The most-cited Articles on
Medulloblastoma

Brown NJ et al., The 100 Most Influential Publications on Medulloblastoma: Areas of Past, Current, and Future Focus. World Neurosurg, 2020


Home > Publications > The most-cited articles > Medulloblastoma > Brown NJ, 2020





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Brown NJ, Wilson B, Shahrestani S, Choi EH, Lien BV, Paladugu A, Tran K, Ransom SC, Tafreshi AR, Ransom RC, Sahyouni R, Chan AY, Yang I.
The 100 Most Influential Publications on Medulloblastoma: Areas of Past, Current, and Future Focus.
World Neurosurg. 2021 Feb;146:119-139→. doi: 10.1016/j.wneu.2020.11.038→. Epub 2020 Nov 16. PMID: 33212273→. Bibliometric analysis. ˍ



Case reports


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Gorlin RJ, Vickers RA, Kellen E, Williamson JJ.
Multiple Basal-Cell Nevi Syndrome. An Analysis Of A Syndrome Consisting Of Multiple Nevoid Basal-Cell Carcinoma, Jaw Cysts, Skeletal Anomalies, Medulloblastoma, And Hyporesponsiveness To Parathormone.
Cancer. 1965 Jan;18:89-104→. doi: 10.1002/1097-0142(196501)18:1<89::aid-cncr2820180114>3.0.co;2-9→. PMID: 14260852→. Case series. ˍ



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St Clair WH, Adams JA, Bues M, Fullerton BC, La Shell S, Kooy HM, Loeffler JS, Tarbell NJ.
Advantage of protons compared to conventional X-ray or IMRT in the treatment of a pediatric patient with medulloblastoma.
Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):727-34→. doi: 10.1016/S0360-3016(03)01574-8→. PMID: 14967427→. Case report. ˍ



Classification


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Cavalli FMG, Remke M, Rampasek L, Peacock J, Shih DJH, Luu B, Garzia L, Torchia J, Nor C, Morrissy AS, Agnihotri S, Thompson YY, Kuzan-Fischer CM, Farooq H, Isaev K, Daniels C, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska WA, Perek-Polnik M, Vasiljevic A, Faure-Conter C, Jouvet A, Giannini C, Nageswara Rao AA, Li KKW, Ng HK, Eberhart CG, Pollack IF, Hamilton RL, Gillespie GY, Olson JM, Leary S, Weiss WA, Lach B, Chambless LB, Thompson RC, Cooper MK, Vibhakar R, Hauser P, van Veelen MC, Kros JM, French PJ, Ra YS, Kumabe T, López-Aguilar E, Zitterbart K, Sterba J, Finocchiaro G, Massimino M, Van Meir EG, Osuka S, Shofuda T, Klekner A, Zollo M, Leonard JR, Rubin JB, Jabado N, Albrecht S, Mora J, Van Meter TE, Jung S, Moore AS, Hallahan AR, Chan JA, Tirapelli DPC, Carlotti CG, Fouladi M, Pimentel J, Faria CC, Saad AG, Massimi L, Liau LM, Wheeler H, Nakamura H, Elbabaa SK, Perezpeña-Diazconti M, Chico Ponce de León F, Robinson S, Zapotocky M, Lassaletta A, Huang A, Hawkins CE, Tabori U, Bouffet E, Bartels U, Dirks PB, Rutka JT, Bader GD, Reimand J, Goldenberg A, Ramaswamy V, Taylor MD.
Intertumoral Heterogeneity within Medulloblastoma Subgroups.
Cancer Cell. 2017 Jun 12;31(6):737-754.e6→. doi: 10.1016/j.ccell.2017.05.005→. PMID: 28609654→. Laboratory investigation. ˍ



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Cho YJ, Tsherniak A, Tamayo P, Santagata S, Ligon A, Greulich H, Berhoukim R, Amani V, Goumnerova L, Eberhart CG, Lau CC, Olson JM, Gilbertson RJ, Gajjar A, Delattre O, Kool M, Ligon K, Meyerson M, Mesirov JP, Pomeroy SL.
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.
J Clin Oncol. 2010 Nov 22. 2011;29(11):1424-30→. doi: 10.1200/JCO.2010.28.5148→. PMID: 21098324→. Laboratory investigation. ˍ



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Kool M, Koster J, Bunt J, Hasselt NE, Lakeman A, van Sluis P, Troost D, Meeteren NS, Caron HN, Cloos J, Mrsić A, Ylstra B, Grajkowska W, Hartmann W, Pietsch T, Ellison D, Clifford SC, Versteeg R.
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features.
PLoS One. 2008 Aug 28;3(8):e3088→. doi: 10.1371/journal.pone.0003088→. PMID: 18769486→. Laboratory investigation. ˍ



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Northcott PA, Buchhalter I, Morrissy AS, Hovestadt V, Weischenfeldt J, Ehrenberger T, Gröbner S, Segura-Wang M, Zichner T, Rudneva VA, Warnatz HJ, Sidiropoulos N, Phillips AH, Schumacher S, Kleinheinz K, Waszak SM, Erkek S, Jones DTW, Worst BC, Kool M, Zapatka M, Jäger N, Chavez L, Hutter B, Bieg M, Paramasivam N, Heinold M, Gu Z, Ishaque N, Jäger-Schmidt C, Imbusch CD, Jugold A, Hübschmann D, Risch T, Amstislavskiy V, Gonzalez FGR, Weber UD, Wolf S, Robinson GW, Zhou X, Wu G, Finkelstein D, Liu Y, Cavalli FMG, Luu B, Ramaswamy V, Wu X, Koster J, Ryzhova M, Cho YJ, Pomeroy SL, Herold-Mende C, Schuhmann M, Ebinger M, Liau LM, Mora J, McLendon RE, Jabado N, Kumabe T, Chuah E, Ma Y, Moore RA, Mungall AJ, Mungall KL, Thiessen N, Tse K, Wong T, Jones SJM, Witt O, Milde T, Von Deimling A, Capper D, Korshunov A, Yaspo ML, Kriwacki R, Gajjar A, Zhang J, Beroukhim R, Fraenkel E, Korbel JO, Brors B, Schlesner M, Eils R, Marra MA, Pfister SM, Taylor MD, Lichter P.
The whole-genome landscape of medulloblastoma subtypes.
Nature. 2017 Jul 20;547(7663):311-317→. doi: 10.1038/nature22973→. PMID: 28726821→. Laboratory investigation. ˍ



