Current
Neuro-Oncology


Volume 23 Number 2
January 2021


Home > Publications > Current Neuro-Oncology > Volume 23, Year 2021 > Number 2, January



Contents


Central nervous system tumors


Gliomas


High-grade gliomas


Low-grade gliomas


Gliomatosis cerebri


Diffuse astrocytic and oligodendroglial tumors


Glioblastoma


Other astrocytic tumors


Pilocytic astrocytoma


Embryonal tumors


Medulloblastoma


CNS embryonal tumor


Meningiomas


Lymphomas


Tumors of the sellar region


Craniopharingioma


Familial tumor syndromes


Metastatic tumors



Central nervous system tumors


Dutz A, Lühr A, Agolli L, Bütof R, Valentini C, Troost EGC, Baumann M, Vermeren X, Geismar D, Lamba N, Lebow ES, Bussière M, Daly JE, Bussière MR, Krause M, Timmermann B, Shih HA, Löck S.
Modelling of late side-effects following cranial proton beam therapy.
Radiother Oncol. 2021 Apr;157:15-23. doi:10.1016/j.radonc.2021.01.004. Epub 2021 Jan 18. PMID: 33482232. Clinical study;




Hajimohammadebrahim-Ketabforoush M, Shahmohammadi M, Keikhaee M, Eslamian G, Vahdat Shariatpanahi Z.
Single high-dose vitamin D3 injection and clinical outcomes in brain tumor resection: A randomized, controlled clinical trial.
Clin Nutr ESPEN. 2021 Feb;41:153-159. doi: 10.1016/j.clnesp.2020.11.027. Epub 2020 Dec 25. PMID: 33487259. Prospective study;




Mascarenhas L, Ogawa C, Laetsch TW, Weigel BJ, Bishop MW, Krystal J, Borinstein SC, Slotkin EK, Muscal JA, Hingorani P, Levy DE, Mo G, Shahir A, Wright J, DuBois SG.
Phase 1 trial of olaratumab monotherapy and in combination with chemotherapy in pediatric patients with relapsed/refractory solid and central nervous system tumors.
Cancer Med. 2021 Feb;10(3):843-856. doi: 10.1002/cam4.3658. Epub 2021 Jan 20. PMID: 33474828. Phase 1 trial.




Wang H, Mejia MC, Gonzalez SJ, Zoorob RJ, Chai W, Du XL.
Cancer incidence and survival trends among infants in the United States from 1975 to 2014.
Pediatr Blood Cancer. 2021 Apr;68(4):e28917
. doi: 10.1002/pbc.28917. Epub 2021 Jan 20. PMID: 33470510. Population-based study;



Gliomas

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Berg TJ, Marques C, Pantazopoulou V, Johansson E, von Stedingk K, Lindgren D, Jeannot P, Pietras EJ, Bergström T, Swartling FJ, Governa V, Bengzon J, Belting M, Axelson H, Squatrito M, Pietras A.
The irradiated brain microenvironment supports glioma stemness and survival via astrocyte-derived Transglutaminase 2.
Cancer Res. 2021 Jan 22:canres.1785.2020. doi: 10.1158/0008-5472.CAN-20-1785. Epub ahead of print. PMID: 33483373. Laboratory investigation.




Decuyper M, Bonte S, Deblaere K, Van Holen R.
Automated MRI based pipeline for segmentation and prediction of grade, IDH mutation and 1p19q co-deletion in glioma.
Comput Med Imaging Graph. 2021 Mar;88:101831. doi: 10.1016/j.compmedimag.2020.101831. Epub 2020 Nov 27. PMID: 33482430. Clinical tool development.




Park SA, Han HR, Ahn S, Ryu CH, Jeun SS.
Combination treatment with VPA and MSCs-TRAIL could increase anti-tumor effects against intracranial glioma.
Oncol Rep. 2021 Mar;45(3):869-878. doi: 10.3892/or.2021.7937. Epub 2021 Jan 14. PMID: 33469674. Laboratory investigation.



High-grade gliomas



Djurovic Z, Jovanovic V, Obrenovic R, Djurovic B, Soldatovic I, Vranic A, Jakovljevic V, Djuric D, Zivkovic V.
The importance of the blood levels of homocysteine, folate and vitamin B12 in patients with primary malignant brain tumors.
J BUON. 2020 Nov-Dec;25(6):2600-2607. PMID: 33455102. Prospective study.




