BRAINLIFE Brain Tumor Medical Database

Molecular Oncology, Markers, Clinical Correlates

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Astrocytic Tumors


Kasumi Araki, Kazuhiko Nozaki, Tetsuya Ueba, Masaaki Tatsuka and Nobuo Hashimoto
High expression of Aurora-B/Aurora and Ipll-like midbody-associated protein (AIM-1) in astrocytomas
J Neurooncol. 2004 Mar-Apr;67(1-2):53-64. (Abstract+)

Teralee Burton, Priti Baijal, Shunzhen Zhang, Elizabeth Henson, Spencer B. Gibson, David D. Eisenstat
The cell death gene BNIP3 is mutated in astrocytic tumors
Proceedings of the AACR, Volume 45, March 2004. Abstract Number: 5236

Basil F. El-Rayes, Camille S. Norton, Wael Sakr, Zosia Maciorowski, Daryn Smith, Haline Pietraszkiewicz, Maria Del Mar Alonso and John F. Ensley
Cellular DNA content parameters as prognostic indicators in human astrocytomas
Journal of Neuro-Oncology, 71(2): 85-89, January 2005. (Abstract+)

L. Girard, J. D. Minna, T. Chen, G. Tomlinson, D. Bowers
Gene expression profiling of progressive and stable childhood pilocytic astrocytomas
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.8546 

Koichi Ichimura, Hiroko Ohgaki, Paul Kleihues, V. Peter Collins
Molecular pathogenesis of astrocytic tumours
J Neurooncol, 70(2):137-160, November 2004. (Abstract+)

Stella M. Ranuncolo, Mirta Varela, Ana Morandi, José Lastiri, Silvia Christiansen, Elisa Bal de Kier Joffé, María G. Pallotta, Lydia Puricelli
Prognostic Value of Mdm2, p53 and p16 in Patients with Astrocytomas
Journal of Neuro-Oncology,
68 (2): 113-121, June 2004. (Abstract+)

M. Uno, S.M. Oba-Shinjo, A. Wakamatsu, N. Huang, V. Avancini Ferreira Alves, S. Rosemberg, P.H. Pires de Aguiar, C. Leite, F. Miura, R. Marino J., M. Scaff, S.K. Nagahashi-Marie
Association of TP53 mutation, p53 overexpression, and p53 codon 72 polymorphism with susceptibility to apoptosis in adult patients with diffuse astrocytomas
Int J Biol Markers 2006; 21: 50 - 57 Volume 21 Number 1 (January - March 2006)
Abstract

Zhang H, Wu G, Tu H, Huang F.
Discovery of serum biomarkers in astrocytoma by SELDI-TOF MS and proteinchip technology.
J Neurooncol. 2007 Sep;84(3):315-23. Epub 2007 Apr 24.
Abstract


Brain Tumors


Scott L Carter, Aron C Eklund, Isaac S Kohane, Lyndsay N Harris & Zoltan Szallasi
A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers
Nature Genetics, Advance online publication, Published online: 20 August 2006; doi:10.1038/ng1861

Lucinda Aguirre-Cruz, Karima Mokhtari, Khê Hoang-Xuan, Yannick Marie, Emmanuelle Criniere, Sophie Taillibert, Manuel Lopes, Jean-Yves Delattre, Marc Sanson
Analysis of the bHLH Transcription Factors Olig1 and Olig2 in Brain Tumors
Journal of Neuro-Oncology,
67 (3): 265-271, May 2004. (Abstract+)

Hainfellner JA, Heinzl H
Neuropathological biomarker candidates in brain tumors: key issues for translational efficiency
Clin Neuropathol. 2010 Jan-Feb;29(1):41-54
  Abstract |   Reprint

Pozsgai E, Gomori E, Szigeti A, Boronkai A, Gallyas F Jr, Sumegi B, Bellyei S
Correlation between the progressive cytoplasmic expression of a novel small heat shock protein (Hsp16.2) and malignancy in brain tumors
BMC Cancer. 2007 Dec 21;7(1):233 [Epub ahead of print]
Abstract | Reprint

Anil Rajendra, Philip C. Spinella, Henry R. Drott, Troy E. Dominguez, Leslie Sutton, Mark Helfaer
S-100β Protein – Serum Levels in Children with Brain Neoplasms and its Potential as a Tumor Marker
Journal of Neuro-Oncology, 67 (3): 345-349, May 2004. (Abstract+)

Alan H. Shih, Eric C. Holland
Developmental neurobiology and the origin of brain tumors
J Neurooncol, 70(2):125-135, November 2004. (Abstract+)

Edward R. Smith, MD; David Zurakowski, PhD; Ali Saad, MD; R. Michael Scott, MD; Marsha A. Moses, PhD
Urinary Biomarkers Predict Brain Tumor Presence and Response to Therapy
American Association of Neurological Surgeons 76th Annual Meeting: Abstract 629. Presented April 28, 2008
 Abstract |  News


