Brain Tumor Reports

Volume 11 Number 5
May 2009

Home > Publications > Brain Tumor Reports > Volume 11, Year 2009 > Number 5, May°



Sepulveda Sanchez JM, Martinez Montero JC, Diez-Lobato R, Hernandez-Lain A, Cabello A, Ramos A, Gonzalez Leon P, Ricoy Campo JR
Classification of oligodendroglial tumors based on histopathology criteria is a significant predictor of survival--clinical, radiological and pathologic long-term follow-up analysis
Clin Neuropathol. 2009 Jan-Feb;28(1):11-20. Erratum in: Clin Neuropathol. 2009 Mar-Apr;28(2):150


Clarke JL, Chang S
Pseudoprogression and pseudoresponse: challenges in brain tumor imaging
Curr Neurol Neurosci Rep. 2009 May;9(3):241-6

Kleinberg L, Yoon G, Weingart JD, Parisi M, Olivi A, Detorie NA, Chan TA
Imaging After GliaSite Brachytherapy: Prognostic MRI Indicators of Disease Control and Recurrence
Int J Radiat Oncol Biol Phys. 2009 Apr 23;. [Epub ahead of print]

Wyss M, Hofer S, Bruehlmeier M, Hefti M, Uhlmann C, Bärtschi E, Buettner UW, Roelcke U
Early metabolic responses in temozolomide treated low-grade glioma patients
J Neurooncol. 2009 Apr 18. [Epub ahead of print]


Brown M, Schrot R, Bauer K, Letendre D
Incidence of first primary central nervous system tumors in California, 2001-2005
J Neurooncol. 2009 Apr 2;. [Epub ahead of print]
  Abstract |   Full Text |   Reprint

Morgan LL
Estimating the risk of brain tumors from cellphone use: Published case-control studies
Pathophysiology. 2009 Apr 6;. [Epub ahead of print]

Etiology & Pathogenesis

di Tomaso E, London N, Fuja D, Logie J, Tyrrell JA, Kamoun W, Munn LL, Jain RK
PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment
PLoS ONE. 2009;4(4):e5123. Epub 2009 Apr 8
  Abstract |   Full Text |   Reprint

Ilhan A, Gartner W, Neziri D, Czech T, Base W, Hörl WH, Wagner L
Angiogenic factors in plasma of brain tumour patients
Anticancer Res. 2009 Feb 1;29(2):731-6
  Abstract |   Full Text |   Reprint

Jensen RL
Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target
J Neurooncol. 2009 May;92(3):317-35. Epub 2009 Apr 9

Kim BH, Song JH, Jeon YC, Jeong BH, Yun SK, Cho HC, Carp RI, Kim YS.
Spontaneous immortalization of oligodendroglial cells derived from an SV40 T antigen-positive human glioblastoma multiforme
Cancer Lett. 2009 Apr 23;. [Epub ahead of print]

Lawler S, Chiocca EA
Emerging functions of microRNAs in glioblastoma
J Neurooncol. 2009 May;92(3):297-306. Epub 2009 Apr 9

Integrative Medicine

Il'yasova D, Marcello JE, McCoy L, Rice T, Wrensch M
Total dietary antioxidant index and survival in patients with glioblastoma multiforme
Cancer Causes Control. 2009 Apr 12;. [Epub ahead of print]

Purkayastha S, Berliner A, Fernando SS, Ranasinghe B, Ray I, Tariq H, Banerjee P.
Curcumin Blocks Brain Tumor Formation
Brain Res. 2009 Feb 10;. [Epub ahead of print]

Siegelin MD, Siegelin Y, Habel A, Gaiser T
Genistein enhances proteasomal degradation of the short isoform of FLIP in malignant glioma cells and thereby augments TRAIL-mediated apoptosis
Neurosci Lett. 2009 Apr 3;453(2):92-7. Epub 2009 Feb 13

Tewari R, Sharma V, Koul N, Ghosh A, Joseph C, Hossain Sk U, Sen E.
Ebselen abrogates TNFalpha induced pro-inflammatory response in glioblastoma
Mol Oncol. 2009 Feb;3(1):77-83. Epub 2008 Nov 5