Gallia GL, Holdhoff M, Brem H, Joshi AD, Hann CL, Bai RY, Staedtke V, Blakeley JO, Sengupta S, Jarrell TC, Wollett J, Szajna K, Helie N, Mattox AK, Ye X, Rudek MA, Riggins GJ.
Mebendazole and temozolomide in patients with newly diagnosed high-grade gliomas: results of a phase 1 clinical trial.
Neurooncol Adv. 2020 Nov 12;3(1):vdaa154. doi: 10.1093/noajnl/vdaa154. PMID: 33506200. Phase 1 trial.




Sui L, Li Y, Xu Z, Shen X.
Therapeutic effect of thalidomide combined with temozolomide and three-dimensional conformal radiotherapy for patients with high-grade gliomas after operation.
J BUON. 2020 Nov-Dec;25(6):2608-2615. PMID: 33455103. Retrospective analysis.



Low-grade gliomas



Park CJ, Han K, Kim H, Ahn SS, Choi D, Park YW, Chang JH, Kim SH, Cha S, Lee SK.
MRI Features May Predict Molecular Features of Glioblastoma in Isocitrate Dehydrogenase Wild-Type Lower-Grade Gliomas.
AJNR Am J Neuroradiol. 2021 ar;42(3):448-456. doi: 10.3174/ajnr.A6983. Epub 2021 Jan 28. PMID: 33509914. Retrospective analysis.



Gliomatosis cerebri



Divé I, Steidl E, Wagner M, Filipski K, Burger MC, Franz K, Harter PN, Bähr O, Fokas E, Herrlinger U, Steinbach JP.
Gliomatosis Cerebri Growth Pattern: Association of Differential First-Line Treatment with Overall Survival in WHO Grade II and III Gliomas.
Oncology. 2021;99(4):215-224. doi: 10.1159/000512562. Epub 2021 Jan 20. PMID: 33472203. Retrospective analysis;



Diffuse astrocytic and oligodendroglial tumors


Haque W, Verma V, Barber S, Tremont IW, Brian Butler E, Teh BS.
Management, outcomes, and prognostic factors of adult primary spinal cord gliomas.
J Clin Neurosci. 2021 Feb;84:8-14. doi: 10.1016/j.jocn.2020.12.015. Epub 2020 Dec 28. PMID: 33485604. Retrospective analysis;



Glioblastoma



Ahmadipour Y, Rauschenbach L, Santos A, Darkwah Oppong M, Lazaridis L, Quesada CM, Junker A, Pierscianek D, Dammann P, Wrede KH, Scheffler B, Glas M, Stuschke M, Sure U, Jabbarli R.
Preoperative and early postoperative seizures in patients with glioblastoma-two sides of the same coin?
Neurooncol Adv. 2020 Nov 18;3(1):vdaa158. doi: 10.1093/noajnl/vdaa158. PMID: 33506201. Retrospective analysis.



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Aldaz P, Auzmendi-Iriarte J, Durántez M, Lasheras-Otero I, Carrasco-Garcia E, Zelaya MV, Bragado L, Olías-Arjona A, Egaña L, Samprón N, Morilla I, Redondo-Muñoz M, Rico M, Squatrito M, Maria-Alonso M, Fernández-Irigoyen J, Santamaria E, Larráyoz IM, Wellbrock C, Matheu A, Arozarena I.
Identification of a Dexamethasone Mediated Radioprotection Mechanism Reveals New Therapeutic Vulnerabilities in Glioblastoma.
Cancers (Basel). 2021 Jan 19;13(2):361. doi: 10.3390/cancers13020361. PMID: 33478100. Cliical study and Laboratory investigation.




Andrews DW, Judy KD, Scott CB, Garcia S, Harshyne LA, Kenyon L, Talekar K, Flanders A, Atsina KB, Kim L, Martinez N, Shi W, Werner-Wasik M, Liu H, Prosniak M, Curtis M, Kean R, Ye DY, Bongiorno E, Sauma S, Exley MA, Pigott K, Hooper DC.
Phase Ib Clinical Trial of IGV-001 for Patients with Newly Diagnosed Glioblastoma.
Clin Cancer Res. 2021 Apr 1;27(7):1912-1922. doi: 10.1158/1078-0432.CCR-20-3805. Epub 2021 Jan 26. PMID: 33500356. Phase 1b trial.




Brenner AJ, Floyd J, Fichtel L, Michalek J, Kanakia KP, Huang S, Reardon D, Wen PY, Lee EQ.
Phase 2 trial of hypoxia activated evofosfamide (TH302) for treatment of recurrent bevacizumab-refractory glioblastoma.
Sci Rep. 2021 Jan 27;11(1):2306. doi: 10.1038/s41598-021-81841-0. PMID: 33504881. Phase 2 trial.