Ependymal Tumors


M. Eva Alonso, M. Josefa Bello, Pilar Gonzalez-Gomez, Dolores Arjona, Jose M. de Campos, Manuel Gutierrez and Juan A. Rey
Aberrant CpG island methylation of multiple genes in ependymal tumors
J Neurooncol. 2004 Mar-Apr;67(1-2):159-65. (Abstract+)

Ebert C, von Haken M, Meyer-Puttlitz B, Wiestler OD, Reifenberger G, Pietsch T, von Deimling A
Molecular genetic analysis of ependymal tumors. NF2 mutations and chromosome 22q loss occur preferentially in intramedullary spinal ependymomas
Am J Pathol. 1999 Aug;155(2):627-32. (PDF Full Text)

Gilhuis HJ, van der Laak J, Wesseling P, Boerman RH, Beute G, Teepen JL, Grotenhuis JA, Kappelle AC
Inverse correlation between genetic aberrations and malignancy grade in ependymal tumors: a paradox?
J Neurooncol. 2004 Jan;66(1-2):111-6. (Abstract+)

Piergiorgio Modena, Joris Weltman, Elena Lualdi, Federica Facchinetti, Irene Janssen, Lisenka Wissers, Felice Giangaspero, Marco Forni, Gaetano Finocchiaro, Riccardo Riccardi, Franca Fossati Bellani, Maura Massimino, Eric Schoenmakers, Gabriella Sozzi
Genome-wide analysis of genomic imbalances in intracranial ependymomas
Proceedings of the AACR, Volume 45, March 2004. Abstract Number: 1671


Glioblastoma


J.L. Blanc, M. Wager, J. Guilhot, S. Kusy, B. Bataille, T. Chantereau, F. Lapierre, C.J. Larsen, L. Karayan-Tapon
Correlation of Clinical Features and Methylation Status of MGMT Gene Promoter in Glioblastomas
Journal of Neuro-Oncology,
68 (3): 275-283, July 2004. (Abstract+)

Carter AN, Cole CL, Playle AG, Ramsay EJ, Shervington AA
GPR26: A marker for primary glioblastoma?
Mol Cell Probes. 2007 Oct 26;. [Epub ahead of print]
Abstract

Charalambous C, Hofman FM, Chen TC
Functional and phenotypic differences between glioblastoma multiforme-derived and normal human brain endothelial cells
J Neurosurg. 2005 Apr;102(4):699-705

Etcheverry A, Aubry M, Tayrac MD, Vauleon E, Boniface R, Guenot F, Saikali S, Hamlat A, Riffaud L, Menei P, Quillien V, Mosser J.
DNA methylation in glioblastoma: impact on gene expression and clinical outcome.
BMC Genomics. 2010 Dec 14;11(1):701. [Epub ahead of print]
  Abstract |   Reprint |
  Related articles

Elstner A, Stockhammer F, Nguyen-Dobinsky TN, Nguyen QL, Pilgermann I, Gill A, Guhr A, Zhang T, von Eckardstein K, Picht T, Veelken J, Martuza RL, von Deimling A, Kurtz A.
Identification of diagnostic serum protein profiles of glioblastoma patients
J Neurooncol. 2010 Jul 9;. [Epub ahead of print]
  Abstract

C. Ford, W. Seiferheld, A. K. Choucair, J. Hansen, B. Dabbas, C. Schultz, A. Schulsinger, M. Mehta, W. Curran
Evaluation of expression of DNA repair molecules as a prognostic factor for long-term survivors with glioblastoma multiforme (GBM) treated on RTOG protocols with irradiation and nitrosoureas
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1509

Inoue R, Isono M, Abe M, Abe T, Kobayashi H
A genotype of the polymorphic DNA repair gene MGMT is associated with de novo glioblastoma
Neurol Res. 2003 Dec;25(8):875-9

Jung CS, Foerch C, Schänzer A, Heck A, Plate KH, Seifert V, Steinmetz H, Raabe A, Sitzer M
Serum GFAP is a diagnostic marker for glioblastoma multiforme
Brain. 2007 Dec;130(Pt 12):3336-41. Epub 2007 Nov 12
  Abstract |   Full Text |   Reprint

H. Kobayashi, N. Ishii, J. Ikeda, Y. Sawamura, Y. Iwasaki
Methylation profiling of the DNA repair genes in glioblastoma multiforme and its clinical relevance
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1572 

Yukiko Nakahara, Tetsuya Shiraishi, Hiroaki Okamoto, Toshihiro Mineta, Tsuyoshi Oishi, Kohsuke Sasaki, Kazuo Tabuchi
Detrended fluctuation analysis of genome-wide copy number profiles of glioblastomas using array-based comparative genomic hybridization
Neuro-oncol, 6(4):281-289, Oct 2004. (Abstract+)

Hiroshi Nawashiro, Naoki Otani, Nariyoshi Shinomiya, Shinji Fukui, Hidetoshi Ooigawa, Katsuji Shima, Hirotaka Matsuo, Yoshikatsu Kanai, Hitoshi Endou
L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors
International Journal of Cancer, Volume 119, CNO 3, Pages 484 - 492, DOI: 10.1002/ijc.21866, Published Online: 22 Feb 2006

