Current
Neuro-Oncology


Volume 23 Number 5
March 2021


Home > Publications > Current Neuro-Oncology > Volume 23, Year 2021 > Number 5, March



Contents


Central nervous system tumors


Gliomas


High-grade gliomas


Low-grade gliomas


Diffuse astrocytic and oligodendroglial tumors


Glioblastoma


Diffuse Midline Glioma


Other astrocytic tumors


Pilocytic astrocytoma


Subependymal giant cell astrocytoma


Ependymal tumors


Ependymoma


Neuronal and mixed neuronal-glial tumors


Paraganglioma


Embryonal tumors


Medulloblastoma


Atypical theratoid/rhabdoid tumor


Meningiomas


Lymphomas


Metastatic tumors



Central nervous system tumors


Cindil E, Sendur HN, Cerit MN, Dag N, Erdogan N, Celebi FE, Oner Y, Tali T.
Validation of combined use of DWI and percentage signal recovery-optimized protocol of DSC-MRI in differentiation of high-grade glioma, metastasis, and lymphoma.
Neuroradiology. 2021 Mar;63(3):331-342. doi: 10.1007/s00234-020-02522-9. Epub 2020 Aug 21. PMID: 32821962. Clinical tool.




Gunasekara SR, Kaldera HNTK, Dissanayake MB.
A Systematic Approach for MRI Brain Tumor Localization and Segmentation Using Deep Learning and Active Contouring.
J Healthc Eng. 2021 Feb 28;2021:6695108. doi: 10.1155/2021/6695108. PMID: 33777346. Clinical tool.




Williamson MR, Klug MG, Schwartz GG.
Brain cancer incidence rates and the presence of nuclear reactors in US states: a hypothesis-generating study.
Environ Geochem Health. 2021 Mar 25. doi: 10.1007/s10653-021-00896-0. Epub ahead of print. PMID: 33768349. Epidemiological study.



Gliomas


Hanania AN, Paulino AC, Ludmir EB, Shah VS, Su JM, McGovern SL, Baxter PA, McAleer MF, Grosshans DR, Okcu MF, Chintagumpala MM.
Early radiotherapy preserves vision in sporadic optic pathway glioma.
Cancer. 2021 Mar 19. doi: 10.1002/cncr.33497. Epub ahead of print. PMID: 33739455. Retrospective analysis;




Platten M, Bunse L, Wick A, Bunse T, Le Cornet L, Harting I, Sahm F, Sanghvi K, Tan CL, Poschke I, Green E, Justesen S, Behrens GA, Breckwoldt MO, Freitag A, Rother LM, Schmitt A, Schnell O, Hense J, Misch M, Krex D, Stevanovic S, Tabatabai G, Steinbach JP, Bendszus M, von Deimling A, Schmitt M, Wick W.
A vaccine targeting mutant IDH1 in newly diagnosed glioma.
Nature. 2021 Mar 24. doi: 10.1038/s41586-021-03363-z. Epub ahead of print. PMID: 33762734. Phase 1 trial.



High-grade gliomas



Papusha L, Zaytseva M, Druy A, Valiakhmetova A, Yasko L, Salnikova E, Shekhtman A, Karachunsky A, Maschan A, Hwang EI, Novichkova G, Packer RJ.
The experience of successful treatment of ETV6-NTRK3-positive infant glioblastoma with entrectinib.
Neurooncol Adv. 2021 Feb 3;3(1):vdab022. doi: 10.1093/noajnl/vdab022. PMID: 33738452. Case report.




Tabouret E, Fabbro M, Autran D, Hoang-Xuan K, Taillandier L, Ducray F, Barrie M, Sanson M, Kerr C, Cartalat-Carel S, Loundou A, Guillevin R, Mokhtari K, Figarella-Branger D, Delattre JY, Chinot O.
TEMOBIC: Phase II Trial of Neoadjuvant Chemotherapy for Unresectable Anaplastic Gliomas: An ANOCEF Study.
Oncologist. 2021 Mar 30. doi: 10.1002/onco.13765. Epub ahead of print. PMID: 33783067. Phase 2 trial.



