[Brainlife] Newsletter, Vol.5, Suppl.9, 25 Sep 2006

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BRAINLIFE NEWSLETTER

Volume 5, Supplement 9 - 25 September 2006	Volume 5 Archive

Astrocytomas
	Staging and Prognosis \| Treatment > Surgical Neuro-Oncology

	Keles GE, Chang EF, Lamborn KR, Tihan T, Chang CJ, Chang SM, Berger MS. Volumetric extent of resection and residual contrast enhancement on initial surgery as predictors of outcome in adult patients with hemispheric anaplastic astrocytoma. J Neurosurg. 2006 Jul;105(1):34-40. Abstract \| Reprint

Brain Tumors
	Etiology and Pathogenesis > Immune Response
	El AA, Han Y, Lesniak MS. Prolongation of survival following depletion of CD4+CD25+ regulatory T cells in mice with experimental brain tumors. J Neurosurg. 2006 Sep;105(3):430-7. Abstract
	Etiology and Pathogenesis > Angiogenesis
Featured Article	Santarelli JG, Udani V, Yung YC, Cheshier S, Wagers A, Brekken RA, Weissman I, Tse V. Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain. Neurosurgery. 2006 Aug;59(2):374-82 Abstract

Ependymoma
	Overall Management > Ependymal Tumors
	Massimino M, Giangaspero F, Garre ML, Genitori L, Perilongo G, Collini P, Riva D, Valentini L, Scarzello G, Poggi G, Spreafico F, Peretta P, Mascarin M, Modena P, Sozzi G, Bedini N, Biassoni V, Urgesi A, Balestrini MR, Finocchiaro G, Sandri A, Gandola L; AIEOP Neuro-Oncology Group. Salvage treatment for childhood ependymoma after surgery only: Pitfalls of omitting "at once" adjuvant treatment. Int J Radiat Oncol Biol Phys. 2006 Aug 1;65(5):1440-5. Abstract

Hemangioblastoma
	Overall Management > Tumors of Uncertain Histogenesis
	Kim JM, Cheong JH, Bak KH, Kim CH, Park DW, Oh YH. Congenital supratentorial hemangioblastoma as an unusual cause of simultaneous supra- and infratentorial intracranial hemorrhage: case report. J Neurooncol. 2006 Mar;77(1):59-63. Epub 2005 Aug 25. Abstract

Ganglioglioma
	Treatment > Radiotherapy
	Zorlu F, Selek U, Onal C, Soylemezoglu F, Gurkaynak M. Postoperative radiotherapy in cranial ganglioglioma. J Neurooncol. 2006 May;77(3):321-4. Epub 2005 Nov 29. Abstract

Glioblastoma
	Treatment > Radiotherapy / Nimustine / / Carboplatin / Vincristine / Interferon
	Aoki T, Takahashi JA, Ueba T, Oya N, Hiraoka M, Matsui K, Fukui T, Nakashima Y, Ishikawa M, Hashimoto N. Phase II study of nimustine, carboplatin, vincristine, and interferon-beta with radiotherapy for glioblastoma multiforme: experience of the Kyoto Neuro-Oncology Group. J Neurosurg. 2006 Sep;105(3):385-91. Abstract
	Etiology and Pathogenesis > Stem Cells / Tumor Biology
	Balenci L, Clarke ID, Dirks PB, Assard N, Ducray F, Jouvet A, Belin MF, Honnorat J, Baudier J. IQGAP1 Protein Specifies Amplifying Cancer Cells in Glioblastoma Multiforme. Cancer Res. 2006 Sep 15;66(18):9074-82. Abstract
	Treatment > Radiotherapy / Lomustine / Temozolomide Clinical Trials
	Herrlinger U, Rieger J, Koch D, Loeser S, Blaschke B, Kortmann RD, Steinbach JP, Hundsberger T, Wick W, Meyermann R, Tan TC, Sommer C, Bamberg M, Reifenberger G, Weller M. Phase II trial of lomustine plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03. J Clin Oncol. 2006 Sep 20;24(27):4412-7. Abstract
	Etiology and Pathogenesis > Epidermal Growth Factor \| Staging and Prognosis \| Treatment > Radiotherapy
	Saito T, Hama S, Kajiwara Y, Sugiyama K, Yamasaki F, Arifin MT, Arita K, Kurisu K. Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas. Anticancer Res. 2006 Mar-Apr;26(2B):1351-7. Abstract
	Integrative Medicine > Angelica Sinensis
	Tsai NM, Chen YL, Lee CC, Lin PC, Cheng YL, Chang WL, Lin SZ, Harn HJ. The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo. J Neurochem. 2006 Sep 20; [Epub ahead of print] Abstract \| Full Text \| Reprint