Goldman DA, Reiner AS, Diamond EL, DeAngelis LM, Tabar V, Panageas KS.
Lack of survival advantage among re-resected elderly glioblastoma patients: a SEER-Medicare study.
Neurooncol Adv. 2020 Nov 29;3(1):vdaa159. doi: 10.1093/noajnl/vdaa159. PMID: 33506202. Retrospective analysis.




Mummareddy N, Salwi SR, Ganesh Kumar N, Zhao Z, Ye F, Le CH, Mobley BC, Thompson RC, Chambless LB, Mistry AM.
Prognostic relevance of CSF and peri-tumoral edema volumes in glioblastoma.
J Clin Neurosci. 2021 Feb;84:1-7. doi: 10.1016/j.jocn.2020.12.014. Epub 2020 Dec 28. PMID: 33485591. Retrospective analysis;



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Patrizz A, Dono A, Zhu P, Tandon N, Ballester LY, Esquenazi Y.
Tumor recurrence or treatment-related changes following chemoradiation in patients with glioblastoma: does pathology predict outcomes?
J Neurooncol. 2021 Mar;152(1):163-172. doi: 10.1007/s11060-020-03690-7. Epub 2021 Jan 22. PMID: 33481149. Retrospective analysis;




Reardon DA, Kim TM, Frenel JS, Simonelli M, Lopez J, Subramaniam DS, Siu LL, Wang H, Krishnan S, Stein K, Massard C.
Treatment with pembrolizumab in programmed death ligand 1-positive recurrent glioblastoma: Results from the multicohort phase 1 KEYNOTE-028 trial.
Cancer. 2021 Jan 26. doi: 10.1002/cncr.33378. Epub ahead of print. PMID: 33496357. Phase 1 trial;




Wefel JS, Armstrong TS, Pugh SL, Gilbert MR, Wendland MM, Brachman DG, Roof KS, Brown PD, Crocker IR, Robins HI, Hunter G, Won M, Mehta MP.
Neurocognitive, Symptom, and Health- Related Quality of Life Outcomes of a Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma (NRG/RTOG 0825).
Neuro Oncol. 2021 Jan 30:noab011. doi: 10.1093/neuonc/noab011. Epub ahead of print. PMID: 33515019. Phase 3 trial;



Other astrocytic tumors



Pilocytic astrocytoma



Chung DJ, Arif B, Odia Y, Siomin V.
Chemotherapy-induced changes in tumor consistency can allow gross total resection of previously unresectable brainstem pilocytic astrocytoma.
Surg Neurol Int. 2021 Jan 13;12:12. doi: 10.25259/SNI_594_2020. PMID: 33500827. Case report.



Embryonal tumors



Medulloblastoma



Massimino M, Signoroni S, Boschetti L, Chiapparini L, Erbetta A, Biassoni V, Schiavello E, Ferrari A, Spreafico F, Terenziani M, Chiaravalli S, Puma N, Bergamaschi L, Ricci MT, Cattaneo L, Gattuso G, Buttarelli FR, Gianno F, Miele E, Poggi G, Vitellaro M.
Medulloblastoma and familial adenomatous polyposis: Good prognosis and good quality of life in the long-term?
Pediatr Blood Cancer. 2021 Apr;68(4):e28912. doi: 10.1002/pbc.28912. Epub 2021 Jan 18. PMID: 33459525. Retrospective analysis;




Reis J, Stahl R, Zimmermann H, Ruf V, Thon N, Kunz M, Liebig T, Forbrig R.
Advanced MRI Findings in Medulloblastomas: Relationship to Genetic Subtypes, Histopathology, and Immunohistochemistry.
J Neuroimaging. 2021 Mar;31(2):306-316. doi: 10.1111/jon.12831. Epub 2021 Jan 19. PMID: 33465267. Retrospective analysis.



CNS embryonal tumor



Xiao X, Liu X, Liang W, Han LY, Li XD, Guo LJ, He WL, Liu XM, Zhou J, Cai Q, Xu YK, Tan XL, Wu YK.
Conventional MRI Features of Central Nervous System Embryonal Tumor, Not Otherwise Specified in Adults: Comparison with Glioblastoma.
Acad Radiol. 2021 Jan 25:S1076-6332(21)00019-2. doi: 10.1016/j.acra.2021.01.010. Epub ahead of print. PMID: 33504445. Retrospective analysis;



Meningiomas


Baumgarten P, Sarlak M, Monden D, Spyrantis A, Bernatz S, Gessler F, Dubinski D, Hattingen E, Marquardt G, Strzelczyk A, Rosenow F, Harter PN, Seifert V, Freiman TM.
Early and Late Postoperative Seizures in Meningioma Patients and Prediction by a Recent Scoring System.
Cancers (Basel). 2021 Jan 25;13(3):450. doi: 10.3390/cancers13030450. PMID: 33504023. Retrospective analysis.




