BRAINLIFE Brain Tumor Medical Database

Immunotherapy

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Astrocytic Tumors


Facoetti A, Nan R, Zelini P, Morbini P, Benericetti E, Ceroni M, Campoli M, Ferrone S
Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors
Clin Cancer Res. 2005 Dec 1;11(23):8304-11


Brain Tumors


David M. Ashley, Brenda Faiola, Smita Nair, Laura P. Hale, Darell D. Bigner, and Eli Gilboa
Bone Marrow-generated Dendritic Cells Pulsed with Tumor Extracts or Tumor RNA Induce Antitumor Immunity against Central Nervous System Tumors
J. Exp. Med., Volume 186, Number 7, October 6, 1997 1177-1182

Abstract | Full Text | Reprint

Denise A. Caruso, Lisa M. Orme, Alana M. Neale, Fiona J. Radcliff, Gerlinda M. Amor, Wirginia Maixner, Peter Downie, Timothy E. Hassall, Mimi L.K. Tang, David M. Ashley
Results of a phase 1 study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children and young adults with brain cancer
Neuro-Oncology, Vol. 6, No. 3, July 2004, 236 -- 246. (Abstract+)

German G. Gomez, Susana B. Read, Lazaro E. Gerschenson, Daniela Santoli, Adam Zweifach, Carol A. Kruse
Interactions of the allogeneic effector leukemic T cell line, TALL-104, with human malignant brain tumors
Neuro-Oncology, April 2004, Volume 6, Number 2, Pages 83 – 95 (Abstract+)

Peter E. Fecci, Duane A. Mitchell, Gary E. Archer, Michael A. Morse, H. Kim Lyerly, Darell D. Bigner and John H. Sampson
The History, Evolution, and Clinical use of Dendritic Cell-Based Immunization Strategies in the Therapy of Brain Tumors
J Neurooncol. 2003 Aug-Sep;64(1-2):161-76. Epub 2004 Oct 31
Abstract | Reprint

Maciej S. Lesniak, Patrick Gabikian, Betty M. Tyler, Drew M. Pardoll, Henry Brem
Dexamethasone Mediated Inhibition of Local IL-2 Immunotherapy is Dose Dependent in Experimental Brain Tumors
J Neurooncol,
70 (1): 23-28, Oct 2004. (Abstract+)

Christoph Mamot, Daryl C Drummond, Keelung Hong, Dmitri B Kirpotin, James D Marks, John Nguyen, Krys Bankiewicz, Mitchel Berger, John W Park
Development of immunoliposomes for brain tumor treatment
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002. Abstract No. 287


Prins RM, Shu CJ, Radu CG, Vo DD, Khan-Farooqi H, Soto H, Yang MY, Lin MS, Shelly S, Witte ON, Ribas A, Liau LM
Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain
Cancer Immunol Immunother. 2008 Feb 6; [Epub ahead of print]
Abstract

Prins, Robert M. Ph.D.; Bruhn, Kevin W. Ph.D.; Craft, Noah M.D., Ph.D.; Lin, Jia Wei M.D.; Kim, Choong-Hyun M.D., Ph.D.; Odesa, Sylvia K. B.S.; Miller, Jeff F. Ph.D.; Liau, Linda M. M.D., Ph.D.
Central Nervous System Tumor Immunity Generated by a Recombinant Listeria monocytogenes Vaccine Targeting Tyrosinase Related Protein-2 and Real-Time Imaging of Intracranial Tumor Burden
Neurosurgery. 58(1):169-178, January 2006
Abstract

Patrizia Tunici, Ph.D., Dwain Irvin, Ph.D., M.P.H., Gentao Liu, Ph.D., Xiangpeng Yuan, Ph.D., Zeng Zhaohui, Ph.D., Hiushan Ng, M.S., and John S. Yu, M.D.
Brain tumor stem cells: new targets for clinical treatments?
Neurosurg Focus 20 (4):E27, April 2006
Abstract | Full Text | Reprint


Cancer Research


Amy M. Hicks, Gregory Riedlinger, Mark C. Willingham, Martha A. Alexander-Miller, C. Von Kap-Herr, Mark J. Pettenati, Anne M. Sanders, Holly M. Weir, Wei Du, Joseph Kim, Andrew J. G. Simpson, Lloyd J. Old, and Zheng Cui
Transferable anticancer innate immunity in spontaneous regression/complete resistance mice
PNAS
, May 16, 2006, vol. 103 no. 20, pp. 7753-7758; Published online before print May 8, 2006, 10.1073/pnas.0602382103
Abstract | Full Text | Reprint |
News

