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Astrocytoma
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Groenendijk
FH, Taal W, Dubbink HJ, Haarloo CR, Kouwenhoven MC, van den Bent MJ, Kros JM,
Dinjens WN.
MGMT promoter hypermethylation is a frequent, early, and consistent event in
astrocytoma progression, and not correlated with TP53 mutation
J Neurooncol. 2010 Jul 1;. [Epub ahead of print]
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Abstract |
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Reprint
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Marucci G, Morandi L.
Assessment
of MGMT promoter methylation status in pleomorphic xanthoastrocytoma.
J Neurooncol.
2011 May 31. [Epub ahead of print]
Abstract |
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Basic
Science
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Li Fan,
Andrew S. Arvai, Priscilla
K. Cooper, Shigenori Iwai,
Fumio Hanaoka, and
John
A. Tainer
Conserved
XPB Core Structure and Motifs for DNA Unwinding: Implications for Pathway
Selection of Transcription or Excision Repair
Molecular Cell, Vol 22, 27-37, 7 April 2006
Abstract
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News
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Kim SJ, Kim JS, Park ES, Lee JS, Lin Q, Langley RR, Maya M, He J, Kim SW, Weihua
Z, Balasubramanian K, Fan D, Mills GB, Hung MC, Fidler IJ.
Astrocytes upregulate survival genes in tumor cells and induce protection
from chemotherapy.
Neoplasia. 2011 Mar;13(3):286-98.
Abstract |
Reprint |
Related articles
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Ian F. Pollack, Ronald
L. Hamilton, Robert W. Sobol, Judith Burnham,
Allan J. Yates, Emiko J. Holmes, Tianni
Zhou, Jonathan L. Finlay
O6-Methylguanine-DNA
Methyltransferase Expression Strongly Correlates With Outcome in Childhood
Malignant Gliomas: Results From the CCG-945 Cohort
Journal of Clinical Oncology, Vol 24, No 21 (July 20), 2006: pp. 3431-3437;
DOI: 10.1200/JCO.2006.05.7265
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Valera
ET, Machado HR, Scrideli CA, Lucio-Eterovic AK, Tone LG.
Drug-Resistance in Central Nervous System Tumors: from
the Traditional Cell-Resistance Model to the Genetically Driven
Approaches on Therapy.
Curr
Pharm Biotechnol. 2007 Apr;8(2):105-113.
PMID: 17430159 [PubMed - as supplied by publisher]
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Valera ET, Lucio-Eterovic AK, Neder L, Scrideli CA, Machado
HR, Carlotti-Junior CG, Queiroz RG, Motta FJ, Tone LG
Quantitative PCR analysis of the expression profile of genes related to
multiple drug resistance in tumors of the central nervous system
J Neurooncol.
2007 Oct;85(1):1-10.
Epub 2007 Apr 12
Abstract
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Brain
Tumors
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Brell
M, Ibáñez J, Tortosa A.
O6-Methylguanine-DNA
methyltransferase protein expression by immunohistochemistry in brain and
non-brain systemic tumours: systematic review and meta-analysis of
correlation with methylation-specific polymerase chain reaction.
BMC
Cancer. 2011 Jan 26;11:35.
Abstract |
Reprint |
Related articles
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Glioblastoma
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Beier
D, Schulz JB, Beier CP.
Chemoresistance of
glioblastoma cancer stem cells - much more complex than expected.
Mol Cancer. 2011 Oct
11;10(1):128. [Epub ahead of print]
Abstract |
Reprint |
Related articles
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Christmann
M, Nagel G, Horn S, Krahn U, Wiewrodt D, Sommer C, Kaina B
MGMT activity, promoter methylation and immunohistochemistry of
pre-treatment and recurrent malignant gliomas: A comparative study on
astrocytoma and glioblastoma
Int J Cancer. 2010 Feb 3;. [Epub ahead of print]
Abstract
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Fischer U, Meese E
Glioblastoma multiforme: the role of DSB repair between genotype and
phenotype
Oncogene. 2007 Dec 10;26(56):7809-15.
Review
Abstract
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Hamilton
MG, Roldán G, Magliocco A, McIntyre JB, Parney I, Easaw JC.
Determination of the methylation status of MGMT in different regions within
glioblastoma multiforme
J Neurooncol. 2010 Jul 21;. [Epub ahead of print]
Abstract
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Jesien-Lewandowicz
E, Jesionek-Kupnicka D, Zawlik I, Szybka M, Kulczycka-Wojdala D, Rieske P,
Sieruta M, Jaskolski D, Och W, Skowronski W, Sikorska B, Potemski P, Papierz
W, Liberski PP, Kordek R.
High incidence of MGMT promoter methylation in primary glioblastomas without
correlation with TP53 gene mutations
Cancer Genet Cytogenet. 2009 Jan 15;188(2):77-82
Abstract
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Jin
F, Li HS, Zhao L, Wei YJ, Zhang H, Guo YJ, Pang R, Jiang XB, Zhao HY.
