Current
Neuro-Oncology


Volume 23 Number 7
April 2021


Home > Publications > Current Neuro-Oncology > Volume 23, Year 2021 > Number 7, April



Contents


Central nervous system tumors


Gliomas


High-grade gliomas


Low-grade gliomas


Diffuse astrocytic and oligodendroglial tumors


Glioblastoma


Diffuse Midline Glioma


Embryonal tumors


Medulloblastoma


Meningiomas


Germ cell tumors


Germinoma


Familial tumor syndromes



Central nervous system tumors


Jazmati D, Steinmeier T, Ahamd Khalil D, Frisch S, Peters S, Schulze Schleithoff S, Bäumer C, Rutkowski S, Frühwald MC, Blase C, Tippelt S, Timmermann B.
Feasibility of Proton Beam Therapy for Infants with Brain Tumours: Experiences from the Prospective KiProReg Registry Study.
Clin Oncol (R Coll Radiol). 2021 Apr 3:S0936-6555(21)00097-2. doi: 10.1016/j.clon.2021.03.006. Epub ahead of print. PMID: 33820696. Retrospective analysis;




Zheng J, Chen W, Huang D, Wang Y, Zheng D, Zhou L, Brelén ME, Huang Z.
Ocular symptoms as the initial clinical manifestations in patients with extraocular tumors.
Ann Transl Med. 2021 Mar;9(6):497. doi: 10.21037/atm-21-830. PMID: 33850894. Retrospective analysis.



Gliomas


Baldovin M, Saratziotis A, Munari S, Emanuelli E.
Diagnosis and treatment of congenital nasal glioma.
BMJ Case Rep. 2021 Apr 13;14(4):e242138. doi: 10.1136/bcr-2021-242138. PMID: 33849883. Case report.




Pellerin A, Khalifé M, Sanson M, Rozenblum-Beddok L, Bertaux M, Soret M, Galanaud D, Dormont D, Kas A, Pyatigorskaya N.
Simultaneously acquired PET and ASL imaging biomarkers may be helpful in differentiating progression from pseudo-progression in treated gliomas.
Eur Radiol. 2021 Mar 31. doi: 10.1007/s00330-021-07732-0. Epub ahead of print. PMID: 33787971. Prospective study;




Wu W, Li J, Ye J, Wang Q, Zhang W, Xu S.
Differentiation of Glioma Mimicking Encephalitis and Encephalitis Using Multiparametric MR-Based Deep Learning.
Front Oncol. 2021 Mar 15;11:639062. doi: 10.3389/fonc.2021.639062. PMID: 33791225. Retrospective analysis.




Zhao M, Fu X, Zhang Z, Li A, Wang X, Li X.
Intracranial 131I-chTNT Brachytherapy in Patients with Deep-Seated Glioma: A Single-center Experience with 10-Year Follow-up from China.
Nuklearmedizin. 2021 Apr 9. English. doi: 10.1055/a-1429-1967. Epub ahead of print. PMID: 33836553. Retrospective analysys;



High-grade gliomas



Friedman GK, Johnston JM, Bag AK, Bernstock JD, Li R, Aban I, Kachurak K, Nan L, Kang KD, Totsch S, Schlappi C, Martin AM, Pastakia D, McNall-Knapp R, Farouk Sait S, Khakoo Y, Karajannis MA, Woodling K, Palmer JD, Osorio DS, Leonard J, Abdelbaki MS, Madan-Swain A, Atkinson TP, Whitley RJ, Fiveash JB, Markert JM, Gillespie GY.
Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas.
N Engl J Med. 2021 Apr 10. doi: 10.1056/NEJMoa2024947. Epub ahead of print. PMID: 33838625. Phase 1 trial;



Low-grade gliomas



Casale R, Lavrova E, Sanduleanu S, Woodruff HC, Lambin P.
Development and external validation of a non-invasive molecular status predictor of chromosome 1p/19q co-deletion based on MRI radiomics analysis of Low Grade Glioma patients.
Eur J Radiol. 2021 Apr 5;139:109678. doi: 10.1016/j.ejrad.2021.109678. Epub ahead of print. PMID: 33848780. Retrospective analysis.




Liu S, Liu Y, Li G, Feng J, Chen L, Qiu X.
High-dose radiation associated with improved survival in IDH-wildtype low-grade glioma.
Chin Neurosurg J. 2021 Apr 1;7(1):22. doi: 10.1186/s41016-021-00239-z. PMID: 33795023. Retrospective analysis.




