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Genetic Alterations

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Astrocytic Tumors


Liu Z, Yao Z, Li C, Lu Y, Gao C.
Gene expression profiling in human high-grade astrocytomas.
Comp Funct Genomics. 2011;2011:245137.
  Abstract |   Reprint |   Related articles


Brain Tumors


Crea F, Hurt EM, Farrar WL.
Clinical significance of Polycomb gene expression in brain tumors.
Mol Cancer. 2010 Sep 30;9(1):265. [Epub ahead of print]
  Abstract |   Reprint |   Related articles

Lee H, Kong SW, Park PJ
Integrative analysis reveals the direct and indirect interactions between DNA copy number aberrations and gene expression changes
Bioinformatics. 2008 Feb 8; [Epub ahead of print]
 Abstract


Glioblastoma


Bredel M, Scholtens DM, Yadav AK, Alvarez AA, Renfrow JJ, Chandler JP, Yu IL, Carro MS, Dai F, Tagge MJ, Ferrarese R, Bredel C, Phillips HS, Lukac PJ, Robe PA, Weyerbrock A, Vogel H, Dubner S, Mobley B, He X, Scheck AC, Sikic BI, Aldape KD, Chakravarti A, Harsh GR.
NFKBIA Deletion in Glioblastomas.
N Engl J Med. 2010 Dec 22. [Epub ahead of print]
  Abstract |   Reprint |   News |
  Related articles

Freire P, Vilela M, Deus H, Kim YW, Koul D, Colman H, Aldape KD, Bogler O, Yung WK, Coombes K, Mills GB, Vasconcelos AT, Almeida JS
Exploratory analysis of the copy number alterations in glioblastoma multiforme
PLoS ONE. 2008;3(12):e4076. Published: December 30, 2008
  Abstract |   Full Text |   Reprint

Hulleman E, Quarto M, Vernell R, Masserdotti G, Colli E, Kros JM, Levi D, Gaetani P, Tunici P, Finocchiaro G, Rodriguez Y Baena R, Capra M, Helin K.
A role for the transcription factor HEY1 in glioblastoma
J Cell Mol Med. 2008 Mar 17; [Epub ahead of print]
 Abstract |  Reprint

Kakkar A, Suri V, Jha P, Srivastava A, Sharma V, Pathak P, Sharma MC, Sharma MS, Kale SS, Chosdol K, Phalak M, Sarkar C. 
Loss of heterozygosity on chromosome 10q in glioblastomas, and its association with other genetic alterations and survival in Indian patients.
Neurol India 2011;59:254-261. Epub 2011 Apr 7.
  Abstract |   Full text


Kaneshiro D, Kobayashi T, Chao ST, Suh J, Prayson RA
Chromosome 1p and 19q Deletions in Glioblastoma Multiforme
Appl Immunohistochem Mol Morphol. 2009 Jul 13;. [Epub ahead of print]
  Abstract

Kavsan VM, Dmitrenko VV, Shostak KO, Bukreieva TV, Vitak NY, Simirenko OE, Malisheva TA, Shamayev MI, Rozumenko VD, Zozulya YA.
Comparison of microarray and sage techniques in gene expression analysis of human glioblastoma.
Tsitol Genet. 2007 Jan-Feb;41(1):36-55.
PMID: 17427416 [PubMed - in process]

Kleihues P and Ohgaki H
Primary and secondary glioblastomas: From concept to clinical diagnosis
Neuro-oncol 1999 January; 1(1): 44-51; DOI:10.1215/15228517-1-1-44
 Abstract |  Reprint

Kleihues P and Ohgaki H
Genetics of glioma progression and the definition of primary and secondary glioblastoma
Brain Pathol. 7,1131–1136 (October 1997)
 Abstract

Lo KC, Bailey D, Burkhardt T, Gardina P, Turpaz Y, Cowell JK
Comprehensive analysis of loss of heterozygosity events in glioblastoma using the 100K SNP mapping arrays and comparison with copy number abnormalities defined by BAC array comparative genomic hybridization
Genes Chromosomes Cancer. 2007 Nov 29;. [Epub ahead of print]
Abstract

Ramon Martinez, Gabriele Schackert and Manel Esteller
Hypermethylation of the proapoptotic gene TMS1/ASC: prognostic importance in glioblastoma multiforme
J Neurooncol. 2006 Oct 18; [Epub ahead of print]
Abstract

Nakamura H, Makino K, Kuratsu JI.
Molecular and clinical analysis of glioblastoma with an oligodendroglial component (GBMO).
Brain Tumor Pathol. 2011 Jun 1. [Epub ahead of print]
  Abstract |   Related articles

