[Brainlife] Newsletter, Vol.5, Suppl.6, 30 Jun 2006

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BRAINLIFE NEWSLETTER

Volume 5, Supplement 6 - 30 June 2006	Volume 5 Archive

30 June 2006
	Steven Benowitz Chromosomal Testing Can Determine Brain Tumor Therapy, Outcomes, Jefferson Radiation Oncologists Find Thomas Jefferson University Hospital, News & Media, 30 June 2006 News
	Gregory Cairncross, Brian Berkey, Edward Shaw, Robert Jenkins, Bernd Scheithauer, David Brachman, Jan Buckner, Karen Fink, Luis Souhami, Normand Laperierre, Minesh Mehta, Walter Curran Phase III Trial of Chemotherapy Plus Radiotherapy Compared With Radiotherapy Alone for Pure and Mixed Anaplastic Oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402 Journal of Clinical Oncology, Vol 24, No 18 (June 20), 2006: pp. 2707-2714. DOI: 10.1200/JCO.2005.04.3414
	Mark R. Gilbert, Frederick F. Lang Anaplastic Oligodendroglial Tumors: A Tale of Two Trials Journal of Clinical Oncology, Vol 24, No 18 (June 20), 2006: pp. 2689-2690. DOI: 10.1200/JCO.2006.05.8594
	Martin J. van den Bent, Antoine F. Carpentier, Alba A. Brandes, Marc Sanson, Martin J.B. Taphoorn, Hans J.J.A. Bernsen, Marc Frenay, Cees C. Tijssen, Wolfgang Grisold, Laslo Sipos, Hanny Haaxma-Reiche, Johannes M. Kros, Mathilde C.M. van Kouwenhoven, Charles J. Vecht, Anouk Allgeier, Denis Lacombe, Thierry Gorlia Adjuvant Procarbazine, Lomustine, and Vincristine Improves Progression-Free Survival but Not Overall Survival in Newly Diagnosed Anaplastic Oligodendrogliomas and Oligoastrocytomas: A Randomized European Organisation for Research and Treatment of Cancer Phase III Trial Journal of Clinical Oncology, Vol 24, No 18 (June 20), 2006: pp. 2715-2722. DOI: 10.1200/JCO.2005.04.6078

29 June 2006
	Scott Merville Researchers find molecular 'brake' to cell death EurekAlert!, 29 June 2006 News
	Dhyan Chandra, Shawn B. Bratton, Maria D. Person, Yanan Tian, Angel G. Martin, Mary Ayres, Howard O. Fearnhead, Varsha Gandhi and Dean G. Tang Intracellular Nucleotides Act as Critical Prosurvival Factors by Binding to Cytochrome C and Inhibiting Apoptosome Cell, Volume 125, Issue 7, 30 June 2006, Pages 1333-1346. doi:10.1016/j.cell.2006.05.026. Available online 29 June 2006

	David Terraso Scientists Uncover Rules for Gene Amplification Georgia Institute of Technology, 29 June 2006 News
	Vidhya Narayanan, Piotr A. Mieczkowski, Hyun-Min Kim, Thomas D. Petes and Kirill S. LobachevThe Pattern of Gene Amplification Is Determined by the Chromosomal Location of Hairpin-Capped Breaks Cell, Vol 125, 1283-1296, 30 June 2006, Available online 29 June 2006, doi:10.1016/j.cell.2006.04.042

27 June 2006
	Kelly Classic Radioactive scorpion venom for fighting cancer EurekAlert!, 12 June 2006 News
	Alan M Jackson, Beth Harkness Radioactive Scorpion Venom Therapy 51st Annual Meeting of the Health Physics Society, June 25-29,2006 - Providence, Rhode Island. Abstract No. WAM-B.11

20 June 2006
	Elizabeth A. Thomson MIT sheds light on how tumor cells form MIT News, 20 June 2006 News
	V M Draviam, I Shapiro, B Aldridge, P K Sorger Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells The EMBO Journal (2006) 25, 2814–2827, doi:10.1038/sj.emboj.7601168. Published online 8 June 2006

