Volume 23 Number 5
March 2021

Home > Publications > Neuro-Oncology Reviews > Volume 23, Year 2021 > Number 5, March


Central nervous system tumors


Diffuse astrocytic and oligodendroglial tumors



Embryonal tumors




Central nervous system tumors

Alemany M, Velasco R, Simó M, Bruna J.
Late effects of cancer treatment: consequences for long-term brain cancer survivors.
Neurooncol Pract. 2020 Jul 16;8(1):18-30. doi: 10.1093/nop/npaa039. PMID: 33664966. Review.

Forghani R.
Precision Digital Oncology: Emerging Role of Radiomics-based Biomarkers and Artificial Intelligence for Advanced Imaging and Characterization of Brain Tumors.
Radiol Imaging Cancer. 2020 Jul 31;2(4):e190047. doi: 10.1148/rycan.2020190047. PMID: 33778721. Review.

Gassama Y, Favereaux A.
Emerging Roles of Extracellular Vesicles in the Central Nervous System: Physiology, Pathology, and Therapeutic Perspectives.
Front Cell Neurosci. 2021 Feb 23;15:626043. doi: 10.3389/fncel.2021.626043. PMID: 33708073. Review.

Ghandour F, Squassina A, Karaky R, Diab-Assaf M, Fadda P, Pisanu C.
Presenting Psychiatric and Neurological Symptoms and Signs of Brain Tumors before Diagnosis: A Systematic Review.
Brain Sci. 2021 Feb 27;11(3):301. doi: 10.3390/brainsci11030301. PMID: 33673559. Review.

Kunigelis KE, Vogelbaum MA.
Therapeutic Delivery to Central Nervous System.
Neurosurg Clin N Am. 2021 Apr;32(2):291-303. doi: 10.1016/ Epub 2021 Feb 18. PMID: 33781509. Review;

Lee J, Uy BR, Liau LM.
Brain Tumor Vaccines.
Neurosurg Clin N Am. 2021 Apr;32(2):225-234. doi: 10.1016/ Epub 2021 Mar 26. PMID: 33781504. Review;

Malouff TD, Seneviratne DS, Ebner DK, Stross WC, Waddle MR, Trifiletti DM, Krishnan S.
Boron Neutron Capture Therapy: A Review of Clinical Applications.
Front Oncol. 2021 Feb 26;11:601820. doi: 10.3389/fonc.2021.601820. PMID: 33718149. Review.

Maziero D, Straza MW, Ford JC, Bovi JA, Diwanji T, Stoyanova R, Paulson ES, Mellon EA.
MR-Guided Radiotherapy for Brain and Spine Tumors.
Front Oncol. 2021 Mar 8;11:626100. doi: 10.3389/fonc.2021.626100. PMID: 33763361. Review.

Mirza FA, Mitha R, Shamim MS.
Current Role of Laser Interstitial Thermal Therapy in the Treatment of Intracranial Tumors.
Asian J Neurosurg. 2020 Dec 21;15(4):800-808. doi: 10.4103%2Fajns.AJNS_185_20. PMID: 33708647. Review.

Molina-Botello D, Rodríguez-Sanchez JR, Cuevas-García J, Cárdenas-Almaraz BV, Morales-Acevedo A, Mejía-Pérez SI, Ochoa-Martinez E.
Pregnancy and brain tumors; a systematic review of the literature.
J Clin Neurosci. 2021 Apr;86:211-216. doi: 10.1016/j.jocn.2021.01.048. Epub 2021 Feb 11. PMID: 33775330. Review;

Rubin DB, Vaitkevicius H.
Neurological complications of cancer immunotherapy (CAR T cells).
J Neurol Sci. 2021 Mar 17:117405. doi: 10.1016/j.jns.2021.117405. Epub ahead of print. PMID: 33773767. Review;

Wu WT, Lin WY, Chen YW, Lin CF, Wang HH, Wu SH, Lee YY.
New Era of Immunotherapy in Pediatric Brain Tumors: Chimeric Antigen Receptor T-Cell Therapy.
Int J Mol Sci. 2021 Feb 27;22(5):2404. doi: 10.3390/ijms22052404. PMID: 33673696. Review.


Carpenter AB, Carpenter AM, Aiken R, Hanft S.
Oncolytic virus in gliomas: a review of human clinical investigations.
Ann Oncol. 2021 Mar 23:S0923-7534(21)01076-0. doi: 10.1016/j.annonc.2021.03.197. Epub ahead of print. PMID: 33771666. Review;

Funakoshi Y, Hata N, Kuga D, Hatae R, Sangatsuda Y, Fujioka Y, Takigawa K, Mizoguchi M.
Pediatric Glioma: An Update of Diagnosis, Biology, and Treatment.
Cancers (Basel). 2021 Feb 12;13(4):758. doi: 10.3390/cancers13040758. PMID: 33673070. Review.

