Current Neuro-Oncology




Volume 21 Number 2
28 February 2019




Home > Publications > Current Neuro-Oncology > Volume 21, Year 2019 > Number 2, 28 February






Mistry AM.
On the subventricular zone origin of human glioblastoma.
Transl Cancer Res. 2019 Feb;8(1):11-13. doi: 10.21037/tcr.2018.11.31. PMID: 30873355. Comment. ˍ
Refers to: Lee JH, et al., Human glioblastoma arises from subventricular zone cells with low-level driver mutations.
Nature. 2018 Aug 1. 2018;560(7717):243-247. doi:: 10.1038/s41586-018-0389-3. PMID: 30069053. Laboratory investigation. ˍ




Perez-Somarriba M, Andión M, López-Pino MA, Lavarino C, Madero L, Lassaletta A.
Old drugs still work! Oral etoposide in a relapsed medulloblastoma.
Childs Nerv Syst. 2019 Feb 1;35(5):865-869. doi: 10.1007/s00381-019-04072-9. PMID: 30707305. Case report. ˍ




Nilsson J, Järås J, Henriksson R, Holgersson G, Bergström S, Estenberg J, Augustsson T, Bergqvist M.
No Evidence for Increased Brain Tumour Incidence in the Swedish National Cancer Register Between Years 1980-2012.
Anticancer Res. 2019 Feb 2;39(2):791-796. doi: 10.21873/anticanres.13176. PMID: 30711958. Observational study. ˍ




Kim JY, Jackman JG, Woodring S, McSherry F, Herndon JE, Desjardins A, Friedman HS, Peters KB.
Second primary cancers in long-term survivors of glioblastoma.
Neurooncol Pract. 2019 Feb 4;6(5):386-391. doi: 10.1093/nop/npz001. PMID: 31555453. Observational study. ˍ




Rodríguez-Lozano DC, Piña-Medina AG, Hansberg-Pastor V, Bello-Alvarez C, Camacho-Arroyo I.
Testosterone Promotes Glioblastoma Cell Proliferation, Migration, and Invasion Through Androgen Receptor Activation.
Front Endocrinol (Lausanne). 2019 Feb 4;10:1. doi: 10.3389/fendo.2019.00016. PMID: 30778332. Laboratory investigation. ˍ




Wen PY, Touat M, Alexander BM, Mellinghoff IK, Ramkissoon S, McCluskey CS, Pelton K, Haidar S, Basu SS, Gaffey SC, Brown LE, Martinez-Ledesma JE, Wu S, Kim J, Wei W, Park MA, Huse JT, Kuhn JG, Rinne ML, Colman H, Agar NYR, Omuro AM, DeAngelis LM, Gilbert MR, de Groot JF, Cloughesy TF, Chi AS, Roberts TM, Zhao JJ, Lee EQ, Nayak L, Heath JR, Horky LL, Batchelor TT, Beroukhim R, Chang SM, Ligon AH, Dunn IF, Koul D, Young GS, Prados MD, Reardon DA, Yung WKA, Ligon KL.
Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.
J Clin Oncol. 2019 Feb 4;37(9):741-750. doi: 10.1200/JCO.18.01207. PMID: 30715997. Interventional study. ˍ




Akgül S, Patch AM, D'Souza RCJ, Mukhopadhyay P, Nones K, Kempe S, Kazakoff SH, Jeffree RL, Stringer BW, Pearson JV, Waddell N, Day BW.
Intratumoural Heterogeneity Underlies Distinct Therapy Responses and Treatment Resistance in Glioblastoma.
Cancers (Basel). 2019 Feb 6;11(2):190. doi: 10.3390/cancers11020190. PMID: 30736342. Laboratory investigation. ˍ




Silvani A, De Simone I, Fregoni V, Biagioli E, Marchioni E, Caroli M, Salmaggi A, Pace A, Torri V, Gaviani P, Quaquarini E, Simonetti G, Rulli E, D'Incalci M; Italian Association of Neuro-Oncology.
Multicenter, single arm, phase II trial on the efficacy of ortataxel in recurrent glioblastoma.
J Neurooncol. 2019 Feb 6;142(3):455-462. doi: 10.1007/s11060-019-03116-z. PMID: 30726533. Interventional study. ˍ