Overall Management

Al-Hussaini M, Sultan I, Abuirmileh N, Jaradat I, Qaddoumi I
Pineal gland tumors: experience from the SEER database
J Neurooncol. 2009 Apr 17;. [Epub ahead of print]

Charfi S, Ayadi L, Khabir A, Daoud E, Kallel R, Kharrat O, Mnif Z, Boudawara Z, Makni S, Boudawara T.
Gliosarcoma with osteosarcomatous features: a short illustrated review
Acta Neurochir (Wien). 2009 Apr 28;. [Epub ahead of print]

Kozak KR, Moody JS.
Giant cell glioblastoma: A glioblastoma subtype with distinct epidemiology and superior prognosis
Neuro Oncol. 2009 Mar 30;. [Epub ahead of print]

Park S, Suh YL, Nam DH, Kim ST
Gliomatosis cerebri: clinicopathologic study of 33 cases and comparison of mass forming and diffuse types.
Clin Neuropathol. 2009 Mar-Apr;28(2):73-82

Piepmeier JM
Current concepts in the evaluation and management of WHO grade II gliomas.
J Neurooncol. 2009 May;92(3):253-9. Epub 2009 Apr 9

Samaras V, Stamatelli A, Samaras E, Stergiou I, Konstantopoulou P, Varsos V, Judkins AR, Biegel JA, Barbatis C
Atypical teratoid/rhabdoid tumor of the central nervous system in an 18-year-old patient.
Clin Neuropathol. 2009 Jan-Feb;28(1):1-10

Walsh MT, Couldwell WT
Management options for cavernous sinus meningiomas.
J Neurooncol. 2009 May;92(3):307-16. Epub 2009 Apr 9

Yoshida S, Takahashi H
Cerebellar metastases in patients with cancer
Surg Neurol. 2009 Feb;71(2):184-7; discussion 187. Epub 2008 Mar 4


Muzumdar D
Glioma: A continuing challenge and a mystery?
Indian J Cancer. 2009 Apr-Jun;46(2):79-81
  Abstract |   Full Text |   Reprint

Sanghvi DA
Recent advances in imaging of brain tumors
Indian J Cancer. 2009 Apr-Jun;46(2):82-7
  Abstract |   Full Text |   Reprint

Omay SB, Vogelbaum MA
Current concepts and newer developments in the treatment of malignant gliomas
Indian J Cancer. 2009 Apr-Jun;46(2):88-95
  Abstract |   Full Text |   Reprint

Khan MK, Hunter GK, Vogelbaum M, Suh JH, Chao ST
Evidence-based adjuvant therapy for gliomas: Current concepts and newer developments
Indian J Cancer. 2009 Apr-Jun;46(2):96-107
  Abstract |   Full Text |   Reprint

Sarkar C, Jain A, Suri V
Current concepts in the pathology and genetics of gliomas
Indian J Cancer. 2009 Apr-Jun;46(2):108-19
  Abstract |   Full Text |   Reprint

Nunez OM, Seol HJ, Rutka JT
The role of surgery in the management of intracranial gliomas: Current concepts
Indian J Cancer. 2009 Apr-Jun;46(2):120-6
  Abstract |   Full Text |   Reprint

Munshi A, Jalali R
Therapy for glioma: Indian perspective
Indian J Cancer. 2009 Apr-Jun;46(2):127-31
  Abstract |   Full Text |   Reprint


Barnes EA, Chow E, Tsao MN, Bradley NM, Doyle M, Li K, Lam K, Danjoux C
Physician Expectations of Treatment Outcomes for Patients with Brain Metastases Referred for Whole Brain Radiotherapy
Int J Radiat Oncol Biol Phys. 2009 Apr 20. [Epub ahead of print]

Chaichana KL, McGirt MJ, Laterra J, Olivi A, Quiñones-Hinojosa A
Recurrence and malignant degeneration after resection of adult hemispheric low-grade gliomas
J Neurosurg. 2009 Apr 10. [Epub ahead of print]

Chaichana KL, Parker SL, Olivi A, Quiñones-Hinojosa A
Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas
J Neurosurg. 2009 Apr 3;. [Epub ahead of print]

