Volume 23 Number 3
February 2021

Home > Publications > Current Neuro-Oncology > Volume 23, Year 2021 > Number 3, February


Central nervous system tumors


High-grade gliomas

Low-grade gliomas

Diffuse astrocytic and oligodendroglial tumors


Diffuse Midline Glioma

Anaplastic Oligodendroglioma

Embryonal tumors





Central nervous system tumors

Bukowinski A, Chang B, Reid JM, Liu X, Minard CG, Trepel JB, Lee MJ, Fox E, Weigel BJ.
A phase 1 study of entinostat in children and adolescents with recurrent or refractory solid tumors, including CNS tumors: Trial ADVL1513, Pediatric Early Phase-Clinical Trial Network (PEP-CTN).
Pediatr Blood Cancer. 2021 Apr;68(4):e28892.. doi: 10.1002/pbc.28892. Epub 2021 Jan 12. PMID: 33438318. Phase 1 trial;

Coomans MB, Dirven L, Aaronson NK, Baumert BG, van den Bent M, Bottomley A, Brandes AA, Chinot O, Coens C, Gorlia T, Herrlinger U, Keime-Guibert F, Malmström A, Martinelli F, Sloan JA, Stupp R, Talacchi A, Weller M, Wick W, Reijneveld JC, Taphoorn MJB.
Calculating the net clinical benefit in neuro-oncology clinical trials using two methods: quality-adjusted survival effect sizes and joint modeling.
Neurooncol Adv. 2020 Oct 29;2(1):vdaa147. doi: 10.1093/noajnl/vdaa147. PMID: 33409496. Methodology.

Dikaios N.
Deep learning magnetic resonance spectroscopy fingerprints of brain tumours using quantum mechanically synthesised data.
NMR Biomed. 2021 Apr;34(4):e4479. doi: 10.1002/nbm.4479. Epub 2021 Jan 14. PMID: 33448078. Tool development;

El Beltagy MA, Atteya MME.
Benefits of endoscope-assisted microsurgery in the management of pediatric brain tumors.
Neurosurg Focus. 2021 Jan;50(1):E7. doi: 10.3171/2020.10.FOCUS20620. PMID: 33386008. Retroaspective analysis.

Habibi Z, Hajizadeh M, Nozarian Z, Safavi M, Monajemzadeh M, Meybodi KT, Nejat F, Vasei M.
Cytomegalovirus DNA in non-glioblastoma multiforme brain tumors of infants.
Childs Nerv Syst. 2021 Jan 7. doi: 10.1007/s00381-021-05038-6. Online ahead of print. PMID: 33409619. Laboratory investigation;

Huynh-Le MP, Tibbs MD, Karunamuni R, Tringale KR, Salans M, Yip A, Connor M, Simon AB, Vitzthum LK, Reyes A, Macari AC, Moiseenko V, McDonald CR, Hattangadi-Gluth JA.
Microstructural injury to corpus callosum and intra-hemispheric white matter tracts correlate with attention and processing speed decline after brain radiation.
Int J Radiat Oncol Biol Phys. 2021 Jan 4. doi: 10.1016/j.ijrobp.2020.12.046. Online ahead of print. PMID: 33412257. Prospective study;

Sadad T, Rehman A, Munir A, Saba T, Tariq U, Ayesha N, Abbasi R.
Brain tumor detection and multi-classification using advanced deep learning techniques.
Microsc Res Tech. 2021 Jan 5. doi: 10.1002/jemt.23688. Online ahead of print. PMID: 33400339. Artificial intelligence investigation;

Sarubbo S, Annicchiarico L, Corsini F, Zigiotto L, Herbet G, Moritz-Gasser S, Dalpiaz C, Vitali L, Tate M, De Benedictis A, Amorosino G, Olivetti E, Rozzanigo U, Petralia B, Duffau H, Avesani P.
Planning Brain Tumor Resection Using a Probabilistic Atlas of Cortical and Subcortical Structures Critical for Functional Processing: A Proof of Concept.
Oper Neurosurg (Hagerstown). 2021 Feb 16;20(3):E175-E183. doi: 10.1093/ons/opaa396. Epub 2020 Dec 29. PMID: 33372966. Tool development;