Gliomas
	Etiology and Pathogenesis > Genetic Alterations \| Staging and Prognosis
	Batistatou A, Kyzas PA, Goussia A, Arkoumani E, Voulgaris S, Polyzoidis K, Agnantis NJ, Stefanou D. Estrogen receptor beta (ERbeta) protein expression correlates with BAG-1 and prognosis in brain glial tumours. J Neurooncol. 2006 Mar;77(1):17-23. Epub 2005 Nov 15. Abstract
	Integrative Medicine > Cannabinoids
	Held-Feindt J, Dorner L, Sahan G, Mehdorn HM, Mentlein R. Cannabinoid receptors in human astroglial tumors. J Neurochem. 2006 Aug;98(3):886-93. Abstract
	Overall Management > Brainstem Gliomas
	Singh S, Bhutani R, Jalali R. Leptomeninges as a site of relapse in locally controlled, diffuse pontine glioma with review of literature. Childs Nerv Syst. 2006 Sep 16; [Epub ahead of print] Abstract

Gliomas (High-grade)
	Etiology and Pathogenesis > Genetic Alterations \| Staging and Prognosis
	Arifin MT, Hama S, Kajiwara Y, Sugiyama K, Saito T, Matsuura S, Yamasaki F, Arita K, Kurisu K. Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas. J Neurooncol. 2006 May;77(3):273-7. Epub 2006 Apr 14. Abstract
	Etiology and Pathogenesis > Genetic Alterations \| Staging and Prognosis
	Dehais C, Laigle-Donadey F, Marie Y, Kujas M, Lejeune J, Benouaich-Amiel A, Pedretti M, Polivka M, Xuan KH, Thillet J, Delattre JY, Sanson M. Prognostic stratification of patients with anaplastic gliomas according to genetic profile. Cancer. 2006 Sep 19; [Epub ahead of print] Abstract
	Treatment > Carboplatin / Cisplatin / Cyclophosphamide / Procarbazine / Vincristine
	Dufour C, Grill J, Lellouch-Tubiana A, Puget S, Chastagner P, Frappaz D, Doz F, Pichon F, Plantaz D, Gentet JC, Raquin MA, Kalifa C. High-grade glioma in children under 5 years of age: A chemotherapy only approach with the BBSFOP protocol. Eur J Cancer. 2006 Sep 6; [Epub ahead of print] Abstract

Gliomas (Low-grade)
	Etiology and Pathogenesis > Genetic Alterations \| Staging and Prognosis
Featured Article	Mariani L, Deiana G, Vassella E, Fathi AR, Murtin C, Arnold M, Vajtai I, Weis J, Siegenthaler P, Schobesberger M, Reinert MM. Loss of Heterozygosity 1p36 and 19q13 Is a Prognostic Factor for Overall Survival in Patients With Diffuse WHO Grade 2 Gliomas Treated Without Chemotherapy. J Clin Oncol. 2006 Sep 11; [Epub ahead of print] Abstract
	Diagnosis and Evaluation \| Staging and Prognosis
	Pallud J, Mandonnet E, Duffau H, Kujas M, Guillevin R, Galanaud D, Taillandier L, Capelle L. Prognostic value of initial magnetic resonance imaging growth rates for World Health Organization grade II gliomas. Ann Neurol. 2006 Sep 18;60(3):380-383 [Epub ahead of print] Abstract
	Treatment > Radiosurgery
	Peraud A, Goetz C, Siefert A, Tonn JC, Kreth FW. Interstitial iodine-125 radiosurgery alone or in combination with microsurgery for pediatric patients with eloquently located low-grade glioma: a pilot study. Childs Nerv Syst. 2006 Sep 14; [Epub ahead of print] Abstract
	Etiology and Pathogenesis > Genetic Alterations \| Gliomas (Low Grade)
	Rorive S, Maris C, Debeir O, Sandras F, Vidaud M, Bieche I, Salmon I, Decaestecker C. Exploring the distinctive biological characteristics of pilocytic and low-grade diffuse astrocytomas using microarray gene expression profiles. J Neuropathol Exp Neurol. 2006 Aug;65(8):794-807. Abstract

Medulloblastoma
	Treatment > Induced Second Neoplasm / Radiation Related Pathology
	Choudry Q, Patel HC, Gurusinghe NT, Evans DG Radiation-induced brain tumours in nevoid basal cell carcinoma syndrome: implications for treatment and surveillance. Childs Nerv Syst. 2006 Sep 15; [Epub ahead of print] Abstract
	Etiology and Pathogenesis > Genetic Alterations \| Staging and Prognosis
	De Bortoli M, Castellino RC, Lu XY, Deyo J, Sturla LM, Adesina AM, Perlaky L, Pomeroy SL, Lau CC, Man TK, Rao PH, Kim JY. Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8. BMC Cancer. 2006 Sep 12;6(1):223 [Epub ahead of print] Abstract \| Reprint