16 June 2006
	Megan Rauscher Brain tumor patients seem capable and motivated to exercise OncoLink, 16 June 2006 News
	Lee W. Jones, Ph.D., Bebe Guill, M.Div., Stephen T. Keir, Dr.PH., Karen Carter B.S., Henry S. Friedman, M.D., Darrell D. Bigner, M.D., David A. Reardon, M.D. Patterns of exercise across the cancer trajectory in brain tumor patients Cancer, Volume 106, Issue 10, Pages 2224 - 2232 (15 May 2006). Published Online: 3 Apr 2006. DOI: 10.1002/cncr.21858

13 June 2006
	Bevacizumab plus Chemotherapy Promising for Recurrent Brain Cancer NCI Cancer Bulletin, 13 June, 2006, Volume 3, Number 24 News
	J. J. Vredenburgh, A. Desjardins, J. E. Herndon, J. Quinn, J. Rich, S. Sathornsumetee, H. S. Friedman, D. Reardon, S. Gururangan, A. Friedman Bevacizumab, a monoclonal antibody to vascular endothelial growth factor (VEGF), and irinotecan for treatment of malignant gliomas Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings (Post-Meeting Edition). Vol 24, No 18S (June 20 Supplement), 2006: 1506
	J. Kirkpatrick, A. Desjardins, J. J. Vredenburgh, J. A. Quinn, J. N. Rich, S. Sathornsumetee, S. Gururangan, A. H. Friedman, H. S. Friedman, D. A. Reardon Combination of bevacizumab, a monoclonal antibody to vascular endothelial growth factor (VEGF), and temozolomide: Study of cases Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings (Post-Meeting Edition). Vol 24, No 18S (June 20 Supplement), 2006: 11522

12 June 2006
	Janet Haley Dubow Scientists tie several cancers to common 'oncogene engine' EurekAlert!, 12 June 2006 News
	Ian J. Davis, Jessica J. Kim, Fatih Ozsolak, Hans R. Widlund, Orit Rozenblatt-Rosen, Scott R. Granter, Jinyan Du, Jonathan A. Fletcher, Christopher T. Denny, Stephen L. Lessnick, W. Marston Linehan, Andrew L. Kung and David E. Fisher Oncogenic MITF dysregulation in clear cell sarcoma: Defining the MiT family of human cancers Cancer Cell, Volume 9, Issue 6, 13 June 2006, Pages 473-484, Available online 12 June 2006; doi:10.1016/j.ccr.2006.04.021

	Heidi Hardman Researchers attack tumor cells by exploiting dependency on sugar metabolism EurekAlert!, 12 June 2006 News
	Valeria R. Fantin,Julie St-Pierre,and Philip Leder Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance Cancer Cell, Vol 9, 425-434, 13 June 2006. DOI 10.1016/j.ccr.2006.04.023. Available online 12 June 2006
	Thi Bui and Craig B. Thompson Cancer's sweet tooth Cancer Cell, Vol 9, 419-420, 13 June 2006. DOI: 10.1016/j.ccr.2006.05.012. Available online 12 June 2006

	Heidi Hardman Activation of microRNA inhibits cancer gene in human cancer cells EurekAlert!, 12 June 2006 News
	Yoshimasa Saito,Gangning Liang,Gerda Egger,Jeffrey M. Friedman,Jody C. Chuang,Gerhard A. Coetzee,and Peter A. Jones Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells Cancer Cell, Vol 9, 435-443, 13 June 2006. DOI: 10.1016/j.ccr.2006.04.020. Available online 12 June 2006

6 June 2006
	Reuters Health Whole brain radiation does not improve on stereotactic radiation OncoLink, 7 June 2006 News
	Hidefumi Aoyama, M.D., Ph.D. Study compares treatment options for patients with brain metastases EurekAlert!, 6 June 2006 News
	Overall Management > Evaluations and Comparisons \| Treatment > Radiosurgery
	Hidefumi Aoyama, MD, PhD; Hiroki Shirato, MD, PhD; Masao Tago, MD, PhD; Keiichi Nakagawa, MD, PhD; Tatsuya Toyoda, MD, PhD; Kazuo Hatano, MD, PhD; Masahiro Kenjyo, MD, PhD; Natsuo Oya, MD, PhD; Saeko Hirota, MD, PhD; Hiroki Shioura, MD, PhD; Etsuo Kunieda, MD, PhD; Taisuke Inomata, MD, PhD; Kazushige Hayakawa, MD, PhD; Norio Katoh, MD; Gen Kobashi, MD, PhD Stereotactic Radiosurgery Plus Whole-Brain Radiation Therapy vs Stereotactic Radiosurgery Alone for Treatment of Brain Metastases JAMA, Vol. 295 No. 21, June 7, 2006 Abstract \| News \| News