Yu Y, Villanueva-Meyer J, Grimmer MR, Hilz S, Solomon DA, Choi S, Wahl M, Mazor T, Hong C, Shai A, Phillips JJ, Wainer BH, McDermott M, Haas-Kogan D, Taylor JW, Butowski N, Clarke JL, Berger MS, Molinaro AM, Chang SM, Costello JF, Oberheim Bush NA.
Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade IDH-mutant gliomas.
Neuro Oncol. 2021 Apr 5:noab081. doi: 10.1093/neuonc/noab081. Epub ahead of print. PMID: 33823014. Prospective study;



Diffuse astrocytic and oligodendroglial tumors


Wu J, Yuan Y, Long Priel DA, Fink D, Peer CJ, Sissung TM, Su YT, Pang Y, Yu G, Butler MK, Mendoza TR, Vera E, Ahmad S, Bryla C, Lindsley M, Grajkowska E, Mentges K, Boris L, Antony R, Garren N, Siegel C, Lollo N, Cordova C, Aboud O, Theeler BJ, Burton EM, Penas-Prado M, Leeper H, Gonzales J, Armstrong TS, Calvo KR, Figg WD, Kuhns DB, Gallin JI, Gilbert MR.
Phase I Study of Zotiraciclib in Combination with Temozolomide for Patients with Recurrent High-grade Astrocytomas.
Clin Cancer Res. 2021 Mar 30:clincanres.4730.2020. doi: 10.1158/1078-0432.CCR-20-4730. Epub ahead of print. PMID: 33785481. Phase 1 trial.



Glioblastoma



Bernchou U, Skak Tranemose Arnold T, Axelsen B, Klüver-Kristensen M, Mahmood F, Severin Gråe Harbo F, Thor Asmussen J, Hansen O, Smedegaard Bertelsen A, Hansen S, Brink C, Hedegaard Dahlrot R.
Evolution of the gross tumour volume extent during radiotherapy for glioblastomas.
Radiother Oncol. 2021 Apr 9:S0167-8140(21)06182-X. doi: 10.1016/j.radonc.2021.04.001. Epub ahead of print. PMID: 33848564. Prospective study;



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Dissaux G, Dissaux B, Bourhis D, Schick U, Querellou S.
18F-FET PET/CT in Early Subventricular Zone Recurrence of Adult Glioblastoma.
Clin Nucl Med. 2021 Apr 1. doi: 10.1097/RLU.0000000000003639. Epub ahead of print. PMID: 33795588. Case report;




Gumrukcu S, Nguyen TX, White RL, Howell GT, Musikanth P.
Allogeneic Natural Killer and Cytomegalovirus (CMV)-pp65 Pulsed Dendritic Cells Induced Complete Response Through 15 Months in a Patient with Recurrent Glioblastoma: A Case Study.
Am J Case Rep. 2021 Mar 31;22:e931030. doi: 10.12659/AJCR.931030. PMID: 33788825. Case report.




Rahman A, Lozada-Martinez ID, Rahman S, Ataullah AHM, Muñoz-Baez K, Moscote-Salazar LR, Agrawal A, Rahman MM.
Letter: A Phase II and Pharmacodynamic Trial of RO4929097 for Patients With Recurrent/Progressive Glioblastoma.
Neurosurgery. 2021 Apr 2:nyab097. doi: 10.1093/neuros/nyab097. Epub ahead of print. PMID: 33822209. Comment.


Peereboom DM, et al., A Phase II and Pharmacodynamic Trial of RO4929097 for Patients With Recurrent/Progressive Glioblastoma.
Neurosurgery. 2021 Feb;88(2):246-251
. doi: 10.1093/neuros/nyaa412. Epub 2020 Oct 7. PMID: 33027815. Phase 2 trial.




Singla AK, Madan R, Gupta K, Goyal S, Kumar N, Sahoo SK, Uppal DK, Ahuja CK.
Clinical behaviour and outcome in pediatric glioblastoma: current scenario.
Radiat Oncol J. 2021 Mar;39(1):72-77. doi: 10.3857/roj.2020.00591. Epub 2021 Mar 30. PMID: 33794576. Case series.



Diffuse midline glioma



Liu Z, Feng S, Li J, Cao H, Huang J, Fan F, Cheng L, Liu Z, Cheng Q.
The Survival Benefits of Surgical Resection and Adjuvant Therapy for Patients With Brainstem Glioma.
Front Oncol. 2021 Mar 25;11:566972. doi: 10.3389/fonc.2021.566972. PMID: 33842307. Retrospective analysis.




