Treatment > Methotrexate


Corneal Angiogenesis


Joussen AM, Kruse FE, Volcker HE, Kirchhof B
Topical application of methotrexate for inhibition of corneal angiogenesis
Graefes Arch Clin Exp Ophthalmol 1999 Nov;237(11):920-7 


Embryonal Tumors


S. J. Kellie, J. Chaku, L. Lockwood, P. O'Regan, K. D. Waters, C. K. F. Wong
Cranial radiation therapy following four courses of high-dose methotrexate: Late follow-up of MRI features of leukoencephalopathy
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003. Abstract No. 439 


Glioblastoma


Price S, Harless W, Rikhye S, Altaha R
A fatal outcome in a patient with glioblastoma multiforme after receiving high-dose methotrexate
J Oncol Pharm Pract. 2008 Mar;14(1):57-60
 Abstract |
DBLinks | BL 7:6


Gliomas


Sylvain F. Dukic, Matthieu L. Kaltenbach, Tony Heurtaux, Guillaume Hoizey, Aude Lallemand and Richard Vistelle
Influence of C6 and CNS1 brain tumors on methotrexate pharmacokinetics in plasma and brain tissue
J Neurooncol. 2004 Mar-Apr;67(1-2):131-8. (Abstract+)


Medulloblastoma


F. Spreafico, M. Massimino, L. Gandola, S. Siena, G. Cefalo, E. Mazza, P. Versari, G. Landonio, P. Pedrazzoli, F. Fossati-Bellani
Survival results in adults treated for medulloblastoma
39th ASCO Annual Meeting, Chicago IL, May 31-June 3, 2003, Abstract No. 479  

Yoshimura J, Nishiyama K, Mori H, Takahashi H, Fujii Y
Intrathecal chemotherapy for refractory disseminated medulloblastoma
Childs Nerv Syst. 2007 Dec 5; [Epub ahead of print]
Full Text | Reprint | DBLinks


Metastatic Tumors


Colleoni M, Rocca A, Sandri MT, Zorzino L, Masci G, Nole F, Peruzzotti G, Robertson C, Orlando L, Cinieri S, de BF, Viale G, Goldhirsch A
Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer: antitumor activity and correlation with vascular endothelial growth factor levels
Ann Oncol 2002 Jan;13(1):73-80 

Andrew B. Lassman, Lauren E. Abrey, Gaurav G. Shah, Katherine S. Panageas, Martin Begemann, Mark G. Malkin and Jeffrey J. Raizer
Systemic high-dose intravenous methotrexate for central nervous system metastases
J Neurooncol. 2006 Jul;78(3):255-60. Epub 2005 Dec 13
Abstract

Andrew B Lassman, Lauren E Abrey, Martin Begemann, Katherine J Picconi, Kelly Vuksanaj, Mark G Malkin, Jeffrey J Raizer
Systemic high dose methotrexate (HD MTX) for central nervous system (CNS) metastases
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002. Abstract No. 2083 

Laura Orlando, Anna Cardillo, Raffaella Ghisini, Andrea Rocca, Alessandra Balduzzi, Rosalba Torrisi, Giulia Peruzzotti, Aron Goldhirsch, Elisabetta Pietri, and Marco Colleoni
Trastuzumab in combination with metronomic cyclophosphamide and methotrexate in patients with HER-2 positive metastatic breast cancer
BMC Cancer. 2006 Sep 15;6:225
Abstract | Full Text | Reprint

M.E.M. Rentinck, H.M. Schrijver, E. Kneppers, J.C.M. Zijlmans, C.J. van Groeningen
Carcinomatous Meningitis in Cancer of the Uterine Cervix
J Neurooncol, 70(1):87-90, Oct. 2004. (Abstract+)


Malignant Lymphoma


Jacob Baram, Yonathan Goldhammer, Zvi Ram, Thomas Tichler, Dvora Nass, Raffael Catane, Raffael Pfeffer, Ilan Blatt
Any role for brain irradiation in the treatment of primary central nervous system lymphoma (PCNSL)?
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002.
 

