Volume 22 Number 8
August 2020

Home > Publications > Neuro-Oncology Reviews > Volume 22, Year 2020 > Number 8, August


Central nervous system tumors


High-grade gliomas

Low-grade gliomas

Diffuse astrocytic and oligodendroglial tumors


Diffuse Midline Glioma

Ependymal tumors

Myxopapillary ependymoma

Embryonal tumors


Atypical theratoid/rhabdoid tumor


Germ cell tumors

Central nervous system tumors

Buday J, Albrecht J, Mareš T, Podgorná G, Horáčková K, Kališová L, Raboch J, Anders M.
Brain Tumors and Electroconvulsive Therapy: A Literature Overview of the Last 80 Years.
Front Neurol. 2020 Jul 31. 2020;11:723. doi: 10.3389/fneur.2020.00723. Review. _

Campanella R, Guarnaccia L, Caroli M, Zarino B, Carrabba G, La Verde N, Gaudino C, Rampini A, Luzzi S, Riboni L, Locatelli M, Navone SE, Marfia G.
Personalized and translational approach for malignant brain tumors in the era of precision medicine: the strategic contribution of an experienced neurosurgery laboratory in a modern neurosurgery and neuro-oncology department.
J Neurol Sci. 2020 Aug 6. 2020;417:117083. doi: 10.1016/j.jns.2020.117083. Review. _

Chi AS et al, PDQ Adult Treatment Editorial Board.
Adult Central Nervous System Tumors Treatment (PDQ®): Health Professional Version.
PDQ Cancer Inf Summ. 2020 Aug 14. NCBI Bookshelf NBK65982. Review. _

Dixit KS, Kumthekar PU.
Optimal Management of Corticosteroids in Patients with Intracranial Malignancies.
Curr Treat Options Oncol. 2020 Jul 30. 2020;21(9):77. doi: 10.1007/s11864-020-00771-7. Review. _

Gatto L, Franceschi E, Di Nunno V, Tomasello C, Bartolini C, Brandes AA.
Glioneuronal tumors: clinicopathological findings and treatment options.
Future Neurol. 2020 Jul 3. 2020;15(3). doi: 10.2217/fnl-2020-0003. Review. _

Gordon D, Maria BL.
Molecular Advances and Targeted Therapies for Pediatric Central Nervous System Tumors.
J Child Neurol. 2020 Aug 18. 2020;0883073820946892. doi: 10.1177/0883073820946892. Meetings. _

Harrup R, White VM, Coory M, Walker R, Anazodo A, Skaczkowski G, Bibby H, Osborn M, Phillips MB, Conyers R, Thompson K, Orme LM, Pinkerton R, Nicholls W.
Treatment and Outcomes for Central Nervous System Tumors in Australian Adolescents and Young Adults: A Population-Based National Study.
J Adolesc Young Adult Oncol. 2020 Aug 26. doi: 10.1089/jayao.2020.0074. Retrospective study. _

Holste KG, Orringer DA.
Laser interstitial thermal therapy.
Neurooncol Adv. 2019 Dec 16. 2020;2(1):vdz035. doi: 10.1093/noajnl/vdz035. Review. _

Li X, Li Y, Li S, Li H, Yang C, Lin J.
The role of Shh signalling pathway in central nervous system development and related diseases.
Cell Biochem Funct. 2020 Aug 25. doi: 10.1002/cbf.3582. Review. _

Liu S, Cadoux-Hudson T, Schofield CJ.
Isocitrate dehydrogenase variants in cancer - Cellular consequences and therapeutic opportunities.
Curr Opin Chem Biol. 2020 Aug 8. 2020;57:122-134. doi: 10.1016/j.cbpa.2020.06.012. Review. _

Lu VM, Shah AH, Eichberg DG, Luther EM, Shah SS, Komotar RJ, Ivan ME.
Utilizing systematic reviews and meta-analyses effectively to evaluate brain tumor biomarkers.
Biomark Med. 2020 Aug 17. doi: 10.2217/bmm-2020-0209. Editorial. _

Martinez NL, Khanna O, Farrell CJ.
A narrative review of targeted therapy in meningioma, pituitary adenoma, and craniopharyngioma of the skull base.
Chin Clin Oncol. 2020 Aug 17. 2020;cco-20-168. doi: 10.21037/cco-20-168. Review. _

Perla A, Fratini L, Cardoso PS, Nör C, Brunetto AT, Brunetto AL, de Farias CB, Jaeger M, Roesler R.
Histone Deacetylase Inhibitors in Pediatric Brain Cancers: Biological Activities and Therapeutic Potential.
Front Cell Dev Biol. 2020 Jul 10. 2020;8:546. doi: 10.3389/fcell.2020.00546. Review. _

