Treatment > Kinase Inhibitors


Glioblastoma


Susan E. Jones-Bolin, Hugh Zhao, Kathryn Hunter, Bruce Ruggeri
Effects of chronic oral administration of the pan VEGF-R kinase inhibitor, CEP-7055, alone and in combination with temozolomide (TMZ), on primary tumor growth, neurological dysfunction, and survival in an orthotopic model of human glioblastoma in nude mice
Proceedings of the AACR, Volume 44, 2nd ed., July 2003, Abstract No. 61


Gliomas


Qi-Wen Fan, Zachary A. Knight, David D. Goldenberg, Wei Yu, Keith E. Mostov, David Stokoe, Kevan M. Shokat, and William A. Weiss
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
Cancer Cell 9, 341–349, May 2006. DOI 10.1016/j.ccr.2006.03.029 
Abstract |
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Goldbrunner RH, Bendszus M, Wood J, Kiderlen M, Sasaki M, Tonn JC
PTK787/ZK222584, an Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Decreases Glioma Growth and Vascularization
Neurosurgery. 2004 Aug;55(2):426-32

Sandstrom M, Johansson M, Andersson U, Bergh A, Bergenheim AT, Henriksson R
The tyrosine kinase inhibitor ZD6474 inhibits tumour growth in an intracerebral rat glioma model
Br J Cancer. 2004 Aug 10 [Epub ahead of print]

 

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