Lorenzoni JG, Devriendt D, Massager N, Desmedt F, Simon S, Van Houtte P, Brotchi J, Levivier M
Brain stem metastases treated with radiosurgery: prognostic factors of survival and life expectancy estimation
Surg Neurol. 2009 Feb;71(2):188-95; discussion 195, 195-6. Epub 2008 Apr 24

Matsumura A, Yamamoto T, Tsurubuchi T, Matsuda M, Shirakawa M, Nakai K, Endo K, Tokuue K, Tsuboi K.
Current practices and future directions of therapeutic strategy in glioblastoma: Survival benefit and indication of BNCT
Appl Radiat Isot. 2009 Mar 24;. [Epub ahead of print]

Molenaar R, Wiggenraad R, Verbeek-de Kanter A, Walchenbach R, Vecht C
Relationship between volume, dose and local control in stereotactic radiosurgery of brain metastasis
Br J Neurosurg. 2009 Apr;23(2):170-8

Nieder C, Marienhagen K, Astner ST, Molls M
Prognostic scores in brain metastases from breast cancer
BMC Cancer. 2009 Apr 7;9(1):105. [Epub ahead of print]
  Abstract |   Full Text |   Reprint

Russell SM, Elliott R, Forshaw D, Golfinos JG, Nelson PK, Kelly PJ
Glioma vascularity correlates with reduced patient survival and increased malignancy
Surg Neurol. 2009 Mar 27. [Epub ahead of print]

Salvati M, Formichella AI, D'Elia A, Brogna C, Frati A, Giangaspero F, Delfini R, Santoro A
Cerebral glioblastoma with oligodendrogliomal component: analysis of 36 cases
J Neurooncol. 2009 Aug;94(1):129-34. Epub 2009 Apr 3.
  Abstract |   Reprint |   Related articles

Psychosocial Aspects

Crom DB
"I Think You Are Pretty; I Don't Know Why Everyone Can't See That": Reflections From a Young Adult Brain Tumor Survivor Camp
J Clin Oncol. 2009 Apr 13. [Epub ahead of print]
  Abstract |   Reprint

Nomura Y, Yasumoto S, Yanai F, Akiyoshi H, Inoue T, Nibu K, Tsugu H, Fukushima T, Hirose S
Survival and late effects on development of patients with infantile brain tumor
Pediatr Int. 2008 Dec 29;. [Epub ahead of print]

Stem Cells

An JH, Lee SY, Jeon JY, Cho KG, Kim SU, Lee MA
Identification of Gliotropic Factors that induce Human Stem Cell Migration to Malignant Tumor
J Proteome Res. 2009 Apr 7;. [Epub ahead of print]

Cheng JX, Liu BL, Zhang X
How powerful is CD133 as a cancer stem cell marker in brain tumors?
Cancer Treat Rev. 2009 Apr 14; [Epub ahead of print]

Clément V, Dutoit V, Marino D, Dietrich PY, Radovanovic I
Limits of CD133 as a marker of glioma self-renewing cells
Int J Cancer. 2009 Jul 1;125(1):244-8. Epub 2009 Feb 10

Laks DR, Masterman-Smith M, Visnyei K, Angenieux B, Orozco NM, Foran I, Yong WH, Vinters HV, Liau LM, Lazareff JA, Mischel PS, Cloughesy TF, Horvath S, Kornblum HI
Neurosphere formation is an independent predictor of clinical outcome in malignant glioma
Stem Cells. 2009 Apr;27(4):980-7

McCord AM, Jamal M, Shankavarum UT, Lang FF, Camphausen K, Tofilon PJ
Physiologic oxygen concentration enhances the stem-like properties of CD133+ human glioblastoma cells in vitro
Mol Cancer Res. 2009 Apr;7(4):489-97

Oka N, Soeda A, Noda S, Iwama T.
Brain tumor stem cells from an adenoid glioblastoma multiforme
Neurol Med Chir (Tokyo). 2009 Apr;49(4):146-50; discussion 150-1
  Abstract |   Reprint