Bunevicius A, Anand RK, Suleiman M, Nabeel AM, Reda WA, Tawadros SR, Abdelkarim K, El-Shehaby AMN, Emad RM, Chytka T, Liscak R, Sheehan K, Sheehan D, Caceres MP, Mathieu D, Lee CC, Yang HC, Picozzi P, Franzini A, Attuati L, Speckter H, Olivo J, Patel S, Cifarelli CP, Cifarelli DT, Hack JD, Strickland BA, Zada G, Chang EL, Fakhoury KR, Rusthoven CG, Warnick RE, Sheehan J.
Stereotactic Radiosurgery for Perioptic Meningiomas: An International, Multicenter Study.
Neurosurgery. 2021 Apr;88(4):828-837. doi: 10.1093/neuros/nyaa544. Epub 2021 Jan 20. PMID: 33475718. Retrospective analysis;




Joubert C, Sellier A, Sahuc P, Beucler N, Desse N, Bernard C, Cungi PJ, Dagain A.
Neurosurgery for intracranial meningioma in patients aged more than 80 years: benefits and rationale.
Br J Neurosurg. 2021 Jan 20:1-6. doi: 10.1080/02688697.2021.1875397. Epub ahead of print. PMID: 33470146. Retrospective analysis;



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Nagai Yamaki V, de Souza Godoy LF, Alencar Bandeira G, Tavares Lucato L, Correa Lordelo G, Fontoura Solla DJ, Santana Neville I, Jacobsen Teixeira M, Silva Paiva W.
Dural-based lesions: is it a meningioma?
Neuroradiology. 2021 Jan 18. doi: 10.1007/s00234-021-02632-y. Epub ahead of print. PMID: 33459822. Retrospective analysis;




Ruge MI, Tutunji J, Rueß D, Celik E, Baues C, Treuer H, Kocher M, Grau S.
Stereotactic radiosurgery for treating meningiomas eligible for complete resection.
Radiat Oncol. 2021 Jan 28;16(1):22. doi: 10.1186/s13014-021-01748-y. PMID: 33509211. Retrospective analysis.




Shepard MJ, Xu Z, Kearns K, Li C, Chatrath A, Sheehan K, Sheehan D, Faramand A, Niranjan A, Kano H, Gurewitz J, Bernstein K, Liscak R, Guseynova K, Grills IS, Parzen JS, Cifarelli CP, Rehman AA, Atik A, Bakhsheshian J, Zada G, Chang E, Giannotta S, Speckter H, Wu HM, Kondziolka D, Golfinos JG, Mathieu D, Lee CC, Warnick RE, Lunsford LD, Sheehan JP.
Stereotactic Radiosurgery for Atypical (World Health Organization II) and Anaplastic (World Health Organization III) Meningiomas: Results From a Multicenter, International Cohort Study.
Neurosurgery. 2021 May;88(5):980-988. doi: 10.1093/neuros/nyaa553. Epub 2021 Jan 19. PMID: 33469655. Prospective study; ⍈



Lymphomas


Zhang Y, Cai J, Lin Z, Yao S, Miao W.
Primary Central Nervous System Lymphoma Revealed by 68Ga-FAPI and 18F-FDG PET/CT.
Clin Nucl Med. 2021 Jan 28. doi: 10.1097/RLU.0000000000003517. Epub ahead of print. PMID: 33512949. Case report;



Tumors of the sellar region



Craniopharingioma



Momin AA, Recinos MA, Cioffi G, Patil N, Soni P, Almeida JP, Kruchko C, Barnholtz-Sloan JS, Recinos PF, Kshettry VR.
Descriptive epidemiology of craniopharyngiomas in the United States.
Pituitary. 2021 Jan 28. doi: 10.1007/s11102-021-01127-6. Epub ahead of print. PMID: 33506438. Retrospective analysis;



Familial tumor syndromes


Bashiri FA, AlZamil LR, Aldhuwayhi RA.
Clinical spectrum of neurofibromatosis type 1 among children in a tertiary care center.
Neurosciences (Riyadh). 2020 Oct;25(5):375-379. doi: 10.17712/nsj.2020.5.20200081. PMID: 33459286. Retrospective analysis.



Metastatic tumors


Kawahara D, Tang X, Lee CK, Nagata Y, Watanabe Y.
Predicting the Local Response of Metastatic Brain Tumor to Gamma Knife Radiosurgery by Radiomics With a Machine Learning Method.
Front Oncol. 2021 Jan 11;10:569461. doi: 10.3389/fonc.2020.569461. PMID: 33505904. Clinical tool development.





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