Expression of anti-apoptotic and multi-drug resistance-associated protein
genes in cancer stem cell isolated from TJ905 glioblastoma multiforme cell
line
Zhonghua Yi Xue Za Zhi. 2008 Aug 26;88(33):2312-6
Abstract
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Le Mercier M, Lefranc F, Mijatovic T, Debeir O,
Haibe-Kains B, Bontempi G, Decaestecker C, Kiss R, Mathieu V.
Evidence of galectin-1 involvement in glioma chemoresistance
Toxicol Appl Pharmacol. 2008 Jan 29; [Epub ahead of print]
Abstract
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Lucio-Eterovic AK, Piao Y, de Groot JF
Mediators
of glioblastoma resistance and invasion during antivascular endothelial
growth factor therapy
in
Cancer Res. 2009 Jul 15;15(14):4589-99. Epub 2009 Jun 30
Abstract
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Martinez
R, Martin-Subero JI, Rohde V, Kirsch M, Alaminos M, Fernandez AF, Ropero S,
Schackert G, Esteller M
A microarray-based DNA methylation study of glioblastoma multiforme
Epigenetics. 2009 May 16;4(4):255-64
Abstract |
Reprint
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Pistollato
F, Abbadi S, Rampazzo E, Persano L, Puppa AD, Frasson C, Sarto E, Scienza R,
D'Avella D, Basso G
Intratumoral Hypoxic Gradient Drives Stem Cells Distribution and MGMT
Expression in Glioblastoma
Stem
Cells. 2010 Mar 22. [Epub ahead of print]
Abstract
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Sciuscio
D, Diserens AC, van Dommelen K, Martinet D, Jones G, Janzer RC, Pollo C,
Hamou MF, Kaina B, Stupp R, Levivier M, Hegi ME.
Extent and Patterns of MGMT Promoter Methylation in Glioblastoma and
Respective Derived Spheres.
Clin Cancer Res. 2010 Nov 19;. [Epub ahead of print]
Abstract |
Related articles
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Shah
N, Lin B, Sibenaller Z, Ryken T, Lee H, Yoon JG, Rostad S, Foltz G.
Comprehensive Analysis of MGMT Promoter Methylation: Correlation with MGMT
Expression and Clinical Response in GBM.
PLoS One. 2011 Jan 7;6(1):e16146.
Abstract |
Reprint |
Related articles
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Sonoda
Y, Yokosawa M, Saito R, Kanamori M, Yamashita Y, Kumabe T, Watanabe M,
Tominaga T.
O (6)-Methylguanine DNA methyltransferase determined by promoter
hypermethylation and immunohistochemical expression is correlated with
progression-free survival in patients with glioblastoma
Int J Clin Oncol. 2010 Mar 16;. [Epub ahead of print]
Abstract
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Yip
S, Miao J, Cahill DP, Iafrate AJ, Aldape K, Nutt CL, Louis DN.
MSH6 mutations arise in glioblastomas during temozolomide therapy and
mediate temozolomide resistance
Clin Cancer Res. 2009 Jul 15;15(14):4622-9. Epub 2009 Jul
7
Abstract
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Pediatric
Patients
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Donson AM, Addo-Yobo SO, Handler MH, Gore L,
Foreman NK
MGMT
promoter methylation correlates with survival benefit and sensitivity to
temozolomide in pediatric glioblastoma
Pediatr Blood Cancer. 2007 Apr;48(4):403-7
Abstract
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Gaspar
N, Marshall L, Perryman L, Bax DA, Little SE, Viana-Pereira M, Sharp SY,
Vassal G, Pearson A, Reis RM, Hargrave D, Workman P, Jones C.
MGMT-independent
temozolomide resistance in paediatric glioblastoma cells associated with a PI3-kinase-mediated
HOX
/ stem cell gene signature.
Cancer Res. 2010 Oct 8;. [Epub ahead of print]
Abstract |
Related articles
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Srivastava
A, Jain A, Jha P, Suri V, Sharma MC, Mallick S, Puri T, Gupta DK, Gupta A,
Sarkar C.
MGMT gene promoter methylation in pediatric glioblastomas
Childs Nerv Syst. 2010 Jun 29;. [Epub ahead of print]
Abstract
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Gliosarcoma
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Kang
SH, Park KJ, Kim CY, Yu MO, Park CK, Park SH, Chung YG.
O6-methylguanine
DNA methyltransferase status determined by promoter methylation and
immunohistochemistry in gliosarcoma and their clinical implications.
J
Neurooncol. 2011 Feb;101(3):477-86. Epub 2010 Jun 17.
Abstract |
Reprint |
Related articles
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Gliomas
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Bi
CL, Fang JS, Chen FH, Wang YJ, Wu J
Chemoresistance of CD133(+) tumor stem cells from human brain glioma
Zhong
Nan Da Xue Xue Bao Yi Xue Ban. 2007 Aug;32(4):568-73
Abstract
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Blough
MD, Beauchamp DC, Westgate MR, Kelly JJ, Cairncross JG
Effect
of aberrant p53 function on temozolomide sensitivity of glioma cell lines
and brain tumor initiating cells from glioblastoma
J
Neurooncol. 2010 Jul 1. [Epub ahead of print]
Abstract
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He J, Shan Z, Li L, Liu F, Liu Z, Song M, Zhu H.