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Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T, Stütz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V, Luu B, Rolider A, Cavalli FM, Wang X, Remke M, Wu X, Chiu RY, Chu A, Chuah E, Corbett RD, Hoad GR, Jackman SD, Li Y, Lo A, Mungall KL, Nip KM, Qian JQ, Raymond AG, Thiessen NT, Varhol RJ, Birol I, Moore RA, Mungall AJ, Holt R, Kawauchi D, Roussel MF, Kool M, Jones DT, Witt H, Fernandez-L A, Kenney AM, Wechsler-Reya RJ, Dirks P, Aviv T, Grajkowska WA, Perek-Polnik M, Haberler CC, Delattre O, Reynaud SS, Doz FF, Pernet-Fattet SS, Cho BK, Kim SK, Wang KC, Scheurlen W, Eberhart CG, Fèvre-Montange M, Jouvet A, Pollack IF, Fan X, Muraszko KM, Gillespie GY, Di Rocco C, Massimi L, Michiels EM, Kloosterhof NK, French PJ, Kros JM, Olson JM, Ellenbogen RG, Zitterbart K, Kren L, Thompson RC, Cooper MK, Lach B, McLendon RE, Bigner DD, Fontebasso A, Albrecht S, Jabado N, Lindsey JC, Bailey S, Gupta N, Weiss WA, Bognár L, Klekner A, Van Meter TE, Kumabe T, Tominaga T, Elbabaa SK, Leonard JR, Rubin JB, Liau LM, Van Meir EG, Fouladi M, Nakamura H, Cinalli G, Garami M, Hauser P, Saad AG, Iolascon A, Jung S, Carlotti CG, Vibhakar R, Ra YS, Robinson S, Zollo M, Faria CC, Chan JA, Levy ML, Sorensen PH, Meyerson M, Pomeroy SL, Cho YJ, Bader GD, Tabori U, Hawkins CE, Bouffet E, Scherer SW, Rutka JT, Malkin D, Clifford SC, Jones SJ, Korbel JO, Pfister SM, Marra MA, Taylor MD.
Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
Nature. 2012 Jul 25;488(7409):49-56→. doi: 10.1038/nature11327→. PMID: 22832581→. Laboratory investigation. ˍ



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Northcott PA, Korshunov A, Witt H, Hielscher T, Eberhart CG, Mack S, Bouffet E, Clifford SC, Hawkins CE, French P, Rutka JT, Pfister S, Taylor MD.
Medulloblastoma comprises four distinct molecular variants.
J Clin Oncol. 2010 Sep 7. 2011;29(11):1408-14→. doi: 10.1200/JCO.2009.27.4324→. PMID: 20823417→. Laboratory investigation. ˍ



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Pugh TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D, Bochicchio J, Carneiro MO, Carter SL, Cibulskis K, Erlich RL, Greulich H, Lawrence MS, Lennon NJ, McKenna A, Meldrim J, Ramos AH, Ross MG, Russ C, Shefler E, Sivachenko A, Sogoloff B, Stojanov P, Tamayo P, Mesirov JP, Amani V, Teider N, Sengupta S, Francois JP, Northcott PA, Taylor MD, Yu F, Crabtree GR, Kautzman AG, Gabriel SB, Getz G, Jäger N, Jones DT, Lichter P, Pfister SM, Roberts TM, Meyerson M, Pomeroy SL, Cho YJ.
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
Nature. 2012 Jul 22;488(7409):106-10→. doi: 10.1038/nature11329→. PMID: 22820256→. Laboratory investigation. ˍ



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Robinson G, Parker M, Kranenburg TA, Lu C, Chen X, Ding L, Phoenix TN, Hedlund E, Wei L, Zhu X, Chalhoub N, Baker SJ, Huether R, Kriwacki R, Curley N, Thiruvenkatam R, Wang J, Wu G, Rusch M, Hong X, Becksfort J, Gupta P, Ma J, Easton J, Vadodaria B, Onar-Thomas A, Lin T, Li S, Pounds S, Paugh S, Zhao D, Kawauchi D, Roussel MF, Finkelstein D, Ellison DW, Lau CC, Bouffet E, Hassall T, Gururangan S, Cohn R, Fulton RS, Fulton LL, Dooling DJ, Ochoa K, Gajjar A, Mardis ER, Wilson RK, Downing JR, Zhang J, Gilbertson RJ.
Novel mutations target distinct subgroups of medulloblastoma.
Nature. 2012 Jun 20;488(7409):43-8→. doi: 10.1038/nature11213→. PMID: 22722829→. Laboratory investigation. ˍ



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Thompson MC, Fuller C, Hogg TL, Dalton J, Finkelstein D, Lau CC, Chintagumpala M, Adesina A, Ashley DM, Kellie SJ, Taylor MD, Curran T, Gajjar A, Gilbertson RJ.
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations.
J Clin Oncol. 2006 Mar 27;24(12):1924-31→. doi: 10.1200/JCO.2005.04.4974→. PMID: 16567768→. Laboratory investigation. ˍ



Diagnosis, Presentation


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Ellison DW, Dalton J, Kocak M, Nicholson SL, Fraga C, Neale G, Kenney AM, Brat DJ, Perry A, Yong WH, Taylor RE, Bailey S, Clifford SC, Gilbertson RJ.
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups.
Acta Neuropathol. 2011 Jan 26;121(3):381-96→. doi: 10.1007/s00401-011-0800-8→. PMID: 21267586→. Laboratory investigation. ˍ



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Northcott PA, Shih DJ, Remke M, Cho YJ, Kool M, Hawkins C, Eberhart CG, Dubuc A, Guettouche T, Cardentey Y, Bouffet E, Pomeroy SL, Marra M, Malkin D, Rutka JT, Korshunov A, Pfister S, Taylor MD.
Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples.
Acta Neuropathol. 2011 Nov 6. 2012;123(4):615-26→. doi: 10.1007/s00401-011-0899-7→. PMID: 22057785→. Laboratory investigation. ˍ



Epidemiology, Risk factors


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Evans DG, Farndon PA, Burnell LD, Gattamaneni HR, Birch JM.
The incidence of Gorlin syndrome in 173 consecutive cases of medulloblastoma.
Br J Cancer. 1991 Nov 1;64(5):959-61→. doi: 10.1038/bjc.1991.435→. PMID: 1931625→. Retrospective analysis. ˍ