Zhiya Yu and Nicholas P. Restifo
Cancer vaccines: progress reveals new complexities
J. Clin. Invest. 110:289-294 (1 August 2002)
  Abstract |   Full Text |   Reprint


Choroid Plexus Tumors


Timothy J, Chumas P, Chakrabarty A, Drake JM, Morrison E
Destruction of choroid plexus cells in vitro: a new concept for the treatment of hydrocephalus
Neurosurgery. 2004 Mar;54(3):727-32


Glioblastoma


Aghi M, Rabkin S, Martuza RL.
Effect of Chemotherapy-Induced DNA Repair on Oncolytic Herpes Simplex Viral Replication
Journal of the National Cancer Institute, Vol. 98, No. 1, 38-50, January 4, 2006
  Abstract |   News

Bryant NL, Suarez-Cuervo C, Gillespie GY, Markert JM, Nabors LB, Meleth S, Lopez RD, Lamb LS Jr
Characterization and immunotherapeutic potential of {gamma}{delta} T cells in patients with glioblastoma
Neuro Oncol. 2009 Feb 11; [Epub ahead of print]
  Abstract

Chamberlain MC.
How Fine a Slice: Treatment of Newly Diagnosed Glioblastoma With an Epidermal Growth Factor Receptor Variant III Peptide Vaccine.
J Clin Oncol. 2011 May 9;. [Epub ahead of print]
  Abstract |   Reprint |   Related articles

Cho DY, Yang WK, Lee HC, Hsu DM, Lin HL, Lin SZ, Chen CC, Harn HJ, Liu CL, Lee WY, Ho LH.
Adjuvant Immunotherapy with Whole-Cell Lysate Dendritic Cells Vaccine for Glioblastoma Multiforme: A Phase II Clinical Trial.
World Neurosurg. 2011 Nov 7;. [Epub ahead of print]
  Abstract |   Related articles

Finocchiaro G, Pellegatta S.
Immunotherapy for glioma: getting closer to the clinical arena?
Curr Opin Neurol. 2011 Dec;24(6):641-7.
  Abstract |   Related articles

Jean WC, Spellman SR, Wallenfriedman MA, Flores CT, Kurtz BP, Hall WA, Low WC
Effects of combined granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-2, and interleukin-12 based immunotherapy against intracranial glioma in the rat
J Neurooncol. 2004 Jan;66(1-2):39-49. (Abstract+)

Katakura R, Suzuki Y, Sekine T, Sasaki YF, Fujimiya Y
Therapeutic Efficacy of Adoptive Cell Transfer on Survival of Patients with Glioblastoma Multiforme: Case Reports
Case Rep Oncol. 2010 Apr 28;3(2):110-124
  Abstract |   Full Text |   Reprint


Keller DM
Vaccine Made of Glioblastoma Lysate Prolongs Survival.
Report on the intervention of Isaac Yang, MD at the
American Association of Neurological Surgeons (AANS) 79th Annual Meeting: Plenary Session I. Presented April 11, 2011, and of a comment of Andrew Parsa, MD, PhD. on Dr. Yang's study.
  Report |
  News

Lesniak MS.
Immunotherapy for Glioblastoma: The Devil Is in the Details.
J Clin Oncol. 2011 Jun 27. [Epub ahead of print]
  Abstract |   Reprint |   Related articles

Lowenstein PR, Geffen D.
Cancer Vaccines in Glioma: How to Balance the Challenges of Small Trials, Efficiency, and Potential Adverse Events.
J Clin Oncol. 2010 Oct 4;. [Epub ahead of print]
  Abstract |   Full Text |   Reprint |   Related articles

Ma YH, Yu JB, Yao HP, Zhan RY, Zheng JS
Treatment of intracerebral glioblastomas with g422 tumour cell vaccine in a mouse model
J Int Med Res. 2008 Mar-Apr;36(2):308-13
  Abstract |   Reprint

McBride WH.
Integration of adenovirus thymidine kinase suicide-gene therapy with surgery and radiation therapy for malignant glioma.
Future Oncol. 2012 Jan;8(1):17-20.
  Abstract |   Related articles

Motomura K, Natsume A, Kishida Y, Higashi H, Kondo Y, Nakasu Y, Abe T, Namba H, Wakai K, Wakabayashi T.
Benefits of interferon-β and temozolomide combination therapy for newly diagnosed primary glioblastoma with the unmethylated MGMT promoter: a multicenter study.
Cancer. 2010 Nov 8. [Epub ahead of print]
  Abstract |   Related articles