Rodriguez-Almaraz JE, Chang S, Clarke J, Oberheim-Bush NA, Taylor J, Buerki R, Berger M, Zablotska L, Lobach I, Butowski N.
A systematic review and meta-analysis examining the effects of cannabis and its derivatives in adults with malignant CNS tumors.
Neurooncol Pract. 2020 Apr 3. 2020;7(4):376-383. doi: 10.1093/nop/npaa013. Review/Meta-analysis. _

Schreck KC, Patel MP, Wemmer J, Grossman SA, Peters KB.
RAF and MEK inhibitor therapy in adult patients with brain tumors: a case-based overview and practical management of adverse events.
Neurooncol Pract. 2020 Feb 27. 2020;7(4):369-375. doi: 10.1093/nop/npaa006. Review. _

Subramanian S, Ahmad T.
Childhood Brain Tumors.
StatPearls 2020 Aug 10. NCBI Bookshelf NBK535415. Review. _


Al-Kharboosh R, ReFaey K, Lara-Velazquez M, Grewal SS, Imitola J, Quiñones-Hinojosa A.
Inflammatory Mediators in Glioma Microenvironment Play a Dual Role in Gliomagenesis and Mesenchymal Stem Cell Homing: Implication for Cellular Therapy.
Mayo Clin Proc Innov Qual Outcomes. 2020 Aug 5. 2020;4(4):443-459. doi: 10.1016/j.mayocpiqo.2020.04.006. Review. _

Luo Y, Hou WT, Zeng L, Li ZP, Ge W, Yi C, Kang JP, Li WM, Wang F, Wu DB, Wang RY, Qu BL, Li XF, Wang JJ.
Progress in the study of markers related to glioma prognosis.
Eur Rev Med Pharmacol Sci. 2020 Jul;24(14):7690-7697. doi: 10.26355/eurrev_202007_22271. Review. _

Lei H, To C, Lei U.
Association between fish intake and glioma risk: a systematic review and meta-analysis.
J Int Med Res. 2020 Aug 25. 2020;48(8):300060520939695. doi: 10.1177/0300060520939695. Review/Meta-analysis. _

Liu Y, Lang F, Chou FJ, Zaghloul KA, Yang C.
Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications.
Biomedicines. 2020 Aug 20. 2020;8(9):E294. doi: 10.3390/biomedicines8090294. Review. _

Mesfin FB, Al-Dhahir MA.
StatPearls. 2020 Aug 10. NCBI Bookshelf NBK441874. Review. _

Sharma A, Graber JJ.
Overview of prognostic factors in adult gliomas.
Ann Palliat Med. 2020 Aug 6. 2020;apm-20-640. doi: 10.21037/apm-20-640. Review. _

Valtorta S, Salvatore D, Rainone P, Belloli S, Bertoli G, Moresco RM.
Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance.
Int J Mol Sci. 2020 Aug 6. 2020;21(16):E5631. doi: 10.3390/ijms21165631. Review. _

Wang Y, Chen R, Zhou X, Guo R, Yin J, Li Y, Ma G.
miR-137: A Novel Therapeutic Target for Human Glioma.

Mol Ther Nucleic Acids. 2020 Jun 30. 2020;21:614-622. doi: 10.1016/j.omtn.2020.06.028. Review. _

Xue BZ, Xiang W, Zhang Q, Wang YH, Wang HF, Yi DY, Xiong NX, Jiang XB, Zhao HY, Fu P.
Roles of long non-coding RNAs in the hallmarks of glioma.
Oncol Lett. 2020 Aug 4. 2020;20(4):83. doi: 10.3892/ol.2020.11944?. Review. _

High-grade gliomas

Elleaume H, Barth RF, Rousseau J, Bobyk L, Balosso J, Yang W, Huo T, Nakkula R.
Radiation therapy combined with intracerebral convection-enhanced delivery of cisplatin or carboplatin for treatment of the F98 rat glioma.
J Neurooncol. 2020 Aug 18. doi: 10.1007/s11060-020-03600-x. Review. _

Ghaemmaghami AB, Mahjoubin-Tehran M, Movahedpour A, Morshedi K, Sheida A, Taghavi SP, Mirzaei H, Hamblin MR.
Role of exosomes in malignant glioma: microRNAs and proteins in pathogenesis and diagnosis.
Cell Commun Signal. 2020 Aug 3. 2020;18(1):120. doi: 10.1186/s12964-020-00623-9. Review. _