5 June 2006
	Michael Bernstein A fundamentally new approach to improving cancer chemotherapy EurekAlert!, 5 June 2006 News
	Treatment > Targeted Therapy
	Muralikrishna Duvvuri, Samidha Konkar, Kwon Ho Hong, Brian S. J. Blagg, and Jeffrey P. Krise A New Approach for Enhancing Differential Selectivity of Drugs to Cancer Cells ACS Chem. Biol., ASAP Article, DOI: 10.1021/cb6001202; Web Release Date: June 2, 2006 Abstract \| News

	Sarah L. White, PhD Clinical trial confirms novel EGFR antibody targets tumors but not normal tissues EurekAlert!, 5 June 2006 News
	Treatment > Monoclonal Antibodies
	A. M. Scott, S. S. Gill, F. Lee, Z. Liu, E. Skrinos, C. Murone, T. Saunder, B. Chappell, A. Papenfuss, L. J. Old A Phase I single dose escalation trial of ch806 in patients with advanced tumors expressing the 806 antigen Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. Vol 24, No. 18S (June 20 Supplement), 2006: 13028 Meeting Abstract \| News

	Lee Clippard Cancer drug extends cognitive function in patients with brain metastases EurekAlert!, 5 June 2006 News
	Quality of Life and Psychosocial Effects \| Treatment > Radiotherapy
	J. Li, S. M. Bentzen, M. Renschler, M. P. Mehta Improvement in neurocognitive function (NCF) correlates with tumor regression after whole brain radiation therapy (WBRT) for brain metastases (BM) Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. Vol 24, No. 18S (June 20 Supplement), 2006: 1504 Meeting Abstract \| News

4 June 2006
	John P. Plastaras, MD, PhD Motexafin gadolinium (MGd) combined with prompt whole brain radiation therapy (RT) prolongs time to neurologic progression in non-small cell lung cancer (NSCLC) patients with brain metastases: Results of a phase III trial Oncolink, 4 June 2006 News
	Quality of Life and Psychosocial Effects \| Treatment > Radiotherapy
	M. P. Mehta, R. Gervais, P. Chabot, W. R. Shapiro, R. A. Patchell, M. J. Glantz, L. Recht, S. Phan, J. A. Smith, M. F. Renschler Motexafin gadolinium (MGd) combined with prompt whole brain radiation therapy (RT) prolongs time to neurologic progression in non-small cell lung cancer (NSCLC) patients with brain metastases: Results of a phase III trial Journal of Clinical Oncology, 2006 ASCO Annual Meeting Proceedings Part I. Vol 24, No. 18S (June 20 Supplement), 2006: 7014 Meeting Abstract \| News

Conferences
	ASCO Annual Meeting, Atlanta, Georgia, June 2-6, 2006 Central Nervous System Tumors
	Contents

Published in June
	Etiology and Pathogenesis > Immune Response
	Junichi Eguchi, Manabu Hatano, Fumihiko Nishimura, Xinmei Zhu, Jill E. Dusak, Hidemitsu Sato, Ian F. Pollack, Walter J. Storkus and Hideho Okada Identification of Interleukin-13 Receptor α2 Peptide Analogues Capable of Inducing Improved Antiglioma CTL Responses Cancer Research, 66, 5883-5891, June 1, 2006 Abstract

	Overall Management > Gliomas (Low Grade)
	Jeanine T. Grier, Tracy Batchelor Low-Grade Gliomas in Adults The Oncologist, Vol. 11, No. 6, 681-693, June 2006; doi:10.1634/theoncologist.11-6-681 Abstract \| Full Text \| Reprint

	Overall Management > Gliomas (Low Grade)
	Emmanuel Mandonnet, Laurent Capelle and Hugues Duffau Extension of paralimbic low grade gliomas: toward an anatomical classification based on white matter invasion patterns J Neurooncol. 2006 Jun;78(2):179-185. Epub 2006 Apr 21. DOI: 10.1007/s11060-005-9084-y Abstract