Nobusawa S, Watanabe T, Kleihues P, Ohgaki H
IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas
Clin Cancer Res. 2009 Oct 1;15(19):6002-7. Epub 2009 Sep 15
  Abstract

Parsons DW.
The evolving picture of the glioblastoma genome.
Oncotarget. 2010 Aug;1(4):237-8.
  Abstract |   Reprint |   Related articles

Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, Nikolsky Y, Busam DA, Tekleab H, Diaz LA Jr, Hartigan J, Smith DR, Strausberg RL, Marie SK, Shinjo SM, Yan H, Riggins GJ, Bigner DD, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW.
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Science. 2008 Sep 4; [Epub ahead of print]
 Abstract |   Reprint

Stéphan Saikali, Tony Avril, Brigitte Collet, Abderrahmane Hamlat, Jean-Yves Bansard, Bernard Drenou, Yvon Guegan and Véronique Quillien 
Expression of nine tumour antigens in a series of human glioblastoma multiforme: interest of EGFRvIII, IL-13Rα2, gp100 and TRP-2 for immunotherapy
J Neurooncol. 2006 Sep 27; [Epub ahead of print]
Abstract

Vital AL, Tabernero MD, Castrillo A, Rebelo O, Tão H, Gomes F, Nieto AB, Resende Oliveira C, Lopes MC, Orfao A.
Gene expression profiles of human glioblastomas are associated with both tumor cytogenetics and histopathology
Neuro Oncol. 2010 May 18;. [Epub ahead of print]
  Abstract

Wang LF, Fokas E, Juricko J, You A, Rose F, Pagenstecher A, Engenhart-Cabillic R, An HX.
Increased expression of EphA7 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients
BMC Cancer. 2008 Mar 25;8(1):79
 Abstract |  Full Text |  Reprint


Gliomas


Batistatou A, Kyzas PA, Goussia A, Arkoumani E, Voulgaris S, Polyzoidis K, Agnantis NJ, Stefanou D.
Estrogen receptor beta (ERbeta) protein expression correlates with BAG-1 and prognosis in brain glial tumours.
J Neurooncol. 2006 Mar;77(1):17-23. Epub 2005 Nov 15.
Abstract

De Witt Hamer PC, Van Tilborg AA, Eijk PP, Sminia P, Troost D, Van Noorden CJ, Ylstra B, Leenstra S.
The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids.
Oncogene. 2007 Oct 15; [Epub ahead of print]
Abstract

Ohgaki H, Kleihues P.
Genetic profile of astrocytic and oligodendroglial gliomas.
Brain Tumor Pathol. 2011 Mar 26;. [Epub ahead of print]
  Abstract |   Related articles


Gliomas (High-Grade)


Arifin MT, Hama S, Kajiwara Y, Sugiyama K, Saito T, Matsuura S, Yamasaki F, Arita K, Kurisu K.
Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas.
J Neurooncol. 2006 May;77(3):273-7. Epub 2006 Apr 14.
Abstract

Dehais C, Laigle-Donadey F, Marie Y, Kujas M, Lejeune J, Benouaich-Amiel A, Pedretti M, Polivka M, Xuan KH, Thillet J, Delattre JY, Sanson M.
Prognostic stratification of patients with anaplastic gliomas according to genetic profile.
Cancer. 2006 Sep 19; [Epub ahead of print]
Abstract

Orzan F, Pellegatta S, Poliani L, Pisati F, Caldera V, Menghi F, Kapetis D, Marras C, Schiffer D, Finocchiaro G.
Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells.
Neuropathol Appl Neurobiol. 2010 Oct 8;. [Epub ahead of print]
  Abstract |   Related articles

Paugh BS, Qu C, Jones C, Liu Z, Adamowicz-Brice M, Zhang J, Bax DA, Coyle B, Barrow J, Hargrave D, Lowe J, Gajjar A, Zhao W, Broniscer A, Ellison DW, Grundy RG, Baker SJ.
Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease
J Clin Oncol. 2010 May 17;. [Epub ahead of print]
  Abstract

Shirahata M, Iwao-Koizumi K, Saito S, Ueno N, Oda M, Hashimoto N, Takahashi JA, Kato K
Gene expression-based molecular diagnostic system for malignant gliomas is superior to histological diagnosis
Clin Cancer Res. 2007 Dec 15;13(24):7341-56
Abstract


Gliomas (Low-Grade)


Ferroli P, Acerbi F, Finocchiaro G.
From standard treatment to personalized medicine: role of IDH1 mutations in low-grade glioma evolution and treatment
World Neurosurg. 2010 Apr;73(4):234-6
  Abstract |   Full Text |   Reprint |   Related articles

