Treatment > Antiangiogenesis top


Contents



Astrocytic Tumors


Zagzag D, Friedlander DR, Miller DC, Dosik J, Cangiarella J, Kostianovsky M, Cohen H, Grumet M, Greco MA
Tenascin expression in astrocytomas correlates with angiogenesis
Cancer Res. 1995 Feb 15; 55(4): 907-14. 



Basic and Translational Inv.


Joussen AM, Kruse FE, Volcker HE, Kirchhof B
Topical application of methotrexate for inhibition of corneal angiogenesis
Graefes Arch Clin Exp Ophthalmol 1999 Nov;237(11):920-7 

Murata T, He S, Hangai M, Ishibashi T, Xi XP, Kim S, Hsueh WA, Ryan SJ, Law RE, Hinton DR
Peroxisome proliferator-activated receptor-gamma ligands inhibit choroidal neovascularization
Invest Ophthalmol Vis Sci 2000 Jul;41(8):2309-17
(PDF Full Text)

Gagliardi AR, Hennig B, Collins DC
Antiestrogens inhibit endothelial cell growth stimulated by angiogenic growth factors

Anticancer Res 1996 May-Jun;16(3A):1101-6 

Gilbertson-Beadling S, Powers EA, Stamp-Cole M, Scott PS, Wallace TL, Copeland J, Petzold G, Mitchell M, Ledbetter S, Poorman R
The tetracycline analogs minocycline and doxycycline inhibit angiogenesis in vitro by a non-metalloproteinase-dependent mechanism
Cancer Chemother Pharmacol 1995;36(5):418-24 


Brain Tumors


Myriam W Ben Arush, Sergey Postovsky, Ronit Elhasid, A Ben-Barak, C Levine, Joseph F Guilburd
Antiangiogenic therapy in pediatric malignancies: experience of the Northern Israel Pediatric Cancer Center

ASCO Proceedings, 2002 Annual Meeting, Abstract No. 2926 

MacDonald TJ, Stewart CF, Kocak M, Goldman S, Ellenbogen RG, Phillips P, Lafond D, Poussaint TY, Kieran MW, Boyett JM, Kun LE
Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012
J Clin Oncol. 2008 Feb 20;26(6):919-24
 Abstract |
DBLinks | BL 7:6


Cancer Research


Arbiser JL, Klauber N, Rohan R, van Leeuwen R, Huang MT, Fisher C, Flynn E, Byers HR
Curcumin is an in vivo inhibitor of angiogenesis
Mol Med 1998 Jun;4(6):376-83 

Boehm T, Folkman J, Browder T, O'Reilly MS
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
Nature 1997 Nov 27;390(6658):404-7  

Jiang C, Agarwal R, Lu J
Anti-angiogenic potential of a cancer chemopreventive flavonoid antioxidant, silymarin: inhibition of key attributes of vascular endothelial cells and angiogenic cytokine secretion by cancer epithelial cells
Biochem Biophys Res Commun 2000 Sep 16;276(1):371-8 

Cai J, Jiang WG, Mansel RE
Inhibition of angiogenic factor- and tumour-induced angiogenesis by gamma linolenic acid
Prostaglandins Leukot Essent Fatty Acids 1999 Jan;60(1):21-9  

Yihai Cao and Renhai Cao
Angiogenesis inhibited by drinking tea

Nature 1999 Apr 1;398(6726):381 

Gorski DH, Mauceri HJ, Salloum RM, Gately S, Hellman S, Beckett MA, Sukhatme VP, Soff GA, Kufe DW, Weichselbaum RR
Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin
Cancer Res 1998 Dec 15;58(24):5686-9  

Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M, Bruns CJ, Zuelke C, Farkas S, Anthuber M, Jauch KW, Geissler EK
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

Nat Med 2002 Feb;8(2):128-35 

Kanoh T, Matsunaga K, Saito K, Fujii T
Suppression of in vivo tumor-induced angiogenesis by the protein-bound polysaccharide PSK
In Vivo 1994 Mar-Apr;8(2):247-50 

Li D, Williams JI, Pietras RJ
Squalamine and cisplatin block angiogenesis and growth of human ovarian cancer cells with or without HER-2 gene overexpression
Oncogene 2002 Apr 25;21(18):2805-14 

Lissoni P, Rovelli F, Malugani F, Bucovec R, Conti A, Maestroni GJ
Anti-angiogenic activity of melatonin in advanced cancer patients
Neuroendocrinol Lett 2001;22(1):45-7

Majewski S, Skopinska M, Marczak M, Szmurlo A, Bollag W, Jablonska S
Vitamin D3 is a potent inhibitor of tumor cell-induced angiogenesis