Pelloski CE, Mahajan A, Maor M, Chang EL, Woo S, Gilbert M, Colman H, Yang H, Ledoux A, Blair H, Passe S, Jenkins RB, Aldape KD
YKL-40 Expression is Associated with Poorer Response to Radiation and Shorter Overall Survival in Glioblastoma
Clin Cancer Res. 2005 May 1;11(9):3326-34

Reddy PS, Umesh S, Thota B, Tandon A, Pandey P, Hegde AS, Balasubramaniam A, Chandramouli BA, Santosh V, Rao MR, Kondaiah P, Somasundaram K.
PBEF1/NAmPRTase/Visfatin: a potential malignant astrocytoma/glioblastoma serum marker with prognostic value
Cancer Biol Ther. 2008 May;7(5):663-8
 Abstract

Reddy SP, Britto R, Vinnakota K, Aparna H, Sreepathi HK, Thota B, Kumari A, Shilpa BM, Vrinda M, Umesh S, Samuel C, Shetty M, Tandon A, Pandey P, Hegde S, Hegde AS, Balasubramaniam A, Chandramouli BA, Santosh V, Kondaiah P, Somasundaram K, Rao MR
Novel Glioblastoma Markers with Diagnostic and Prognostic Value Identified through Transcriptome Analysis
Clin Cancer Res. 2008 May 15;14(10):2978-87
 Abstract

F. Rojo, C. Iglesias, J. Tabernero, J. Jimenez, S. Rodriguez, J. Bellmunt, S. Ramon, J. Baselga
Molecular markers of the mTOR pathway activation in human tumors: A baseline analysis
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.9524

Simon, Matthias M.D.; Ludwig, Michael Ph.D.; Fimmers, Rolf Ph.D.; Mahlberg, Ralph; Muller-Erkwoh, Angelika M.D.; Koster, Gertraud Ph.D.; Schramm, Johannes M.D.
Variant Of The Chek2 Gene As A Prognostic Marker In Glioblastoma Multiforme. Clinicopathological Study
Neurosurgery. 2006 Sep 28; [Epub ahead of print]
Abstract

Sreekanthreddy P, Srinivasan H, Kumar DM, Nijaguna MB, Sridevi S, Vrinda M, Arivazhagan A, Balasubramaniam A, Hegde AS, Chandramouli BA, Santosh V, Rao MR, Kondaiah P, Somasundaram K
Identification of potential serum biomarkers of glioblastoma: serum osteopontin levels correlate with poor prognosis
Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1409-22
  Abstract |   Full Text |   Reprint

Srivastava T, Chattopadhyay P, Mahapatra AK, Sarkar C, Sinha S
Increased hMSH2 protein expression in glioblastoma multiforme
J Neurooncol. 2004 Jan;66(1-2):51-7. (Abstract+)

Zhang R, Tremblay TL, McDermid A, Thibault P, Stanimirovic D
Identification of differentially expressed proteins in human glioblastoma cell lines and tumors
Glia 2003 Apr 15;42(2):194-208


Gliomas


Kenichiro Asano, Christopher D. Duntsch, Qihong Zhou, James D. Weimar, Dwight Bordelon, Jon H. Robertson, Tayebeh Pourmotabbed
Correlation of N-cadherin expression in high grade gliomas with tissue invasion
Journal of Neuro-Oncology,
70 (1): 3-15, October 2004. (Abstract+)

Bradley SV, Holland EC, Liu GY, Thomas D, Hyun TS, Ross TS. 
Huntingtin Interacting Protein 1 Is a Novel Brain Tumor Marker that Associates with Epidermal Growth Factor Receptor.
Cancer Res. 2007 Apr 15;67(8):3609-15.
PMID: 17440072 [PubMed - in process]

Conti A, Ageunnouz M, La Torre D, Cardali S, Angileri FF, Buemi C, Tomasello C, Iacopino DG, D'Avella D, Vita G, Tomasello F
Expression of the tumor necrosis factor receptor-associated factors 1 and 2 and regulation of the nuclear factor-kappaB antiapoptotic activity in human gliomas
J Neurosurg. 2005 Nov;103(5):873-81

de Groot JF, Gilbert MR.
New molecular targets in malignant gliomas.
Curr Opin Neurol. 2007 Dec;20(6):712-8.
Abstract

Tim Demuth, Michael E. Berens
Molecular Mechanisms of Glioma Cell Migration and Invasion
J Neurooncol, 70(2):217-228, November 2004. (Abstract+)

Charles Dichamp, Sophie Taillibert, Lucinda Aguirre-Cruz, Julie Lejeune, Yannick Marie, Michèle Kujas, Jean-Yves Delattre, Khe Hoang-Xuan and Marc Sanson
Loss of 14q Chromosome in Oligodendroglial and Astrocytic Tumors
Journal of Neuro-Oncology,
67 (3): 281-285, May 2004. (Abstract+)