Low-grade gliomas



Liu H, Shen L, Huang X, Zhang G.
Maximal tumor diameter in the preoperative tumor magnetic resonance imaging (MRI) T2 image is associated with prognosis of Grade II Glioma.
Medicine (Baltimore). 2021 Mar 12;100(10):e24850. doi: 10.1097/MD.0000000000024850. PMID: 33725839. Retrospective analysis.



Diffuse astrocytic and oligodendroglial tumors


Tesileanu CMS, Vallentgoed WR, Sanson M, Taal W, Clement PM, Wick W, Brandes AA, Baurain JF, Chinot OL, Wheeler H, Gill S, Griffin M, Rogers L, Rudà R, Weller M, McBain C, Reijneveld J, Enting RH, Caparrotti F, Lesimple T, Clenton S, Gijtenbeek A, Lim E, de Vos F, Mulholland PJ, Taphoorn MJB, de Heer I, Hoogstrate Y, de Wit M, Boggiani L, Venneker S, Oosting J, Bovée JVMG, Erridge S, Vogelbaum MA, Nowak AK, Mason WP, Kros JM, Wesseling P, Aldape K, Jenkins RB, Dubbink HJ, Baumert B, Golfinopoulos V, Gorlia T, van den Bent M, French PJ.
Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations.
Acta Neuropathol. 2021 Mar 19. doi: 10.1007/s00401-021-02291-6. Epub ahead of print. PMID: 33740099. Retrospective analysis.



Glioblastoma


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Bakas S, Shukla G, Akbari H, Erus G, Sotiras A, Rathore S, Sako C, Min Ha S, Rozycki M, Singh A, Shinohara R, Bilello M, Davatzikos C.
Integrative radiomic analysis for pre-surgical prognostic stratification of glioblastoma patients: from advanced to basic MRI protocols.
Proc SPIE Int Soc Opt Eng. 2020 Feb;11315:113151S. doi: 10.1117/12.2566505. Epub 2020 Mar 16. PMID: 33746333. Retrospective analysis.




Carrano A, Zarco N, Phillipps J, Lara-Velazquez M, Suarez-Meade P, Norton ES, Chaichana KL, Quiñones-Hinojosa A, Asmann YW, Guerrero-Cázares H.
Human Cerebrospinal Fluid Modulates Pathways Promoting Glioblastoma Malignancy.
Front Oncol. 2021 Mar 4;11:624145. doi: 10.3389/fonc.2021.624145. PMID: 33747938. Laboratory investigation.



*

Fyllingen EH, Bø LE, Reinertsen I, Jakola AS, Sagberg LM, Berntsen EM, Salvesen Ø, Solheim O.
Survival of glioblastoma in relation to tumor location: a statistical tumor atlas of a population-based cohort.
Acta Neurochir (Wien). 2021 Mar 20. doi: 10.1007/s00701-021-04802-6. Epub ahead of print. PMID: 33742279. Population-based cohort study.




Gumrukcu S, Nguyen TX, White RL, Howell GT, Musikanth P.
Allogeneic Natural Killer and Cytomegalovirus (CMV)-pp65 Pulsed Dendritic Cells Induced Complete Response Through 15 Months in a Patient with Recurrent Glioblastoma: A Case Study.
Am J Case Rep. 2021 Mar 31;22:e931030. doi: 10.12659/AJCR.931030. Epub 2021 Mar 24. PMID: 33788825. Case report.




Lasorella A, Iavarone A.
The making of the glioblastoma classification.
Br J Cancer. 2021 Mar 25. doi: 10.1038/s41416-021-01360-7. Epub ahead of print. PMID: 33767415. Laboratory investigation;



*

Le NQK, Hung TNK, Do DT, Lam LHT, Dang LH, Huynh TT.
Radiomics-based machine learning model for efficiently classifying transcriptome subtypes in glioblastoma patients from MRI.
Comput Biol Med. 2021 Mar 9;132:104320. doi: 10.1016/j.compbiomed.2021.104320. Epub ahead of print. PMID: 33735760. Retrospective analysis;




Pinto G, Saenz-de-Santa-Maria I, Chastagner P, Perthame E, Delmas C, Toulas C, Moyal-Jonathan-Cohen E, Brou C, Zurzolo C.
Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids.
Biochem J. 2021 Jan 8;478(1):21-39. doi: 10.1042/BCJ20200710. PMID: 33245115. Laboratory investigation.