Muragaki Y, Maruyama T, Iseki H, Tanaka M, Shinohara C, Takakura K, Tsuboi K, Yamamoto T, Matsumura A, Matsutani M, Karasawa K, Shimada K, Yamaguchi N, Nakazato Y, Sato K, Uemae Y, Ohno T, Okada Y, Hori T.
Phase I/IIa trial of autologous formalin-fixed tumor vaccine concomitant with fractionated radiotherapy for newly diagnosed glioblastoma.
J Neurosurg. 2011 May 13;. [Epub ahead of print]
  Abstract |   Related articles

Akihiro Otsuki, Suzanne Camilli, Ankita Patel, Shigeru Tanaka, E. Antonio Chiocca, and Yoshinaga Saeki
Characterizing an oncolytic virotherapy targeted towards brain tumor stem cells
AACR Meeting Abstracts, Apr 2006; 2006: 703
  Abstract

Ian F. Parney, Lung-Ji Chang, Maxine A. Farr-Jones, Chunhai Hao, Michael Smylie and Kenneth C. Petruk
Technical hurdles in a pilot clinical trial of combined B7-2 and GM-CSF immunogene therapy for glioblastomas and melanomas J Neurooncol. 2006 May;78(1):71-80. Epub 2006 Apr 21. DOI: 10.1007/s11060-005-9058-0
Abstract

Pellegatta S, Poliani PL, Stucchi E, Corno D, Colombo CA, Orzan F, Ravanini M, Finocchiaro G.
Intra-tumoral dendritic cells increase efficacy of peripheral vaccination by modulation of glioma microenvironment
Neuro Oncol. 2010 Apr;12(4):377-88. Epub 2010 Jan 6
  Abstract

Pellegatta, S., Poliani, P.L., Corno, D., Grisoli, M., Cusimano, M., Ubiali, F., Baggi, F., Bruzzone, M.G., Finocchiaro, G.
Dendritic cells pulsed with glioma lysates induce immunity against syngeneic intracranial gliomas and increase survival of tumor-bearing mice
Neurological Research, Volume 28, Number 5, July 2006, pp. 527-531(5)

Prins RM, Soto H, Konkankit V, Odesa SK, Eskin A, Yong WH, Nelson SF, Liau LM.
Gene expression profile correlates with T cell infiltration and survival in glioblastoma patients vaccinated with dendritic cell immunotherapy.
Clin Cancer Res. 2010 Dec 6. [Epub ahead of print]
  Abstract |   Related articles |   News

Stéphan Saikali, Tony Avril, Brigitte Collet, Abderrahmane Hamlat, Jean-Yves Bansard, Bernard Drenou, Yvon Guegan and Véronique Quillien 
Expression of nine tumour antigens in a series of human glioblastoma multiforme: interest of EGFRvIII, IL-13Rα2, gp100 and TRP-2 for immunotherapy
J Neurooncol. 2006 Sep 27; [Epub ahead of print]
Abstract

Sakamoto N, Ishikawa E, Yamamoto T, Satomi K, Nakai K, Sato M, Enomoto T, Morishita Y, Takano S, Ohno T, Tsuboi K, Matsumura A.
Pathological changes after autologous formalin-fixed tumor vaccine therapy combined with temozolomide for glioblastoma.
Neurol Med Chir (Tokyo). 2011;51(4):319-25.
Release date 2011 Apr 25.
  Abstract |   Reprint |   Related articles

Schneider T, Gerhards R, Kirches E, Firsching R
Preliminary results of active specific immunization with modified tumor cell vaccine in glioblastoma multiforme
J Neurooncol 2001 May;53(1):39-46

Söderlund J, Erhardt S, Kast RE.
Acyclovir inhibition of IDO to decrease Tregs as a glioblastoma treatment adjunct.
J Neuroinflammation. 2010 Aug 6;7:44.
  Abstract |   Reprint |
  Related articles

Van Gool S, Maes W, Ardon H, Verschuere T, Van Cauter S, De Vleeschouwer S
Dendritic cell therapy of high-grade gliomas
Brain Pathol. 2009 Oct;19(4):694-712. Published Online: 4 Sep 2009
  Abstract |   Full Text |   Reprint

Vauleon E, Avril T, Collet B, Mosser J, Quillien V.
Overview of cellular immunotherapy for patients with glioblastoma.
Clin Dev Immunol. 2010;2010. Published online 2010 October 4.
  Abstract |   Full Text |   Reprint |   Related articles

Wheeler CJ
Dendritic cell vaccines to combat glioblastoma
Expert Rev Neurother. 2010 Apr;10(4):483-6
  Abstract |   Full Text |   Reprint

Wheeler CJ, Black KL, Liu G, Mazer M, Zhang XX, Pepkowitz S, Goldfinger D, Ng H, Irvin D, Yu JS
Vaccination elicits correlated immune and clinical responses in glioblastoma multiforme patients
Cancer Res. 2008 Jul 15;68(14):5955-64
  Abstract |   Reprint

