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The deprotonated guanine-cytosine base pair PNAS, May 16, 2006, vol. 103, no. 20, pp. 7554-7559; Published online before print May 9, 2006, 10.1073/pnas.0600654103
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16 May 2006 |
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Edward R. Winstead
Tumors May Promote Inflammation to Evade Detection NCI Cancer Bulletin, 16 May 2006, Volume 3, Number 20
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| Etiology and Pathogenesis > Inflammation | |
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John L. Langowski, Xueqing Zhang, Lingling Wu,
Jeanine D. Mattson, Taiying Chen, Kathy Smith, Beth Basham, Terrill
McClanahan, Robert A. Kastelein and Martin Oft
IL-23 promotes tumour incidence and growth Nature, Advance online publication 10 May 2006; DOI:10.1038/nature04808
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Tumor Stem Cells May
Improve Research on Brain Tumors
NCI Cancer Bulletin, 16 May 2006, Volume 3, Number 20
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| Etiology and Pathogenesis > Stem Cells | |
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Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines Cancer Cell, Vol 9, 391-403, May 2006
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15 May 2006 |
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Wallace Ravven
New compound unusually potent at blocking brain cancer growth EurekAlert!, 15 May 2006 News
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Heidi Hardman
Unique dual target specificity of kinase inhibitor key for success against cancer EurekAlert!, 15 May 2006 News
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| Treatment > Kinase Inhibitors | |
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A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma Cancer Cell 9, 341349, May 2006. DOI 10.1016/j.ccr.2006.03.029
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12 May 2006 |
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Russell Vanderboom, Ph.D.
Carcinogens from parents' tobacco smoke found in their babies' urine EurekAlert!, 12 May 2006
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| Etiology and Pathogenesis > Tobacco Smoke | |
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4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol and its Glucuronides in the Urine of Infants Exposed to Environmental Tobacco Smoke Cancer Epidemiology Biomarkers & Prevention, Vol. 15, 988-992, May 2006
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9 May 2006 |
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Jonathan Modie
OHSU study says stem cell 'fusion' occurs in tumors EurekAlert!, 9 May 2006
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| Etiology and Pathogenesis > Tumorigenesis | |
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Bone marrow-derived cells fuse with normal and transformed intestinal stem cells PNAS, April 18, 2006, vol. 103, no. 16, 6321-6325; Published online before print April 10, 2006; DOI: 10.1073/pnas.0508593103
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Nancy Jensen
M. D. Anderson: Setting the benchmark in brain tumor treatment EurekAlert!, 9 May 2006 News
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8 May 2006 |
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Brad Allen
Knowledge of dendritic cells branches out EurekAlert!, 8 May 2006 News
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| Etiology and Pathogenesis > Immune Response | |
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Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes Nature Immunology, Published online: 7 May 2006; doi:10.1038/ni1340
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Robert Conn
White blood cells from cancer-resistant mice cure cancers in ordinary mice EurekAlert!, 8 May 2006 News
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| Treatment > Immunotherapy | |
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Transferable anticancer innate immunity in spontaneous regression/complete resistance mice PNAS, May 16, 2006, vol. 103 no. 20, pp. 7753-7758; Published online before print May 8, 2006, 10.1073/pnas.0602382103
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4 May 2006 |
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Reuters Health hTERT expression points to prognosis of pediatric brain tumors OncoLink, 4 May 2006
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| Etiology and Pathogenesis > Telomere Maintenance - Staging and Prognosis | |
Human Telomere Reverse Transcriptase Expression Predicts Progression and Survival in Pediatric Intracranial Ependymoma Journal of Clinical Oncology, Vol 24, No 10 (April 1), 2006: pp. 1522-1528; DOI: 10.1200/JCO.2005.04.2127
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| Etiology and Pathogenesis > Telomere Maintenance | |
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Tabori, Uri; Vukovic, Bisera; Zielenska,
Maria; Hawkins, Cynthia; Braude, Ilan; Rutka, James; Bouffet,
Eric; Squire, Jeremy; Malkin, David The Role of Telomere Maintenance in the Spontaneous Growth Arrest of Pediatric Low-Grade Gliomas Neoplasia, Volume 8, Number 2, February 2006, pp. 136-142(7)
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2 May 2006 |
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Scott Merville Targeted Virus Compels Cancer Cells to Eat Themselves The University of Texas M. D. Anderson Cancer Center, News Releases, 2 May 2006
