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Gliosarcoma - clinical study
P. S. Sridhar, R.
Prabhakar, M. B. Pandey, D. N. Sharma,
P. K. Julka and G. K. Rath
All India Institute Medcl Sciences
(AIIMS), New Delhi, India
Background. Gliosarcomas
are rare neoplasm of central nervous system.
Consisting gliomatous and sarcomatous components.
No clear data is available regarding its cell of origin and
behavior.
This study examines clinical features, treatment and survival.
Methods. 14 patients of
Gliosarcomas treated between Jan 1993 to June 2004 were
analyzed retrospectively.
10 were male, 4 female, with median age of 50 years (range
12–70 yrs).
All were situated in supratentorium, 8 were left side, 6
right side.
7 in temporal region, 4 in temporoparietal and 3 in
parietal region.
All patients underwent surgery and 12 patients received postoperative
radiotherapy to dose of 60 Gy/30 fractions in 6 weeks.
10 patients received platinum based chemotherapy.
2 patient received concurrent taxane and
radiotherapy.
Results. Median survival
was 9.3 months, 10 patients died of disease, 2 patients
stable disease, and 1 patient is in PR and 1 in CR.
Conclusions. Gliosarcoma
is aggressive neoplasm; Clinically indistinguishable from
GBM.
Chemoradiotherapy is beneficial.
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