Van Mater D, Gururangan S, Becher O, Campagne O, Leary S, Phillips JJ, Huang J, Lin T, Poussaint TY, Goldman S, Baxter P, Dhall G, Robinson G, DeWire-Schottmiller M, Hwang EI, Stewart CF, Onar-Thomas A, Dunkel IJ, Fouladi M.
A phase I trial of the CDK 4/6 inhibitor palbociclib in pediatric patients with progressive brain tumors: A Pediatric Brain Tumor Consortium study (PBTC-042).
Pediatr Blood Cancer. 2021 Apr;68(4):e28879. doi: 10.1002/pbc.28879. Epub 2021 Jan 6. PMID: 33405376. Phase 1 trial;


Hu Y, Chen Y, Wang J, Kang JJ, Shen DD, Jia ZZ.
Non-Invasive Estimation of Glioma IDH1 Mutation and VEGF Expression by Histogram Analysis of Dynamic Contrast-Enhanced MRI.
Front Oncol. 2020 Dec 8;10:593102. doi: 10.3389/fonc.2020.593102. PMID: 33425744. Retrospective analysis.

Hua T, Zhou W, Zhou Z, Guan Y, Li M.
Heterogeneous parameters based on <sup>18</sup>F-FET PET imaging can non-invasively predict tumor grade and isocitrate dehydrogenase gene 1 mutation in untreated gliomas.
Quant Imaging Med Surg. 2021 Jan;11(1):317-327. doi: 10.21037/qims-20-723. PMID: 33392031. Retrospective analysis.

Munir S, Khan SA, Hanif H, Khan M.
Diagnostic accuracy of magnetic resonance imaging in detection of intra-axial gliomas.
Pak J Med Sci. Jan-Feb 2021;37(1):125-130. doi: 10.12669/pjms.37.1.2489. Epub 2020 Dec 8. PMID: 33437263. Prospective study.

Nakajo K, Uda T, Kawashima T, Terakawa Y, Ishibashi K, Tsuyuguchi N, Tanoue Y, Nagahama A, Uda H, Koh S, Sasaki T, Ohata K, Kanemura Y, Goto T.
Diagnostic performance of 11C-methionine PET in newly diagnosed and untreated glioma based on the revised WHO 2016 classification.
World Neurosurg. 2021 Jan 11;S1878-8750(21)00033-4.. doi: 10.1016/j.wneu.2021.01.012. Online ahead of print. PMID: 33444827. Retrospective analysis;

Shetty P, Yeole U, Singh V, Moiyadi A.
Navigated ultrasound-based image guidance during resection of gliomas: practical utility in intraoperative decision-making and outcomes.
Neurosurg Focus. 2021 Jan;50(1):E14. doi: 10.3171/2020.10.FOCUS20550. PMID: 33386014. Retrospective analysis.

Valente Aguiar P, Carvalho B, Vaz R, Linhares P.
Body mass index as an independent prognostic factor in glioblastoma.
Cancer Causes Control. 2021 Apr;32(4):327-336. doi: 10.1007/s10552-020-01388-9. Epub 2021 Jan 15. PMID: 33447892. Retrospective analysis;

Wang Z, Su G, Dai Z, Meng M, Zhang H, Fan F, Liu Z, Zhang L, Weygant N, He F, Fang N, Zhang L, Cheng Q.
Circadian clock genes promote glioma progression by affecting tumour immune infiltration and tumour cell proliferation.
Cell Prolif. 2021 Mar;54(3):e12988. doi: 10.1111/cpr.12988. Epub 2021 Jan 13. PMID: 33442944 Laboratory investigation.