Geiger KD, Hendruschk S, Rieber EP, Morgenroth A, Weigle B, Juratli T, Senner V, Schackert G, Temme A.
The prostate stem cell antigen represents a novel glioma-associated antigen.
Oncol Rep. 2011 Apr 15;. [Epub ahead of print]
  Abstract |   Related articles

Griguer CE, Oliva CR, Gillespie GY
Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines
J Neurooncol. 2005 Sep;74(2):123-33. Online 2005 Sep 29
 Abstract

Hägerstrand D, Smits A, Eriksson A, Sigurdardottir S, Olofsson T, Hartman M, Nistér M, Kalimo H, Ostman A.
Gene expression analyses of grade II gliomas and identification of rPTP{beta}/{zeta} as a candidate oligodendroglioma marker Neuro Oncol. 2007 Nov 14; [Epub ahead of print]
Abstract

Hofer S, Lassman AB.
Molecular markers in gliomas: impact for the clinician.
Target Oncol. 2010 Sep;5(3):201-10. Epub 2010 Aug 31.
  Abstract |   Reprint |   Related articles

Idbaih A, Omuro A, Ducray F, Hoang-Xuan K
Molecular genetic markers as predictors of response to chemotherapy in gliomas
Curr Opin Oncol. 2007 Nov;19(6):606-11
 Abstract

Jansen M, Yip S, Louis DN.
Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers
Lancet Neurol. 2010 Jul;9(7):717-726
  Abstract

Joki T, Heese O, Nikas DC, Bello L, Zhang J, Kraeft SK, Seyfried NT, Abe T, Chen LB, Carroll RS, Black PM
Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398
Cancer Res 2000 Sep 1;60(17):4926-31(PDF Full Text)

Balveen Kaur, Chalet Tan, Daniel J. Brat, Erwin G. Van Meir
Genetic and hypoxic regulation of angiogenesis in gliomas
J Neurooncol, 70(2):229-243, November 2004. (Abstract+)

Kuhlmann T, Gutenberg A, Schulten HJ, Paulus W, Rohde V, Bruck W.
Nogo-A Expression in Glial CNS Tumors: A Tool to Differentiate Between Oligodendrogliomas and Other Gliomas?
Am J Surg Pathol. 2008 Aug 5; [Epub ahead of print]
 Abstract

Leuraud P, Taillandier L, Aguirre-Cruz L, Medioni J, Criniere E, Marie Y, Dutrillaux AM, Kujas M, Duprez A, Delattre JY, Poupon MF, Sanson M
Correlation between genetic alterations and growth of human malignant glioma xenografted in nude mice
Br J Cancer. 2003 Dec 15;89(12):2327-32

Li A, Bozdag S, Kotliarov Y, Fine HA.
GliomaPredict: a clinically useful tool for assigning glioma patients to specific molecular subtypes
BMC Med Inform Decis Mak. 2010 Jul 15;10(1):38. [Epub ahead of print]
  Abstract |   Full Text |   Reprint

Ljubimova JY, Fugita M, Khazenzon NM, Das A, Pikul BB, Newman D, Sekiguchi K, Sorokin LM, Sasaki T, Black KL
Association between laminin-8 and glial tumor grade, recurrence, and patient survival
Cancer. 2004 Aug 1;101(3):604-12

Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA
Malignant glioma: genetics and biology of a grave matter
Genes Dev. 2001 Jun 1;15(11):1311-33 (
PDF Full Text)

Q. Richard Lu, John K. Park, Elizabeth Noll, Jennifer A. Chan, John Alberta, Dongin Yuk, M. Garcia Alzamora, David N. Louis, Charles D. Stiles, David H. Rowitch, and Peter M. Black
Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors
, September 11, 2001, Vol. 98, No. 19, Pages 10851-10856. (PDF Full Text)

Timothy E. Van Meter, William C. Broaddus, Harcharan K. Rooprai, Geoffrey J. Pilkington, Helen L. Fillmore
Induction of membrane-type-1 matrix metalloproteinase by epidermal growth factor-mediated signaling in gliomas
Neuro-Oncology, Vol. 6, No. 3, July 2004, 188 -- 199.  (Abstract+)

Satoshi Nakasu, Tadateru Fukami, Kazumi Baba, Masayuki Matsuda
Immunohistochemical study for O6-methylguanine-DNA methyltransferase in the non-neoplastic and neoplastic components of gliomas
Journal of Neuro-Oncology, 70(3): 333-340, December 2004. (Abstract+)

A. Ohnishi, M. Tsuda, Y. Sawamura, H. Sawa, K. Nagashima
Testing for glioma uniformity by Olig expression
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003.
Abstract No. 467

Peria FM, Neder L, Marie SK, Rosemberg S, Oba-Shinjo SM, Colli BO, Gabbai AA, Malheiros SM, Zago MA, Panepucci RA, Moreira-Filho CA, Okamoto OK, Carlotti CG Jr. 
Pleiotrophin expression in astrocytic and oligodendroglial tumors and it's correlation with histological diagnosis, microvascular density, cellular proliferation and overall survival.
J Neurooncol. 2007 Apr 19; [Epub ahead of print]
PMID: 17443289 [PubMed - as supplied by publisher]