Shin DH, Melnick KF, Tran DD, Ghiaseddin AP.
In situ vaccination with laser interstitial thermal therapy augments immunotherapy in malignant gliomas.
J Neurooncol. 2020 Aug 5. doi: 10.1007/s11060-020-03557-x. Review. _

Low-grade gliomas

Albuquerque LAF, Almeida JP, de Macêdo Filho LJM, Joaquim AF, Duffau H.
Extent of resection in diffuse low-grade gliomas and the role of tumor molecular signature-a systematic review of the literature.
Neurosurg Rev. 2020 Aug 7. doi: 10.1007/s10143-020-01362-8. Review. _

Diffuse astrocytic and oligodendroglial tumors

Cohen KJ et al, PDQ Pediatric Treatment Editorial Board.
Childhood Astrocytomas Treatment (PDQ®): Health Professional Version.
PDQ Cancer Inf Summ. 2020 Aug 13. NCBI Bookshelf NBK65944. Review. _

Lasocki A, Anjari M, Ӧrs Kokurcan S, Thust SC.
Conventional MRI features of adult diffuse glioma molecular subtypes: a systematic Review..
Neuroradiology. 2020 Aug 25. doi: 10.1007/s00234-020-02532-7. Review. _

Raza IJ, Tingate CA, Gkolia P, Romero L, Tee JW, Hunn MK.
Blood Biomarkers of Glioma in Response Assessment Including Pseudoprogression and Other Treatment Effects: A Systematic Review.
Front Oncol. 2020 Aug 14. doi: 10.3389/fonc.2020.01191. Review. _


Balasa A, Serban G, Chinezu R, Hurghis C, Tamas F, Manu D.
The Involvement of Exosomes in Glioblastoma Development, Diagnosis, Prognosis, and Treatment.
Brain Sci. 2020 Aug 13. 2020;10(8):E553. doi: 10.3390/brainsci10080553. Review. _

DeCordova S, Shastri A, Tsolaki AG, Yasmin H, Klein L, Singh SK, Kishore U.
Molecular Heterogeneity and Immunosuppressive Microenvironment in Glioblastoma.
Front Immunol. 2020 Jul 17, 2020;11:1402. doi: 10.3389/fimmu.2020.01402. Review. _

de Melo SM, Marta GN, Yan M, Cruz C, Moraes FY, Riera R.
Management of elderly patients with glioblastoma: current status with a focus on the post-operative radiation therapy.
Ann Palliat Med. 2020 Aug 11. 2020;apm-20-768. doi: 10.21037/apm-20-768. Review. _

Di Nunno V, Franceschi E, Tosoni A, Di Battista M, Gatto L, Lamperini C, Minichillo S, Mura A, Bartolini S, Brandes AA.
Treatment of recurrent glioblastoma: state-of-the-art and future perspectives.
Expert Rev Anticancer Ther. 2020 Aug 17. 2020;1-11. doi: 10.1080/14737140.2020.1807949. Review. _

Gallego L, Ceña V.
Potential advancements in the treatment of difficult-to-treat glioblastoma through nanoparticle drug delivery.
Expert Opin Drug Deliv. 2020 Aug 13. doi: 10.1080/17425247.2020.1810015. Review. _

Gedeon PC, Champion CD, Rhodin KE, Woroniecka K, Kemeny HR, Bramall AN, Bernstock JD, Choi BD, Sampson JH.
Checkpoint inhibitor immunotherapy for glioblastoma: current progress, challenges and future outlook.
Expert Rev Clin Pharmacol. 2020 Aug 29. doi: 10.1080/17512433.2020.1817737. Review. _

Ghiaseddin AP, Shin D, Melnick K, Tran DD.
Tumor Treating Fields in the Management of Patients with Malignant Gliomas.
Curr Treat Options Oncol. 2020 Jul 30. 2020;21(9):76. doi: 10.1007/s11864-020-00773-5. Review. _

Gupta T, Chatterjee A, Patil V.
Extended adjuvant temozolomide in newly-diagnosed glioblastoma: is more less?
Neuro Oncol. 2020 Aug 10. 2020;noaa194. doi: 10.1093/neuonc/noaa194. Letter to the editor. _

Hotchkiss KM, Sampson JH.
Temozolomide treatment outcomes and immunotherapy efficacy in brain tumor.
J Neurooncol. 2020 Aug 19. doi: 10.1007/s11060-020-03598-2. Review. _