Wakimoto H, Kesari S, Farrell CJ, Curry WT Jr, Zaupa C, Aghi M, Kuroda T, Stemmer-Rachamimov A, Shah K, Liu TC, Jeyaretna DS, Debasitis J, Pruszak J, Martuza RL, Rabkin SD
Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors
Cancer Res. 2009 Apr 15;69(8):3472-81. Epub 2009 Apr 7


Clinical Investigations

Akbar U, Jones T, Winestone J, Michael M, Shukla A, Sun Y, Duntsch C
Delivery of temozolomide to the tumor bed via biodegradable gel matrices in a novel model of intracranial glioma with resection
J Neurooncol. 2009 Apr 1. [Epub ahead of print]

Al-Shamy G, Sawaya R
Management of brain metastases: the indispensable role of surgery
J Neurooncol. 2009 May;92(3):275-82. Epub 2009 Apr 9

Allen J, Donahue B, Mehta M, Miller DC, Rorke LB, Jakacki R, Robertson P, Sposto R, Holmes E, Vezina G, Muraszko K, Puccetti D, Prados M, Chan KW
A Phase II Study of Preradiotherapy Chemotherapy Followed by Hyperfractionated Radiotherapy for Newly Diagnosed High-Risk Medulloblastoma/Primitive Neuroectodermal Tumor: A Report from the Children's Oncology Group (CCG 9931)
Int J Radiat Oncol Biol Phys. 2009 Apr 6. [Epub ahead of print]

Arifin DY, Lee KY, Wang CH.
Chemotherapeutic drug transport to brain tumor
J Control Release. 2009 Apr 17;. [Epub ahead of print]

Beauchesne PD, Taillandier L, Bernier V, Carnin C.
Concurrent radiotherapy: fotemustine combination for newly diagnosed malignant glioma patients, a phase II study
Cancer Chemother Pharmacol. 2009 Apr 8;. [Epub ahead of print]

Butturini AM, Jacob M, Aguajo J, Vander-Walde NA, Villablanca J, Jubran R, Erdreich-Epstein A, Marachelian A, Dhall G, Finlay JL.
High-dose chemotherapy and autologous hematopoietic progenitor cell rescue in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors: the impact of prior radiotherapy on outcome
Cancer. 2009 Apr 28;. [Epub ahead of print]

Defachelles AS, Rey A, Oberlin O, Spooner D, Stevens MC
Treatment of nonmetastatic cranial parameningeal rhabdomyosarcoma in children younger than 3 years old: results from international society of pediatric oncology studies MMT 89 and 95
J Clin Oncol. 2009 Mar 10;27(8):1310-5. Epub 2009 Feb 9

Fabi A, Metro G, Russillo M, Vidiri A, Carapella CM, Maschio M, Cognetti F, Jandolo B, Mirri MA, Sperduti I, Telera S, Carosi M, Pace A
Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation
BMC Cancer. 2009 Mar 31;9:101
  Abstract |   Full Text |   Reprint

Fokas E, Wacker U, Gross MW, Henzel M, Encheva E, Engenhart-Cabillic R.
Hypofractionated Stereotactic Reirradiation of Recurrent Glioblastomas: A Beneficial Treatment Option after High-Dose Radiotherapy?
Strahlenther Onkol. 2009 Apr;185(4):235-240. Epub 2009 Apr 16

Galanis E, Jaeckle KA, Maurer MJ, Reid JM, Ames MM, Hardwick JS, Reilly JF, Loboda A, Nebozhyn M, Fantin VR, Richon VM, Scheithauer B, Giannini C, Flynn PJ, Moore DF Jr, Zwiebel J, Buckner JC
Phase II Trial of Vorinostat in Recurrent Glioblastoma Multiforme: A North Central Cancer Treatment Group Study
J Clin Oncol. 2009 Mar 23. [Epub ahead of print]

Hahn CA, Zhou SM, Raynor R, Tisch A, Light K, Shafman T, Wong T, Kirkpatrick J, Turkington T, Hollis D, Marks LB
Dose-dependent effects of radiation therapy on cerebral blood flow, metabolism, and neurocognitive dysfunction
Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):1082-7. Epub 2008 Aug 27