K Sakai, A Peraud, T Mainprize, J Nakayama, A Tsugu, K Hongo, S Kobayashi, James T. Rutka
Inducible Expression of p57KIP2 Inhibits Glioma Cell Motility and Invasion
Journal of Neuro-Oncology,
68 (3): 217-223, July 2004. (Abstract+)

Andrea Salmaggi, Maurizio Gelati, Bianca Pollo, Simona Frigerio, Marica Eoli, Antonio Silvani, Giovanni Broggi, Emilio Ciusani, Danilo Croci, Amerigo Boiardi, Marco De Rossi
CXCL12 in Malignant Glial Tumors: A Possible Role in Angiogenesis and Cross-Talk between Endothelial and Tumoral Cells
Journal of Neuro-Oncology,
67 (3): 305-317, May 2004. (Abstract+)

Shono T, Tofilon PJ, Bruner JM, Owolabi O, Lang FF
Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations
Cancer Res 2001 Jun 1;61(11):4375-81 (PDF Full Text)

Joachim P. Steinbach, Michael Weller
Apoptosis in Gliomas: Molecular Mechanisms and Therapeutic Implications
J Neurooncol, 70(2):245-254, November 2004. (Abstract+)

Strege RJ, Godt C, Stark AM, Hugo HH, Mehdorn HM
Protein expression of Fas, Fas ligand, Bcl-2 and TGFbeta2 and correlation with survival in initial and recurrent human gliomas
J Neurooncol. 2004 Mar-Apr;67(1-2):29-39. (Abstract+)

Tanwar MK, Gilbert MR, Holland EC.
Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma
Cancer Res 2002 Aug 1;62(15):4364-8
 Abstract |  Full Text |  Reprint

K. D. Weaver, S. Grossman, J. Herman
Methylated tumor-specific DNA as a plasma biomarker in patients with glioma
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1527

Manfred Westphal, Peter McL. Black
Perspectives of Cellular and Molecular Neurosurgery
J Neurooncol, 70(2):255-269, November 2004. (Abstract+)

R Yamanaka, T Arao, N Yajima, N Tsuchiya, J Homma, R Tanaka, M Sano, A Oide, M Sekijima and K Nishio
Identification of expressed genes characterizing long-term survival in malignant glioma patients
Oncogene advance online publication 1 May 2006; doi: 10.1038/sj.onc.1209585
Abstract

Zhang X, Zhao M, Huang AY, Fei Z, Zhang W, Wang XL
The effect of cyclin D expression on cell proliferation in human gliomas
J Clin Neurosci. 2005 Feb;12(2):166-168

Yi-Hong Zhou, Fang Tan, Kenneth R. Hess and W. K. Alfred Yung
The Expression of PAX6, PTEN, Vascular Endothelial Growth Factor, and Epidermal Growth Factor Receptor in Gliomas. Relationship to Tumor Grade and Survival
Clinical Cancer Research Vol. 9, 3369-3375, August 2003. (PDF Full Text)


Gliomas (High-Grade)


Brommeland T, Rosengren L, Fridlund S, Hennig R, Isaksen V
Serum levels of glial fibrillary acidic protein correlate to tumour volume of high-grade gliomas
Acta Neurol Scand. 2007 Dec;116(6):380-4
  Abstract

Adília Hormigo, Bin Gu, Sasan Karimi, Elyn Riedel, Katherine S. Panageas, Mark A. Edgar, Meena K. Tanwar, Jasti S. Rao, Martin Fleisher, Lisa M. DeAngelis and Eric C. Holland
YKL-40 and Matrix Metalloproteinase-9 as Potential Serum Biomarkers for Patients with High-Grade Gliomas
Clin Cancer Res. 2006 Oct 1;12(19):5698-704.

Fatima W. Khwaja, Jonathan S. Duke-Cohan, Daniel J. Brat and Erwin G. Van Meir
Attractin Is Elevated in the Cerebrospinal Fluid of Patients with Malignant Astrocytoma and Mediates Glioma Cell Migration
Clin Cancer Res. 2006 Nov 1;12(21):6331-6

Yip S, Iafrate AJ, Louis DN
Molecular diagnostic testing in malignant gliomas: a practical update on predictive markers
J Neuropathol Exp Neurol. 2008 Jan;67(1):1-15
Abstract

Wager M, Menei P, Guilhot J, Levillain P, Michalak S, Bataille B, Blanc JL, Lapierre F, Rigoard P, Milin S, Duthe F, Bonneau D, Larsen CJ, Karayan-Tapon L.
Prognostic molecular markers with no impact on decision-making: the paradox of gliomas based on a prospective study
Br J Cancer. 2008 Jun 3;98(11):1830-8. Epub 2008 May 27
 Abstract


Gliomas (Low-Grade)