Zanello M, Roux A, Senova S, Peeters S, Edjlali M, Espariat AT, Dezamis E, Parraga E, Zah-Bi G, Harislur M, Oppenheim C, Sauvageon X, Chretien F, Devaux B, Varlet P, Pallud J.
Robot-assisted stereotactic biopsies in 377 consecutive adult patients with supratentorial diffuse gliomas: diagnostic yield, safety and postoperative outcomes.
World Neurosurg. 2021 Jan 4. doi: 10.1016/j.wneu.2020.12.127. Online ahead of print. PMID: 33412330. Retrospective analysis;

Zhang S, Sun H, Su X, Yang X, Wang W, Wan X, Tan Q, Chen N, Yue Q, Gong Q.
Automated machine learning to predict the co-occurrence of isocitrate dehydrogenase mutations and O6-methylguanine-DNA methyltransferase promoter methylation in patients with gliomas.
J Magn Reson Imaging. 2021 Jan 3. doi: 10.1002/jmri.27498. Online ahead of print. PMID: 33393131. Retrospective analysis;

Zhou Q, Yan X, Liu W, Yin W, Xu H, Cheng D, Jiang X, Ren C.
Three Immune-Associated Subtypes of Diffuse Glioma Differ in Immune Infiltration, Immune Checkpoint Molecules, and Prognosis.
Front Oncol. 2020 Dec 23;10:586019. doi: 10.3389/fonc.2020.586019. PMID: 33425739. Laboratory investigation.

High-grade gliomas

Barbagallo GMV, Certo F, Di Gregorio S, Maione M, Garozzo M, Peschillo S, Altieri R.
Recurrent high-grade glioma surgery: a multimodal intraoperative protocol to safely increase extent of tumor resection and analysis of its impact on patient outcome.
Neurosurg Focus. 2021 Jan;50(1):E20. doi: 10.3171/2020.10.FOCUS20744. PMID: 33386001. Retrospective analysis.

Low-grade gliomas

Wang J, Zheng X, Zhang J, Xue H, Wang L, Jing R, Chen S, Che F, Heng X, Li G, Xue F.
An MRI-based radiomics signature as a pretreatment noninvasive predictor of overall survival and chemotherapeutic benefits in lower-grade gliomas.
Eur Radiol. 2021 Apr;31(4):1785-1794. doi: 10.1007/s00330-020-07581-3. Epub 2021 Jan 6. PMID: 33409797. Artificial intelligence investigation;

Pinto Dos Santos D, Garcia Santos JM.
Radiomics for prediction of survival in lower-grade gliomas-it's time to move beyond the crystal ball.
Eur Radiol.
2021 Apr;31(4):1783-1784. doi: 10.1007/s00330-020-07603-0. Epub 2020 Dec 19. PMID: 33341906. Comment.

Wei RL, Zhang LW, Li JG, Yang FD, Xue YK, Wei XT.
Behavior-Oriented Nomogram for the Stratification of Lower-Grade Gliomas to Improve Individualized Treatment.
Front Oncol. 2020 Dec 17;10:538133. doi: 10.3389/fonc.2020.538133. PMID: 33392065. Nomogram development.

Diffuse astrocytic and oligodendroglial tumors


Abbas S, Singh SK, Saxena AK, Tiwari S, Sharma LK, Tiwari M.
Role of autophagy in regulation of glioma stem cells population during therapeutic stress.
J Stem Cells Regen Med. 2020 Dec 11;16(2):80-89. doi: 10.46582/jsrm.1602012. PMID: 33414584. Laboratory investigation.

Beig Zali S, Alinezhad F, Ranjkesh M, Daghighi MH, Poureisa M.
Accuracy of apparent diffusion coefficient in differentiation of glioblastoma from metastasis.
Neuroradiol J. 2021 Jan 8:1971400920983678. doi: 10.1177/1971400920983678. Online ahead of print. PMID: 33417503. Retrospective analysis;

Bettag C, Schregel K, Langer P, Thomas C, Behme D, Stadelmann C, Rohde V, Mielke D.
Endoscope-assisted fluorescence-guided resection allowing supratotal removal in glioblastoma surgery.
Neurosurg Focus. 2021 Jan;50(1):E3. doi: 10.3171/2020.10.FOCUS20560. PMID: 33386004. Retrospective analysis.