Han JH, Park CK, Lee SH, Kim CY, Kim DW, Paek SH, Kim DG, Heo DS, Kim IH, Jung HW.
Preradiation Chemotherapy with ACNU-CDDP in Patients with Newly Diagnosed Glioblastoma: A Retrospective Analysis
Chemotherapy. 2009 Apr 22;55(3):145-154. [Epub ahead of print]

Hasselblatt M, Mühlisch J, Wrede B, Kallinger B, Jeibmann A, Peters O, Kutluk T, Wolff JE, Paulus W, Frühwald MC
Aberrant MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation in choroid plexus tumors
J Neurooncol. 2009 Jan;91(2):151-5. Epub 2008 Sep 16

Jabbour SK, Zhang Z, Arnold D, Wharam MD
Risk of second tumor in intracranial germinoma patients treated with radiation therapy: the Johns Hopkins experience
J Neurooncol. 2009 Jan;91(2):227-32. Epub 2008 Sep 24

Jagannathan J, Yen CP, Ray DK, Schlesinger D, Oskouian RJ, Pouratian N, Shaffrey ME, Larner J, Sheehan JP
Gamma Knife radiosurgery to the surgical cavity following resection of brain metastases
J Neurosurg. 2009 Apr 10. [Epub ahead of print]

Kamoun WS, Ley CD, Farrar CT, Duyverman AM, Lahdenranta J, Lacorre DA, Batchelor TT, di Tomaso E, Duda DG, Munn LL, Fukumura D, Sorensen AG, Jain RK
Edema Control by Cediranib, a Vascular Endothelial Growth Factor Receptor-Targeted Kinase Inhibitor, Prolongs Survival Despite Persistent Brain Tumor Growth in Mice
J Clin Oncol. 2009 Mar 30. [Epub ahead of print]

Kano H, Niranjan A, Khan A, Flickinger JC, Kondziolka D, Lieberman F, Lunsford LD
Does radiosurgery have a role in the management of oligodendrogliomas?
J Neurosurg. 2009 Mar;110(3):564-71

Kased N, Binder DK, McDermott MW, Nakamura JL, Huang K, Berger MS, Wara WM, Sneed PK
Gamma Knife Radiosurgery for Brain Metastases from Primary Breast Cancer
Int J Radiat Oncol Biol Phys. 2009 Apr 2. [Epub ahead of print]

Kawabata S, Miyatake SI, Nonoguchi N, Hiramatsu R, Iida K, Miyata S, Yokoyama K, Doi A, Kuroda Y, Kuroiwa T, Michiue H, Kumada H, Kirihata M, Imahori Y, Maruhashi A, Sakurai Y, Suzuki M, Masunaga SI, Ono K
Survival benefit from boron neutron capture therapy for the newly diagnosed glioblastoma patients
Appl Radiat Isot. 2009 Mar 25;. [Epub ahead of print]

Komotar RJ, Roguski M, Bruce JN
Surgical management of craniopharyngiomas
J Neurooncol. 2009 May;92(3):283-96. Epub 2009 Apr 9

Koukourakis GV, Kouloulias V, Zacharias G, Papadimitriou C, Pantelakos P, Maravelis G, Fotineas A, Beli I, Chaldeopoulos D, Kouvaris J
Temozolomide with radiation therapy in high grade brain gliomas: pharmaceuticals considerations and efficacy; a review article
Molecules. 2009 Apr 16;14(4):1561-77

Matsuda M, Yamamoto T, Kumada H, Nakai K, Shirakawa M, Tsurubuchi T, Matsumura A
Dose distribution and clinical response of glioblastoma treated with boron neutron capture therapy
Appl Radiat Isot. 2009 Mar 27;. [Epub ahead of print]

Miyatake SI, Kawabata S, Yokoyama K, Kuroiwa T, Michiue H, Sakurai Y, Kumada H, Suzuki M, Maruhashi A, Kirihata M, Onoc K
Survival benefit of boron neutron capture therapy for recurrent malignant gliomas
Appl Radiat Isot. 2009 Mar 27;. [Epub ahead of print]

Kunert P, Matyja E, Janowski M, Marchel A
Rapid growth of small, asymptomatic meningioma following radiosurgery
Br J Neurosurg. 2009 Apr;23(2):206-8