Ludmir EB, Mahajan A, Paulino AC, Jones JY, Ketonen LM, Su JM, Grosshans DR, McAleer MF, McGovern SL, Lassen-Ramshad YA, Adesina AM, Dauser RC, Weinberg JS, Chintagumpala MM.
Increased Risk of Pseudoprogression among Pediatric Low-Grade Glioma Patients Treated with Proton versus Photon Radiotherapy.
Neuro Oncol. 2019 Feb 7;21(5):686-695. doi: 10.1093/neuonc/noz042. PMID: 30753704. Observational study. ˍ




Murphy M, Dowling A, Thien C, Priest E, Morgan Murray D, Kesari S.
A feasibility study of the Nativis Voyager® device in patients with recurrent glioblastoma in Australia.
CNS Oncol. 2019 Feb 7;8(1):CNS31. doi: 10.2217/cns-2018-0017. PMID: 30727742. Interventional study. ˍ




Salloum R, Chen Y, Yasui Y, Packer R, Leisenring W, Wells E, King A, Howell R, Gibson TM, Krull KR, Robison LL, Oeffinger KC, Fouladi M, Armstrong GT.
Late Morbidity and Mortality Among Medulloblastoma Survivors Diagnosed Across Three Decades: A Report From the Childhood Cancer Survivor Study.
J Clin Oncol. 2019 Feb 7;37(9):731-740. doi: 10.1200/JCO.18.00969. PMID: 30730781. Observational study. ˍ




Cloughesy TF, Mochizuki AY, Orpilla JR, Hugo W, Lee AH, Davidson TB, Wang AC, Ellingson BM, Rytlewski JA, Sanders CM, Kawaguchi ES, Du L, Li G, Yong WH, Gaffey SC, Cohen AL, Mellinghoff IK, Lee EQ, Reardon DA, O'Brien BJ, Butowski NA, Nghiemphu PL, Clarke JL, Arrillaga-Romany IC, Colman H, Kaley TJ, de Groot JF, Liau LM, Wen PY, Prins RM.
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma.
Nat Med. 2019 Feb 11;25(3):477-486. doi: 10.1038/s41591-018-0337-7. PMID: 30742122. Interventional study. ˍ




Schalper KA, Rodriguez-Ruiz ME, Diez-Valle R, López-Janeiro A, Porciuncula A, Idoate MA, Inogés S, de Andrea C, López-Diaz de Cerio A, Tejada S, Berraondo P, Villarroel-Espindola F, Choi J, Gúrpide A, Giraldez M, Goicoechea I, Gallego Perez-Larraya J, Sanmamed MF, Perez-Gracia JL, Melero I.
Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma.
Nat Med. 2019 Feb 11;25(3):470-476. doi: 10.1038/s41591-018-0339-5. PMID: 30742120. Interventional study. ˍ




Zhao J, Chen AX, Gartrell RD, Silverman AM, Aparicio L, Chu T, Bordbar D, Shan D, Samanamud J, Mahajan A, Filip I, Orenbuch R, Goetz M, Yamaguchi JT, Cloney M, Horbinski C, Lukas RV, Raizer J, Rae AI, Yuan J, Canoll P, Bruce JN, Saenger YM, Sims P, Iwamoto FM, Sonabend AM, Rabadan R.
Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma.
Nat Med. 2019 Feb 11;25(3):462-469. doi: 10.1038/s41591-019-0349-y. PMID: 30742119. Laboratory investigation. ˍ




Migliorini D, Dutoit V, Allard M, Hallez NG, Marinari E, Widmer V, Philippin G, Corlazzoli F, Gustave R, Kreutzfeldt M, Blazek N, Wasem J, Hottinger A, Koka A, Momjian S, Lobrinus A, Merkler D, Vargas MI, Walker PR, Patrikidou A, Dietrich PY.
Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients.
Neuro Oncol. 2019 Feb 12;21(7):923-933. doi: 10.1093/neuonc/noz040. PMID: 30753611. Interventional study. ˍ




Huang J, Chaudhary R, Cohen AL, Fink K, Goldlust S, Boockvar J, Chinnaiyan P, Wan L, Marcus S, Campian JL.
A multicenter phase II study of temozolomide plus disulfiram and copper for recurrent temozolomide-resistant glioblastoma.
J Neurooncol. 2019 Feb 15;142(3):537-544. doi: 10.1007/s11060-019-03125-y. PMID: 30771200. Interventional study. ˍ