Bourne TD, Schiff D.
Update on molecular findings, management and outcome in low-grade gliomas.
Nat Rev Neurol. 2010 Dec;6(12):695-701. Epub 2010 Nov 2.
  Abstract |   Reprint |
  Related articles

J. C. Buckner, K. V. Ballman, B. W. Scheithauer, R. M. Arusell, H. E. Blair, S. M. Passe, P. D. Brown, K. A. Jaeckle, E. G. Shaw, R. B. Jenkins
NCCTG 94-72-53: Diagnostic and prognostic significance of 1p and 19q deletions in patients (pts) with low-grade oligodendroglioma and astrocytoma
2005 ASCO Annual Meeting. Orlando, FL. May 13-17. Abstract No. 1502
Journal of Clinical Oncology, Vol 23, No 16S (June 1 Supplement), 2005: 1502

Kujas M, Lejeune J, Benouaich-Amiel A, Criniere E, Laigle-Donadey F, Marie Y, Mokhtari K, Polivka M, Bernier M, Chretien F, Couvelard A, Capelle L, Duffau H, Cornu P, Broet P, Thillet J, Carpentier AF, Sanson M, Hoang-Xuan K, Delattre JY.
Chromosome 1p loss: A favorable prognostic factor in low-grade gliomas
Ann Neurol. 2005 Jul 27;58(2):322-326 [Epub ahead of print]

Ribom D, Larsson A, Pietras K, Smits A
Growth factor analysis of low-grade glioma CSF: PDGF and VEGF are not detectable
Neurol Sci. 2003 Jun;24(2):70-3

Ribom D, Westman-Brinkmalm A, Smits A, Davidsson P
Elevated levels of alpha-2-Heremans-Schmid glycoprotein in CSF of patients with low-grade gliomas

Tumour Biol. 2003 Mar-Apr;24(2):94-9

Walker C, du Plessis DG, Fildes D, Haylock B, Husband D, Jenkinson MD, Joyce KA, Broome J, Kopitski K, Prosser J, Smith T, Vinjamuri S, Warnke PC
Correlation of molecular genetics with molecular and morphological imaging in gliomas with an oligodendroglial component
Clin Cancer Res. 2004 Nov 1;10(21):7182-91


Hereditary Tumor Syndr.


J. Spaulding, R. Brekken, L. Robinson, K. Koeneman, B. Mickey, J. Cadeddu, C. Croft, A. Sagalowsky, N. Ahmad, G. E. Tomlinson
Serum markers of angiogenesis in patients with von Hippel-Lindau Disease
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1033


Malignant Lymphoma


L. E. Abrey, D. A. Filippa, L. M. DeAngelis
Clinical correlation of histologic and genetic features in primary CNS lymphoma (PCNSL)
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003. Abstract No. 417


Medulloblastoma


Boon K, Eberhart CG, Riggins GJ
Genomic amplification of orthodenticle homologue 2 in medulloblastomas
Cancer Res. 2005 Feb 1;65(3):703-7

Brandes AA, Franceschi E.
Neuro-oncology: Genetic variation in pediatric and adult brain tumors.
Nat Rev Neurol. 2010 Dec;6(12):653-4.
  Abstract |
  Related articles

Di C, Liao S, Adamson DC, Parrett TJ, Broderick DK, Shi Q, Lengauer C, Cummins JM, Velculescu VE, Fults DW, McLendon RE, Bigner DD, Yan H
Identification of OTX2 as a Medulloblastoma Oncogene Whose Product can be Targeted by All-Trans Retinoic Acid
Cancer Res. 2005 Feb 1;65(3):919-24. (Abstract+)

Fernandez-Teijeiro A, Betensky RA, Sturla LM, Kim JY, Tamayo P, Pomeroy SL
Combining Gene Expression Profiles and Clinical Parameters for Risk Stratification in Medulloblastomas
Journal of Clinical Oncology, Vol 22, No 6 (March 15), 2004: pp. 994-998 (PDF Full Text)

Paul Graham Fisher, Peter C. Burger, Charles G. Eberhart
Biologic Risk Stratification of Medulloblastoma: The Real Time Is Now 
Journal of Clinical Oncology, Vol 22, No 6 (March 15), 2004: pp. 971-974. (PDF Full Text)

Amar Gajjar, Roberto Hernan, Mehmet Kocak, Christine Fuller, Youngsoo Lee, Peter J. McKinnon, Dana Wallace, Ching Lau, Murali Chintagumpala, David M. Ashley, Stewart J. Kellie, Larry Kun, Richard J. Gilbertson 
Clinical, Histopathologic, and Molecular Markers of Prognosis: Toward a New Disease Risk Stratification System for Medulloblastoma 
Journal of Clinical Oncology, Vol 22, No 6 (March 15), 2004: pp. 984-993. (Full Text)

A. J. Gajjar, R. Hernan, C. Fuller, Y. Lee, M. Kocak, C. Lau, M. Chintagumpala, D. Ashley, S. Kellie, R. Gilbertson
Molecular markers predictive of disease outcome in medulloblastoma
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003.  