Mariani L, Deiana G, Vassella E, Fathi AR, Murtin C, Arnold M, Vajtai I, Weis J, Siegenthaler P, Schobesberger M, Reinert MM.
Loss of Heterozygosity 1p36 and 19q13 Is a Prognostic Factor for Overall Survival in Patients With Diffuse WHO Grade 2 Gliomas Treated Without Chemotherapy.
J Clin Oncol. 2006 Sep 11; [Epub ahead of print]
Abstract

Rorive S, Maris C, Debeir O, Sandras F, Vidaud M, Bieche I, Salmon I, Decaestecker C.
Exploring the distinctive biological characteristics of pilocytic and low-grade diffuse astrocytomas using microarray gene expression profiles.
J Neuropathol Exp Neurol. 2006 Aug;65(8):794-807.
Abstract


Medulloblastoma


De Bortoli M, Castellino RC, Lu XY, Deyo J, Sturla LM, Adesina AM, Perlaky L, Pomeroy SL, Lau CC, Man TK, Rao PH, Kim JY.
Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8.
BMC Cancer. 2006 Sep 12;6(1):223 [Epub ahead of print]
Abstract | Reprint

De Smaele E, Di Marcotullio L, Moretti M, Pelloni M, Occhione MA, Infante P, Cucchi D, Greco A, Pietrosanti L, Todorovic J, Coni S, Canettieri G, Ferretti E, Bei R, Maroder M, Screpanti I, Gulino A.
Identification and Characterization of KCASH2 and KCASH3, 2 Novel Cullin3 Adaptors Suppressing Histone Deacetylase and Hedgehog Activity in Medulloblastoma.
Neoplasia. 2011 Apr;13(4):374-85.
  Abstract |   Reprint |   Related articles

Korshunov A, Benner A, Remke M, Lichter P, von Deimling A, Pfister S
Accumulation of genomic aberrations during clinical progression of medulloblastoma
Acta Neuropathol. 2008 Oct;116(4):383-90. Epub 2008 Aug 15
 Abstract | Full Text |  Reprint

McCabe MG, Bäcklund LM, Leong HS, Ichimura K, Collins VP.
Chromosome 17 alterations identify good-risk and poor-risk tumors independently of clinical factors in medulloblastoma.
Neuro Oncol. 2011 Feb 2;. [Epub ahead of print]
  Abstract |   Reprint |   Related articles

K Urbanska, J Trojanek, L Del Valle, M B Eldeen, F Hofmann, C Garcia-Echeverria, K Khalili and K Reiss
Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3β constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines
Oncogene. 2006 Oct 2; [Epub ahead of print]
Abstract

Pediatric Patients


Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR, Gerhard DS, Fults DW, Vandenberg S, Berger MS, Marie SK, Shinjo SM, Clara C, Phillips PC, Minturn JE, Biegel JA, Judkins AR, Resnick AC, Storm PB, Curran T, He Y, Rasheed BA, Friedman HS, Keir ST, McLendon R, Northcott PA, Taylor MD, Burger PC, Riggins GJ, Karchin R, Parmigiani G, Bigner DD, Yan H, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE.
The Genetic Landscape of the Childhood Cancer Medulloblastoma.
Science. 2010 Dec 16. [Epub ahead of print]
  Abstract |   News |
  Related articles


Meningioma


Hiroaki Okamoto, Jie Li, Alexander O. Vortmeyer, Howard Jaffe, Youn-Soo Lee, Sven Gläsker, Tae-Sung Sohn, Weifen Zeng, Barbara Ikejiri, Martin A. Proescholdt, Christina Mayer, Robert J. Weil, Edward H. Oldfield and Zhengping Zhuang
Comparative Proteomic Profiles of Meningioma Subtypes
Cancer Res. 2006 Oct 15;66(20):10199-204.
Abstract

Stuart JE, Lusis EA, Scheck AC, Coons SW, Lal A, Perry A, Gutmann DH.
Identification of Gene Markers Associated With Aggressive Meningioma by Filtering Across Multiple Sets of Gene Expression Arrays.
J Neuropathol Exp Neurol. 2010 Dec 11. [Epub ahead of print]
  Abstract |
  Related articles


Metastatic Tumors


Zohrabian VM, Nandu H, Gulati N, Khitrov G, Zhao C, Mohan A, Demattia J, Braun A, Das K, Murali R, Jhanwar-Uniyal M.
Gene expression profiling of metastatic brain cancer.
Oncol Rep. 2007 Aug;18(2):321-8.
PMID: 17611651 [PubMed - in process]