Perez A, Merlini L, El-Ayadi M, Korff C, Ansari M, von Bueren AO.
Comment on: Ketogenic diet treatment in recurrent diffuse intrinsic pontine glioma in children: A safety and feasibility study.
Pediatr Blood Cancer. 2019 Feb 15;66(7):e27664. doi: 10.1002/pbc.27664. PMID: 30767367. Comment. ˍ
Refers to: van der Louw EJTM, et al., Ketogenic diet treatment in recurrent diffuse intrinsic pontine glioma in children: A safety and feasibility study.
Pediatr Blood Cancer. 2018 Nov 28, 2019:e27561. doi: 10.1002/pbc.27561. PMID: 30484948. Observational study. ˍ




Herrlinger U, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Sabel M, Hau P, Kortmann RD, Krex D, Grauer O, Goldbrunner R, Schnell O, Bähr O, Uhl M, Seidel C, Tabatabai G, Kowalski T, Ringel F, Schmidt-Graf F, Suchorska B, Brehmer S, Weyerbrock A, Renovanz M, Bullinger L, Galldiks N, Vajkoczy P, Misch M, Vatter H, Stuplich M, Schäfer N, Kebir S, Weller J, Schaub C, Stummer W, Tonn JC, Simon M, Keil VC, Nelles M, Urbach H, Coenen M, Wick W, Weller M, Fimmers R, Schmid M, Hattingen E, Pietsch T, Coch C, Glas M; Neurooncology Working Group of the German Cancer Society.
Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial.
Lancet. 2019 Feb 16;393(10172):678-688. doi: 10.1016/S0140-6736(18)31791-4. PMID: 30782343. Interventional study. ˍ




Stupp R, Lukas RV, Hegi ME.
Improving survival in molecularly selected glioblastoma.
Lancet. 2019 Feb 16;393(10172):615-617. doi: 10.1016/S0140-6736(18)33211-2. PMID: 30782332. Comment. ˍ
Refers to: Herrlinger U, et al., Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial.
Lancet. 2019 Feb 16;393(10172):678-688. doi: 10.1016/S0140-6736(18)31791-4. PMID: 30782343. Interventional study. ˍ




Wang T, Long Q, Gao T.
Letter: Thalamic Glioblastoma: Clinical Presentation, Management Strategies, and Outcomes.
Neurosurgery. 2019 Feb 16;84(5):E288. doi: 10.1093/neuros/nyz009. PMID: 30770537. Comment. ˍ
Refers to: Esquenazi Y, et al., Thalamic Glioblastoma: Clinical Presentation, Management Strategies, and Outcomes.
Neurosurgery. 2018 Jul 1, 2018;83(1):76-85. doi: 10.1093/neuros/nyx349. PMID: 28973417. Observational study. ˍ




Franceschi E, Tosoni A, De Biase D, Lamberti G, Danieli D, Pizzolitto S, Zunarelli E, Visani M, Di Oto E, Mura A, Minichillo S, Scafati C, Asioli S, Paccapelo A, Bartolini S, Brandes AA.
Postsurgical Approaches in Low-Grade Oligodendroglioma: Is Chemotherapy Alone Still an Option?
Oncologist. 2019 Feb 18;24(5):664-670. doi: 10.1634/theoncologist.2018-0549. PMID: 30777895. Observational study. ˍ




Kamran SC, Dworkin M, Niemierko A, Bussiere M, Oh KS, Loeffler JS, Shih HA.
Patterns of failure among low-grade glioma patients treated with proton radiotherapy.
Pract Radiat Oncol. 2019 Feb 18;9(4):e356-e361. doi: 10.1016/j.prro.2019.02.002. PMID: 30790717. Observational study. ˍ




De Barros A, Attal J, Roques M, Nicolau J, Sol JC, Cohen-Jonathan-Moyal E, Roux FE.
Impact on survival of early tumor growth between surgery and radiotherapy in patients with de novo glioblastoma.
J Neurooncol. 2019 Feb 19;142(3):489-497. doi: 10.1007/s11060-019-03120-3. PMID: 30783874. Observational study. ˍ