Holland H, Koschny R, Krupp W, Meixensberger J, Bauer M, Schober R, Kirsten H, Ganten TM, Ahnert P.
Cytogenetic and molecular biological characterization of an adult medulloblastoma.
Cancer Genet Cytogenet. 2007 Oct 15;178(2):104-13.
Abstract

Jung HL, Wang KC, Kim SK, Sung KW, Koo HH, Shin HY, Ahn HS, Shin HJ, Cho BK
Loss of heterozygosity analysis of chromosome 17p13.1-13.3 and its correlation with clinical outcome in medulloblastomas
J Neurooncol. 2004 Mar-Apr;67(1-2):41-6. (Abstract+)

Brian R. Rood, Huizhen Zhang, Philip H. Cogen
Intercellular heterogeneity of expression of the MGMT DNA repair gene in pediatric medulloblastoma
Neuro-Oncology, Vol. 6, No. 3, July 2004, 200 -- 207.  (Abstract+)

Tong CY, Hui AB, Yin XL, Pang JC, Zhu XL, Poon WS, Ng HK
Detection of oncogene amplifications in medulloblastomas by comparative genomic hybridization and array-based comparative genomic hybridization
J Neurosurg. 2004 Feb;100(2 Suppl):187-93


Meningioma


Bernhard Braun, Manfred Lange, Reinhard Oeckler, Margareta M. Mueller
Expression of G-CSF and GM-CSF in Human Meningiomas Correlates with Increased Tumor Proliferation and Vascularization
Journal of Neuro-Oncology,
68 (2): 131-140, June 2004. (Abstract+)

Angel Maíllo, Alberto Orfao, José María Sayagués, Pedro Díaz, Juan Antonio Gómez-Moreta, Marcelino Caballero, David Santamarta, Angel Santos-Briz, Francisco Morales, María Dolores Tabernero
New Classification Scheme for the Prognostic Stratification of Meningioma on the Basis of Chromosome 14 Abnormalities, Patient Age, and Tumor Histopathology
Journal of Clinical Oncology, Vol 21, No 17 (September 1), 2003: 3285-3295. (PDF Full Text) 

Okada M, Miyake K, Matsumoto Y, Kawai N, Kunishio K, Nagao S
Matrix metalloproteinase-2 and matrix metalloproteinase-9 expressions correlate with the recurrence of intracranial meningiomas
J Neurooncol. 2004 Jan;66(1-2):29-37. (Abstract+)

Shinji Otsuka, Takashi Tamiya, Yasuhiro Ono, Hiroyuki Michiue, Kazuhiko Kurozumi, Shigeru Daido, Hirokazu Kambara, Isao Date, Takashi Ohmoto
The relationship between peritumoral brain edema and the expression of vascular endothelial growth factor and its receptors in intracranial meningiomas
Journal of Neuro-Oncology, 70(3): 349-357, December 2004. (Abstract+)

Arie Perry, David H. Gutmann, Guido Reifenberger
Molecular pathogenesis of meningiomas
J Neurooncol, 70(2):183-202, November 2004. (Abstract+)

Torsten Pietsch, Michael D. Taylor, James T. Rutka
Molecular pathogenesis of childhood brain tumors
J Neurooncol, 70(2):203-215, November 2004. (Abstract+)

Wolfgang K. Pfisterer, Nicole C. Hank, Mark C. Preul, William P. Hendricks, Jeanette Pueschel, Stephen W. Coons, Adrienne C. Scheck
Diagnostic and prognostic significance of genetic regional heterogeneity in meningiomas
Neuro-oncol, 6(4):290-299, Oct 2004. (Abstract+)


Metastatic Tumors


Saad AG, Yeap BY, Thunnissen FB, Pinkus GS, Pinkus JL, Loda M, Sugarbaker DJ, Johnson BE, Chirieac LR.
Immunohistochemical markers associated with brain metastases in patients with nonsmall cell lung carcinoma
Cancer. 2008 Aug 20. [Epub ahead of print]
 Abstract


Neuroblastoma


J. Mora, M. Alaminos, N.-K. Cheung, J. Rios, W. Gerald
Gene expression profiling of neuroblastoma: Analysis of nonmetastatic versus metastatic tumors
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.8538

Weber A, Huesken C, Bergmann E, Kiess W, Christiansen NM, Christiansen H
Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas
Clin Cancer Res. 2003 Nov 15;9(15):5683-92. (PDF Full Text)


Non-Nervous System Tum.