Christopher J. Wheeler, Asha Das, Gentao Liu, John S. Yu and Keith L. Black
Clinical Responsiveness of Glioblastoma Multiforme to Chemotherapy after Vaccination
Clinical Cancer Research Vol. 10, 5316-5326, August 15, 2004

Wu A, Oh S, Gharagozlou S, Vedi RN, Ericson K, Low WC, Chen W, Ohlfest JR
In Vivo Vaccination With Tumor Cell Lysate Plus CpG Oligodeoxynucleotides Eradicates Murine Glioblastoma
J Immunother (1997). 2007 November/December;30(8):789-797
Abstract

Wu AH, Hall WA, Low WC.
Identification of HLA a*0201 glioblastoma multiforme cell lines for immunotherapy by PCR-SSP and DNA sequencing
J Neurooncol. 2004 Jan;66(1-2):1-8. (Abstract+)

Recurrent Tumors


De Vleeschouwer S, Fieuws S, Rutkowski S, Van Calenbergh F, Van Loon J, Goffin J, Sciot R, Wilms G, Demaerel P, Warmuth-Metz M, Soerensen N, Wolff JE, Wagner S, Kaempgen E, Van Gool SW
Postoperative adjuvant dendritic cell-based immunotherapy in patients with relapsed glioblastoma multiforme
Clin Cancer Res. 2008 May 15;14(10):3098-104
 Abstract

R. O. Dillman, C. Duma, P. M. Schiltz, C. Depriest, L. Beutel, K. Okamoto, C. De Leon
Intracavitary placement of lymphokine-activated killer (LAK) cells after resection of recurrent glioblastoma
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003.
Abstract No. 434

Prins RM, Soto H, Konkankit V, Odesa SK, Eskin A, Yong WH, Nelson SF, Liau LM.
Gene expression profile correlates with T cell infiltration and survival in glioblastoma patients vaccinated with dendritic cell immunotherapy.
Clin Cancer Res. 2010 Dec 6. [Epub ahead of print]
  Abstract |   Related articles

Terasaki M, Shibui S, Narita Y, Fujimaki T, Aoki T, Kajiwara K, Sawamura Y, Kurisu K, Mineta T, Yamada A, Itoh K.
Phase I Trial of a Personalized Peptide Vaccine for Patients Positive for Human Leukocyte Antigen-A24 With Recurrent or Progressive Glioblastoma Multiforme.
J Clin Oncol. 2010 Dec 13. [Epub ahead of print]
  Abstract |
  Related articles


Gliomas


Amano T, Kajiwara K, Yoshikawa K, Morioka J, Nomura S, Fujisawa H, Kato S, Fujii M, Fukui M, Hinoda Y, Suzuki M.
Antitumor effects of vaccination with dendritic cells transfected with modified receptor for hyaluronan-mediated motility mRNA in a mouse glioma model.
J Neurosurg. 2007 Apr;106(4):638-45.
PMID: 17432716 [PubMed - in process]


Koji Adachi
Synergistic Antiglioma Activity of  Interleukin-12 and Interleukin-18
15th International Conference on Brain Tumor Research and Therapy. Sorrento, Italy. May 24–27, 2003. Abstract No. 1
Neuro-Oncology, Volume 5, CNO 4, October 2003

Barba D, Saris SC, Holder C, Rosenberg SA, Oldfield EH
Intratumoral LAK cell and interleukin-2 therapy of human gliomas
J Neurosurg. 1989 Feb; 70(2): 175-82

Ciesielski MJ, Apfel L, Barone TA, Castro CA, Weiss TC, Fenstermaker RA
Antitumor effects of a xenogeneic survivin bone marrow derived dendritic cell vaccine against murine GL261 gliomas
Cancer Immunol Immunother. 2006 Dec;55(12):1491-503. Epub 2006 Feb 17
 Abstract

K. M. Dhodapkar, B. Cirignano, J. L. Finlay, R. M. Steinman
Invariant natural killer T cells are preserved in patients with glioma and exhibit anti-tumor lytic activity
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003.
Abstract No. 398

Friese MA, Platten M, Lutz SZ, Naumann U, Aulwurm S, Bischof F, Buhring HJ, Dichgans J, Rammensee HG, Steinle A, Weller M
MICA/NKG2D-mediated immunogene therapy of experimental gliomas
Cancer Res. 2003 Dec 15;63(24):8996-9006

Grauer OM, Sutmuller RP, van Maren W, Jacobs JF, Bennink E, Toonen LW, Nierkens S, Adema GJ.
Elimination of regulatory T cells is essential for an effective vaccination with tumor lysate-pulsed dendritic cells in a murine glioma model
Int J Cancer. 2007 Dec 12; [Epub ahead of print]
Abstract