Expression
of glioma stem cell marker CD133 and O6-methylguanine-DNA methyltransferase
is associated with resistance to radiotherapy in gliomas.
Oncol Rep. 2011 Jul 18.
[Epub
ahead of print]
Abstract |
Related articles
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Fassan
M, Tassone E, Onisto M, Perilongo G, D'Avella D, Gardiman MP.
MGMT promoter methylation in pediatric high-grade gliomas.
Childs
Nerv Syst. 2010 Oct 30. [Epub ahead of print]
Abstract |
Reprint |
Related articles
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Frosina G.
DNA repair and resistance of gliomas to chemotherapy and radiotherapy.
Mol Cancer Res. 2009 Jul;7(7):989-99
Abstract | |
Reprint |
Related articles
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Kang
MK, Kang SK.
Tumorigenesis of Chemotherapeutic Drug-Resistant
Cancer Stem-Like Cells in Brain Glioma.
Stem Cells Dev.
2007 Oct;16(5):837-848.
Abstract
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Kil WJ, Cerna D, Burgan WE, Beam K, Carter D, Steeg PS, Tofilon PJ,
Camphausen K.
In
vitro and in vivo radiosensitization induced by the DNA methylating agent
temozolomide.
Clin
Cancer Res. 2008 Feb 1;14(3):931-8.
Abstract |
Reprint |
Related articles
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Ngo
TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC,
Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO,
Kang DW, Park JK.
The 1p-encoded protein stathmin and
resistance of malignant gliomas to nitrosoureas.
J Natl
Cancer Inst. 2007 Apr 18;99(8):639-52.
PMID: 17440165 [PubMed - in process]
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Oliva
CR, Moellering DR, Gillespie GY, Griguer CE.
Acquisition of
Chemoresistance in Gliomas Is Associated with Increased Mitochondrial
Coupling and Decreased ROS Production.
PLoS One.
2011;6(9):e24665.
Published online 2011 September 9.
Abstract |
Reprint |
Related articles°
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Parkinson JF, Wheeler HT, McDonald KL
Contribution of DNA repair mechanisms to determining chemotherapy
response in high-grade glioma
J Clin Neurosci. 2007 Nov 26;. [Epub ahead of print]
Abstract
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Riemenschneider
MJ, Hegi ME, Reifenberger G.
MGMT promoter methylation in malignant gliomas
Target Oncol. 2010 Aug 20;. [Epub ahead of print]
Abstract
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Short SC, Giampieri S, Worku M, Alcaide-German M, Sioftanos G, Bourne S, Lio
KI, Shaked-Rabi M, Martindale C.
Rad51
inhibition is an effective means of targeting DNA repair in glioma models
and CD133+ tumor-derived cells.
Neuro Oncol. 2011 May;13(5):487-99.
Epub 2011 Mar 1.
Abstract |
Related articles
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Short
SC, Martindale C, Bourne S, Brand G, Woodcock M, Johnston P
DNA repair after irradiation in glioma cells and normal human astrocytes
Neuro Oncol.
2007 Oct;9(4):404-11. Epub 2007 Aug 17
Abstract
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Full
Text |
Reprint
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Suri V, Jha P, Sharma MC, Sarkar C.
O 6 -methylguanine DNA methyltransferase gene promoter
methylation in high-grade gliomas: A review of current status.
Neurol India 2011;59:229-235. Epub 2011 Apr 7.
Abstract |
Full
text
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Vassella E, Vajtai I, Bandi N, Arnold M, Kocher V, Mariani L.
Primer
extension based quantitative polymerase chain reaction reveals consistent
differences in the methylation status of the MGMT promoter in diffusely
infiltrating gliomas (WHO grade II-IV) of adults.
J
Neurooncol. 2010 Dec 22. [Epub ahead of print]
Abstract |
Reprint
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Related articles
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Medulloblastoma |
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Blazek ER, Foutch JL, Maki G
Daoy medulloblastoma cells that express CD133 are radioresistant relative to
CD133- cells, and the CD133+ sector is enlarged by hypoxia
Int
J Radiat Oncol Biol Phys. 2007 Jan 1;67(1):1-5.
Epub 2006 Nov 2
Abstract
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Faoro
D, von Bueren AO, Shalaby T, Sciuscio D, Hürlimann ML, Arnold L, Gerber NU,
Haybaeck J, Mittelbronn M, Rutkowski S, Hegi M, Grotzer MA
Expression
of O(6)-methylguanine-DNA methyltransferase in childhood medulloblastoma
J
Neurooncol. 2010 Sep 5. [Epub ahead of print]
Abstract |
Related articles
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Side
Population
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Chua C, Zaiden N, Chong KH, See SJ, Wong MC, Ang
BT, Tang C
Characterization
of a side population of astrocytoma cells in response to temozolomide
J Neurosurg.
2008 Nov;109(5):856-66
Abstract |
Reprint
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Related articles
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