S Fan, Q Meng, K Auborn, T Carter and E M Rosen
BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells
British Journal of Cancer (2006) 94, 407-426. Published online 24 January 2006
Abstract | BrainLife | Full Text | Reprint | News


Oligodendroglial Tumors


L. S. Ashby, J. K. Pueschel, A. C. Scheck, S. W. Coons, W. R. Shapiro
Prognostic factors for patients with newly diagnosed low-grade oligodendroglial tumors: molecular genetics, histopathology, and neuroimag
2005 ASCO Annual Meeting. Orlando, FL. May 13-17. Abstract No. 1501
Journal of Clinical Oncology, Vol 23, No 16S (June 1 Supplement), 2005: 1501

Sandra H. Bigner, Mark R. Matthews, B. K. A. Rasheed, Rodney N. Wiltshire, Henry S. Friedman, Allan H. Friedman, Timothy T. Stenzel, Donald M. Dawes, Roger E. McLendon and Darell D. Bigner
Molecular Genetic Aspects of Oligodendrogliomas Including Analysis by Comparative Genomic Hybridization
American Journal of Pathology. August 1999;155:375-386. (PDF Full Text)

JG Cairncross, K Ueki, MC Zlatescu, DK Lisle, DM Finkelstein, RR Hammond, JS Silver, PC Stark, DR Macdonald, Y Ino, DA Ramsay and DN Louis
Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas
Journal Of The National Cancer Institute, Vol 90, 1473-1479; 7 October 1998. (PDF Full Text)

E. Franceschi, G. Cavallo, A. Paioli, L. Scopece, R. Degli Esposti, E. Leonardi, F. Spagnolli, A. M. Cremonini, A. Pession, L. Crino
Evaluation of 1p and 19q chromosomal alterations in oligodendroglial neoplasms using microdissection and microsatellite analysis technique and correlations with response to chemotherapy
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1568

M.T. Giordana, C. Ghimenti, E. Leonardo, I. Balteri, M. Iudicello, D. Duò
Molecular Genetic Study of a Metastatic Oligodendroglioma
Journal of Neuro-Oncology, 66 (3): 265-271, February 2004 (Abstract+)

Hamlat A, Saikali S, Chaperon J, Le Calve M, Gedouin D, Ben-Hassel M, Guegan Y
Oligodendroglioma: clinical study and survival analysis correlated with chromosomal anomalies
Neurosurg Focus. 2005 Nov 15;19(5):E15

Hoang-Xuan K, He J, Huguet S, Mokhtari K, Marie Y, Kujas M, Leuraud P, Capelle L, Delattre JY, Poirier J, Broet P, Sanson M
Molecular heterogeneity of oligodendrogliomas suggests alternative pathways in tumor progression

Neurology. 2001 Oct 9;57(7):1278-81

Judith W.M. Jeuken, Andreas Von Deimling, Pieter Wesseling
Molecular pathogenesis of oligodendroglial tumors
J Neurooncol, 70(2):161-181, November 2004. (Abstract+)

Laigle-Donadey F, Martin-Duverneuil N, Lejeune J, Criniere E, Capelle L, Duffau H, Cornu P, Broet P, Kujas M, Mokhtari K, Carpentier A, Sanson M, Hoang-Xuan K, Thillet J, Delattre JY
Correlations between molecular profile and radiologic pattern in oligodendroglial tumors

Neurology. 2004 Dec 28;63(12):2360-2

Marie Y, Sanson M, Mokhtari K, Leuraud P, Kujas M, Delattre JY, Poirier J, Zalc B, Hoang-Xuan K
OLIG2 as a specific marker of oligodendroglial tumour cells

Lancet. 2001 Jul 28;358(9278):298-300

Mokhtari K, Paris S, Aguirre-Cruz L, Privat N, Criniere E, Marie Y, Hauw JJ, Kujas M, Rowitch D, Hoang-Xuan K, Delattre JY, Sanson M
Olig2 expression, GFAP, p53 and 1p loss analysis contribute to glioma subclassification
Neuropathol Appl Neurobiol. 2005 Feb;31(1):62-9

Walker C, du Plessis DG, Joyce KA, Fildes D, Gee A, Haylock B, Husband D, Smith T, Broome J, Warnke PC
Molecular pathology and clinical characteristics of oligodendroglial neoplasms
Ann Neurol. 2005 Jun;57(6):855-65

Weller M, Berger H, Hartmann C, Schramm J, Westphal M, Simon M, Goldbrunner R, Krex D, Steinbach JP, Ostertag CB, Loeffler M, Pietsch T, von Deimling A; German Glioma Network
Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker?
Clin Cancer Res. 2007 Dec 1;13(23):6933-7
 Abstract


Primer


Ivanchuk SM, Rutka JT
The cell cycle: accelerators, brakes, and checkpoints
Neurosurgery. 2004 Mar;54(3):692-9; discussion 699-700. (Abstract+)


Schwannoma


A. M. Cappellano, M. T. Grande, S. N. Oliveira, L. J. G. Zambaldi, M. Araujo, F. A. Freitas, I. A. Cardinalli, S. R. Brandalise, S. S. Aguiar
A novel translocation (x;4)(p22.1;q32) in a child with malignant Schwannoma
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.8572


SPNET


VE Gould, DS Jansson, WM Molenaar, LB Rorke, JQ Trojanowski, VM Lee, RJ Packer and WW Franke
Primitive neuroectodermal tumors of the central nervous system. Patterns of expression of neuroendocrine markers, and all classes of intermediate filament proteins
Lab Invest. 1990 Apr;62(4):498-509

 

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