Jinwei Hu, Xiangpeng Yuan, Maria L. Belladonna, John M. Ong, Sebastian Wachsmann-Hogiu, Daniel L. Farkas, Keith L. Black and John S. Yu
Induction of Potent Antitumor Immunity by Intratumoral Injection of Interleukin 23–Transduced Dendritic Cells
Cancer Research 66, 8887-8896, September 1, 2006
  Abstract |   News

Ulrich Herrlinger, Steffen Aulwurm, Herwig Strik, Simone Weit, Ulrike Naumann and Michael Weller
MIP-1α antagonizes the effect of a GM-CSF-enhanced subcutaneous vaccine in a mouse glioma model
Journal of Neuro-Oncology 66: 147–154, January
2004. (Abstract+)

Kjaergaard J, Wang LX, Kuriyama H, Shu S, Plautz GE
Active immunotherapy for advanced intracranial murine tumors by using dendritic cell-tumor cell fusion vaccines
J Neurosurg. 2005 Jul;103(1):156-64

Liau LM, Black KL, Prins RM, Sykes SN, DiPatre PL, Cloughesy TF, Becker DP, Bronstein JM
Treatment of intracranial gliomas with bone marrow-derived dendritic cells pulsed with tumor antigens
J Neurosurg 1999 Jun;90(6):1115-24

Maatta AM, Liimatainen T, Wahlfors T, Wirth T, Vaha-Koskela M, Jansson L, Valonen P, Hakkinen K, Rautsi O, Pellinen R, Makinen K, Hakumaki J, Hinkkanen A, Wahlfors J. 
Evaluation of cancer virotherapy with attenuated replicative Semliki forest virus in different rodent tumor models.
Int J Cancer. 2007 Apr 18; [Epub ahead of print]
PMID: 17443493 [PubMed - as supplied by publisher]


Morioka J, Kajiwara K, Yoshikawa K, Ideguchi M, Uchida T, Suzuki M
Vaccine therapy for murine glioma using tumor cells genetically modified to express b7.1
Neurosurgery. 2004 Jan;54(1):182-90

Newcomb EW, Demaria S, Lukyanov Y, Shao Y, Schnee T, Kawashima N, Lan L, Dewyngaert JK, Zagzag D, McBride WH, Formenti SC
The combination of ionizing radiation and peripheral vaccination produces long-term survival of mice bearing established invasive GL261 gliomas
Clin Cancer Res. 2006 Aug 1;12(15):4730-7
  Abstract |   Full Text |   Reprint

Okada H, Pollack IF.
Do we need novel radiologic response criteria for brain tumor immunotherapy?
Expert Rev Neurother. 2011 May;11(5):619-22.
  Abstract |   Reprint |   Related articles

Prins RM, Odesa SK, Liau LM
Immunotherapeutic Targeting of Shared Melanoma-Associated Antigens in a Murine Glioma Model
Cancer Res. 2003 Dec 1;63(23):8487-8491

Shah AC, Parker JN, Gillespie GY, Lakeman FD, Meleth S, Markert JM, Cassady KA.
Enhanced antiglioma activity of chimeric HCMV/HSV-1 oncolytic viruses.
Gene Ther. 2007 Apr 12; [Epub ahead of print]
PMID: 17429445 [PubMed - as supplied by publisher]

Spagnolo A, Glick RP, Lin H, Cohen EP, Feinstein DL, Lichtor T
Prolonged survival of mice with established intracerebral glioma receiving combined treatment with peroxisome proliferator-activated receptor-gamma thiazolidinedione agonists and interleukin-2-secreting syngeneic/allogeneic fibroblasts
J Neurosurg. 2007 Feb;106(2):299-305
  Abstract

Vetter M, Hofer MJ, Roth E, Pircher HP, Pagenstecher A
Intracerebral Interleukin 12 Induces Glioma Rejection in the Brain Predominantly by CD8+ T Cells and Independently of Interferon-gamma
J Neuropathol Exp Neurol. 2009 May;68(5):525-34
  Abstract

Wheeler CJ, Black KL
Dendritic cell vaccines and obstacles to beneficial immunity in glioma patients
Curr Opin Mol Ther. 2005 Feb;7(1):35-47. Epub 2005 Jan 26
  Abstract 

Yamini B, Yu X, Pytel P, Galanopoulos N, Rawlani V, Veerapong J, Bickenbach K, Weichselbaum RR
Adenovirally delivered tumor necrosis factor-alpha improves the antiglioma efficacy of concomitant radiation and temozolomide therapy
Clin Cancer Res. 2007 Oct 15;13(20):6217-23
  Abstract