Kim DS.
Cancer stem cell plasticity in glioblastoma multiforme: a perspective on future directions in oncolytic virotherapy.
Future Oncol. 2020 Aug 2. doi: 10.2217/fon-2019-0606. Perspective. _

Li ZG, Zheng MY, Zhao Q, Liu K, Du JX, Zhang SW.
Solitary vertebral metastatic glioblastoma in the absence of primary brain tumor relapse: a case report and literature review.
BMC Med Imaging. 2020 Aug 7. 2020;20(1):89. doi: 10.1186/s12880-020-00488-x. Case report/Review. _

Linhares P, Carvalho B, Vaz R, Costa BM.
Glioblastoma: Is There Any Blood Biomarker with True Clinical Relevance?
Int J Mol Sci. 2020 Aug 13. 2020;21(16):E5809. doi: 10.3390/ijms21165809. Review. _

Sabbagh Q, Andre-Gregoire G, Guevel L, Gavard J.
Vesiclemia: counting on extracellular vesicles for glioblastoma patients.
Oncogene. 2020 Aug 14. doi: 10.1038/s41388-020-01420-x. Review. _

Shaaban A, Rajeswaran A, Elbadry RG, Haddad R, Al-Bozom I, Ayyad A, Belkhair S.
Spinal metastasis of cerebral Glioblastoma (GBM) with genetic profile: case report and review of literature.
World Neurosurg. 2020 Jul 31. 2020;S1878-8750(20)31685-5. doi: 10.1016/j.wneu.2020.07.163. Case report/Review. _

Souberan A, Tchoghandjian A.
Practical Review on Preclinical Human 3D Glioblastoma Models: Advances and Challenges for Clinical Translation.
Cancers (Basel). 2020 Aug 19. 2020;12(9):E2347. doi: 10.3390/cancers12092347. Review. _

Taiarol L, Formicola B, Magro RD, Sesana S, Re F.
An update of nanoparticle-based approaches for glioblastoma multiforme immunotherapy.
Nanomedicine (Lond). 2020 Jul 31. 2020;15(19):1861-1871. doi: 10.2217/nnm-2020-0132. Review. _

Tsakiris C, Siempis T, Alexiou GA, Zikou A, Sioka C, Voulgaris S, Argyropoulou MI.
Differentiation between True Tumor Progression of Glioblastoma and Pseudoprogression using Diffusion-weighted imaging and Perfusion-weighted imaging: A Systematic Review and Meta-analysis.
World Neurosurg. 2020 Aug 7. 2020;S1878-8750(20)31750-2. doi: 10.1016/j.wneu.2020.07.218. Review/Meta-analysis. _

Yang M, Oh IY, Mahanty A, Jin WL, Yoo JS.
Immunotherapy for Glioblastoma: Current State, Challenges, and Future Perspectives.
Cancers (Basel). 2020 Aug 19. 2020;12(9):E2334. doi: 10.3390/cancers12092334. Review. _

Young JS.
Achieving Efficacious Immunotherapy for Patients with Glioblastoma.
Expert Rev Anticancer Ther. 2020 Aug 27. doi: 10.1080/14737140.2020.1814747. Editorial. _

Wlodarczyk A, Grot D, Stoczynska-Fidelus E, Rieske P.
Gaps and Doubts in Search to Recognize Glioblastoma Cellular Origin and Tumor Initiating Cells.
J Oncol. 2020 Jul 22. 2020;2020:6783627. doi: 10.1155/2020/6783627. Review. _

Zhang X, Deibert CP, Kim WJ, Jaman E, Rao AV, Lotze MT, Amankulor NM.
Autophagy inhibition is the next step in the treatment of glioblastoma patients following the Stupp era.
Cancer Gene Ther. 2020 Aug 5. doi: 10.1038/s41417-020-0205-8. Review. _

Diffuse midline glioma

Erdman CM, Christie C, Iqbal MO, Mazzola CA, Tomycz L.
The utilization of sodium fluorescein in pediatric brain stem gliomas: a case report and review of the literature.
Childs Nerv Syst. 2020 Aug 11. doi: 10.1007/s00381-020-04857-3. Case report/Review. _

Hashii Y, Oka Y, Kagawa N, Hashimoto N, Saitou H, Fukuya S, Kanegae M, Ikejima S, Oji Y, Ozono K, Tsuboi A, Sugiyama H.
Encouraging Clinical Evolution of a Pediatric Patient With Relapsed Diffuse Midline Glioma Who Underwent WT1-Targeting Immunotherapy: A Case Report and Literature Review.
Front Oncol. 2020 Jul 24. 2020;10:1188. doi: 10.3389/fonc.2020.01188. Case report/Review. _