Etiology, Pathogenesis, Pathology


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Bandopadhayay P, Bergthold G, Nguyen B, Schubert S, Gholamin S, Tang Y, Bolin S, Schumacher SE, Zeid R, Masoud S, Yu F, Vue N, Gibson WJ, Paolella BR, Mitra SS, Cheshier SH, Qi J, Liu KW, Wechsler-Reya R, Weiss WA, Swartling FJ, Kieran MW, Bradner JE, Beroukhim R, Cho YJ.
BET bromodomain inhibition of MYC-amplified medulloblastoma.
Clin Cancer Res. 2013 Dec 2. 2014;20(4):912-25→. doi: 10.1158/1078-0432.CCR-13-2281→. PMID: 24297863→. Laboratory investigation. ˍ



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Berman DM, Karhadkar SS, Hallahan AR, Pritchard JI, Eberhart CG, Watkins DN, Chen JK, Cooper MK, Taipale J, Olson JM, Beachy PA.
Medulloblastoma growth inhibition by hedgehog pathway blockade.
Science. 2002 Aug 30;297(5586):1559-61→. doi: 10.1126/science.1073733→. PMID: 12202832→. Laboratory investigation. ˍ



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Bigner SH, Friedman HS, Vogelstein B, Oakes WJ, Bigner DD.
Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts.
Cancer Res. 1990 Apr 15;50(8):2347-50→. PMID: 2180567→. Laboratory investigation. ˍ
Erratum in: Cancer Res 1990 Jun 15;50(12):3809→. Correction.ˍ



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Bigner SH, Mark J, Friedman HS, Biegel JA, Bigner DD.
Structural chromosomal abnormalities in human medulloblastoma.
Cancer Genet Cytogenet. 1988 Jan 1;30(1):91-101→. doi: 10.1016/0165-4608(88)90096-9→. PMID: 3422050→. Laboratory investigation. ˍ



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Blazek ER, Foutch JL, Maki G.
Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133- cells, and the CD133+ sector is enlarged by hypoxia.
Int J Radiat Oncol Biol Phys. 2006 Nov 2. 2007;67(1):1-5→. doi: 10.1016/j.ijrobp.2006.09.037→. PMID: 17084552→. Laboratory investigation. ˍ



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Buonamici S, Williams J, Morrissey M, Wang A, Guo R, Vattay A, Hsiao K, Yuan J, Green J, Ospina B, Yu Q, Ostrom L, Fordjour P, Anderson DL, Monahan JE, Kelleher JF, Peukert S, Pan S, Wu X, Maira SM, García-Echeverría C, Briggs KJ, Watkins DN, Yao YM, Lengauer C, Warmuth M, Sellers WR, Dorsch M.
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.
Sci Transl Med. 2010 Sep 29;2(51):51ra70→. doi: 10.1126/scitranslmed.3001599→. PMID: 20881279→. Laboratory investigation. ˍ



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Corcoran RB, Scott MP.
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells.
Proc Natl Acad Sci USA. 2006 May 17;103(22):8408-13→. doi: 10.1073/pnas.0602852103→. PMID: 16707575→. Laboratory investigation. ˍ



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Ferretti E, De Smaele E, Po A, Di Marcotullio L, Tosi E, Espinola MS, Di Rocco C, Riccardi R, Giangaspero F, Farcomeni A, Nofroni I, Laneve P, Gioia U, Caffarelli E, Bozzoni I, Screpanti I, Gulino A.
MicroRNA profiling in human medulloblastoma.
Int J Cancer. 2008 Oct 30. 2009;124(3):568-77→. doi: 10.1002/ijc.23948→. PMID: 18973228→. Laboratory investigation. ˍ



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Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang ZJ, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ.
Subtypes of medulloblastoma have distinct developmental origins.
Nature. 2010 Dec 8;468(7327):1095-9→. doi: 10.1038/nature09587→. PMID: 21150899→. Laboratory investigation. ˍ



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Goodrich LV, Milenković L, Higgins KM, Scott MP.
Altered neural cell fates and medulloblastoma in mouse patched mutants.
Science. 1997 Aug 22;277(5329):1109-13→. doi: 10.1126/science.277.5329.1109→. PMID: 9262482→. Laboratory investigation. ˍ



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Hahn H, Wojnowski L, Specht K, Kappler R, Calzada-Wack J, Potter D, Zimmer A, Müller U, Samson E, Quintanilla-Martinez L, Zimmer A.
Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma.
J Biol Chem. 2000 Sep 15;275(37):28341-4→. doi: 10.1074/jbc.C000352200→. PMID: 10884376→. Laboratory investigation. ˍ



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Hambardzumyan D, Becher OJ, Rosenblum MK, Pandolfi PP, Manova-Todorova K, Holland EC.
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo.
Genes Dev. 2008 Feb 15;22(4):436-48→. doi: 10.1101/gad.1627008→. PMID: 18281460→. Laboratory investigation. ˍ



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Han YG, Kim HJ, Dlugosz AA, Ellison DW, Gilbertson RJ, Alvarez-Buylla A.
Dual and opposing roles of primary cilia in medulloblastoma development.
Nat Med. 2009 Aug 23;15(9):1062-5→. doi: 10.1038/nm.2020→. PMID: 19701203→. Laboratory investigation. ˍ



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Hovestadt V, Jones DT, Picelli S, Wang W, Kool M, Northcott PA, Sultan M, Stachurski K, Ryzhova M, Warnatz HJ, Ralser M, Brun S, Bunt J, Jäger N, Kleinheinz K, Erkek S, Weber UD, Bartholomae CC, von Kalle C, Lawerenz C, Eils J, Koster J, Versteeg R, Milde T, Witt O, Schmidt S, Wolf S, Pietsch T, Rutkowski S, Scheurlen W, Taylor MD, Brors B, Felsberg J, Reifenberger G, Borkhardt A, Lehrach H, Wechsler-Reya RJ, Eils R, Yaspo ML, Landgraf P, Korshunov A, Zapatka M, Radlwimmer B, Pfister SM, Lichter P.
Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing.
Nature. 2014 May 18;510(7506):537-41→. doi: 10.1038/nature13268→. PMID: 24847876→. Laboratory investigation. ˍ



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Jacobsen PF, Jenkyn DJ, Papadimitriou JM.
Establishment of a human medulloblastoma cell line and its heterotransplantation into nude mice.
J Neuropathol Exp Neurol. 1985 Sep 1;44(5):472-85→. doi: 10.1097/00005072-198509000-00003→. PMID: 2993532→. Laboratory investigation. ˍ



