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Brain
Tumors
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Laura
K. Aguilar, Estuardo
Aguilar-Cordova
Evolution
of a Gene Therapy Clinical Trial
Journal of Neuro-Oncology, 65 (3): 307-315, December 2003
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Ciafré SA,
Wannenes F and Farace MG
New ribozymes targeting vegf production to
inhibit neoangiogenic potential of brain tumor cell lines
Proc. Int. Symp. "New Treatments for Brain Tumors: Gene Therapy and
Neural Stem Cells". Parma, Italy, October 17-20, 2001. Abstract No.
P-2
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P.
Hadaczek, H. Mirek, M. S. Berger, K. Bankiewicz
HSV-TK/GCV gene therapy approaches for treating
brain tumors is limited by the efficacy of gene transfer
39th ASCO Annual Meeting.
Chicago, IL. May 31-June 3, 2003.
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Paula Y.P. Lam and Xandra O.
Breakefield
Potential of gene therapy for brain tumors
Human Molecular Genetics, Volume 10, Number 7, April 1, 2001, 777-787.
(PDF Full Text)
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Terry
Lichtor, Roberta P. Glick
Cytokine
Immuno-Gene Therapy for Treatment of Brain Tumors
Journal of Neuro-Oncology, 65 (3): 247-259, December 2003
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Magrassi L, Finocchiaro G, Milanesi G, Benvenuto F,
Spadari S, Focher F
Lack
of enantioselectivity of herpes virus thymidine kinase allows safer
imaging of gene delivery
Gene Ther. 2003 Dec;10(25):2052-8
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Packer
RJ, Raffel C, Villablanca JG, Tonn JC, Burdach SE, Burger K, LaFond D,
McComb JG, Cogen PH, Vezina G, Kapcala LP
Treatment
of progressive or recurrent pediatric malignant supratentorial brain
tumors with herpes simplex virus thymidine kinase gene vector-producer
cells followed by intravenous ganciclovir administration
J Neurosurg. 2000
Feb;92(2):249-54
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Giacomo
G. Vecil, Frederick F. Lang
Clinical Trials of Adenoviruses in Brain Tumors:
A Review of Ad-p53 and Oncolytic Adenoviruses
Journal of Neuro-Oncology, 65 (3): 237-246, December 2003
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Jun
Yoshida, Masaaki Mizuno
Clinical
Gene Therapy for Brain Tumors. Liposomal Delivery of Anticancer Molecule
to Glioma
Journal of Neuro-Oncology, 65 (3): 261-267, December 2003
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Glioblastoma
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Benedetti S, Bruzzone MG, Pollo B, DiMeco F,
Magrassi L, Pirola B, Cirenei N, Colombo MP, Finocchiaro G
Eradication
of rat malignant gliomas by retroviral-mediated, in vivo delivery of the
interleukin 4 gene
Cancer Res. 1999
Feb 1;59(3):645-52.(Animal Study, Abstract & PDF Full Text)
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L.K. Csatary,
G. Gosztonyi, J. Szeberenyi, Z. Fabian, V. Liszka, B. Bodey and C.M.
Csatary
MTH-68/H oncolytic viral treatment in human
high-grade gliomas
J Neurooncol. 2004 Mar-Apr;67(1-2):83-93. (Clinical
Study, Abstract+)
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R. A. Dewey, G. Morrissey, C. M.
Cowsill, D. Stone, F. Bolognani, N.J.F. Dodd, T. D. Southgate, D. Klatzmann, H.
Lassmann, M.G. Castro & P.R. Löwenstein
Chronic brain
inflammation and persistent herpes simplex virus 1 thymidine kinase expression
in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy:
Implications for clinical trials
Nature Medicine, November 1999 Volume 5 Number 11 pp 1256 - 1263.