Neuroblastoma


John M. Maris, M.D., Yael P. Mosse, M.D., Jonathan P. Bradfield, B.S., Cuiping Hou, B.S., Stefano Monni, Ph.D., Richard H. Scott, M.B., B.S., Shahab Asgharzadeh, M.D., Edward F. Attiyeh, M.D., Sharon J. Diskin, Ph.D., Marci Laudenslager, B.S., Cynthia Winter, B.A., Kristina A. Cole, M.D., Ph.D., Joseph T. Glessner, M.S., Cecilia Kim, B.A., Edward C. Frackelton, B.A., Tracy Casalunovo, M.S., Andrew W. Eckert, M.S., Mario Capasso, Ph.D., Eric F. Rappaport, Ph.D., Carmel McConville, Ph.D., Wendy B. London, Ph.D., Robert C. Seeger, M.D., Nazneen Rahman, M.D., Ph.D., Marcella Devoto, Ph.D., Struan F.A. Grant, Ph.D., Hongzhe Li, Ph.D., and Hakon Hakonarson, M.D., Ph.D.
Chromosome 6p22 Locus Associated with Clinically Aggressive Neuroblastoma
N Engl J Med, Published at www.nejm.org May 7, 2008 (10.1056/NEJMoa0708698)
 Abstract |  Full Text |  Reprint |  News


Oligodendroglial Tumors


Alba A. Brandes, Alicia Tosoni, Giovanna Cavallo, Michele Reni, Enrico Franceschi, Laura Bonaldi, Roberta Bertorelle, Marina Gardiman, Claudio Ghimenton, Paolo Iuzzolino, Annalisa Pession, Valeria Blatt, Mario Ermani
Correlations Between O6-Methylguanine DNA Methyltransferase Promoter Methylation Status, 1p and 19q Deletions, and Response to Temozolomide in Anaplastic and Recurrent Oligodendroglioma: A Prospective GICNO Study
J Clin Oncol. 2006 Oct 10;24(29):4746-53. Epub 2006 Sep 5. DOI: 10.1200/JCO.2006.06.3891

Woehrer A, Sander P, Haberler C, Kern S, Maier H, Preusser M, Hartmann C, Kros JM, Hainfellner JA; Research Committee of the European Confederation of Neuropathological Societies.
FISH-based detection of 1p 19q codeletion in oligodendroglial tumors: procedures and protocols for neuropathological practice - a publication under the auspices of the Research Committee of the European Confederation of Neuropathological Societies (Euro-CNS).
Clin Neuropathol. 2011 Mar-Apr;30(2):47-55.
  Abstract |   Reprint |   Related articles


Pediatric Patients


Jacobs JF, Grauer OM, Brasseur F, Hoogerbrugge PM, Wesseling P, Gidding CE, van de Rakt MW, Figdor CG, Coulie PG, de Vries IJ, Adema GJ
Selective cancer-germline gene expression in pediatric brain tumors
J Neurooncol. 2008 Apr 9; [Epub ahead of print]
 Abstract |  Full Text |  Reprint | Supplemental Data

Liang ML, Ma J, Ho M, Solomon L, Bouffet E, Rutka JT, Hawkins C.
Tyrosine kinase expression in pediatric high grade astrocytoma
J Neurooncol. 2008 May;87(3):247-53. Epub 2008 Jan 10
 Abstract


Pilocytic Astrocytoma


Addo-Yobo SO, Straessle J, Anwar A, Donson AM, Kleinschmidt-Demasters BK, Foreman NK.
Paired overexpression of ErbB3 and Sox10 in pilocytic astrocytoma.
J Neuropathol Exp Neurol. 2006 Aug;65(8):769-75.
Abstract

Taillibert S, Vincent LA, Granger B, Marie Y, Carpentier C, Guillevin R, Bellanger A, Mokhtari K, Rousseau A, Psimaras D, Dehais C, Sierra del Rio M, Meng Y, Laigle-Donadey F, Hoang-Xuan K, Sanson M, Delattre JY
Pilocytic astrocytoma of the optic pathway: a tumour deriving from radial glia cells with a specific gene signature
Brain. 2009 Jun;132(Pt 6):1523-35. Epub 2009 Mar 31
  Abstract


Primary CNS Lymphoma


Schwindt H, Akasaka T, Zuhlke-Jenisch R, Hans V, Schaller C, Klapper W, Dyer MJ, Siebert R, Deckert M.
Chromosomal translocations fusing the BCL6 gene to different partner loci are recurrent in primary central nervous system lymphoma and may be associated with aberrant somatic hypermutation or defective class switch recombination.
J Neuropathol Exp Neurol. 2006 Aug;65(8):776-82.
Abstract


PNET


Kampman WA, Kros JM, De Jong TH, Lequin MH
Primitive neuroectodermal tumours (PNETs) located in the spinal canal; the relevance of classification as central or peripheral PNET : case report of a primary spinal PNET occurrence with a critical literature review.

J Neurooncol. 2006 Mar;77(1):65-72. Epub 2005 Nov 15.
Abstract

 

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