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Jones DT, Jäger N, Kool M, Zichner T, Hutter B, Sultan M, Cho YJ, Pugh TJ, Hovestadt V, Stütz AM, Rausch T, Warnatz HJ, Ryzhova M, Bender S, Sturm D, Pleier S, Cin H, Pfaff E, Sieber L, Wittmann A, Remke M, Witt H, Hutter S, Tzaridis T, Weischenfeldt J, Raeder B, Avci M, Amstislavskiy V, Zapatka M, Weber UD, Wang Q, Lasitschka B, Bartholomae CC, Schmidt M, von Kalle C, Ast V, Lawerenz C, Eils J, Kabbe R, Benes V, van Sluis P, Koster J, Volckmann R, Shih D, Betts MJ, Russell RB, Coco S, Tonini GP, Schüller U, Hans V, Graf N, Kim YJ, Monoranu C, Roggendorf W, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, von Deimling A, Witt O, Maass E, Rössler J, Ebinger M, Schuhmann MU, Frühwald MC, Hasselblatt M, Jabado N, Rutkowski S, von Bueren AO, Williamson D, Clifford SC, McCabe MG, Collins VP, Wolf S, Wiemann S, Lehrach H, Brors B, Scheurlen W, Felsberg J, Reifenberger G, Northcott PA, Taylor MD, Meyerson M, Pomeroy SL, Yaspo ML, Korbel JO, Korshunov A, Eils R, Pfister SM, Lichter P.
Dissecting the genomic complexity underlying medulloblastoma.
Nature. 2012 Jul 25;488(7409):100-5→. doi: 10.1038/nature11284→. PMID: 22832583→. Laboratory investigation. ˍ



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Kool M, Jones DT, Jäger N, Northcott PA, Pugh TJ, Hovestadt V, Piro RM, Esparza LA, Markant SL, Remke M, Milde T, Bourdeaut F, Ryzhova M, Sturm D, Pfaff E, Stark S, Hutter S, Seker-Cin H, Johann P, Bender S, Schmidt C, Rausch T, Shih D, Reimand J, Sieber L, Wittmann A, Linke L, Witt H, Weber UD, Zapatka M, König R, Beroukhim R, Bergthold G, van Sluis P, Volckmann R, Koster J, Versteeg R, Schmidt S, Wolf S, Lawerenz C, Bartholomae CC, von Kalle C, Unterberg A, Herold-Mende C, Hofer S, Kulozik AE, von Deimling A, Scheurlen W, Felsberg J, Reifenberger G, Hasselblatt M, Crawford JR, Grant GA, Jabado N, Perry A, Cowdrey C, Croul S, Zadeh G, Korbel JO, Doz F, Delattre O, Bader GD, McCabe MG, Collins VP, Kieran MW, Cho YJ, Pomeroy SL, Witt O, Brors B, Taylor MD, Schüller U, Korshunov A, Eils R, Wechsler-Reya RJ, Lichter P, Pfister SM; ICGC PedBrain Tumor Project.
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.
Cancer Cell. 2014 Mar 17;25(3):393-405→. doi: 10.1016/j.ccr.2014.02.004→. PMID: 24651015→. Laboratory investigation. ˍ



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Luther MA, Schoepfer R, Whiting P, Casey B, Blatt Y, Montal MS, Montal M, Linstrom J.
A muscle acetylcholine receptor is expressed in the human cerebellar medulloblastoma cell line TE671.
J Neurosci. 1989 Mar 1;9(3):1082-96→. doi: 10.1523/JNEUROSCI.09-03-01082.1989→. PMID: 2564429→. Laboratory investigation. ˍ



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McAllister RM, Isaacs H, Rongey R, Peer M, Au W, Soukup SW, Gardner MB.
Establishment of a human medulloblastoma cell line.
Int J Cancer. 1977 Aug 15;20(2):206-12→. doi: 10.1002/ijc.2910200207→. PMID: 892931→. Laboratory investigation. ˍ



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Northcott PA, Lee C, Zichner T, Stütz AM, Erkek S, Kawauchi D, Shih DJ, Hovestadt V, Zapatka M, Sturm D, Jones DT, Kool M, Remke M, Cavalli FM, Zuyderduyn S, Bader GD, VandenBerg S, Esparza LA, Ryzhova M, Wang W, Wittmann A, Stark S, Sieber L, Seker-Cin H, Linke L, Kratochwil F, Jäger N, Buchhalter I, Imbusch CD, Zipprich G, Raeder B, Schmidt S, Diessl N, Wolf S, Wiemann S, Brors B, Lawerenz C, Eils J, Warnatz HJ, Risch T, Yaspo ML, Weber UD, Bartholomae CC, von Kalle C, Turányi E, Hauser P, Sanden E, Darabi A, Siesjö P, Sterba J, Zitterbart K, Sumerauer D, van Sluis P, Versteeg R, Volckmann R, Koster J, Schuhmann MU, Ebinger M, Grimes HL, Robinson GW, Gajjar A, Mynarek M, von Hoff K, Rutkowski S, Pietsch T, Scheurlen W, Felsberg J, Reifenberger G, Kulozik AE, von Deimling A, Witt O, Eils R, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Korbel JO, Wechsler-Reya RJ, Pfister SM.
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.
Nature. 2014 Jun 22;511(7510):428-34→. doi: 10.1038/nature13379→. PMID: 25043047→. Laboratory investigation. ˍ



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Northcott PA, Nakahara Y, Wu X, Feuk L, Ellison DW, Croul S, Mack S, Kongkham PN, Peacock J, Dubuc A, Ra YS, Zilberberg K, McLeod J, Scherer SW, Sunil Rao J, Eberhart CG, Grajkowska W, Gillespie Y, Lach B, Grundy R, Pollack IF, Hamilton RL, Van Meter T, Carlotti CG, Boop F, Bigner D, Gilbertson RJ, Rutka JT, Taylor MD.
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma.
Nat Genet. 2009 Mar 8;41(4):465-72→. doi: 10.1038/ng.336→. PMID: 19270706→. Laboratory investigation. ˍ



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Oliver TG, Read TA, Kessler JD, Mehmeti A, Wells JF, Huynh TT, Lin SM, Wechsler-Reya RJ.
Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.
Development. 2005 Apr 20;132(10):2425-39→. doi: 10.1242/dev.01793→. PMID: 15843415→. Laboratory investigation. ˍ



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Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR, Gerhard DS, Fults DW, VandenBerg S, Berger MS, Marie SK, Shinjo SM, Clara C, Phillips PC, Minturn JE, Biegel JA, Judkins AR, Resnick AC, Storm PB, Curran T, He Y, Rasheed BA, Friedman HS, Keir ST, McLendon R, Northcott PA, Taylor MD, Burger PC, Riggins GJ, Karchin R, Parmigiani G, Bigner DD, Yan H, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE.
The genetic landscape of the childhood cancer medulloblastoma.
Science. 2010 Dec 16. 2011;331(6016):435-9→. doi: 10.1126/science.1198056→. PMID: 21163964→. Laboratory investigation. ˍ