Muftuoglu Y, Pajonk F.
Targeting Glioma Stem Cells.
Neurosurg Clin N Am. 2021 Apr;32(2):283-289. doi: 10.1016/ Epub 2021 Feb 18. PMID: 33781508. Review;

Peeters SM, Muftuoglu Y, Na B, Daniels DJ, Wang AC.
Pediatric Gliomas: Molecular Landscape and Emerging Targets.
Neurosurg Clin N Am. 2021 Apr;32(2):181-190. doi: 10.1016/ Epub 2021 Feb 18. PMID: 33781501. Review;

Piper K, DePledge L, Karsy M, Cobbs C.
Glioma Stem Cells as Immunotherapeutic Targets: Advancements and Challenges.
Front Oncol. 2021 Feb 24;11:615704. doi: 10.3389/fonc.2021.615704. PMID: 33718170. Review.

Sprugnoli G, Golby AJ, Santarnecchi E.
Newly discovered neuron-to-glioma communication: new noninvasive therapeutic opportunities on the horizon?
Neurooncol Adv. 2021 Feb 4;3(1):vdab018. doi: 10.1093/noajnl/vdab018. PMID: 33738449. Review.

Zhang H, Yuan F, Qi Y, Liu B, Chen Q.
Circulating Tumor Cells for Glioma.
Front Oncol. 2021 Mar 10;11:607150. doi: 10.3389/fonc.2021.607150. PMID: 33777749. Review.

Diffuse astrocytic and oligodendroglial tumors


Akintola OO, Reardon DA.
The Current Landscape of Immune Checkpoint Blockade in Glioblastoma.
Neurosurg Clin N Am. 2021 Apr;32(2):235-248. doi: 10.1016/ Epub 2021 Mar 26. PMID: 33781505. Review;

Bello-Alvarez C, Camacho-Arroyo I.
Impact of sex in the prevalence and progression of glioblastomas: the role of gonadal steroid hormones.
Biol Sex Differ. 2021 Mar 22;12(1):28. doi: 10.1186/s13293-021-00372-5. PMID: 33752729. Review.

Benmelouka AY, Munir M, Sayed A, Attia MS, Ali MM, Negida A, Alghamdi BS, Kamal MA, Barreto GE, Ashraf GM, Meshref M, Bahbah EI.
Neural Stem Cell-Based Therapies and Glioblastoma Management: Current Evidence and Clinical Challenges.
Int J Mol Sci. 2021 Feb 24;22(5):2258. doi: 10.3390/ijms22052258. PMID: 33668356. Review.

Chen Y, Jin Y, Wu N.
Role of Tumor-Derived Extracellular Vesicles in Glioblastoma.
Cells. 2021 Feb 28;10(3):512. doi: 10.3390/cells10030512. PMID: 33670924. Review.

El-Khayat SM, Arafat WO.
Therapeutic strategies of recurrent glioblastoma and its molecular pathways 'Lock up the beast'.
Ecancermedicalscience. 2021 Jan 22;15:1176. doi: 10.3332/ecancer.2021.1176. PMID: 33680090. Review.

Estevez-Ordonez D, Chagoya G, Salehani A, Atchley TJ, Laskay NMB, Parr MS, Elsayed GA, Mahavadi AK, Rahm SP, Friedman GK, Markert JM.
Immunovirotherapy for the Treatment of Glioblastoma and Other Malignant Gliomas.
Neurosurg Clin N Am. 2021 Apr;32(2):265-281. doi: 10.1016/ Epub 2021 Feb 18. PMID: 33781507. Review;

Goenka A, Tiek D, Song X, Huang T, Hu B, Cheng SY.
The Many Facets of Therapy Resistance and Tumor Recurrence in Glioblastoma.
Cells. 2021 Feb 24;10(3):484. doi: 10.3390/cells10030484. PMID: 33668200. Review.

Huang B, Li X, Li Y, Zhang J, Zong Z, Zhang H.
Current Immunotherapies for Glioblastoma Multiforme.
Front Immunol. 2021 Mar 9;11:603911. doi: 10.3389/fimmu.2020.603911. PMID: 33767690. Review.

Kast RE.
Adding high dose celecoxib to increase effectiveness of standard glioblastoma chemoirradiation.
Ann Pharm Fr. 2021 Mar 6:S0003-4509(21)00042-0. doi: 10.1016/j.pharma.2021.03.001. Epub ahead of print. PMID: 33689795. Review;

Kotecha R, Tom MC, Mehta MP.
Novel Radiation Approaches.
Neurosurg Clin N Am. 2021 Apr;32(2):211-223. doi: 10.1016/ Epub 2021 Mar 26. PMID: 33781503. Review;

Lopes Abath Neto O, Aldape K.
Morphologic and Molecular Aspects of Glioblastomas.
Neurosurg Clin N Am. 2021 Apr;32(2):149-158. doi: 10.1016/ Epub 2021 Mar 26. PMID: 33781498. Review;