Xiang-Peng Yuan, Jinwei Hu, Gentao Liu, Zhaohui Zheng, Patrizia Tunici, Yasuharu Akasaki, Takayuki Yoshimoto, Keith L. Black, and John S. Yu
Neural stem cell can mediate immune therapy for brain tumor
AACR Meeting Abstracts, Apr 2006; 2006: 241
  Abstract

Xiangpeng Yuan, Jinwei Hu, Maria L. Belladonna, Keith L. Black and John S. Yu
Interleukin-23–Expressing Bone Marrow–Derived Neural Stem-Like Cells Exhibit Antitumor Activity against Intracranial Glioma
Cancer Research 66, 2630-2638, March 1, 2006
  Abstract |   News


Gliomas (High-Grade)


Chang CN, Huang YC, Yang DM, Kikuta K, Wei KJ, Kubota T, Yang WK.
A phase I/II clinical trial investigating the adverse and therapeutic effects of a postoperative autologous dendritic cell tumor vaccine in patients with malignant glioma.
J Clin Neurosci. 2011 Aug;18(8):1048-54. Epub 2011 Jun 28.
  Abstract |   Related articles

Chiocca EA, Aguilar LK, Bell SD, Kaur B, Hardcastle J, Cavaliere R, McGregor J, Lo S, Ray-Chaudhuri A, Chakravarti A, Grecula J, Newton H, Harris KS, Grossman RG, Trask TW, Baskin DS, Monterroso C, Manzanera AG, Aguilar-Cordova E, New PZ.
Phase IB Study of Gene-Mediated Cytotoxic Immunotherapy Adjuvant to Up-Front Surgery and Intensive Timing Radiation for Malignant Glioma.
J Clin Oncol. 2011 Aug 15. [Epub ahead of print]
  Abstract |   Related articles

Choi BD, Archer GE, Mitchell DA, Heimberger AB, McLendon RE, Bigner DD, Sampson JH
EGFRvIII-targeted vaccination therapy of malignant glioma
Brain Pathol. 2009 Oct;19(4):713-23
. Published Online: 4 Sep 2009
  Abstract |   Full Text |   Reprint

Grauer OM, Wesseling P, Adema GJ
Immunotherapy of diffuse gliomas: biological background, current status and future developments
Brain Pathol. 2009 Oct;19(4):674-93
. Published Online: 4 Sep 2009
  Abstract |   Full Text |   Reprint

Gromeier M, Lachmann S, Rosenfeld MR, Gutin PH, Wimmer E
Intergeneric poliovirus recombinants for the treatment of malignant glioma
Proc Natl Acad Sci U S A 2000 Jun 6;97(12):6803-8 (PDF Full Text)

Gentao Liu, Keith L Black and John S Yu
Sensitization of malignant glioma to chemotherapy through dendritic cell vaccination
Expert Review of Vaccines, Apr 2006, Vol. 5, No. 2, Pages 233-247
Abstract

Hickey MJ, Malone CC, Erickson KL, Jadus MR, Prins RM, Liau LM, Kruse CA.
Cellular and vaccine therapeutic approaches for gliomas.
J Transl Med. 2010 Oct 14;8:100.
  Abstract |   Reprint |   Related articles

Lun XQ, Jang JH, Tang N, Deng H, Head R, Bell JC, Stojdl DF, Nutt CL, Senger DL, Forsyth PA, McCart JA
Efficacy of systemically administered oncolytic vaccinia virotherapy for malignant gliomas is enhanced by combination therapy with rapamycin or cyclophosphamide
Clin Cancer Res. 2009 Apr 15;15(8):2777-88. Epub 2009 Apr 7
  Abstract

XueQing Lun, Donna L. Senger, Tommy Alain, Andra Oprea, Kelley Parato, Dave Stojdl, Brian Lichty, Anthony Power, Randal N. Johnston, Mark Hamilton, Ian Parney, John C. Bell, Peter A. Forsyth
Effects of Intravenously Administered Recombinant Vesicular Stomatitis Virus (VSVΔM51) on Multifocal and Invasive Gliomas
Journal of the National Cancer Institute, Vol. 98, No. 21, 1546-1557, November 1, 2006
Abstract | Full Text | Reprint | News

Serena Pellegatta, Pietro Luigi Poliani, Daniela Corno, Francesca Menghi, Francesco Ghielmetti, Blanca Suarez-Merino, Valentina Caldera, Sara Nava, Maria Ravanini, Fabio Facchetti, Maria Grazia Bruzzone, and Gaetano Finocchiaro
Neurospheres Enriched in Cancer Stem–Like Cells Are Highly Effective in Eliciting a Dendritic Cell–Mediated Immune Response against Malignant Gliomas
Cancer Res 2006 Nov 1; 66: 10247-10252