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Pei Y, Moore CE, Wang J, Tewari AK, Eroshkin A, Cho YJ, Witt H, Korshunov A, Read TA, Sun JL, Schmitt EM, Miller CR, Buckley AF, McLendon RE, Westbrook TF, Northcott PA, Taylor MD, Pfister SM, Febbo PG, Wechsler-Reya RJ.
An animal model of MYC-driven medulloblastoma.
Cancer Cell. 2012 Feb 14;21(2):155-67→. doi: 10.1016/j.ccr.2011.12.021→. PMID: 22340590→. Laboratory investigation. ˍ



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Rao G, Pedone CA, Del Valle L, Reiss K, Holland EC, Fults DW.
Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice.
Oncogene. 2004 June 14;23(36):6156-62→. doi: 10.1038/sj.onc.1207818→. PMID: 15195141→. Laboratory investigation. ˍ



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Rausch T, Jones DT, Zapatka M, Stütz AM, Zichner T, Weischenfeldt J, Jäger N, Remke M, Shih D, Northcott PA, Pfaff E, Tica J, Wang Q, Massimi L, Witt H, Bender S, Pleier S, Cin H, Hawkins C, Beck C, von Deimling A, Hans V, Brors B, Eils R, Scheurlen W, Blake J, Benes V, Kulozik AE, Witt O, Martin D, Zhang C, Porat R, Merino DM, Wasserman J, Jabado N, Fontebasso A, Bullinger L, Rücker FG, Döhner K, Döhner H, Koster J, Molenaar JJ, Versteeg R, Kool M, Tabori U, Malkin D, Korshunov A, Taylor MD, Lichter P, Pfister SM, Korbel JO.
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.
Cell. 2012 Jan 20;148(1-2):59-71→. doi: 10.1016/j.cell.2011.12.013→. PMID: 22265402→. Laboratory investigation. ˍ



◽

Read TA, Fogarty MP, Markant SL, McLendon RE, Wei Z, Ellison DW, Febbo PG, Wechsler-Reya RJ.
Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.
Cancer Cell. 2009 Feb 3;15(2):135-47→. doi: 10.1016/j.ccr.2008.12.016→. PMID: 19185848→. Laboratory investigation. ˍ
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Schüller U, Heine VM, Mao J, Kho AT, Dillon AK, Han YG, Huillard E, Sun T, Ligon AH, Qian Y, Ma Q, Alvarez-Buylla A, McMahon AP, Rowitch DH, Ligon KL.
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.
Cancer Cell. 2008 Aug 12;14(2):123-34→. doi: 10.1016/j.ccr.2008.07.005→. PMID: 18691547→. Laboratory investigation. ˍ



◽

Taylor MD, Liu L, Raffel C, Hui CC, Mainprize TG, Zhang X, Agatep R, Chiappa S, Gao L, Lowrance A, Hao A, Goldstein AM, Stavrou T, Scherer SW, Dura WT, Wainwright B, Squire JA, Rutka JT, Hogg D.
Mutations in SUFU predispose to medulloblastoma.
Nat Genet. 2002 Jun 17;31(3):306-10→. doi: 10.1038/ng916→. PMID: 12068298→. Laboratory investigation. ˍ



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Uziel T, Karginov FV, Xie S, Parker JS, Wang YD, Gajjar A, He L, Ellison D, Gilbertson RJ, Hannon G, Roussel MF. The miR-17~92 cluster The miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma.
Proc Natl Acad Sci USA. 2009 Feb 5;106(8):2812-7→. doi: 10.1073/pnas.0809579106→. PMID: 19196975→. Laboratory investigation. ˍ



◽

Wetmore C, Eberhart DE, Curran T.
Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.
Cancer Res. 2001 Jan 15;61(2):513-6→. PMID: 11212243→. Laboratory investigation. ˍ



◽

Wu X, Northcott PA, Dubuc A, Dupuy AJ, Shih DJ, Witt H, Croul S, Bouffet E, Fults DW, Eberhart CG, Garzia L, Van Meter T, Zagzag D, Jabado N, Schwartzentruber J, Majewski J, Scheetz TE, Pfister SM, Korshunov A, Li XN, Scherer SW, Cho YJ, Akagi K, MacDonald TJ, Koster J, McCabe MG, Sarver AL, Collins VP, Weiss WA, Largaespada DA, Collier LS, Taylor MD.
Clonal selection drives genetic divergence of metastatic medulloblastoma.
Nature. 2012 Feb 15;482(7386):529-33→. doi: 10.1038/nature10825→. PMID: 22343890→. Laboratory investigation. ˍ



◽

Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M, Schüller U, Machold R, Fishell G, Rowitch DH, Wainwright BJ, Wechsler-Reya RJ.
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.
Cancer Cell. 2008 Aug 12;14(2):135-45→. doi: 10.1016/j.ccr.2008.07.003→. PMID: 18691548→. Laboratory investigation. ˍ



◽

Yauch RL, Dijkgraaf GJ, Alicke B, Januario T, Ahn CP, Holcomb T, Pujara K, Stinson J, Callahan CA, Tang T, Bazan JF, Kan Z, Seshagiri S, Hann CL, Gould SE, Low JA, Rudin CM, de Sauvage FJ.
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
Science. 2009 Sep 2;326(5952):572-4→. doi: 10.1126/science.1179386→. PMID: 19726788→. Laboratory investigation. ˍ



Follow-up, Side effects, Quality of life

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Huang E, Teh BS, Strother DR, Davis QG, Chiu JK, Lu HH, Carpenter LS, Mai WY, Chintagumpala MM, South M, Grant WH 3rd, Butler EB, Woo SY.
Intensity-modulated radiation therapy for pediatric medulloblastoma: early report on the reduction of ototoxicity.
Int J Radiat Oncol Biol Phys. 2002 Mar 1;52(3):599-605→. doi: 10.1016/s0360-3016(01)02641-4→. PMID: 11849779→. Retrospective analysis. ˍ



◽

Mulhern RK, Palmer SL, Merchant TE, Wallace D, Kocak M, Brouwers P, Krull K, Chintagumpala M, Stargatt R, Ashley DM, Tyc VL, Kun L, Boyett J, Gajjar A.
Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma.
J Clin Oncol. 2005 Aug 20;23(24):5511-9→. doi: 10.1200/JCO.2005.00.703→. PMID: 16110011→. Prospective study. ˍ



