BRAINLIFE Brain Tumor Medical Database

Tumor Biology

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Basic Science

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Thi Bui and Craig B. Thompson
Cancer's sweet tooth
Cancer Cell, Vol 9, 419-420, 13 June 2006. DOI: 10.1016/j.ccr.2006.05.012. Available online 12 June 2006

Charles NA, Holland EC, Gilbertson R, Glass R, Kettenmann H.
The brain tumor microenvironment.
Glia. 2011 Mar 28;. [Epub ahead of print]
  Abstract |   Related articles

Ian J. Davis, Jessica J. Kim, Fatih Ozsolak, Hans R. Widlund, Orit Rozenblatt-Rosen, Scott R. Granter, Jinyan Du, Jonathan A. Fletcher, Christopher T. Denny, Stephen L. Lessnick, W. Marston Linehan, Andrew L. Kung and David E. Fisher
Oncogenic MITF dysregulation in clear cell sarcoma: Defining the MiT family of human cancers
Cancer Cell, Volume 9, CNO 6, 13 June 2006, Pages 473-484, Available online 12 June 2006; doi:10.1016/j.ccr.2006.04.021

Miryam Ducasse and Mark A Brown
Epigenetic aberrations and cancer
Molecular Cancer 2006, 5:60; doi:10.1186/1476-4598-5-60; Published: 8 November 2006.

Adam Ertel, Arun Verghese, Stephen W Byers, Michael Ochs and Aydin Tozeren
Pathway-specific differences between tumor cell lines and normal and tumor tissue cells
Molecular Cancer 2006, 5:55; doi:10.1186/1476-4598-5-55; Published 2 November 2006

Valeria R. Fantin, Julie St-Pierre, and Philip Leder
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
Cancer Cell, Vol 9, 425-434, 13 June 2006. DOI 10.1016/j.ccr.2006.04.023. Available online 12 June 2006

Peter Grandics
The cancer stem cell: Evidence for its origin as an injured autoreactive T Cell
Molecular Cancer 2006, 5:6; doi:10.1186/1476-4598-5-6; Published 14 February 2006

Andrei P Kozlov, Yuri P Galachyants, Ilya V Duhovlinov, Nickolai A Samusik, Anna V Baranova, Dmitry E Polev and Larisa L Krukovskaja
Evolutionarily new sequences expressed in tumors
Infectious Agents and Cancer 2006, 1:8; doi:10.1186/1750-9378-1-8; Published 25 December 2006

Lauren M.F. Merlo, John W. Pepper, Brian J. Reid and Carlo C. Maley
Cancer as an evolutionary and ecological process
Nature Reviews Cancer 6, 924-935 (December 2006)

Thuy L. Phung, Keren Ziv, Donnette Dabydeen, Godfred Eyiah-Mensah, Marcela Riveros, Carole Perruzzi, Jingfang Sun, Rita A. Monahan-Earley, Ichiro Shiojima, Janice A. Nagy, Michelle I. Lin, Kenneth Walsh, Ann M. Dvorak, David M. Briscoe, Michal Neeman, William C. Sessa, Harold F. Dvorak, and Laura E. Benjamin
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin
Cancer Cell, Vol 10, 159-170, August 2006. Published: August 14, 2006.

Raul A. Ruggiero and Oscar D. Bustuoabad
The biological sense of cancer: a hypothesis
Theoretical Biology and Medical Modelling 2006, 3:43; doi:10.1186/1742-4682-3-43; Published 15 December 2006

Zhang W, Shannon WD, Duncan J, Scheffer GL, Scheper RJ, McLeod HL. 
Expression of drug pathway proteins is independent of tumor type
Journal of Pathology, Early View, Published Online: 28 Feb 2006, DOI: 10.1002/path.1955
Abstract | News


Brain Tumors

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Dirks P.
Bmi1 and cell of origin determinants of brain tumor phenotype.
Cancer Cell. 2007 Oct;12(4):295-7.
Abstract