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Brian G. Gentry,
Paul D. Boucher, Randall J. Ruch, Donna S. Shewach
Low level GAP junction intercellular
communication results in bystander cytotoxicity and increased survival of
HSV-TK-expressing cells
Proceedings
of the AACR, Volume 44, 2nd ed., July 2003, Abstract No. 728
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A. I. Freeman,
J. M. Gomori, E. Linetsky, Z. Zakay-Rones, A. Panet, E. Libson, C. S.
Irving, E. Galun, T. Siegal
Phase I/II trial of intravenous OV001 oncolytic
virus in resistant glioblastoma multiforme (GBM)
40th
ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1515 (Clinical
Study)
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Klatzmann D, Valery CA, Bensimon G, Marro B, Boyer O, Mokhtari K,
Diquet B, Salzmann JL, Philippon J
A
phase I/II study of herpes simplex virus type 1 thymidine kinase
"suicide" gene therapy for recurrent glioblastoma. Study Group on Gene
Therapy for Glioblastoma
Hum
Gene Ther 1998 Nov 20;9(17):2595-604
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Lorico
A, Mercapide J, Soloduschko V, Alexeyev M, Fodstad O, Rappa G.
Primary neural stem/progenitor cells expressing endostatin or cytochrome
P450 for gene therapy of glioblastoma
Cancer Gene Ther. 2008 Apr 18; [Epub ahead of print]
 Abstract |
DBLinks | BL 7:9
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Nestler U, Wakimoto H, Siller-Lopez F, Aguilar LK,
Chakravarti A, Muzikansky A, Stemmer-Rachamimov A, Chiocca EA,
Aguilar-Cordova E, Hochberg FH
The combination of adenoviral HSV TK gene
therapy and radiation is effective in athymic mouse glioblastoma
xenografts without increasing toxic side effects
J Neurooncol. 2004 Mar-Apr;67(1-2):177-88. (Laboratory
Investigation, Abstract+)
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Tomoko Ozawa, Sergei M. Gryaznov, Lily J. Hu,
Krisztina Pongracz, Raquel A. Santos, Andrew W. Bollen, Kathleen R.
Lamborn, Dennis F. Deen
Antitumor effects of specific telomerase
inhibitor GRN163 in human glioblastoma xenografts
Neuro-Oncology, Vol. 6, No. 3, July
2004, 218 -- 226. (Laboratory
Investigation, Abstract+)
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Michael
D. Prados, Michael
McDermott, Susan M. Chang, Charles B. Wilson, James Fick, Kenneth W.
Culver, John Van Gilder, G. Evren Keles, Alex Spence, Mitchel
Berger
Treatment of Progressive or Recurrent
Glioblastoma Multiforme in Adults with Herpes Simplex Virus Thymidine
Kinase Gene Vector-Producer Cells Followed by Intravenous Ganciclovir
Administration: A Phase I/II Multi-Institutional Trial
Journal
of Neuro-Oncology, 65
(3): 269-278, December 2003
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Guido Wollmann, Peter
Tattersall, and Anthony N. van den Pol
Targeting Human Glioblastoma Cells:
Comparison of Nine Viruses with Oncolytic Potential
Journal of Virology, May 2005, p. 6005-6022, Vol. 79, No. 10.
(Laboratory Investigation, Abstract)
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Wongkajornsilp
A, Ouyprasertkul M, Sangruchi T, Huabprasert S, Pan Y, Tisavipat N,
Chanyavanich V, Sangruchi S, Chomsamut K, Anthony DD
The
analysis of peri-tumor necrosis following the subcutaneous implantation of
autologous tumor cells transfected with an episome transcribing an
antisense insulin-like growth factor 1 RNA in a glioblastoma multiforme
subject
J Med Assoc Thai. 2001 Dec;84 Suppl 3:S740-7 (Case
Report, Abstract)
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Guoying Zhou,
and Bernard Roizman
Construction and properties of a
herpes simplex virus 1 designed to enter cells solely via the IL-13α2
receptor
PNAS, April 4, 2006, vol. 103, no. 14. 5508-5513; Published online before
print March 22, 2006, 10.1073/pnas.0601258103
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Guoying Zhou
and Bernard
Roizman
Characterization of a Recombinant Herpes
Simplex Virus 1 Designed To Enter Cells via the IL13Rα2
Receptor of Malignant Glioma Cells
Journal of Virology, May 2005, p. 5272-5277, Vol. 79, No. 9;
doi:10.1128/JVI.79.9.5272-5277.2005
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Gliomas
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W. O. Arafat, D. Rein, D.