Lozano-Ureña A, Jiménez-Villalba E, Pinedo-Serrano A, Jordán-Pla A, Kirstein M, Ferrón SR.
Aberrations of Genomic Imprinting in Glioblastoma Formation.
Front Oncol. 2021 Mar 12;11:630482. doi: 10.3389/fonc.2021.630482. PMID: 33777782. Review

McAleenan A, Kelly C, Spiga F, Kernohan A, Cheng HY, Dawson S, Schmidt L, Robinson T, Brandner S, Faulkner CL, Wragg C, Jefferies S, Howell A, Vale L, Higgins JPT, Kurian KM.
Prognostic value of test(s) for O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation for predicting overall survival in people with glioblastoma treated with temozolomide.
Cochrane Database Syst Rev. 2021 Mar 12;3:CD013316. doi: 10.1002/14651858.CD013316.pub2. PMID: 33710615. Review;

Nguyen HM, Saha D.
The Current State of Oncolytic Herpes Simplex Virus for Glioblastoma Treatment.
Oncolytic Virother. 2021 Feb 24;10:1-27. doi: 10.2147/OV.S268426. PMID: 33659221. Review.

Shirvalilou S, Khoei S, Esfahani AJ, Kamali M, Shirvaliloo M, Sheervalilou R, Mirzaghavami P.
Magnetic Hyperthermia as an adjuvant cancer therapy in combination with radiotherapy versus radiotherapy alone for recurrent/progressive glioblastoma: a systematic review.
J Neurooncol. 2021 Mar 13. doi: 10.1007/s11060-021-03729-3. Epub ahead of print. PMID: 33713248. Review;

Smith-Cohn MA, Celiku O, Gilbert MR.
Molecularly Targeted Clinical Trials.
Neurosurg Clin N Am. 2021 Apr;32(2):191-210. doi: 10.1016/ Epub 2021 Feb 18. PMID: 33781502. Review;

Tudor T, Binder ZA, O'Rourke DM.
CAR T Cells.
Neurosurg Clin N Am. 2021 Apr;32(2):249-263. doi: 10.1016/ Epub 2021 Feb 18. PMID: 33781506. Review;

Wang X, Lu J, Guo G, Yu J.
Immunotherapy for recurrent glioblastoma: practical insights and challenging prospects.
Cell Death Dis. 2021 Mar 19;12(4):299. doi: 10.1038/s41419-021-03568-0. PMID: 33741903. Review.

Yang R, Isaacs AM, Cadieux M, Hirmer TJ, CreveCoeur TS, Lapointe AP, Opoku-Darko M, Premji Z, Riva-Cambrin J, Gallagher CN.
Primary and metastatic glioblastoma of the spine in the pediatric population: a systematic review.
Childs Nerv Syst. 2021 Mar 6. doi: 10.1007/s00381-021-05098-8. Epub ahead of print. PMID: 33675391. Review;


Fogh SE, Boreta L, Nakamura JL, Johnson DR, Chi AS, Kurz SC.
Neuro-Oncology Practice Clinical Debate: Early treatment or observation for patients with newly diagnosed oligodendroglioma and small-volume residual disease.
Neurooncol Pract. 2020 Jun 27;8(1):11-17. doi: 10.1093/nop/npaa037. PMID: 33664965. Review.

Embryonal tumors


Danilenko M, Clifford SC, Schwalbe EC.
Inter and intra-tumoral heterogeneity as a platform for personalized therapies in medulloblastoma.
Pharmacol Ther. 2021 Mar 1:107828. doi: 10.1016/j.pharmthera.2021.107828. Epub ahead of print. PMID: 33662447. Review;

Werbowetski-Ogilvie TE.
From sorting to sequencing in the molecular era: the evolution of the cancer stem cell model in medulloblastoma.
FEBS J. 2021 Mar 13. doi: 10.1111/febs.15817. Epub ahead of print. PMID: 33714236. Review.


Dumitru AE, Panaitescu A, Iancu G, Paslaru FG, Paslaru AC, Gorgan RM, Peltecu G.
Management strategies and clinical follow-up of pregnant women with intracranial meningioma.
J Med Life. 2021 Jan-Mar;14(1):2-6. doi: 10.25122/jml-2021-0012(?). PMID: 33767778. Review.

Jumah F, AbuRmilah A, Raju B, Jaber S, Adeeb N, Narayan V, Sun H, Cuellar H, Gupta G, Nanda A.
Does preoperative embolization improve outcomes of meningioma resection? A systematic review and meta-analysis.
Neurosurg Rev. 2021 Mar 16. doi: 10.1007/s10143-021-01519-z. Epub ahead of print. PMID: 33723970. Review & Meta-analysis;


Raval V, Binkley E, Aronow ME, Valenzuela J, Peereboom DM, Singh AD.
Primary Central Nervous System Lymphoma - Ocular Variant (PCNSL-O): An Interdisciplinary Review on Management.
Surv Ophthalmol. 2021 Mar 21:S0039-6257(21)00077-1. doi: 10.1016/j.survophthal.2021.03.004. Epub ahead of print. PMID: 33762182. Review;