	Diagnosis and Evaluation \| Staging and Prognosis
	Law, Meng M.D.; Oh, Sarah M.D.; Johnson, Glyn Ph.D.; Babb, James S. Ph.D.; Zagzag, David M.D., Ph.D.; Golfinos, John M.D.; Kelly, Patrick J. M.D. Perfusion Magnetic Resonance Imaging Predicts Patient Outcome as an Adjunct to Histopathology: A Second Reference Standard in the Surgical and Nonsurgical Treatment of Low-grade Gliomas Neurosurgery. 58(6):1099-1107, June 2006 Abstract \| Full Text \| Reprint

	Treatment > Radiotherapy - Temozolomide Clinical Trials
	René-Olivier Mirimanoff, Thierry Gorlia, Warren Mason, Martin J. Van den Bent, Rolf-Dieter Kortmann, Barbara Fisher, Michele Reni, Alba A. Brandes, Jüergen Curschmann, Salvador Villa, Gregory Cairncross, Anouk Allgeier, Denis Lacombe, Roger Stupp Radiotherapy and Temozolomide for Newly Diagnosed Glioblastoma: Recursive Partitioning Analysis of the EORTC 26981/22981-NCIC CE3 Phase III Randomized Trial J Clin Oncol. 2006 Jun 1;24(16):2563-9. DOI: 10.1200/JCO.2005.04.5963 Abstract

	Overall Management > Lymphomas and Haemopoietic Neoplasms
	Sean J. Nagel, MD; Richard A. Prayson, MD; Robert J. Weil, MD A 65-year-old woman with a left occipital lobe tumor. Diffuse large B-Cell, primary central nervous system lymphoma Archives of Pathology and Laboratory Medicine, Vol. 130, No. 6, pp. e96–e99 (June 2006) Reference \| Full Text \| Reprint

	Diagnosis and Evaluation
	James M. Provenzale, MD, Srinivasan Mukundan, PhD, MD and Daniel P. Barboriak, MD Diffusion-weighted and Perfusion MR Imaging for Brain Tumor Characterization and Assessment of Treatment Response Radiology. 2006 Jun;239(3):632-49; DOI: 10.1148/radiol.2393042031 Abstract

	Overall Management > Gliomas (Low Grade)
	Roth, Jonathan M.D.; Nass, Dvora M.D.; Ram, Zvi M.D. Cerebellar Tumor Extension as a Late Event of Long-standing, Supratentorial Low-grade Gliomas: Case Report Neurosurgery. 58(6):E1210, June 2006 Abstract

	Treatment > Radiation Related Pathology
	Saba Sharif, Rosalie Ferner, Jillian M. Birch, James E. Gillespie, H. Rao Gattamaneni, Michael E. Baser, D. Gareth R. Evans Second Primary Tumors in Neurofibromatosis 1 Patients Treated for Optic Glioma: Substantial Risks After Radiotherapy J Clin Oncol. 2006 Jun 1;24(16):2570-5. DOI: 10.1200/JCO.2005.03.8349 Abstract

	B Stea, E Shaw, T Pintér, J Hackman, M Craig, J May, R P Steffen and J H SuhEfaproxiral red blood cell concentration predicts efficacy in patients with brain metastases British Journal of Cancer, 94:1777-1784 (19 June 2006). doi: 10.1038/sj.bjc.6603169

	Overall Management > Tumors of Uncertain Histogenesis
	Annika M. Svensson, MD, PhD; Yijun Pang, MD, PhD; Nicholas J. E. Moore, MD; Barbara H. Tindle, MD Cystic tumor of the cerebellum with megaloblastic erythropoiesis. Hemangioblastoma with megaloblastic hematopoiesis Archives of Pathology and Laboratory Medicine, Vol. 130, No. 6, pp. 886–889 (June 2006) Reference \| Full Text \| Reprint

	Epidemiology and Risk Factors
	Michelle C. Turner, Yue Chen, Daniel Krewski, Parviz Ghadirian An overview of the association between allergy and cancer Int J Cancer. 2006 Jun 15;118(12):3124-32; Published Online: 4 Jan 2006: DOI: 10.1002/ijc.21752 Abstract

	Treatment > Infections
	P.-S. Yen, C.-c. Lin, C.-C. Lee, T. Harnod, T.-W. Loh and Y.-H. Hsu *CNS Clostridium perfringens* Infection: A Rare Complication of Preoperative Embolization of Meningioma** American Journal of Neuroradiology 27:1355-1356, June-July 2006 Abstract