J Investig Dermatol Symp Proc 1996 Apr;1(1):97-101 

Redman BG, Esper P, Pan Q, Dunn RL, Hussain HK, Chenevert T, Brewer GJ, Merajver SD
Phase II trial of tetrathiomolybdate in patients with advanced kidney cancer
Clin Cancer Res. 2003 May;9(5):1666-72

Verheul HM, Panigrahy D, Yuan J, D'Amato RJ
Combination oral antiangiogenic therapy with thalidomide and sulindac inhibits tumour growth in rabbits
Br J Cancer 1999 Jan;79(1):114-8 

Xin X, Yang S, Kowalski J, Gerritsen ME
Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo

J Biol Chem 1999 Mar 26;274(13):9116-21 (FPD Full Text)

Yokoyama Y, Dhanabal M, Griffioen AW, Sukhatme VP, Ramakrishnan S
Synergy between angiostatin and endostatin: inhibition of ovarian cancer growth
Cancer Res 2000 Apr 15;60(8):2190-6 (PDF Full Text)

Yoshiji H, Kuriyama S, Kawata M, Yoshii J, Ikenaka Y, Noguchi R, Nakatani T, Tsujinoue H, Fukui H
The angiotensin-I-converting enzyme inhibitor perindopril suppresses tumor growth and angiogenesis: possible role of the vascular endothelial growth factor
Clin Cancer Res 2001 Apr;7(4):1073-8 (PDF Full Text)

Zhou JR, Gugger ET, Tanaka T, Guo Y, Blackburn GL, Clinton SK
Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice
J Nutr 1999 Sep;129(9):1628-35  


Glioblastoma


S. Brem, S. A. Grossman, K. A. Carson, P. New, S. Phuphanich, J. B. Alavi, T. Mikkelsen, R. Priet
Phase II trial of copper depletion as angiosuppressive treatment in newly diagnosed Glioblastoma Multiforme: Final report
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1530 

Michael A. Badruddoja, Hendrikus G. J. Krouwer, Scott D. Rand, Kelly J. Rebro, Arvind P. Pathak, Kathleen M. Schmainda
Antiangiogenic effects of dexamethasone in 9L gliosarcoma assessed by MRI cerebral blood volume maps
Neuro-Oncology, Volume 5, Number 4, Pages 235 -- 243 (October 2003)  

Christiana Charalambous, Johanna Milan, Ligaya Pen, Florence Hofman, and Thomas Chen
The role of IL-8 in the regulation of normal and tumor-derived human brain endothelial cells
Society for Neuro-Oncology Eighth Annual Meeting. Keystone, Colorado. November 13–16, 2003. Abstract No. AN-06.
Neuro-Oncology, Volume 5, Issue 4, October 2003
 

C. Conrad, H. Friedman, D. Reardon, J. Provenzale, E. Jackson, H. Serajuddin, D. Laurent, B. Chen, W. K. A. Yung
A phase I/II trial of single-agent PTK 787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in patients with recurrent glioblastoma multiforme (GBM)
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1512 

Gerstner ER, Duda DG, Tomaso ED, Sorensen G, Jain RK, Batchelor TT
Antiangiogenic agents for the treatment of glioblastoma
Expert Opin Investig Drugs. 2007 Dec;16(12):1895-1908
Abstract | DBLinks

Jo Glass, Gruber Michael , Anit Nirenberg
Phase I/II Study of Carboplatin and Thalidomide in Recurrent Glioblastoma Multiforme

ASCO Proceedings, 1999 Annual Meeting, Abstract
No. 551 

Reardon DA, Wen PY, Desjardins A, Batchelor TT, Vredenburgh JJ.
Glioblastoma multiforme: an emerging paradigm of anti-VEGF therapy
Expert Opin Biol Ther. 2008 Apr;8(4):541-53
 Abstract |
DBLinks | BL 7:7

D. Reardon, H. Friedman, W. K. A. Yung, M. Brada, C. Conrad, J. Provenzale, E. Jackson, H. Serajuddin, B. Chen, D. Laurent
A phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM)
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1513 

D. Reardon, H. S. Friedman, W. K. A. Yung, M. Brada, C. Conrad, J. Provenzale, E. F. Jackson, H. Serajuddin, D. Laurent, D. Reitsma
A phase I trial of PTK787/ZK 222584 (PTK/ZK), an oral VEGF tyrosine kinase inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM)
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003. Abstract No. 412 

Saidi A, Javerzat S, Bellahcène A, De Vos J, Bello L, Castronovo V, Deprez M, Loiseau H, Bikfalvi A, Hagedorn M
Experimental anti-angiogenesis causes upregulation of genes associated with poor survival in glioblastoma
Int J Cancer. 2007 Dec 18; [Epub ahead of print]

Abstract | DBLinks | BL 7:2

Snowden AW, Zhang L, Urnov F, Dent C, Jouvenot Y, Zhong X, Rebar EJ, Jamieson AC, Zhang HS, Tan S, Case CC, Pabo CO, Wolffe AP, Gregory PD
Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors
Cancer Res. 2003 Dec 15;63(24):8968-76.