Azorín DD, Winkler F.
Two routes of direct intercellular communication in brain cancer.
Biochem J. 2021 Mar 23;478(6):1283-1286. doi: 10.1042/BCJ20200990. PMID: 33755120. Comment.



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Qin X, Liu R, Akter F, Qin L, Xie Q, Li Y, Qiao H, Zhao W, Jian Z, Liu R, Wu S.
Peri-tumoral brain edema associated with glioblastoma correlates with tumor recurrence.
J Cancer. 2021 Feb 5;12(7):2073-2082. doi: 10.7150/jca.53198. PMID: 33754006. Retrospective analysis.




Shibahara I, Miyasaka K, Sekiguchi A, Ishiyama H, Inukai M, Yasui Y, Watanabe T, Sato S, Hide T, Kumabe T.
Long-term follow-up after BCNU wafer implantation in patients with newly diagnosed glioblastoma.
J Clin Neurosci. 2021 Apr;86:202-210. doi: 10.1016/j.jocn.2021.01.037. Epub 2021 Feb 10. PMID: 33775329. Retrospective analysis;




Shin I, Kim H, Ahn SS, Sohn B, Bae S, Park JE, Kim HS, Lee SK.
Development and Validation of a Deep Learning-Based Model to Distinguish Glioblastoma from Solitary Brain Metastasis Using Conventional MR Images.
AJNR Am J Neuroradiol. 2021 Mar 18. doi: 10.3174/ajnr.A7003. Epub ahead of print. PMID: 33737268. Clinical tool.




Soliman S, Ghaly M.
Ischemic Stroke After Tumor Resection in a Patient With Glioblastoma Multiforme.
Cureus. 2021 Feb 8;13(2):e13232. doi: 10.7759/cureus.13232. PMID: 33728181. Case report.




Subramanian S, Scheufele K, Mehl M, Biros G.
Where did the tumor start? An inverse solver with sparse localization for tumor growth models.
Inverse Probl. 2020 Apr;36(4):045006. doi: 10.1088/1361-6420/ab649c. Epub 2020 Feb 26. PMID: 33746330. Clinical tool. ⍈




Tepe M, Saylisoy S, Toprak U, Inan I.
The Potential Role of Peritumoral Apparent Diffusion Coefficient Evaluation in Differentiating Glioblastoma and Solitary Metastatic Lesions of the Brain.
Curr Med Imaging. 2021 Mar 16. doi: 10.2174/1573405617666210316120314. Epub ahead of print. PMID: 33726654. Clinical tool;




Wang Y, Liang D, Chen J, Chen H, Fan R, Gao Y, Gao Y, Tao R, Zhang H.
Targeted Therapy with Anlotinib for a Patient with an Oncogenic FGFR3-TACC3 Fusion and Recurrent Glioblastoma.
Oncologist. 2021 Mar;26(3):173-177. doi: 10.1002/onco.13530. Epub 2020 Sep 19. PMID: 32949176. Case report.



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Xi J, Hassan B, Katumba RGN, Khaddour K, Govindan A, Luo J, Huang J, Campian JL.
The predictive value of absolute lymphocyte counts on tumor progression and pseudoprogression in patients with glioblastoma.
BMC Cancer. 2021 Mar 16;21(1):285. doi: 10.1186/s12885-021-08004-2(?). PMID: 33726710. Retrospective analysis.