Kikuchi R, Ueda R, Saito K, Shibao S, Nagashima H, Tamura R, Morimoto Y, Sasaki H, Noji S, Kawakami Y, Yoshida K, Toda M.
A Pilot Study of Vaccine Therapy with Multiple Glioma Oncoantigen/Glioma Angiogenesis-Associated Antigen Peptides for Patients with Recurrent/Progressive High-Grade Glioma.
J Clin Med. 2019 Feb 20;8(2):263. doi: 10.3390/jcm8020263. PMID: 30791546. Interventional study. ˍ




Al-Holou WN, Hodges TR, Everson RG, Freeman J, Zhou S, Suki D, Rao G, Ferguson SD, Heimberger AB, McCutcheon IE, Prabhu SS, Lang FF, Weinberg JS, Wildrick DM, Sawaya R.
Perilesional Resection of Glioblastoma Is Independently Associated With Improved Outcomes.
Neurosurgery. 2019 Feb 25, 2020;86(1):112-121. doi: 10.1093/neuros/nyz008. PMID: 30799490. Observational study. ˍ




Przystal JM, Waramit S, Pranjol MZI, Yan W, Chu G, Chongchai A, Samarth G, Olaciregui NG, Tabatabai G, Carcaboso AM, Aboagye EO, Suwan K, Hajitou A.
Efficacy of systemic temozolomide-activated phage-targeted gene therapy in human glioblastoma.
EMBO Mol Med. 2019 Feb 26;11(4):e8492. doi: 10.15252/emmm.201708492. PMID: 30808679. Laboratory investigation. ˍ




Fang X, Kong W, Yu Z, Qiu J, Duan H.
Letter to the Editor Regarding "Can Early Postoperative O-(2-18FFluoroethyl)-l-Tyrosine Positron Emission Tomography After Resection of Glioblastoma Predict the Location of Later Tumor Recurrence?"
World Neurosurg. 2019 Feb 26;123:469
. doi: 10.1016/j.wneu.2018.10.050. PMID: 30832182. Comment. ˍ
Refers to: Buchmann N et al., Can Early Postoperative O-(2-18FFluoroethyl)-l-Tyrosine Positron Emission Tomography After Resection of Glioblastoma Predict the Location of Later Tumor Recurrence?
World Neurosurg. 2018 Sep 27;121:e467-e474. doi: 10.1016/j.wneu.2018.09.139. PMID: 30267942. Observational study. ˍ




Mahzouni P, Shavakhi M.
Prostate-Specific Membrane Antigen Expression in Neovasculature of Glioblastoma Multiforme.
Adv Biomed Res. 2019 Feb 27;8:18. doi: 10.4103/abr.abr_209_18. PMID: 30993088. Laboratory investigation. ˍ




Bhalerao S, Nagarkar R, Adhav A.
A case report of high-grade astroblastoma in a young adult.
CNS Oncol. 2019 Feb 28;8(1):CNS29
. doi: 10.2217/cns-2018-0012. PMID: 30813777. Case report. ˍ




Kebir S, Rauschenbach L, Radbruch A, Lazaridis L, Schmidt T, Stoppek AK, Pierscianek D, Stuschke M, Forsting M, Sure U, Keyvani K, Kleinschnitz C, Scheffler B, Glas M.
Regorafenib in patients with recurrent high-grade astrocytoma.
J Cancer Res Clin Oncol. 2019 Feb 28;145(4):1037-1042
. doi: 10.1007/s00432-019-02868-5. PMID: 30820715. Observational study. ˍ




Raman R, Raman A.
A pituitary tumor turned-to-be a glioma: A surgical case from the Madras General Hospital 1928.
Indian J Cancer. 2019 Feb 28, 2018;55(4):424-427
. doi: 10.4103/ijc.IJC_12_19. PMID: 30829288. Case report. ˍ




Rodriguez J, Dionne K, Wu GF, Goyal MS, Bucelli RC.
Primary Spinal Cord Glioblastoma Multiforme in the Young and Old.
Neurohospitalist. 2019 Feb 28;9(4):243-244. doi: 10.1177/1941874419832443. PMID: 31534618. Case report. ˍ




Sherif RS, Elshemey WM, Attalla EM.
The risk of secondary cancer in pediatric medulloblastoma patients due to three-dimensional conformal radiotherapy and intensity-modulated radiotherapy.
Indian J Cancer. 2019 Feb 28, 2018;55(4):372-376
. doi: 10.4103/ijc.IJC_410_18. PMID: 30829273. Observational study. ˍ