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| Treatment > Gene Therapy | |
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Autophagic Cell Death of Malignant Glioma Cells Induced by a Conditionally Replicating Adenovirus Journal of the National Cancer Institute, Vol. 98, No. 9, 625-636, May 3, 2006; DOI: 10.1093/jnci/djj161
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Karen Richardson
Scientist Works to Improve Treatment for Brain Tumors Wake Forest University Baptist Medical Center, Medical Center News, 2 May 2006
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| Treatment > Toxin Therapy | |
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Madhankumar, A.B., Mintz, Akiva, Debinski,
Waldemar Interleukin 13 Mutants of Enhanced Avidity Toward the Glioma-Associated Receptor, IL13Rα2 Neoplasia, Volume 6, Number 1, January/February 2004, pp. 15-22(8)
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May 2006 |
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Developing
patterns
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| Etiology and Pathogenesis > Cell Biology | |
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Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis Cancer Cell, Vol 9, 157-173, March 2006
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Published in May |
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Münevver Büyükpamukçu, MD;
Ali Varan, MD; Nalan Yazici, MD; Nejat Akalan, MD; Figen Söylemezoglu, MD;
Faruk Zorlu, MD; Canan Akyüz, MD; M. Tezer Kutluk, MD, PhD
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| Treatment > Cetuximab - Temozolomide Clinical Trials | |
Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT) - phase I/II trial: study protocol BMC Cancer 2006, 6:133; Published: 18 May 2006; doi:10.1186/1471-2407-6-133 Abstract
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| Treatment > Radiation Related Pathology | |
| Terese L. Howes,
John M. Buatti, Patricia A. Kirby, Thomas L. Carlisle
and Timothy C. Ryken
Radiation induced adult medulloblastoma: a case report J Neurooncol. 2006 May 19; [Epub ahead of print]; DOI: 10.1007/s11060-006-9175-4 Abstract
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| Overall Management > Lymphomas and Haemopoietic Neoplasms | |
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Kristoph Jahnke, MD, Agnieszka Korfel, MD,
Brian Patrick O'Neill, MD, Jean-Yves Blay, MD, PhD, Lauren E. Abrey, MD,
Peter Martus, PhD, Philip M. P. Poortmans, MD, PhD, Tamara N. Shenkier,
MD, Tracy T. Batchelor, MD, Edward A. Neuwelt, MD, Jeffrey J. Raizer, MD,
David Schiff, MD, Hendrik Pels, MD, Ulrich Herrlinger, MD, Harald Stein,
MD, Eckhard Thiel, MD
International study on low-grade primary central nervous system lymphoma Annals of Neurology, Volume 59, Issue 5, Pages 755 - 762, May 2006; Published Online: 3 Apr 2006, DOI: 10.1002/ana.20804
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| Etiology and Pathogenesis > Tumorigenesis | |
| Katariina Korhonen,
Tiina Salminen, Jani Raitanen, Anssi Auvinen, Jorma Isola
and Hannu Haapasalo
Female predominance in meningiomas can not be explained by differences in progesterone, estrogen, or androgen receptor expression J Neurooncol. 2006 May 13; [Epub ahead of print]; DOI: 10.1007/s11060-006-9146-9 Abstract
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| Treatment > Temozolomide Clinical Trials | |
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Netta Levin, M.D., Iris Lavon, Ph.D., R.A., Bracha
Zelikovitsh, Dana Fuchs, Bs.C., Felix Bokstein, M.D., Yakov Fellig, M.D., Tali
Siegal, M.D.
Progressive low-grade oligodendrogliomas: response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression Cancer, Volume 106, Issue 8, Pages 1759-1765, 2006 Apr 15; Published Online:15 Mar 2006; DOI: 10.1002/cncr.21809
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| Treatment > Immunotherapy | |
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Ian F. Parney, Lung-Ji Chang,
Maxine A. Farr-Jones, Chunhai Hao, Michael Smylie and
Kenneth C. Petruk
Technical hurdles in a pilot clinical trial of combined B7-2 and GM-CSF immunogene therapy for glioblastomas and melanomas J Neurooncol. 2006 May;78(1):71-80. Epub 2006 Apr 21. DOI: 10.1007/s11060-005-9058-0
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| Overall Management > Fetal and Congenital CNS Tumors | |
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Takashi Tamiya, Soichiro Takao, Tomotsugu
Ichikawa, Kosuke Chayama, Isao Date Successful Chemotherapy for Congenital Malignant Gliomas: A Report of Two Cases Pediatric Neurosurgery May 2006;42:240-244; DOI: 10.1159/000092362
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| Treatment > Carboplatin - Tamoxifen | |
| P. Tang,
G. Roldan, P.M.A Brasher, D. Fulton, W. Roa, A. Murtha,
J.G. Cairncross and P.A. Forsyth
A phase II study of carboplatin and chronic high-dose tamoxifen in patients with recurrent malignant glioma J Neurooncol. 2006 May 19; [Epub ahead of print]; DOI: 10.1007/s11060-005-9104-y Abstract
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| Etiology and Pathogenesis > Molecular Oncology | |
| R Yamanaka, T Arao,
N Yajima, N Tsuchiya, J Homma, R Tanaka, M Sano,
A Oide, M Sekijima and K Nishio
Identification of expressed genes characterizing long-term survival in malignant glioma patients Oncogene, Advance online publication 1 May 2006; doi: 10.1038/sj.onc.1209585
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