Clavreul A, Aubin G, Delion M, Lemée JM, Ter Minassian A, Menei P.
What effects does awake craniotomy have on functional and survival outcomes for glioblastoma patients?
J Neurooncol. 2021 Jan;151(2):113-121. doi: 10.1007/s11060-020-03666-7. Epub 2021 Jan 4. PMID: 33394262. Retrospective analysis;

Cuenca MB, Canedo L, Perez-Castro C, Grecco HE.
An Integrative and Modular Framework to Recapitulate Emergent Behavior in Cell Migration.
Front Cell Dev Biol. 2020 Dec 22;8:615759. doi: 10.3389/fcell.2020.615759. PMID: 33415111. Tool development.

Farshchian M, Bardhi R, Daveluy S.
Desquamative skin rash associated with temozolomide in a patient with glioblastoma.
Dermatol Ther. 2021 Jan 9:e14771. doi: 10.1111/dth.14771. Online ahead of print. PMID: 33421249. Letter;

Eftekhar Javadi A, Moradi Tabriz H, Zandnejadi A.
Postoperative Extra-Cranial Metastasis of Glioblastoma: A Case Report.
Iran J Pathol. Winter 2021;16(1):90-94. doi: 10.30699/ijp.2020.122780.2349. Epub 2020 Oct 10. PMID: 33391387. Case report.

Ferguson SD, Hodges TR, Majd NK, Alfaro-Munoz K, Al-Holou WN, Suki D, de Groot JF, Fuller GN, Xue L, Li M, Jacobs C, Rao G, Colen RR, Xiu J, Verhaak R, Spetzler D, Khasraw M, Sawaya R, Long JP, Heimberger AB.
A validated integrated clinical and molecular glioblastoma long-term survival-predictive nomogram.
Neurooncol Adv. 2020 Oct 31;3(1):vdaa146. doi: 10.1093/noajnl/vdaa146. PMID: 33426529. Nomogram development.

Gerstner ER, Emblem KE, Yen YF, Dietrich J, Jordan JT, Catana C, Wenchin KL, Hooker JM, Duda DG, Rosen BR, Kalpathy-Cramer J, Jain RK, Batchelor TT.
Vascular dysfunction promotes regional hypoxia after bevacizumab therapy in recurrent glioblastoma patients.
Neurooncol Adv. 2020 Nov 17;2(1):vdaa157. doi: 10.1093/noajnl/vdaa157. PMID: 33392506. Clinical study.

Gomes I, Moreno DA, Dos Reis MB, da Silva LS, Leal LF, Gonçalves GM, Pereira CA, Oliveira MA, de Medeiros Matsushita M, Reis RM.
Low MGMT digital expression is associated with a better outcome of IDH1 wildtype glioblastomas treated with temozolomide.
J Neurooncol. 2021 Jan;151(2):135-144. doi: 10.1007/s11060-020-03675-6. Epub 2021 Jan 5. PMID: 33400009. Laboratory investigation;

Gromeier M, Brown MC, Zhang G, Lin X, Chen Y, Wei Z, Beaubier N, Yan H, He Y, Desjardins A, Herndon JE 2nd, Varn FS, Verhaak RG, Zhao J, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Lipp ES, Nair SK, Khasraw M, Peters KB, Randazzo D, Sampson JH, McLendon RE, Bigner DD, Ashley DM.
Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy.
Nat Commun. 2021 Jan 13;12(1):352. doi: 10.1038/s41467-020-20469-6. PMID: 33441554. Laboratory investigation.

Katsigiannis S, Grau S, Krischek B, Er K, Pintea B, Goldbrunner R, Stavrinou P.
MGMT-Positive vs MGMT-Negative Patients With Glioblastoma: Identification of Prognostic Factors and Resection Threshold.
Neurosurgery. 2021 Apr;88(4):E323-E329. doi: 10.1093/neuros/nyaa562. Epub 2021 Jan 12 PMID: 33432978. Retrospective analysis.

