Etiology and Pathogenesis > Epidermal Growth Factor


Brain Tumors


Antonyak MA, Kenyon LC, Godwin AK, James DC, Emlet DR, Okamoto I, Tnani M, Holgado-Madruga M, Moscatello DK, Wong AJ.
Elevated JNK activation contributes to the pathogenesis of human brain tumors
Oncogene 2002 Aug 1;21(33):5038-46
Abstract |
Full Text | Reprint |   DBLinks | BL 1:2

Kurihara M, Tokunaga Y, Ochi A, Kawaguchi T, Tsutsumi K, Shigematsu K, Niwa M, Mori K
Expression of insulin-like growth factor I receptors in human brain tumors: comparison with epidermal growth factor receptor by using quantitative autoradiography
No To Shinkei. 1989 Jul;41(7):719-25



Cancer Research


Clarke K, Smith K, Gullick WJ, Harris AL
Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway
Br J Cancer. 2001 May 18;84(10):1322-9

Resnicoff M, Cui S, Coppola D, Hoek JB, Rubin R
Ethanol-induced inhibition of cell proliferation is modulated by insulin-like growth factor-I receptor levels
Alcohol Clin Exp Res. 1996 Aug;20(5):961-6


Gliomas


J. C. Buckner, K. D. Aldape, K. Ballman, B. W. Scheithauer, P. C. Burger, C. Giannini, P. L. Schaefer, R. B. Jenkins, C. D. James
Immunohistochemical detection of EGFRvIII and prognostic significance in patients with malignant glioma enrolled in NCCTG clinical trials
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1508 

T. Burton, P. Baijal, E. Henson, S. Zhang, S.B. Gibson, and D.D. Eisenstat
The Hypoxia-Inducible Cell Death Gene BNIP3 In Malignant Gliomas
Society for Neuro-Oncology Eighth Annual Meeting. Keystone, Colorado. November 13–16, 2003. Abstract No. AN-05.
Neuro-Oncology, Volume 5, Issue 4, October 2003

Webster K. Cavenee
Genetics and new approaches to cancer therapy
Carcinogenesis, Vol. 23, No. 5, 683-686, May 2002. (PDF Full Text)

Marie Y, Carpentier AF, Omuro AM, Sanson M, Thillet J, Hoang-Xuan K, Delattre JY
EGFR tyrosine kinase domain mutations in human gliomas
Neurology. 2005 Apr 26;64(8):1444-5

Soeda A, Inagaki A, Oka N, Ikegame Y, Aoki H, Yoshimura SI, Nakashima S, Kunisada T, Iwama T
Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells
J Biol Chem. 2008 Feb 20; [Epub ahead of print]
 Abstract |  Reprint |
DBLinks | BL 7:5

Arabel Vollmann, Hans-Peter Vornlocher, Anke Geick, Thilo Spruss, Rainer Apfel, Gerhard Giegerich, Ulrich Bogdahn
RNAi mediated effective inhibition of EGFP and EGF-R gene expression in malignant glioma
Proceedings of the AACR, Volume 44, 2nd ed., July 2003, Abstract No. 737


Glioblastoma


Marc A. Brockmann, Ulrike Ulbricht, Regina Fillbrandt, Manfred Westphal, and Katrin Lamszus
Stimulation Of Glioblastoma And Cerebral Microvascular Endothelial Cell Migration By Tumor-Associated Growth Factors
Society for Neuro-Oncology Eighth Annual Meeting. Keystone, Colorado. November 13–16, 2003. Abstract No. AN-04.
Neuro-Oncology, Volume 5, Issue 4, October 2003

Chakravarti A, Loeffler JS, Dyson NJ
Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
Cancer Res 2002 Jan 1;62(1):200-7

Gillaspy GE, Mapstone TB, Samols D, Goldthwait DA
Transcriptional patterns of growth factors and proto-oncogenes in human glioblastomas and normal glial cells
Cancer Lett. 1992 Jul 31;65(1):55-60

B. K. Kleinschmidt-DeMasters, MD; K. O. Lillehei, MD; M. Varella-Garcia, PhD
Glioblastomas in the Older Old
Arch Pathol Lab Med. 2005 May;129(5):624-631. (HTML & PDF Full Text)

Penar PL, Khoshyomn S, Bhushan A, Tritton TR
Inhibition of epidermal growth factor receptor-associated tyrosine kinase blocks glioblastoma invasion of the brain
Neurosurgery 1997 Jan;40(1):141-51  

Deepti B. Ramnarain, Seongmi Park, Diana Y. Lee, Kimmo J. Hatanpaa, Shane O. Scoggin, Hasan Otu, Towia A. Libermann, Jack M. Raisanen, Raheela Ashfaq, Eric T. Wong, Julian Wu, Robert Elliott and Amyn A. Habib
Differential Gene Expression Analysis Reveals Generation of an Autocrine Loop by a Mutant Epidermal Growth Factor Receptor in Glioma Cells
Cancer Research, 66, 867-874, January 15, 2006
Abstract | BrainLife | News

Saito T, Hama S, Kajiwara Y, Sugiyama K, Yamasaki F, Arifin MT, Arita K, Kurisu K.
Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas.
Anticancer Res. 2006 Mar-Apr;26(2B):1351-7.
Abstract 


Metastatic Tumors


Nichon L. Grupka, MD, Kelly C. Lear-Kaul, MD, Bette K. Kleinschmidt-DeMasters, MD, and Meenakshi Singh, MD
Epidermal Growth Factor Receptor Status in Breast Cancer Metastases to the Central Nervous System. Comparison With HER-2/neu Status  
Arch of Path and Laboratory Medicine, Vol. 128, No. 9, Sept 2004, pp. 974–979. (PDF Full Text)


Non-Nervous System Tumors


Jianmin Chen, P. Mark Stavro, Lilian U. Thompson
Dietary Flaxseed Inhibits Human Breast Cancer Growth and Metastasis and Downregulates Expression of Insulin-Like Growth Factor and Epidermal Growth Factor Receptor
Nutrition and Cancer, Volume: 43 Number: 2 Page: 187 -- 192 (2002)


M.W. Pedersen, V. Tkach, N. Pedersen, V. Berezin, H.S. Poulsen
A naturally occurring constitutively active variant of the epidermal growth factor receptor increases cell motility
ECCO 12 - the European Cancer Conference Copenhagen, Denmark, 21-25 September 2003. Abstract No. 625
European Journal of Cancer Supplements; Vol. 1, No. 5, September 2003, page S188

 

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