Melanocytoma
	Treatment > Radiotherapy
	Rades D, Schild SE. Dose-response relationship for fractionated irradiation in the treatment of spinal meningeal melanocytomas: a review of the literature. J Neurooncol. 2006 May;77(3):311-4. Epub 2005 Dec 3. Abstract

Metastatic Tumors
	Treatment > Brachytherapy
	Rogers LR, Rock JP, Sills AK, Vogelbaum MA, Suh JH, Ellis TL, Stieber VW, Asher AL, Fraser RW, Billingsley JS, Lewis P, Schellingerhout D, Shaw EG; Brain Metastasis Study Group. Results of a phase II trial of the gliasite radiation therapy system for the treatment of newly diagnosed, resected single brain metastases. J Neurosurg. 2006 Sep;105(3):375-84. Abstract

Neurocytoma
	Overall Management > Neuronal and Mixed Neuronal-Glial Tumors
	Rades D, Schild SE. Treatment recommendations for the various subgroups of neurocytomas. J Neurooncol. 2006 May;77(3):305-9. Epub 2006 Mar 31. Abstract

Pilocytic Astrocytoma
	Etiology and Pathogenesis > Genetic Alterations \| Tumorigenesis
	Addo-Yobo SO, Straessle J, Anwar A, Donson AM, Kleinschmidt-Demasters BK, Foreman NK. Paired overexpression of ErbB3 and Sox10 in pilocytic astrocytoma. J Neuropathol Exp Neurol. 2006 Aug;65(8):769-75. Abstract

Primary CNS Lymphoma
	Treatment > Carmustine / Cytarabine / Methotrexate / Thiotepa / Radiotherapy / Stem Cells Methotrexate / Thiotepa / Radiotherapy / Stem Cells Methotrexate / Thiotepa / Radiotherapy / Stem Cells Methotrexate / Thiotepa / Radiotherapy / Stem Cells Methotrexate / Thiotepa / Radiotherapy / Stem Cells
	Illerhaus G, Marks R, Ihorst G, Guttenberger R, Ostertag C, Derigs G, Frickhofen N, Feuerhake F, Volk B, Finke J. High-dose chemotherapy with autologous stem-cell transplantation and hyperfractionated radiotherapy as first-line treatment of primary CNS lymphoma. J Clin Oncol. 2006 Aug 20;24(24):3865-70. Epub 2006 Jul 24. Abstract
	Treatment > Methylprednisolone / Radiotherapy
	Laack NN, Ballman KV, Brown PB, O'Neill BP; North Central Cancer Treatment Group. Whole-brain radiotherapy and high-dose methylprednisolone for elderly patients with primary central nervous system lymphoma: Results of North Central Cancer Treatment Group (NCCTG) 96-73-51. Int J Radiat Oncol Biol Phys. 2006 Aug 1;65(5):1429-39. Abstract
	Treatment > Radiosurgery
	Sakamoto M, Oya N, Mizowaki T, Araki N, Nagata Y, Takayama K, Takahashi JA, Kano H, Katsuki T, Hashimioto N, Hiraoka M. Initial experiences of palliative stereotactic radiosurgery for recurrent brain lymphomas. J Neurooncol. 2006 Mar;77(1):53-8. Abstract
	Etiology and Pathogenesis > Genetic Alterations
	Schwindt H, Akasaka T, Zuhlke-Jenisch R, Hans V, Schaller C, Klapper W, Dyer MJ, Siebert R, Deckert M. Chromosomal translocations fusing the BCL6 gene to different partner loci are recurrent in primary central nervous system lymphoma and may be associated with aberrant somatic hypermutation or defective class switch recombination. J Neuropathol Exp Neurol. 2006 Aug;65(8):776-82. Abstract

Primitive Neuroectodermal Tumors
	Etiology and Pathogenesis > Genetic Alterations \| Overall Management > Embryonal Tumors \| Staging and Prognosis
	Kampman WA, Kros JM, De Jong TH, Lequin MH Primitive neuroectodermal tumours (PNETs) located in the spinal canal; the relevance of classification as central or peripheral PNET : case report of a primary spinal PNET occurrence with a critical literature review. J Neurooncol. 2006 Mar;77(1):65-72. Epub 2005 Nov 15. Abstract
	Staging and Prognosis
Featured Article	Krampulz T, Hans VH, Oppel F, Dietrich U, Puchner MJ. Long-term relapse-free survival with supratentorial primitive neuroectodermal tumor in an adult: a case report. J Neurooncol. 2006 May;77(3):291-4. Epub 2006 Mar 10. Abstract