Picart T, Meyronet D, Pallud J, Dumot C, Metellus P, Zouaoui S, Berhouma M, Ducray F, Bauchet L, Guyotat J; French Brain Tumor DataBase; Club de Neuro-Oncologie of the Société Française de Neurochirurgie.
Management, functional outcomes and survival in a French multicentric series of 118 adult patients with cerebellar glioblastoma.
J Cancer Res Clin Oncol. 2021 Jan 5. doi: 10.1007/s00432-020-03474-6. Online ahead of print. PMID: 33399987. Retrospective analysis;

Rades D, Witteler J, Schild SE, Trillenberg P, Bonsanto MM, Leppert J.
A New Survival Score for Patients Receiving Radiotherapy for Newly Diagnosed Glioblastoma Multiforme.
Anticancer Res. 2021 Jan;41(1):379-384. doi: 10.21873/anticanres.14786. PMID: 33419834. Tool development;

Rahman MH, Rana HK, Peng S, Hu X, Chen C, Quinn JMW, Moni MA.
Bioinformatics and machine learning methodologies to identify the effects of central nervous system disorders on glioblastoma progression.
Brief Bioinform. 2021 Jan 6:bbaa365. doi: 10.1093/bib/bbaa365. PMID: 33406529. Artificial intelligence investigation;

Sever ON, Oktay K, Güzel E, Kaya V, Güzel A, Yıldırım M.
Reoperation does not provide a survival advantage in patients with recurrent Glioblastoma treated with irinotecan/bevacizumab treatment.
Indian J Cancer. Jan-Mar 2021;58(1):91-95. doi: 10.4103/ijc.IJC_758_18? Epub 2021 Jan 6. PMID: 33402574. Retrospective analysis.

Sinha R, Dijkshoorn ABC, Li C, Manly T, Price SJ.
Glioblastoma surgery related emotion recognition deficits are associated with right cerebral hemisphere tract changes.
Brain Commun. 2020 Oct 12;2(2):fcaa169. doi: 10.1093/braincomms/fcaa169. PMID: 33426526. Prospective study.

Tatari N, Maich WT, Salim SK, Mckenna D, Venugopal C, Singh S.
Preclinical Testing of CAR T Cells in a Patient-Derived Xenograft Model of Glioblastoma.
STAR Protoc. 2020 Dec 2;1(3):100174. doi: 10.1016/j.xpro.2020.100174. PMID: 33377068. Laboratory investigation.

Vora P, et al.
The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma.
Cell Stem Cell.
2020 Jun 4;26(6):832-844.e6. doi: 10.1016/j.stem.2020.04.008. Epub 2020 May 27. PMID: 32464096. Laboratory investigation.

Vora P, Venugopal C, Salim SK, Tatari N, Bakhshinyan D, Singh M, Seyfrid M, Upreti D, Rentas S, Wong N, Williams R, Qazi MA, Chokshi C, Ding A, Subapanditha M, Savage N, Mahendram S, Ford E, Adile AA, McKenna D, McFarlane N, Huynh V, Wylie RG, Pan J, Bramson J, Hope K, Moffat J, Singh S.
The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma.
Cell Stem Cell. 2020 Jun 4;26(6):832-844.e6. doi: 10.1016/j.stem.2020.04.008. Epub 2020 May 27. PMID: 32464096. Laboratory investigation.

Witteler J, Schild SE, Rades D.
Palliative Radiotherapy of Primary Glioblastoma.
In Vivo. 2021 Jan. 2021 Jan-Feb;35(1):483-487. doi: 10.21873/invivo.12282. PMID: 33402500. Retrospective analysis.