◽

Mulhern RK, Palmer SL, Reddick WE, Glass JO, Kun LE, Taylor J, Langston J, Gajjar A.
Risks of young age for selected neurocognitive deficits in medulloblastoma are associated with white matter loss.
J Clin Oncol. 2001 Jan 15;19(2):472-9→. doi: 10.1200/JCO.2001.19.2.472→. PMID: 11208841→. Cross-sectional study ˍ



◽

Palmer SL, Goloubeva O, Reddick WE, Glass JO, Gajjar A, Kun L, Merchant TE, Mulhern RK.
Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis.
J Clin Oncol. 2001 Apr 15;19(8):2302-8→. doi: 10.1200/JCO.2001.19.8.2302→. PMID: 11304784→. Prospective study. ˍ



◽

Ris MD, Packer R, Goldwein J, Jones-Wallace D, Boyett JM.
Intellectual outcome after reduced-dose radiation therapy plus adjuvant chemotherapy for medulloblastoma: a Children's Cancer Group study.
J Clin Oncol. 2001 Aug 1;19(15):3470-6→. doi: 10.1200/JCO.2001.19.15.3470→. PMID: 11481352→. Prospective study. ˍ



◽

Robertson PL, Muraszko KM, Holmes EJ, Sposto R, Packer RJ, Gajjar A, Dias MS, Allen JC; Children's Oncology Group.
Incidence and severity of postoperative cerebellar mutism syndrome in children with medulloblastoma: a prospective study by the Children's Oncology Group.
J Neurosurg. 2006 Dec;105(6 Suppl):444-51→. doi: 10.3171/ped.2006.105.6.444→. PMID: 17184075→. Prospective study. ˍ



Overall management

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Crawford JR, MacDonald TJ, Packer RJ.
Medulloblastoma in childhood: new biological advances.
Lancet Neurol. 2007 Dec 1;6(12):1073-85→. doi: 10.1016/S1474-4422(07)70289-2→. PMID: 18031705→. Review. ˍ



◽

Gilbertson RJ, Ellison DW.
The origins of medulloblastoma subtypes.
Annu Rev Pathol. 2008 Feb 28;3:341-65→. doi: 10.1146/annurev.pathmechdis.3.121806.151518→. PMID: 18039127→. Review. ˍ



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Gilbertson RJ.
Medulloblastoma: signalling a change in treatment.
Lancet Oncol. 2004 Apr 1;5(4):209-18→. doi: 10.1016/S1470-2045(04)01424-X→. PMID: 15050952→. Review. ˍ



◽

Huse JT, Holland EC.
Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma.
Nat Rev Cancer. 2010 May;10(5):319-31→. doi: 10.1038/nrc2818→. PMID: 20414201→. Review. ˍ



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Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, Cho YJ, Koster J, Schouten-van Meeteren A, van Vuurden D, Clifford SC, Pietsch T, von Bueren AO, Rutkowski S, McCabe M, Collins VP, Bäcklund ML, Haberler C, Bourdeaut F, Delattre O, Doz F, Ellison DW, Gilbertson RJ, Pomeroy SL, Taylor MD, Lichter P, Pfister SM.
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.
Acta Neuropathol. 2012 Feb 23;123(4):473-84→. doi: 10.1007/s00401-012-0958-8→. PMID: 22358457→. Meta-analysis. ˍ



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Marino S.
Medulloblastoma: developmental mechanisms out of control.
Trends Mol Med. 2005 Jan 1;11(1):17-22→. doi: 10.1016/j.molmed.2004.11.008→. PMID: 15649818→. Review. ˍ



◽

Northcott PA, Korshunov A, Pfister SM, Taylor MD.
The clinical implications of medulloblastoma subgroups.
Nat Rev Neurol. 2012 May 8;8(6):340-51→. doi: 10.1038/nrneurol.2012.78→. PMID: 22565209→. Review. ˍ



◽

Packer RJ, Cogen P, Vezina G, Rorke LB.
Medulloblastoma: clinical and biologic aspects.
Neuro Oncol. 1999 Jul 1;1(3):232-50→. doi: 10.1093/neuonc/1.3.232→. PMID: 11550316→. Review. ˍ



◽

Rorke LB.
The cerebellar medulloblastoma and its relationship to primitive neuroectodermal tumors.
J Neuropathol Exp Neurol. 1983 Jan 1;42(1):1-15→. doi: 10.1097/00005072-198301000-00001→. PMID: 6296325→. Review. ˍ



◽

Rubinstein LJ, Northfield DW.
The medulloblastoma and the so-called "Arachnoidal cerebellar sarcoma".
Brain. 1964 Jun 1;87:379-412→. doi: 10.1093/brain/87.2.379→. PMID: 14188281→. Review. ˍ



◽

Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, Eberhart CG, Parsons DW, Rutkowski S, Gajjar A, Ellison DW, Lichter P, Gilbertson RJ, Pomeroy SL, Kool M, Pfister SM.
Molecular subgroups of medulloblastoma: the current consensus.
Acta Neuropathol. 2011 Dec 2. 2012;123(4):465-72→. doi: 10.1007/s00401-011-0922-z→. PMID: 22134537→. Meeting report. ˍ



◽

Teglund S, Toftgård R.
Hedgehog beyond medulloblastoma and basal cell carcinoma.
Biochim Biophys Acta. 2010 Jan 18;1805(2):181-208→. doi: 10.1016/j.bbcan.2010.01.003→. PMID: 20085802→. Review. ˍ



Prognosis, Outcomes

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Albright AL, Wisoff JH, Zeltzer PM, Boyett JM, Rorke LB, Stanley P.
Effects of medulloblastoma resections on outcome in children: a report from the Children's Cancer Group.
Neurosurgery. 1996 Feb 1;38(2):265-71→. doi: 10.1097/00006123-199602000-00007→. PMID: 8869053→. Retrospective analysis. ˍ



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Chatty EM, Earle KM.
Medulloblastoma. A report of 201 cases with emphasis on the relationship of histologic variants to survival.
Cancer. 1971 Oct;28(4):977-83→. doi: 10.1002/1097-0142(1971)28:4<977::aid-cncr2820280422>3.0.co;2-7→. PMID: 5111749→. Retrospective analysis. ˍ



◽

Ellison DW, Onilude OE, Lindsey JC, Lusher ME, Weston CL, Taylor RE, Pearson AD, Clifford SC; United Kingdom Children's Cancer Study Group Brain Tumour Committee.
beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee.
J Clin Oncol. 2005 Nov 1;23(31):7951-7→. doi: 10.1200/JCO.2005.01.5479→. PMID: 16258095→. Laboratory investigation. ˍ