Xu Y, He X, Li Y, Pang P, Shu Z, Gong X.
The Nomogram of MRI-based Radiomics with Complementary Visual Features by Machine Learning Improves Stratification of Glioblastoma Patients: A Multicenter Study.
J Magn Reson Imaging. 2021 Feb 8. doi: 10.1002/jmri.27536. Epub ahead of print. PMID: 33559302. Nomogram;




Yu L, Zhang G, Qi S.
Aggressive Treatment in Glioblastoma: What Determines the Survival of Patients?
J Neurol Surg A Cent Eur Neurosurg. 2021 Mar;82(2):112-117. doi: 10.1055/s-0040-1713172. Epub 2020 Nov 6. PMID: 33157564. Retrospective analysis;



Diffuse midline glioma



Handis C, Tanrıkulu B, Danyeli AE, Özek MM.
Spinal intramedullary H3K27M mutant glioma with vertebral metastasis: a case report.
Childs Nerv Syst. 2021 Mar 19. doi: 10.1007/s00381-021-05119-6. Epub ahead of print. PMID: 33742289. Case report;



Other astrocytic tumors



Pilocytic astrocytoma



Francis JV, Tanrıkulu B, Danyeli AE, Özek MM.
Is it a new culprit? "TERT promoter mutation" in an aggressive pediatric pilocytic astrocytoma.
Childs Nerv Syst. 2021 Mar;37(3):1003-1008. doi: 10.1007/s00381-020-04803-3. Epub 2020 Aug 19. PMID: 32813054. Case report.



Subependymal giant cell astrocytoma



Tomoto K, Fujimoto A, Inenaga C, Okanishi T, Imai S, Ogai M, Fukunaga A, Nakamura H, Sato K, Obana A, Masui T, Arai Y, Enoki H.
Experience using mTOR inhibitors for subependymal giant cell astrocytoma in tuberous sclerosis complex at a single facility.
BMC Neurol. 2021 Mar 31;21(1):139. doi: 10.1186/s12883-021-02160-5. PMID: 33784976. Retrospective analysis.



Ependymal tumors



Ependymoma



Dong J, Li L, Liang S, Zhao S, Zhang B, Meng Y, Zhang Y, Li S.
Differentiation Between Ependymoma and Medulloblastoma in Children with Radiomics Approach.
Acad Radiol. 2021 Mar;28(3):318-327. doi: 10.1016/j.acra.2020.02.012. Epub 2020 Mar 26. PMID: 32222329. Retrospective analysis.



Neuronal and mixed neuronal-glial tumors



Paraganglioma



Goyal-Honavar A, Chacko G, Chacko AG.
Supratentorial primary paraganglioma with good long-term outcome following radical excision.
Br J Neurosurg. 2021 Mar 23:1-4. doi: 10.1080/02688697.2021.1902476. Epub ahead of print. PMID: 33754919. Case report.



Embryonal tumors



Medulloblastoma



Liu KX, Ioakeim-Ioannidou M, Susko MS, Rao AD, Yeap BY, Snijders AM, Ladra MM, Vogel J, Zaslowe-Dude C, Marcus KJ, Yock TI, Grassberger C, Braunstein SE, Haas-Kogan DA, Terezakis SA, MacDonald SM.
A Multi-institutional Comparative Analysis of Proton and Photon Therapy-Induced Hematologic Toxicity in Patients With Medulloblastoma.
Int J Radiat Oncol Biol Phys. 2021 Mar 1;109(3):726-735. doi: 10.1016/j.ijrobp.2020.09.049. Epub 2020 Nov 23. PMID: 33243479. Retrospective analysis;