German G. Gomez, Susana B. Read, Lazaro E. Gerschenson, Daniela Santoli, Adam Zweifach, Carol A. Kruse
Interactions of the allogeneic effector leukemic T cell line, TALL-104, with human malignant brain tumors
Neuro-Oncology, April 2004, Volume 6, Number 2, Pages 83 – 95 (Abstract+)

Yang I, Liau LM.
American Association for Cancer Research Genetics and Biology of Brain Cancers 2009, December 13-15, 2009, San Diego, CA
J Neurooncol. 2010 Aug 17;. [Epub ahead of print]
  Abstract |   Full Text |   Reprint

Yao Y, Tao R, Wang X, Wang Y, Mao Y, Zhou L
B7-H1 is correlated with the malignancy grade of gliomas but it is not the privilege of tumor stem-like cells
Neuro Oncol. 2009 Mar 5;. [Epub ahead of print]
  Abstract


Ependymoma

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Korshunov A, Witt H, Hielscher T, Benner A, Remke M, Ryzhova M, Milde T, Bender S, Wittmann A, Schöttler A, Kulozik AE, Witt O, von Deimling A, Lichter P, Pfister S
Molecular staging of intracranial ependymoma in children and adults
J Clin Oncol. 2010 Jul 1;28(19):3182-90. Epub 2010 Jun 1
  Abstract


Glioblastoma

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Balenci L, Clarke ID, Dirks PB, Assard N, Ducray F, Jouvet A, Belin MF, Honnorat J, Baudier J.
IQGAP1 Protein Specifies Amplifying Cancer Cells in Glioblastoma Multiforme.
Cancer Res. 2006 Sep 15;66(18):9074-82.
Abstract

Bruzzone MG, Eoli M, Cuccarini V, Grisoli M, Valletta L, Finocchiaro G.
Genetic signature of adult gliomas and correlation with MRI features
Expert Rev Mol Diagn. 2009 Oct;9(7):709-20
  Abstract

Chen J, Kesari S, Rooney C, Strack PR, Chen J, Shen H, Wu L, Griffin JD.
Inhibition of Notch Signaling Blocks Growth of Glioblastoma Cell Lines and Tumor Neurospheres.
Genes Cancer. 2010 Aug 1;1(8):822-835.
  Abstract |   Reprint |   Related articles

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Clavreul A, Etcheverry A, Chassevent A, Quillien V, Avril T, Jourdan ML, Michalak S, François P, Carré JL, Mosser J; The Grand Ouest Glioma Project Network, Menei P.
Isolation of a new cell population in the glioblastoma microenvironment.
J Neurooncol. 2011 Sep 18. [Epub ahead of print]
  Abstract |   Related articles

Franco-Hernandez C, Marti Nez-Glez V, Rey JA.
Biology molecular of glioblastomas
Neurocirugia (Astur). 2007 Oct;18(5):373-382. Spanish.
  Reprint

Govindan A, Chakraborti S, Mahadevan A, Chickabasavaiah YT, Santosh V, Shankar SK.
Histopathologic and immunohistochemical profile of spinal glioblastoma: a study of six cases.
Brain Tumor Pathol. 2011 Jun 4. [Epub ahead of print]
  Abstract |   Related articles

Lathia JD, Venere M, Rao MS, Rich JN.
Seeing is Believing: Are Cancer Stem Cells the Loch Ness Monster of Tumor Biology?
Stem Cell Rev. 2010 Oct 19;. [Epub ahead of print]
  Abstract |   Full Text |   Reprint |   Related articles

Lim SK, Llaguno SR, McKay RM, Parada LF.
Glioblastoma multiforme: a perspective on recent findings in human cancer and mouse models.
BMB Rep. 2011 Mar;44(3):158-64.
  Abstract |   Reprint |   Related articles

Linz U
Aspects on the survival of patients with glioblastoma and the origin and histology of oligodendrogliomas
Nat Rev Cancer. 2003 Jul;3(7):doi:10.1038/nrc1121-c1
  Abstract