Buchsbaum, D. Curiel, Z. Zhu
Survivin as a novel radiation/CIS platinum/tumor
specific promoter for conditional oncolytic viral therapy
40th
ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1535 (Laboratory
Investigation)
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Gary Archer, Darell Bigner, Allan
Friedman, Henry Friedman, Amy Heimberger, and John Sampson
Induction of CD4 And CD8 T Cells to the
Tumor-Specific Antigen EGFRvIII
15th International Conference on Brain Tumor Research and Therapy.
Sorrento, Italy. May 24–27, 2003. Abstract No. 5
Neuro-Oncology, Volume 5, Issue 4, October 2003
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Ardourel
M, Blin M, Moret JL, Dufour T, Duc HT, Hevor T, Trojan J, Cloix JF.
A New Putative Target for Antisense Gene Therapy of Glioma: Glycogen
Synthase.
Cancer Biol
Ther. 2007 May 3;6(5) [Epub ahead of print]
PMID: 17426442 [PubMed - as supplied by publisher]
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Giulia Fulci, Laura
Breymann, Davide Gianni, Kazuhiko Kurozomi, Sarah
S. Rhee, Jianhua Yu, Balveen Kaur, David
N. Louis, Ralph Weissleder, Michael A. Caligiuri,
and E. Antonio Chiocca
Cyclophosphamide enhances glioma
virotherapy by inhibiting innate immune responses
PNAS, August 22, 2006, vol. 103, no. 34, 12873-12878; Published online before
print August 14, 2006, 10.1073/pnas.0605496103
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Hua C, Qiang H, Jun D, De-Zhong Z, Ai-Dong W,
Qing L
Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibits
proliferation of human glioma cells in vitro and in vivo
BMC Cancer. 2008 Jan 29;
8(1):29;
doi:10.1186/1471-2407-8-29
Abstract |
Reprint |
DBLinks | BL 7:4
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Im SA, Gomez-Manzano C, Fueyo J, Liu TJ, Ke LD, Kim JS, Lee HY,
Steck PA, Kyritsis AP, Yung WK
Antiangiogenesis treatment for gliomas: transfer of
antisense-vascular endothelial growth factor inhibits tumor growth in vivo
Cancer Res
1999 Feb 15;59(4):895-900 (Animal Study, Abstract & PDF Full Text)
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Geoerger B, Vassal G, Opolon P, Dirven CM, Morizet J, Laudani L, Grill J,
Giaccone G, Vandertop WP, Gerritsen WR, van Beusechem VW
Oncolytic activity of p53-expressing conditionally
replicative adenovirus AdDelta24-p53 against human malignant glioma
Cancer Res. 2004 Aug 15;64(16):5753-9. (Laboratory Investigation,
Abstract)
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Isabelle
M. Germano, Jennifer
Fable, S.
Humayun Gultekin, Adam
Silvers
Adenovirus/Herpes Simplex-Thymidine
Kinase/Ganciclovir Complex: Preliminary Results of a Phase I trial in
Patients with Recurrent Malignant Gliomas
Journal of Neuro-Oncology, 65 (3): 279-289, December 2003
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Hideaki Ito, Hiroshi
Aoki, Florian Kühnel, Yasuko Kondo, Stefan
Kubicka, Thomas Wirth, Eiji Iwado, Arifumi
Iwamaru, Keishi Fujiwara, Kenneth R. Hess,
Frederick F. Lang, Raymond Sawaya, Seiji
Kond
Autophagic
Cell Death of Malignant Glioma Cells Induced by a Conditionally
Replicating Adenovirus
Journal of the National Cancer Institute, Vol. 98, No. 9, 625-636, May 3,
2006; DOI: 10.1093/jnci/djj161
Abstract
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News
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A.H.
Jacobs, J.
Voges, L.W.
Kracht, C.
Dittmar, A.
Winkeler, A.
Thomas, K.
Wienhard, K.
Herholz, W.D.