◽

Gajjar A, Hernan R, Kocak M, Fuller C, Lee Y, McKinnon PJ, Wallace D, Lau C, Chintagumpala M, Ashley DM, Kellie SJ, Kun L, Gilbertson RJ.
Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma.
J Clin Oncol. 2004 Feb 17;22(6):984-93→. doi: 10.1200/JCO.2004.06.032→. PMID: 14970185→. Laboratory investigation. ˍ



◽

Gilbertson RJ, Perry RH, Kelly PJ, Pearson AD, Lunec J.
Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma.
Cancer Res. 1997 Aug 1;57(15):3272-80→. PMID: 9242460→. Laboratory investigation. ˍ



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Harisiadis L, Chang CH.
Medulloblastoma in children: a correlation between staging and results of treatment.
Int J Radiat Oncol Biol Phys. 1977 Sep-Oct;2(9-10):833-41→. doi: 10.1016/0360-3016(77)90181-x→. PMID: 597384→. Prospective study. ˍ



◽

Hirsch JF, Renier D, Czernichow P, Benveniste L, Pierre-Kahn A.
Medulloblastoma in childhood. Survival and functional results.
Acta Neurochir (Wien). 1979 March;48(1-2):1-15→. doi: 10.1007/BF01406016→. PMID: 495234→. Retrospective analysis. ˍ



◽

Mendrzyk F, Radlwimmer B, Joos S, Kokocinski F, Benner A, Stange DE, Neben K, Fiegler H, Carter NP, Reifenberger G, Korshunov A, Lichter P.
Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma.
J Clin Oncol. 2005 Dec 1;23(34):8853-62→. doi: 10.1200/JCO.2005.02.8589→. PMID: 16314645→. Laboratory investigation. ˍ



◽

Packer RJ, Sutton LN, Elterman R, Lange B, Goldwein J, Nicholson HS, Mulne L, Boyett J, D'Angio G, Wechsler-Jentzsch K, et al.
Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy.
J Neurosurg. 1994 Nov;81(5):690-8→. doi: 10.3171/jns.1994.81.5.0690→. PMID: 7931615→. Prospective study. ˍ



◽

Packer RJ, Sutton LN, Goldwein JW, Perilongo G, Bunin G, Ryan J, Cohen BH, D'Angio G, Kramer ED, Zimmerman RA, et al.
Improved survival with the use of adjuvant chemotherapy in the treatment of medulloblastoma.
J Neurosurg. 1991 Mar;74(3):433-40→. doi: 10.3171/jns.1991.74.3.0433→. PMID: 1847194→. Retrospective analysis. ˍ



◽

Park TS, Hoffman HJ, Hendrick EB, Humphreys RP, Becker LE.
Medulloblastoma: clinical presentation and management. Experience at the hospital for sick children, toronto, 1950-1980.
J Neurosurg. 1983 Apr;58(4):543-52→. doi: 10.3171/jns.1983.58.4.0543→. PMID: 6827349→. Retrospective analysis. ˍ



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Pfister S, Remke M, Benner A, Mendrzyk F, Toedt G, Felsberg J, Wittmann A, Devens F, Gerber NU, Joos S, Kulozik A, Reifenberger G, Rutkowski S, Wiestler OD, Radlwimmer B, Scheurlen W, Lichter P, Korshunov A.
Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci.
J Clin Oncol. 2009 Mar 2;27(10):1627-36→. doi: 10.1200/JCO.2008.17.9432→. PMID: 19255330→. Laboratory investigation. ˍ



◽

Segal RA, Goumnerova LC, Kwon YK, Stiles CD, Pomeroy SL.
Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma.
Proc Natl Acad Sci USA. 1994 Dec 20;91(26):12867-71→. doi: 10.1073/pnas.91.26.12867→. PMID: 7809137→. Laboratory investigation. ˍ



◽

Zeltzer PM, Boyett JM, Finlay JL, Albright AL, Rorke LB, Milstein JM, Allen JC, Stevens KR, Stanley P, Li H, Wisoff JH, Geyer JR, McGuire-Cullen P, Stehbens JA, Shurin SB, Packer RJ.
Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study.
J Clin Oncol. 1999 Mar 1;17(3):832-45→. doi: 10.1200/JCO.1999.17.3.832→. PMID: 10071274→. Phase 3 trial. ˍ



Treatment

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Bailey CC, Gnekow A, Wellek S, Jones M, Round C, Brown J, Phillips A, Neidhardt MK.
Prospective randomised trial of chemotherapy given before radiotherapy in childhood medulloblastoma. International Society of Paediatric Oncology (SIOP) and the (German) Society of Paediatric Oncology (GPO): SIOP II.
Med Pediatr Oncol. 1995 Sep;25(3):166-78→. doi: 10.1002/mpo.2950250303→. PMID: 7623725→. Prospective study. ˍ



◽

Bailey P, Cushing H.
Medulloblastoma cerebelli. A common type of midcerebellar glioma of childhood.
Arch Neur Psych. 1925 Aug;14(2):192-224→. doi: 10.1001/archneurpsyc.1925.02200140055002→. Retrospective analysis. ˍ



◽

Berry MP, Jenkin RD, Keen CW, Nair BD, Simpson WJ.
Radiation treatment for medulloblastoma. A 21-year review.
J Neurosurg. 1981 Jul;55(1):43-51→. doi: 10.3171/jns.1981.55.1.0043→. PMID: 7241214→. Retrospective analysis. ˍ



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Bloom HJ, Wallace EN, Henk JM.
The treatment and prognosis of medulloblastoma in children. A study of 82 verified cases.
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Burger PC, Yu IT, Tihan T, Friedman HS, Strother DR, Kepner JL, Duffner PK, Kun LE, Perlman EJ.
Atypical teratoid/rhabdoid tumor of the central nervous system: a highly malignant tumor of infancy and childhood frequently mistaken for medulloblastoma: a Pediatric Oncology Group study.
Am J Surg Pathol. 1998 Sep;22(9):1083-92→. doi: 10.1097/00000478-199809000-00007→. PMID: 9737241→. Retrospective study; ˍ



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Evans AE, Jenkin RD, Sposto R, Ortega JA, Wilson CB, Wara W, Ertel IJ, Kramer S, Chang CH, Leikin SL, et al.
The treatment of medulloblastoma. Results of a prospective randomized trial of radiation therapy with and without CCNU, vincristine, and prednisone.
J Neurosurg. 1990 Apr;72(4):572-82→. doi: 10.3171/jns.1990.72.4.0572→. PMID: 2319316→. Prospective study. ˍ