Plautz GE, Barnett GH, Miller DW, Cohen BH, Prayson RA, Krauss JC, Luciano M, Kangisser DB, Shu S
Systemic T cell adoptive immunotherapy of malignant gliomas
J Neurosurg 1998 Jul;89(1):42-51

Salazar AM, Levy HB, Ondra S, Kende M, Scherokman B, Brown D, Mena H, Martin N, Schwab K, Donovan D, Dougherty D, Pulliam M, Ippolito M, Graves M, Brown H, Ommaya A
Long-term treatment of malignant gliomas with intramuscularly administered polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose: an open pilot study
Neurosurgery 1996 Jun;38(6):1096-103

Smith KE, Fritzell S, Badn W, Eberstål S, Janelidze S, Visse E, Darabi A, Siesjö P
Cure of established GL261 mouse gliomas after combined immunotherapy with GM-CSF and IFNgamma is mediated by both CD8(+) and CD4(+) T-cells
Int J Cancer. 2008 Sep 9. [Epub ahead of print]
  Abstract

Christopher J. Wheeler, Asha Das, Gentao Liu, John S. Yu and Keith L. Black
Clinical Responsiveness of Glioblastoma Multiforme to Chemotherapy after Vaccination
Clinical Cancer Research Vol. 10, 5316-5326, August 15, 2004
Abstract | Full Text | Reprint

Wakabayashi T, Kayama T, Nishikawa R, Takahashi H, Hashimoto N, Takahashi J, Aoki T, Sugiyama K, Ogura M, Natsume A, Yoshida J.
A multicenter phase I trial of combination therapy with
interferon-β and temozolomide for high-grade gliomas (INTEGRA study): the final report.
J Neurooncol. 2011 Feb 14;. [Epub ahead of print]
  Abstract |   Related articles

Wakabayashi T, Kayama T, Nishikawa R, Takahashi H, Yoshimine T, Hashimoto N, Aoki T, Kurisu K, Natsume A, Ogura M, Yoshida J.
A multicenter phase I trial of interferon-beta and temozolomide combination therapy for high-grade gliomas (INTEGRA Study).
Jpn J Clin Oncol. 2008 Oct;38(10):715-8.
  Abstract |   Reprint |   Related articles

Wesseling P, Adema GJ
Immunotherapy of diffuse gliomas: helping the brain fight back!
Brain Pathol. 2009 Oct;19(4):672-3
. Published Online: 4 Sep 2009
  Abstract |   Full Text |   Reprint

Wilcox ME, Yang W, Senger D, Rewcastle NB, Morris DG, Brasher PM, Shi ZQ, Johnston RN, Nishikawa S, Lee PW, Forsyth PA
Reovirus as an oncolytic agent against experimental human malignant gliomas

J Natl Cancer Inst 2001 Jun 20;93(12):903-12

Wu A, Wiesner S, Xiao J, Ericson K, Chen W, Hall WA, Low WC, Ohlfest JR
Expression of MHC I and NK ligands on human CD133+ glioma cells: possible targets of immunotherapy
J Neurooncol. 2007 Jun;83(2):121-31. Epub 2006 Nov 1. Erratum in: J Neurooncol. 2007 Jun;83(2):133
 Abstract |  Reprint

John S. Yu, Gentao Liu, Han Ying, William H. Yong, Keith L. Black and Christopher J. Wheeler
Vaccination with Tumor Lysate-Pulsed Dendritic Cells Elicits Antigen-Specific, Cytotoxic T-Cells in Patients with Malignant Glioma
Cancer Research 64, 4973-4979, July 15, 2004

Recurrent Tumors


Hayes RL, Koslow M, Hiesiger EM, Hymes KB, Hochster HS, Moore EJ, Pierz DM, Chen DK, Budzilovich GN, Ransohoff J
Improved long term survival after intracavitary interleukin-2 and lymphokine-activated killer cells for adults with recurrent malignant glioma
Cancer 1995 Sep 1;76(5):840-52

Okada H, Kalinski P, Ueda R, Hoji A, Kohanbash G, Donegan TE, Mintz AH, Engh JA, Bartlett DL, Brown CK, Zeh H, Holtzman MP, Reinhart TA, Whiteside TL, Butterfield LH, Hamilton RL, Potter DM, Pollack IF, Salazar AM, Lieberman FS.
Induction of CD8+ T-Cell Responses Against Novel Glioma-Associated Antigen Peptides and Clinical Activity by Vaccinations With {alpha}-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma.
J Clin Oncol. 2010 Dec 13. [Epub ahead of print]
  Abstract |
  Related articles