Lafay-Cousin L, Strother D.
Current treatment approaches for infants with malignant central nervous system tumors.
Oncologist. 2009 Apr;14(4):433-44. Epub 2009 Apr 2.
  Abstract |   Reprint |   Related articles

Lassaletta A, Lopez-Ibor B, Mateos E, Gonzalez-Vicent M, Perez-Martinez A, Sevilla J, Diaz MA, Madero L
Intrathecal liposomal cytarabine in children under 4 years with malignant brain tumors
J Neurooncol. 2009 Apr 18. [Epub ahead of print]

Lefranc F, Rynkowski M, DeWitte O, Kiss R
Present and potential future adjuvant issues in high-grade astrocytic glioma treatment
Adv Tech Stand Neurosurg. 2009;34:3-35

Lun XQ, Jang JH, Tang N, Deng H, Head R, Bell JC, Stojdl DF, Nutt CL, Senger DL, Forsyth PA, McCart JA
Efficacy of systemically administered oncolytic vaccinia virotherapy for malignant gliomas is enhanced by combination therapy with rapamycin or cyclophosphamide
Clin Cancer Res. 2009 Apr 15;15(8):2777-88. Epub 2009 Apr 7

Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen M, Kalayjian LA, Kanner A, Liporace JD, Pennell PB, Privitera M, Loring DW; NEAD Study Group
Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs
N Engl J Med. 2009 Apr 16;360(16):1597-605

Meador KJ
Effects of in utero antiepileptic drug exposure
Epilepsy Curr. 2008 Nov-Dec;8(6):143-7
  Abstract |   Full Text |   Reprint

Mohammed S, Kovacs K, Mason W, Smyth H, Cusimano MD
Use of temozolomide in aggressive pituitary tumors: case report
Neurosurgery. 2009 Apr;64(4):E773-4

Nghiemphu PL, Liu W, Lee Y, Than T, Graham C, Lai A, Green RM, Pope WB, Liau LM, Mischel PS, Nelson SF, Elashoff R, Cloughesy TF
Bevacizumab and chemotherapy for recurrent glioblastoma: a single-institution experience
Neurology. 2009 Apr 7;72(14):1217-22

Petr MJ, McPherson CM, Breneman JC, Warnick RE
Management of newly diagnosed single brain metastasis with surgical resection and permanent I-125 seeds without upfront whole brain radiotherapy
J Neurooncol. 2009 May;92(3):393-400. Epub 2009 Apr 9

Roberge D, Petrecca K, El Refae M, Souhami L
Whole-brain radiotherapy and tumor bed radiosurgery following resection of solitary brain metastases
J Neurooncol. 2009 Apr 21. [Epub ahead of print]

Silvani A, Gaviani P, Fiumani A, Scaioli V, Lamperti E, Eoli M, Botturi A, Salmaggi A
Systemic sagopilone (ZK-EPO) treatment of patients with recurrent malignant gliomas
J Neurooncol. 2009 Apr 21. [Epub ahead of print]

Virrey JJ, Golden EB, Sivakumar W, Wang W, Pen L, Schönthal AH, Hofman FM, Chen TC
Glioma-associated endothelial cells are chemoresistant to temozolomide
J Neurooncol. 2009 Apr 18. [Epub ahead of print]

Williams BJ, Suki D, Fox BD, Pelloski CE, Maldaun MV, Sawaya RE, Lang FF, Rao G
Stereotactic radiosurgery for metastatic brain tumors: a comprehensive review of complications
J Neurosurg. 2009 Mar 20. [Epub ahead of print]

Wo JY, Viswanathan AN
Impact of radiotherapy on fertility, pregnancy, and neonatal outcomes in female cancer patients
Int J Radiat Oncol Biol Phys. 2009 Apr 1;73(5):1304-12

Yamamoto T, Nakai K, Tsurubuchi T, Matsuda M, Shirakawa M, Zaboronok A, Endo K, Matsumura A
Boron neutron capture therapy for newly diagnosed glioblastoma: A pilot study in Tsukuba
Appl Radiat Isot. 2009 Mar 24;. [Epub ahead of print]