Elizabeth A. Maher, Cameron Brennan, Patrick Y. Wen, Laura Durso, Keith L. Ligon, Aaron Richardson, Deepak Khatry, Bin Feng, Raktim Sinha, David N. Louis, John Quackenbush, Peter McL. Black, Lynda Chin and Ronald A. DePinho
Marked Genomic Differences Characterize Primary and Secondary Glioblastoma Subtypes and Identify Two Distinct Molecular and Clinical Secondary Glioblastoma Entities
  Cancer Research 66, 11502-11513, December 1, 2006.Published Online First November 17, 2006;doi: 10.1158/0008-5472.CAN-06-2072

Marie SK, Shinjo SM.
Metabolism and brain cancer.
Clinics (Sao Paulo). 2011
June;66 Suppl 1:33-43.
  Abstract |   Reprint |   Related articles

Panicker SP, Raychaudhuri B, Sharma P, Tipps R, Mazumdar T, Mal AK, Palomo JM, Vogelbaum MA, Haque SJ.
p300- and Myc-mediated regulation of glioblastoma multiforme cell differentiation.
Oncotarget. 2010 Aug;1(4):289-303.
  Abstract |   Reprint |   Related articles

Parsons DW.
The evolving picture of the glioblastoma genome.
Oncotarget. 2010 Aug;1(4):237-8.
  Abstract |   Reprint |   Related articles

Martinez R, Rohde V, Schackert G
Different molecular patterns in glioblastoma multiforme subtypes upon recurrence
J Neurooncol. 2009 Jul 31;. [Epub ahead of print]
  Abstract |   Full Text |   Reprint

Rao JS
Molecular mechanisms of glioma invasiveness: the role of proteases
Nat Rev Cancer. 2003 Jul;3(7):489-501
  Abstract

Rieske P, Golanska E, Zakrzewska M, Piaskowski S, Hulas-Bigoszewska K, Wolanczyk M, Szybka M, Witusik-Perkowska M, Jaskolski DJ, Zakrzewski K, Biernat W, Krynska B, Liberski PP
Arrested neural and advanced mesenchymal differentiation of glioblastoma cells- comparative study with neural progenitors
BMC Cancer. 2009 Feb 14;9(1):54. [Epub ahead of print]
  Abstract |   Reprint

Roth P, Mittelbronn M, Wick W, Meyermann R, Tatagiba M, Weller M. 
Malignant Glioma Cells Counteract Antitumor Immune Responses through Expression of Lectin-Like Transcript-1.
Cancer Res. 2007 Apr 15;67(8):3540-4.
PMID: 17440061 [PubMed - in process]

Ruano Y, Mollejo M, Camacho FI, de Lope AR, Fiaño C, Ribalta T, Martínez P, Hernández-Moneo JL, Meléndez B
Identification of survival-related genes of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma multiforme
Cancer. 2008 Feb 7; [Epub ahead of print]
 Abstract

Suri V, Das P, Jain A, Sharma MC, Borkar SA, Suri A, Gupta D, Sarkar C.
Pediatric glioblastomas: A histopathological and molecular genetic study
Neuro Oncol. 2008 Nov 11; [Epub ahead of print] First published on November 3, 2008
  Abstract

Vik-Mo EO, Sandberg C, Joel M, Stangeland B, Watanabe Y, Mackay-Sim A, Moe MC, Murrell W, Langmoen IA.
A comparative study of the structural organization of spheres derived from the adult human subventricular zone and glioblastoma biopsies.
Exp Cell Res. 2011 Jan 1;. [Epub ahead of print]
  Abstract |   Related articles


Gliosarcoma

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Jimenez C, Powers M, Parsa AT, Glastonbury C, Hagenkord JM, Tihan T.
Sarcoma arising as a distinct nodule within glioblastoma: a morphological and molecular perspective on gliosarcoma.
J Neurooncol. 2011 May 1;. [Epub ahead of print]
  Abstract |   Related articles