Yavuz BB, Kanyilmaz G, Aktan M.
Factors affecting survival in glioblastoma patients below and above 65 years of age: A retrospective observational study.
Indian J Cancer. 2021 Jan 6. doi: 10.4103/ijc.IJC_36_19? Online ahead of print. PMID: 33402568. Retrospective analysis.

Young JS, Gogos AJ, Pereira MP, Morshed RA, Li J, Barkovich MJ, Hervey-Jumper SL, Berger MS.
Effects of ventricular entry on patient outcome during glioblastoma resection.
J Neurosurg. 2021 Jan 8:1-9. doi: 10.3171/2020.7.JNS201362. Online ahead of print. PMID: 33418530. Retrospective analysis;

Diffuse midline glioma

Chen X, Zhong L, Lin J, Yu J.
A rare case of adult diffuse midline glioma with H3 K27M mutant in the prepontine cistern.
J Int Med Res. 2021 Jan 13;49(1):300060520981266. doi: 10.1177/0300060520981266. PMID: 33435779. Case report.

Zhu X, Lazow MA, Schafer A, Bartlett A, Senthil Kumar S, Mishra DK, Dexheimer P, DeWire M, Fuller C, Leach JL, Fouladi M, Drissi R.
A pilot radiogenomic study of DIPG reveals distinct subgroups with unique clinical trajectories and therapeutic targets.
Acta Neuropathol Commun. 2021 Jan 11;9(1):14. doi: 10.1186/s40478-020-01107-0. PMID: 33431066. Retrospective analysis.

Anaplastic oligodendroglioma

Padovan M, Caccese M, Zagonel V, Lombardi G.
Prolonged benefit to pembrolizumab in anaplastic oligodendroglioma patient with mismatch repair deficiency: a case report.
Anticancer Drugs. 2021 Feb 1;32(2):218-221. doi: 10.1097/CAD.0000000000001011. PMID: 33395066. Case report;

Embryonal tumors


Gajjar A, Robinson GW, Smith KS, Lin T, Merchant TE, Chintagumpala M, Mahajan A, Su J, Bouffet E, Bartels U, Schechter T, Hassall T, Robertson T, Nicholls W, Gururangan S, Schroeder K, Sullivan M, Wheeler G, Hansford JR, Kellie SJ, McCowage G, Cohn R, Fisher MJ, Krasin MJ, Stewart CF, Broniscer A, Buchhalter I, Tatevossian RG, Orr BA, Neale G, Klimo P Jr, Boop F, Srinivasan A, Pfister SM, Gilbertson RJ, Onar-Thomas A, Ellison DW, Northcott PA.
Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03).
J Clin Oncol. 2021 Mar 1;39(7):822-835. doi: 10.1200/JCO.20.01372. Epub 2021 Jan 6. PMID: 33405951. Phase 3 trial;



Bunevicius A, Suleiman M, Patel S, Martínez Álvarez R, Martinez Moreno NE, Liscak R, Hanuska J, Langlois AM, Mathieu D, Mau C, Caldwell C, Tuanquin LC, Zacharia BE, McInerney J, Lee CC, Yang HC, Peterson JL, Trifiletti DM, Ogino A, Kano H, Warnick RE, Saylany A, Buch LY, Lee JYK, Strickland BA, Zada G, Chang EL, Lunsford LD, Sheehan J.
Stereotactic radiosurgery for treatment of radiation-induced meningiomas: a multiinstitutional study.
J Neurosurg. 2021 Jan 1:1-9. doi: 10.3171/2020.7.JNS202064. Online ahead of print. PMID: 33385995. Clinical study;


Alvarez-Pinzon AM, Wolf A, Valerio JE, Borro M, Herrera D, Alonso JR.
Gamma knife stereotactic radiosurgery as an effective tool in primary CNS lymphoma: Evaluation of stereotactic radiosurgery and methotrexate treatment in a prospective and observational clinical research study.
Clin Neurol Neurosurg. 2021 Feb;201:106457. doi: 10.1016/j.clineuro.2020.106457. Epub 2020 Dec 29. PMID: 33418336. Prospective study;