Wong ET, Brem S.
Taming glioblastoma: targeting angiogenesis.
J Clin Oncol. 2007 Oct 20;25(30):4705-6.
Full Text | Reprint

W. K. A. Yung, H. Friedman, C. Conrad, D. Reardon, J. Provenzale, E. Jackson, N. Leeds, H. Serajuddin, D. Laurent, D. Reitsma
A phase I trial of single-agent PTK 787/ZK 222584 (PTK/ZK), an oral VEGFR tyrosine kinase inhibitor, in patients with recurrent glioblastoma multiforme
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003. Abstract No. 395 

W.K. A Yung, Henry Friedman, E Jackson, J Provenzale, N Leeds, C Conrad, A Walker, A Henry, J Huang, D Laurent, M Dugan
A phase I trial of PTK787/ZK 222584 (PTK/ZK), a novel oral VEGFR TK inhibitor in recurrent glioblastoma
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002.
315 

Mateo Ziu, Nils O. Schmidt, Yanping Sun, Mitchell Albert, Peter M. Black, Rona S. Carroll
Local delivery of anti-angiogenic compounds to human orthotopic glioblastoma xenografts improves treatment efficacy and survival
Proceedings of the AACR, Volume 44, 2nd ed., July 2003, Abstract No. 6464 


Gliomas


H. A. Fine, L. Kim, C. Royce, D. Draper, I. Haggarty, H. Ellinzano, P. Albert, P. Kinney, L. Musib, D. Thornton
Results from phase II trial of Enzastaurin (LY317615) in patients with recurrent high grade gliomas
2005 ASCO Annual Meeting. Orlando, FL. May 13-17. Abstract No. 1504. 
Journal of Clinical Oncology, Vol 23, No 16S (June 1 Supplement), 2005: 1504

H. A. Fine, L. Kim, C. Royce, S. Mitchell, J. P. Duic, P. Albert, L. Musib, D. Thornton
A phase II trial of LY317615 in patients with recurrent high grade gliomas
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1511 

HA Fine, JS Loeffler, A Kyritsis, P Wen, PM Black, VA Levin, S Graham, WKA Yung
A phase II trial of the anti-angiogenic agent, thalidomide, in patients with recurrent high-grade gliomas

ASCO Proceedings, 1997 Annual Meeting, Abstract No. 1372 

Im SA, Gomez-Manzano C, Fueyo J, Liu TJ, Ke LD, Kim JS, Lee HY, Steck PA, Kyritsis AP, Yung WK
Antiangiogenesis treatment for gliomas: transfer of antisense-vascular endothelial growth factor inhibits tumor growth in vivo
Cancer Res 1999 Feb 15;59(4):895-900 (PDF Full Text)

Reardon DA, Desjardins A, Rich JN, Vredenburgh JJ
The Emerging Role of Anti-Angiogenic Therapy for Malignant Glioma
Curr Treat Options Oncol. 2008 Feb 7; [Epub ahead of print]
Abstract |
DBLinks | BL 7:4


Medulloblastoma


Grizzi F, Weber C, Di Ieva A.
Anti-angiogenic strategies in medulloblastoma: reality or mystery?
Pediatr Res. 2008 Jan 24; [Epub ahead of print]
 Abstract |
DBLinks | BL 7:6


Metastatic Tumors


Brewer GJ, Dick RD, Grover DK, LeClaire V, Tseng M, Wicha M, Pienta K, Redman BG, Jahan T, Sondak VK, Strawderman M, LeCarpentier G, Merajver SD
Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study
Clin Cancer Res 2000 Jan;6(1):1-10 (PDF Full Text)


Oligodendroglial Tumors


B. S. Abdulkarim, A. Hasbini, J. Cougnard, L. Djafari, C. Lacroix, F. Parker, C. Haie, C. Cioloca, E. Deutsch, E. Raymond
Baseline pathological and radiological assessment of tumor angiogenesis predicts survival in patients with oligodendrogliomas
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1545 

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