Gliomas

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Marcela Assanah, Richard Lochhead, Alfred Ogden, Jeffrey Bruce, James Goldman, and Peter Canoll
Glial Progenitors in Adult White Matter Are Driven to Form Malignant Gliomas by Platelet-Derived Growth Factor-Expressing Retroviruses
The Journal of Neuroscience, June 21, 2006, 26(25):6781-6790

  Abstract |   Full Text |   Reprint

Balss J, Meyer J, Mueller W, Korshunov A, Hartmann C, von Deimling A
Analysis of the IDH1 codon 132 mutation in brain tumors
Acta Neuropathol. 2008 Dec;116(6):597-602. Epub 2008 Nov 5
  Abstract |   Full Text |   Reprint

Cantini G, Pisati F, Mastropietro A, Frattini V, Iwakura Y, Finocchiaro G, Pellegatta S.
A critical role for regulatory T cells in driving cytokine profiles of Th17 cells and their modulation of glioma microenvironment.
Cancer Immunol Immunother. 2011 Jul 21. [Epub ahead of print]
  Abstract |   Related articles

de Groot J, Sontheimer H.
Glutamate and the biology of gliomas.
Glia. 2010 Dec 29;. [Epub ahead of print]
  Abstract |   Reprint
|   Related articles

Huse JT, Holland EC.
Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma
Nat Rev Cancer. 2010 May;10(5):319-31
  Abstract |   Full Text |   Reprint

Santandreu FM, Brell M, Gene AH, Guevara R, Oliver J, Couce ME, Roca P
Differences in mitochondrial function and antioxidant systems between regions of human glioma
Cell Physiol Biochem. 2008;22(5-6):757-68. Epub 2008 Dec 9
  Abstract |   Reprint

Sarkar C, Jain A, Suri V
Current concepts in the pathology and genetics of gliomas
Indian J Cancer. 2009 Apr-Jun;46(2):108-19
  Abstract |   Full Text |   Reprint

Beth Stevens and R. Douglas Fields
Regulation of the Cell Cycle in Normal and Pathological Glia
The Neuroscientist, Apr 2002; vol. 8: pp. 93 - 97
  Abstract |   Reprint

Wu X, Hu J, Zhou L, Mao Y, Yang B, Gao L, Xie R, Xu F, Zhang D, Liu J, Zhu J
In vivo tracking of superparamagnetic iron oxide nanoparticle-labeled mesenchymal stem cell tropism to malignant gliomas using magnetic resonance imaging
J Neurosurg. 2008 Feb;108(2):320-9
Abstract


Gliomas (Low-Grade)

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Hägerstrand D, Smits A, Eriksson A, Sigurdardottir S, Olofsson T, Hartman M, Nistér M, Kalimo H, Ostman A.
Gene expression analyses of grade II gliomas and identification of rPTP{beta}/{zeta} as a candidate oligodendroglioma marker.
Neuro Oncol. 2007 Nov 14; [Epub ahead of print]
Abstract

Louis DN
Molecular pathology of malignant gliomas
Annu Rev Pathol. 2006;1:97-117. Epub 2005 Oct 3
Abstract

Riemenschneider MJ, Reifenberger G
Molecular neuropathology of low-grade gliomas and its clinical impact
Adv Tech Stand Neurosurg. 2010;35:35-64
  Abstract


Medulloblastoma

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Barresi V, Caffo M, Ieni A, Alafaci C, Tuccari G.
Osteoblastic meningiomas: clinico-pathological and immunohistochemical features of an uncommon variant.
J Neurooncol. 2011 Apr 22. [Epub ahead of print]
  Abstract |   Related articles


de Bont JM, Packer RJ, Michiels EM, den Boer ML, Pieters R.
Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective.
Neuro Oncol. 2008 Dec;10(6):1040-60. Epub 2008 Aug 1.
  Abstract |   Reprint |
  Related articles