Skowron P, Farooq H, Cavalli FMG, Morrissy AS, Ly M, Hendrikse LD, Wang EY, Djambazian H, Zhu H, Mungall KL, Trinh QM, Zheng T, Dai S, Stucklin ASG, Vladoiu MC, Fong V, Holgado BL, Nor C, Wu X, Abd-Rabbo D, Bérubé P, Wang YC, Luu B, Suarez RA, Rastan A, Gillmor AH, Lee JJY, Zhang XY, Daniels C, Dirks P, Malkin D, Bouffet E, Tabori U, Loukides J, Doz FP, Bourdeaut F, Delattre OO, Masliah-Planchon J, Ayrault O, Kim SK, Meyronet D, Grajkowska WA, Carlotti CG, de Torres C, Mora J, Eberhart CG, Van Meir EG, Kumabe T, French PJ, Kros JM, Jabado N, Lach B, Pollack IF, Hamilton RL, Rao AAN, Giannini C, Olson JM, Bognár L, Klekner A, Zitterbart K, Phillips JJ, Thompson RC, Cooper MK, Rubin JB, Liau LM, Garami M, Hauser P, Li KKW, Ng HK, Poon WS, Yancey Gillespie G, Chan JA, Jung S, McLendon RE, Thompson EM, Zagzag D, Vibhakar R, Ra YS, Garre ML, Schüller U, Shofuda T, Faria CC, López-Aguilar E, Zadeh G, Hui CC, Ramaswamy V, Bailey SD, Jones SJ, Mungall AJ, Moore RA, Calarco JA, Stein LD, Bader GD, Reimand J, Ragoussis J, Weiss WA, Marra MA, Suzuki H, Taylor MD.
The transcriptional landscape of Shh medulloblastoma.
Nat Commun. 2021 Mar 19;12(1):1749. doi: 10.1038/s41467-021-21883-0. PMID: 33741928. Laboratory investigation.



Atypical theratoid/rhabdoid tumor



Thomas C, Federico A, Sill M, Bens S, Oyen F, Nemes K, Johann PD, Hartmann C, Hartmann W, Sumerauer D, Paterno V, Samii A, Kordes U, Siebert R, Frühwald MC, Paulus W, Kool M, Hasselblatt M.
Atypical Teratoid/Rhabdoid Tumor (AT/RT) With Molecular Features of Pleomorphic Xanthoastrocytoma.
Am J Surg Pathol. 2021 Feb 24. doi: 10.1097/PAS.0000000000001694. Epub ahead of print. PMID: 33739782. Case report;



Meningiomas


Bender L, Somme F, Lhermitte B, Ahle G, Boone M, Blonski M, Pouget C, Truc G, Cebula H, Noël G.
High risk of recurrence for grade II meningioma: a 10-year multicenter analysis of prognosis factors.
Chin Clin Oncol. 2021 Mar 10:cco-20-226. doi: 10.21037/cco-20-226. Epub ahead of print. PMID: 33752411. Retrospective analysis.




Ceccato GHW, Kalkmann GF, Veríssimo DCA, Borba LAB.
Microsurgical Resection of Petroclival Meningioma via the Posterior Petrosal Approach: Three-Dimensional Operative Video.
World Neurosurg. 2021 Mar;147:37. doi: 10.1016/j.wneu.2020.12.035. Epub 2020 Dec 16. PMID: 33338671. Operative video. Case report.




Zahid A, Johnson DR, Kizilbash SH.
Efficacy of 177Lu-Dotatate Therapy in the Treatment of Recurrent Meningioma.
Mayo Clin Proc Innov Qual Outcomes. 2021 Jan 13;5(1):236-240. doi: 10.1016/j.mayocpiqo.2020.09.015. PMID: 33718799. Case report.



Lymphomas


Gupta M, Burns E, Georgantas NZ, Thierauf J, Nayyar N, Gordon A, Jones S, Pisapia M, Sun Y, Burns RP, Velarde JK, Jordan JT, Frigault MJ, Nahed BV, Jones PS, Barker FG, Curry W, Gupta R, Batchelor TT, Romero J, Brastianos P, Marble H, Martinez-Lage M, Tateishi K, Lennerz JK, Dietrich J, Cahill D, Carter B, Shankar GM.
A Rapid Genotyping Panel for Detection of Primary Central Nervous System Lymphoma.
Blood. 2021 Mar 18:blood.2020010137. doi: 10.1182/blood.2020010137. Epub ahead of print. PMID: 33735913. Clinical tool;



Metastatic tumors


Niesel K, Schulz M, Anthes J, Alekseeva T, Macas J, Salamero-Boix A, Möckl A, Oberwahrenbrock T, Lolies M, Stein S, Plate KH, Reiss Y, Rödel F, Sevenich L.
The immune suppressive microenvironment affects efficacy of radio-immunotherapy in brain metastasis.
EMBO Mol Med. 2021 Mar 23:e13412. doi: 10.15252/emmm.202013412. Epub ahead of print. PMID: 33755340. Laboratory investigation.





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