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Gajjar A, Chintagumpala M, Ashley D, Kellie S, Kun LE, Merchant TE, Woo S, Wheeler G, Ahern V, Krasin MJ, Fouladi M, Broniscer A, Krance R, Hale GA, Stewart CF, Dauser R, Sanford RA, Fuller C, Lau C, Boyett JM, Wallace D, Gilbertson RJ.
Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial.
Lancet Oncol. 2006 Sep 7;7(10):813-20→. doi: 10.1016/S1470-2045(06)70867-1→. PMID: 17012043→. Phase 2 trial. ˍ
Erratum in: Lancet Oncol. 2006 Oct;7(10):797→. doi: 10.1016/S1470-2045(06)70881-6→. Correction. ˍ



◽

Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Vecchio LD, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M.
MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma.
PLoS One. 2009 Mar 24;4(3):e4998→. doi: 10.1371/journal.pone.0004998→. PMID: 19308264→. Laboratory investigation. ˍ



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Geoerger B, Kerr K, Tang CB, Fung KM, Powell B, Sutton LN, Phillips PC, Janss AJ.
Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy.
Cancer Res. 2001 Feb 15;61(4):1527-32→. PMID: 11245461→. Laboratory investigation. ˍ



◽

Grill J, Sainte-Rose C, Jouvet A, Gentet JC, Lejars O, Frappaz D, Doz F, Rialland X, Pichon F, Bertozzi AI, Chastagner P, Couanet D, Habrand JL, Raquin MA, Le Deley MC, Kalifa C; French Society of Paediatric Oncology.
Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children.
Lancet Oncol. 2005 Jul 14;6(8):573-80→. doi: 10.1016/S1470-2045(05)70252-7→. PMID: 16054568→. Prospective study. ˍ



◽

Kortmann RD, Kühl J, Timmermann B, Mittler U, Urban C, Budach V, Richter E, Willich N, Flentje M, Berthold F, Slavc I, Wolff J, Meisner C, Wiestler O, Sörensen N, Warmuth-Metz M, Bamberg M.
Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of the German prospective randomized trial HIT '91.
Int J Radiat Oncol Biol Phys. 2000 Jan 15;46(2):269-79→. doi: 10.1016/s0360-3016(99)00369-7→. PMID: 10661332→. Prospective study. ˍ



◽

MacDonald TJ, Brown KM, LaFleur B, Peterson K, Lawlor C, Chen Y, Packer RJ, Cogen P, Stephan DA.
Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease.
Nat Genet. 2001 Sep 4;29(2):143-52→. doi: 10.1038/ng731→. PMID: 11544480→. Laboratory investigation. ˍ
Erratum in: Nat Genet. 2003 Nov 1;35(3):287→. doi: 10.1038/ng1103-287a→. Correction. ˍ



◽

Mulhern RK, Kepner JL, Thomas PR, Armstrong FD, Friedman HS, Kun LE.
Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced-dose craniospinal irradiation: a Pediatric Oncology Group study.
J Clin Oncol. 1998 May 1;16(5):1723-8→. doi: 10.1200/JCO.1998.16.5.1723→. PMID: 9586884→. Prospective study. ˍ



◽

Packer RJ, Gajjar A, Vezina G, Rorke-Adams L, Burger PC, Robertson PL, Bayer L, LaFond D, Donahue BR, Marymont MH, Muraszko K, Langston J, Sposto R.
Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma.
J Clin Oncol. 2006 Sep 1;24(25):4202-8→. doi: 10.1200/JCO.2006.06.4980→. PMID: 16943538→. Phase 3 trial. ˍ



◽

Romer JT, Kimura H, Magdaleno S, Sasai K, Fuller C, Baines H, Connelly M, Stewart CF, Gould S, Rubin LL, Curran T.
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
Cancer Cell. 2004 Sep 1;6(3):229-40→. doi: 10.1016/j.ccr.2004.08.019→. PMID: 15380514→. Laboratory investigation. ˍ



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Rudin CM, Hann CL, Laterra J, Yauch RL, Callahan CA, Fu L, Holcomb T, Stinson J, Gould SE, Coleman B, LoRusso PM, Von Hoff DD, de Sauvage FJ, Low JA.
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.
N Engl J Med. 2009 Sep 2;361(12):1173-8→. doi: 10.1056/NEJMoa0902903→. PMID: 19726761→. Case report. ˍ



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Rutkowski S, Bode U, Deinlein F, Ottensmeier H, Warmuth-Metz M, Soerensen N, Graf N, Emser A, Pietsch T, Wolff JE, Kortmann RD, Kuehl J.
Treatment of early childhood medulloblastoma by postoperative chemotherapy alone.
N Engl J Med. 2005 Mar 10;352(10):978-86→. doi: 10.1056/NEJMoa042176→. PMID: 15758008→. Prospective study. ˍ



◽

Taylor RE, Bailey CC, Robinson K, Weston CL, Ellison D, Ironside J, Lucraft H, Gilbertson R, Tait DM, Walker DA, Pizer BL, Imeson J, Lashford LS; International Society of Paediatric Oncology; United Kingdom Children's Cancer Study Group.
Results of a randomized study of preradiation chemotherapy versus radiotherapy alone for nonmetastatic medulloblastoma: The International Society of Paediatric Oncology/United Kingdom Children's Cancer Study Group PNET-3 Study.
J Clin Oncol. 2003 Apr 15;21(8):1581-91→. doi: 10.1200/JCO.2003.05.116→. PMID: 12697884→. Prospective study. ˍ



◽

Tait DM, Thornton-Jones H, Bloom HJ, Lemerle J, Morris-Jones P.
Adjuvant chemotherapy for medulloblastoma: the first multi-centre control trial of the International Society of Paediatric Oncology (SIOP I).
Eur J Cancer. 1990 Apr;26(4):464-9→. doi: 10.1016/0277-5379(90)90017-N→. PMID: 2141512→. Prospective study. ˍ



◽

Thomas PR, Deutsch M, Kepner JL, Boyett JM, Krischer J, Aronin P, Albright L, Allen JC, Packer RJ, Linggood R, Mulhern R, Stehbens JA, Langston J, Stanley P, Duffner P, Rorke L, Cherlow J, Friedman HS, Finlay JL, Vietti TJ, Kun LE.
Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation.
J Clin Oncol. 2000 Aug 16;18(16):3004-11→. doi: 10.1200/JCO.2000.18.16.3004→. PMID: 10944134→. Prospective study. ˍ