E Ferretti, L Di Marcotullio, M Gessi, T Mattei, A Greco, A Po, E De Smaele, F Giangaspero, R Riccardi, C Di Rocco, S Pazzaglia, M Maroder, M Alimandi, I Screpanti and A Gulino
Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets
Oncogene advance online publication 31 July 2006; doi: 10.1038/sj.onc.1209716

Hauptman JS.
From the bench to the bedside: Medulloblastoma subtypes, cholinergic neuron function in the nucleus accumbens, and mechanisms of chronic neuropathic pain.
Surg Neurol Int. 2011 Feb 14;2:16.
  Abstract |   Full text |   Related articles

Monje M, Beachy PA, Fisher PG.
Hedgehogs, Flies, Wnts and MYCs: The Time Has Come for Many Things in Medulloblastoma.
J Clin Oncol. 2011 Feb 28;. [Epub ahead of print]
  Abstract |   Reprint |   Related articles

Packer RJ, Michiels EM, den Boer ML, Pieters R, de Bont JM.
Biological background of pediatric medulloblastoma and ependymoma: A review from a translational research perspective
Neuro Oncol. 2008 Aug 1; [Epub ahead of print]
 Abstract

Pomeroy SL, Cho YJ.
Molecular fingerprints of medulloblastoma and their application to clinical practice.
Future Oncol. 2011 Mar;7(3):327-9.
  Abstract |   Reprint |   Related articles

Rossi A, Caracciolo V, Russo G, Reiss K, Giordano A.
Medulloblastoma: from molecular pathology to therapy.
Clin Cancer Res. 2008 Feb 15;14(4):971-6.
 Abstract |   Reprint |   Related articles

Salsano E, Paterra R, Figus M, Menghi F, Maderna E, Pollo B, Solero CL, Massimi L, Finocchiaro G.
Expression profile of frizzled receptors in human medulloblastomas. 
J Neurooncol. 2011 Aug 18. [Epub ahead of print]
  Abstract |   Related articles


Meningioma

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Kalamarides M, Stemmer-Rachamimov AO, Niwa-Kawakita M, Chareyre F, Taranchon E, Han ZY, Martinelli C, Lusis EA, Hegedus B, Gutmann DH, Giovannini M.
Identification of a progenitor cell of origin capable of generating diverse meningioma histological subtypes.
Oncogene. 2011 Jan 17. [Epub ahead of print]
  Abstract |   Related articles


Oligodendroglioma

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Keisuke Ueki
Oligodendroglioma: Impact of molecular biology on its definition, diagnosis and management
Neuropathology 25(3), 247–253; September 2005; doi:10.1111/j.1440-1789.2005.00637.x
 Abstract |   Full Text |   Reprint

Kouwenhoven MC, Gorlia T, Kros JM, Ibdaih A, Brandes AA, Bromberg JE, Mokhtari K, van Duinen SG, Teepen JL, Wesseling P, Vandenbos F, Grisold W, Sipos L, Mirimanoff R, Vecht CJ, Allgeier A, Lacombe D, van den Bent MJ
Molecular analysis of anaplastic oligodendroglial tumors in a prospective randomized study: A report from EORTC study 26951
Neuro Oncol. 2009 Feb 17. [Epub ahead of print]
  Abstract


Pediatric Patients

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Mandeep S. Tamber, Krishan Bansal, Muh-Lii Liang, Todd G. Mainprize, Bodour Salhia, Paul Northcott, Michael Taylor and James T. Rutka
Current concepts in the molecular genetics of pediatric brain tumors: implications for emerging therapies
Child's Nervous System, Vol 22, No 11, Nov, 2006, Pages 1379-1394. DOI: 10.1007/s00381-006-0187-3, Published online: 2 Sept 2006


Pilocytic Astrocytoma

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Rodriguez FJ, Giannini C, Asmann YW, Sharma MK, Perry A, Tibbetts KM, Jenkins RB, Scheithauer BW, Anant S, Jenkins S, Eberhart CG, Sarkaria JN, Gutmann DH
Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes
J Neuropathol Exp Neurol. 2008 Dec;67(12):1194-204
  Abstract

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