Pellot JE, De Jesus O.
Diffuse Intrinsic Pontine Glioma.
StatPearls. 2020 Aug 10. NCBI Bookshelf NBK560640. Review. _

Ritchey AK et al, PDQ Pediatric Treatment Editorial Board.
Childhood Brain Stem Glioma Treatment (PDQ®): Patient Version.
PDQ Cancer Inf Summ. 2020 Aug 13. NCBI Bookshelf NBK65856. Review. _

Cooney TM, Lubanszky E, Prasad R, Hawkins C, Mueller S.
Diffuse midline glioma: review of epigenetics.
J Neurooncol. 2020 Aug 17. doi: 10.1007/s11060-020-03553-1. Review. _

Ependymal tumors

Myxopapillary ependymoma

Gitto L, Serinelli S, Galbraith K, Williams M, Mirchia K, Galgano MA, Krishnamurthy S, de la Roza G, Viapiano MS, Walker JM, Jour G, Serrano J, DeLorenzo M, Snuderl M, Richardson TE.
Anaplastic Transformation in Myxopapillary Ependymoma: A Report of 2 Cases and Review of the Literature.
J Neuropathol Exp Neurol. 2020 Aug 2. 2020;nlaa077. doi: 10.1093/jnen/nlaa077. Case report/Review. _

Embryonal tumors


Carrie C, Kieffer V, Figarella-Branger D, Masliah-Planchon J, Bolle S, Bernier V, Laprie A, Supiot S, Leseur J, Habrand JL, Alapetite C, Kerr C, Dufour C, Claude L, Chapet S, Huchet A, Bondiau PY, Escande A, Truc G, Nguyen TD, Pasteuris C, Vigneron C, Muracciole X, Bourdeaut F, Appay R, Dubray B, Colin C, Ferlay C, Dussart S, Chabaud S, Padovani L; French Group of Pediatric Radiotherapy (GFRP) and the French Society of Pediatric Cancers (SFCE).
Exclusive Hyper-fractionated Radiotherapy and reduced boost volume for standard-risk medulloblastoma: pooled analysis of the two French multicentric studies MSFOP98 and MSFOP 2007 and correlation with molecular subgroups.
Int J Radiat Oncol Biol Phys. 2020 Aug 5. 2020:S0360-3016(20)33743-3. doi: 10.1016/j.ijrobp.2020.07.2324. Review. _

Gendreau JL, Gupta S, Giles TX, Stone CE, Abraham ME, Lindley JG.
A Retrospective Analysis of the Demographics, Treatment, and Survival Outcomes of Patients with Desmoplastic Nodular Medulloblastoma Using the Surveillance, Epidemiology, and End Results (SEER) Database.
Cureus. 2020 Jul 7. 2020;12(7):e9042. doi: 10.7759/cureus.9042. Retrospective study. _

Haltom AR, Toll SA, Cheng D, Maegawa S, Gopalakrishnan V, Khatua S.
Medulloblastoma epigenetics and the path to clinical innovation.
J Neurooncol. 2020 Aug 20. doi: 10.1007/s11060-020-03591-9. Review. _

Klein O.
Medulloblastoma - Introduction.
Neurochirurgie. 2020 Aug 28. 2020;S0028-3770(20)30390-8. doi: 10.1016/j.neuchi.2020.07.002; Review. _

Atypical theratoid/rhabdoid tumor

Greeneway GP, Page PS, Patel V, Ahmed AS.
Atypical teratoid/rhabdoid tumor of the cerebellum in an adult: case report and literature review.
World Neurosurg. 2020 Aug 15. 2020:S1878-8750(20)31846-5. doi: 10.1016/j.wneu.2020.08.079. Case report/Review. _


de Souza MR, Fagundes CF, Rabelo NN, Teixeira MJ, Figueiredo EG.
Association between intracranial aneurysm and meningiomas: An integrative survival Analysis with identification of prognostic factors.
Clin Neurol Neurosurg. 2020 Aug 8. 2020;198:106128. doi: 10.1016/j.clineuro.2020.106128. Review. _

Germ cell tumors

Cohen KJ et al, PDQ Pediatric Treatment Editorial Board.
Childhood Central Nervous System Germ Cell Tumors Treatment (PDQ®): Health Professional Version.
PDQ Cancer Inf Summ. 2020 Aug 7. NCBI Bookshelf NBK82800. Review. _