Heiss
Imaging
in Gene Therapy of Patients with Glioma
Journal
of Neuro-Oncology, 65
(3): 291-305, December 2003 (Clinical
Study Design, Abstract)
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Hirokazu Kambara, Yoshinaga
Saeki and E. Antonio Chiocca
Cyclophosphamide Allows for In vivo
Dose Reduction of a Potent Oncolytic Virus
Cancer Research 65, 11255-11258, December 15, 2005
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Hirokazu Kambara,
Hideyuki Okano, E. Antonio Chiocca
and Yoshinaga Saeki
An Oncolytic HSV-1 Mutant Expressing
ICP34.5 under Control of a Nestin Promoter Increases Survival of Animals
even when Symptomatic from a Brain Tumor
Cancer Research 65, 2832-2839, April 1, 2005
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Kazuhiko
Kurozumi, Takashi Tamiya, Yasuhiro Ono, Shinji Otsuka, Hirokazu
Kambara, Yoshiaki Adachi, Tomotsugu Ichikawa, Hirofumi Hamada and Takashi
Ohmoto
Apoptosis
induction with 5-fluorocytosine/cytosine deaminase gene therapy for human
malignant glioma cells mediated by adenovirus
Journal of Neuro-Oncology 66: 117–127,
January 2004. (Laboratory Investigation, Abstract+)
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Shaoyi
Li, Yun Gao, Tsutomu Tokuyama,
Junkoh Yamamoto, Naoki Yokota, Seiji Yamamoto, Susumu Terakawa, Masatoshi
Kitagawa and Hiroki Namba
Genetically engineered neural
stem cells migrate and suppress glioma cell growth at distant intracranial
sites
Cancer Lett. 2006 Dec 28; [Epub ahead of
print]
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Shaoyi
Li, Tsutomu Tokuyama, Junkoh Yamamoto, Masayo Koide, Naoki Yokota,
Hiroki Namba
Potent Bystander Effect in
Suicide Gene Therapy Using Neural Stem Cells Transduced with Herpes
Simplex Virus Thymidine Kinase Gene
Oncology. 2005;69(6):503-8. Epub 2006 Jan 16
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Ly
A, Duc HT, Kalamarides M, Trojan LA, Pan Y, Shevelev A, Francois JC,
Noel T, Kane A, Henin D, Anthony DD, Trojan J
Human
glioma cells transformed by IGF-I triple helix technology show immune and
apoptotic characteristics determining cell selection for gene therapy of
glioblastoma
Mol Pathol. 2001 Aug;54(4):230-9
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Melinda K. Merrill, Guenter Bernhardt, John H. Sampson,
Carol J. Wikstrand, Darell D. Bigner, Matthias Gromeier
Poliovirus receptor
CD155-targeted oncolysis of glioma
Neuro-Oncology, Vol. 6, No. 3, July
2004, 208 -- 217. (Abstract+)
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Miletic H, Fischer YH, Giroglou T, Rueger MA,
Winkeler A, Li H, Himmelreich U, Stenzel W, Jacobs AH, von Laer D.
Normal Brain Cells Contribute to the Bystander Effect
in Suicide Gene Therapy of Malignant Glioma.
Clin Cancer Res. 2007 Nov 15;13(22):6761-6768.
Abstract
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DBLinks
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Papanastassiou V, Rampling R, Fraser M,
Petty
R, Hadley D, Nicoll J, Harland J, Mabbs R, Brown M
The potential for efficacy of the
modified (ICP 34.5(-)) herpes simplex virus HSV1716 following
intratumoural injection into human malignant glioma: a proof of
principle study
Gene Ther. 2002 Mar;9(6):398-406.
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Nikolai
G. Rainov, Huan
Ren
Clinical Trials with Retrovirus Mediated Gene
Therapy – what Have we Learned?
Journal of Neuro-Oncology, 65 (3): 227-236, December 2003
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Amish
C. Shah, Dale
Benos, G.
Yancey Gillespie, James
M. Markert
Oncolytic
Viruses: Clinical Applications as Vectors for the Treatment of Malignant Gliomas
Journal
of Neuro-Oncology, 65
(3): 203-226, December 2003
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Sabine
Steffens, Jessica Tebbets, Christof M. Kramm, Dirk
Lindemann, Alan
Flake, Miguel Sena-Esteves
Transduction
of human glial and neuronal tumor cells with different lentivirus vector
pseudotypes
J
Neurooncol,
70(3):
281-288, December 2004. (Abstract+)
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Arabel
Vollmann, Hans-Peter Vornlocher, Anke Geick, Thilo Spruss, Rainer
Apfel, Gerhard Giegerich, Ulrich Bogdahn
RNAi
mediated effective inhibition of EGFP and EGF-R gene expression in
malignant glioma
Proceedings of the AACR, Volume 44, 2nd ed., July 2003, Abstract No. 737
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