Rampling R, Cruickshank G, Papanastassiou V, Nicoll J, Hadley D, Brennan D, Petty R, MacLean A, Harland J, McKie E, Mabbs R, Brown M
Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma
Gene Ther 2000 May;7(10):859-66

Koji Tsuboi, Kaoru Saijo, Eiichi Ishikawa, Hideo Tsurushima, Shingo Takano, Yukio Morishita and Tadao Ohno
Effects of Local Injection of ex Vivo Expanded Autologous Tumor-specific T Lymphocytes in Cases with Recurrent Malignant Gliomas
Clinical Cancer Research Vol. 9, 3294-3302, August 2003. (PDF Full Text)


Laboratory Research


Haapasalo J, Nordfors K, Jarvela S, Bragge H, Rantala I, Parkkila AK, Haapasalo H, Parkkila S. 
Carbonic anhydrase II in the endothelium of glial tumors: A potential target for therapy.
Neuro-oncol. 2007 Apr 13; [Epub ahead of print]
PMID: 17435181 [PubMed - as supplied by publisher]


Roth P, Mittelbronn M, Wick W, Meyermann R, Tatagiba M, Weller M. 
Malignant Glioma Cells Counteract Antitumor Immune Responses through Expression of Lectin-Like Transcript-1.
Cancer Res. 2007 Apr 15;67(8):3540-4.
PMID: 17440061 [PubMed - in process]



Medulloblastoma


Peter A Forsyth, Wen Qing Yang, Donna Senger, Huong Muzik, Zhong Q Shi, Penny Brasher, Richard Dyck
Reovirus oncolysis in medulloblastoma is effective in vivo and safe in rodents and primates
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002. Abstract No. 289



Neuroblastoma


A. Batova, A. L. Yu, D. Strother, P. Angelini, A. Eskenazi
Promising results of a pilot trial of a GD2 directed anti-idiotypic antibody as a vaccine for high risk neuroblastoma
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.8511

Joshi AD, Clark EM, Wang P, Munger CM, Hegde GV, Sanderson S, Dave HP, Joshi SS
Immunotherapy of human neuroblastoma using umbilical cord blood-derived effector cells
J Neuroimmune Pharmacol. 2007 Jun;2(2):202-12. Epub 2006 Oct 11
Abstract

Tahira Khan, Julie A. Hixon, Jimmy K. Stauffer, Erin Lincoln, Timothy C. Back, Jason Brenner, Stephen Lockett, Kunio Nagashima, Douglas Powell, Jon M. Wigginton
Therapeutic Modulation of Akt Activity and Antitumor Efficacy of Interleukin-12 Against Orthotopic Murine Neuroblastoma
Journal of the National Cancer Institute, Vol. 98, No. 3, 190-202, February 1, 2006
  Abstract |   News

Mario Otto, Raymond C. Barfield, William J. Martin, Rekha Iyengar, Wing Leung, Thasia Leimig, Stanley Chaleff, Stephen D. Gillies and Rupert Handgretinger
Combination Immunotherapy with Clinical-Scale Enriched Human γδ T cells, hu14.18 Antibody, and the Immunocytokine Fc-IL7 in Disseminated Neuroblastoma
Clinical Cancer Research Vol. 11, 8486-8491, December 1, 2005
  Abstract |   News


Non-CNS Tumors


Batliwalla FM, Bateman BA, Serrano D, Murray D, Macphail S, Maino VC, Ansel JC, Gregersen PK, Armstrong CA
A 15-year follow-up of AJCC stage III malignant melanoma patients treated postsurgically with Newcastle disease virus (NDV) oncolysate and determination of alterations in the CD8 T cell repertoire
Mol Med 1998 Dec;4(12):783-94

Csatary LK, Eckhardt S, Bukosza I, Czegledi F, Fenyvesi C, Gergely P, Bodey B, Csatary CM
Attenuated veterinary virus vaccine for the treatment of cancer
Cancer Detect Prev 1993;17(6):619-27

Grant SC, Kris MG, Houghton AN, Chapman PB
Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus Bacillus Calmette-Guerin
Clin Cancer Res 1999 Jun;5(6):1319-23

Pecora AL, Rizvi N, Cohen GI, Meropol NJ, Sterman D, Marshall JL, Goldberg S, Gross P, O'Neil JD, Groene WS, Roberts MS, Rabin H, Bamat MK, Lorence RM
Phase I trial of intravenous administration of PV701, an oncolytic virus, in patients with advanced solid cancers
J Clin Oncol 2002 May 1;20(9):2251-66


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