Ung C, Tsoli M, Liu J, Cassano D, Pocoví-Martínez S, Upton DH, Ehteda A, Mansfeld FM, Failes TW, Farfalla A, Katsinas C, Kavallaris M, Arndt GM, Vittorio O, Cirillo G, Voliani V, Ziegler DS.
Doxorubicin-Loaded Gold Nanoarchitectures as a Therapeutic Strategy against Diffuse Intrinsic Pontine Glioma.
Cancers (Basel). 2021 Mar 13;13(6):1278. doi: 10.3390/cancers13061278. PMID: 33805713. Laboratory investigation.




Wang Y, Xu J, Luo N, Qi C, Tao R.
Successful treatment of an adult patient with diffuse midline glioma employing olaparib combined with bevacizumab.
Invest New Drugs. 2021 Apr 13. doi: 10.1007/s10637-021-01116-3. Epub ahead of print. PMID: 33851364. Case report;




Zhou C, Zhao H, Yang F, Huangfu L, Dong C, Wang S, Zhang J.
Clinical and Genetic Features of Brainstem Glioma in Adults: A Report of 50 Cases in a Single Center.
J Clin Neurol. 2021 Apr;17(2):220-228. doi: 10.3988/jcn.2021.17.2.220. Epub 2021 Jan 18. PMID: 33835742. Retrospective analysis.



Embryonal tumors



Medulloblastoma



Frappaz D, Barritault M, Montané L, Laigle-Donadey F, Chinot O, Le Rhun E, Bonneville-Levard A, Hottinger AF, Meyronnet D, Bidaux AS, Garin G, Pérol D.
MEVITEM - A Phase I/II of vismodegib + temozolomide vs temozolomide in patients with recurrent/refractory medulloblastoma with Sonic Hedgehog pathway activation.
Neuro Oncol. 2021 Apr 7:noab087. doi: 10.1093/neuonc/noab087. Epub ahead of print. PMID: 33825892. Phase 1/2 trial;




Levy AS, Krailo M, Chi S, Villaluna D, Springer L, Williams-Hughes C, Fouladi M, Gajjar A.
Temozolomide with irinotecan versus temozolomide, irinotecan plus bevacizumab for recurrent medulloblastoma of childhood: Report of a COG randomized Phase II screening trial.
Pediatr Blood Cancer. 2021 Apr 12:e29031. doi: 10.1002/pbc.29031. Epub ahead of print. PMID: 33844469. Phase 2 trial;



Meningiomas


Hong S, Sato K, Kagawa K, Ichi S.
The long-term outcome of CyberKnife-based stereotactic radiotherapy for central skull base meningiomas: a single-center experience.
Neurosurg Rev. 2021 Apr 10. doi: 10.1007/s10143-021-01535-z. Epub ahead of print. PMID: 33839946. Retrospective analysis;



Germ cell tumors



Germinoma



Nosrati J, Olch AJ, Abel RJ, Wong K.
Neoadjuvant Chemotherapy and Whole Ventricular Irradiation for Pure Intracranial Germinoma: A Comparison of Three Brain-Sparing Techniques.
Cureus. 2021 Mar 3;13(3):e13670. doi: 10.7759/cureus.13670. PMID: 33824821. Retrospective analysis.



Familial tumor syndromes


Cai JW, Chen XY, Chen JY, Wu ZY, Wu XY, Yu LH, You HH.
Glioblastoma in a female neurofibromatosis 1 patient without IDH1, BRAF V600E, and TERT promoter mutations: A case report.
Medicine (Baltimore). 2021 Apr 2;100(13):e25346. doi: 10.1097/MD.0000000000025346. PMID: 33787635. Case report.




Kertels O, Breun M, Hänscheid H, Kircher M, Hartrampf PE, Schirbel A, Monoranu CM, Ernestus RI, Buck AK, Löhr M, Matthies C, Lapa C.
Peptide Receptor Radionuclide Therapy in Patients With Neurofibromatosis Type 2: Initial Experience.
Clin Nucl Med. 2021 Apr 5. doi: 10.1097/RLU.0000000000003627. Epub ahead of print. PMID: 33826573. Retrospective analysis;




Sinai Khandeparkar SG, Gosavi SS, Gogate BP, Talathi N.
A rare case of cerebellar pilomyxoid astrocytoma associated with neurofibromatosis-1 in a young female; case report highlighting immunohistochemical features.
Indian J Pathol Microbiol. 2021 Apr-Jun;64(2):354-357. doi: 10.4103/IJPM.IJPM_209_20(?). Epub 2021 Apr 9. PMID: 33851634. Case report.





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