T. Batchelor, S. Grossman, K. Carson, J. Fisher
Updated results from NABTT CNS consortium studies in primary CNS lymphoma
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1519 

P. Colombat, T. Lamy, A. Lemevel, V. Delwail, M. Gardembas, A. Brion, C. Berthou, J.-O. Bay, R. Delepine, C. Linassier
Phase II trial of high-dose chemotherapy with autologous stem cell transplantation in first-line therapy of primary central nervous system (CNS) lymphoma
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003.
Abstract No. 400 

Andrés J Ferreri, Massimo Bernardi, Stefania Dell'Oro, Alba A Brandes, Michele Reni, Fabio Ciceri, Lara M Pasetto, Michele Spina, Caterina Stelitano, Monica Balzarotti, Fiorella Ilariucci, Maurilio Ponzoni, Alberto Franzin, Romano Danesi, Eugenio Villa
CLIMT-2: an ongoing phase-II multicentre trial of MATILde chemotherapy regimen (methotrexate-cytarabine-thiotepa-idarubicin) in HIV-negative primary CNS lymphomas (PCNSL)
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002.  

K. Jahnke, A. Korfel, P. Martus, M. Weller, U. Herrlinger, L. Fischer, E. Thiel
Comparison of high-dose methotrexate (HDMTX) toxicity in elderly and younger patients (pts) with primary central nervous system lymphoma (PCNSL)
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.8041 

A. Korfel, M.R. Nowrousian Sr., D. K Hossfeld Sr., W. Weber Sr., J. Brücher, W. E Berdel Sr., J. Birkmann Sr., Ch. Peschel, R. Pasold, B. Gleissner, L. Fischer, E. Thiel
Chemotherapy +/- whole-brain irradiation (WBI) for primary CNS lymphoma (PCNSL) - first experience with a randomized trial
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002.
298 

Benjamin E Lawler, Rebecca Betensky, Fred Hochberg, Tracy Batchelor
Primary central nervous system lymphoma: the Massachusetts General Hospital experience, 1987-2001
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002. 299 

Omuro AM, Taillandier L, Chinot O, Carnin C, Barrie M, Hoang-Xuan K.
Temozolomide and methotrexate for primary central nervous system lymphoma in the elderly
J Neurooncol. 2007 Nov;85(2):207-11. Epub 2007 Sep 21
 Abstract |
DBLinks | BL 7:6

Hendrik Pels, Ingo G.H. Schmidt-Wolf, Axel Glasmacher, Holger Schulz, Andreas Engert, Volker Diehl, Anton Zellner, Gabriele Schackert, Heinz Reichmann, Frank Kroschinsky, Marlies Vogt-Schaden, Gerlinde Egerer, Udo Bode, Carlo Schaller, Martina Deckert, Rolf Fimmers, Christoph Helmstaedter, Aslihan Atasoy, Thomas Klockgether, Uwe Schlegel
Primary Central Nervous System Lymphoma: Results of a Pilot and Phase II Study of Systemic and Intraventricular Chemotherapy With Deferred Radiotherapy
Journal of Clinical Oncology, Vol 21, Issue 24 (December), 2003: 4489-4495 

Philip M.P. Poortmans, Hanneke C. Kluin-Nelemans, Hanny Haaxma-Reiche, Mars Van’t Veer, Mads Hansen, Pierre Soubeyran, Martin Taphoorn, José Thomas, Martin Van den Bent, Martin Fickers, Gustaaf Van Imhoff, Cynthia Rozewicz, Ivana Teodorovic, Martine van Glabbeke
High-Dose Methotrexate-Based Chemotherapy Followed by Consolidating Radiotherapy in Non–AIDS-Related Primary Central Nervous System Lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962
Journal of Clinical Oncology, Vol 21, Issue 24 (December), 2003: 4483-4488 

Silvani A, Salmaggi A, Eoli M, Lamperti E, Broggi G, Marras CE, Fariselli L, Milanesi I, Fiumani A, Gaviani P, Erbetta A, Giovagnoli AR, Pollo B, Botturi A, Boiardi A.
Methotrexate based chemotherapy and deferred radiotherapy for primary central nervous system lymphoma (PCNSL): single institution experience.
J Neurooncol. 2007 May;82(3):273-9. Epub 2006 Nov 17.
PMID: 17111190 [PubMed - indexed for MEDLINE]


Pediatric Brain Tumors


Maura Massimino, Lorenza Gandola, Roberto Luksch, Filippo Spreafico, Daria Riva, Carlo Solero, Felice Giangaspero, Franco Locatelli, Marta Podda, Fabio Bozzi, Emanuele Pignoli, Paola Collini, Graziella Cefalo, Marco Zecca, Michela Casanova, Andrea Ferrari, Monica Terenziani, Cristina Meazza, Daniela Polastri, Davide Scaramuzza, Fernando Ravagnani, and Franca Fossati-Bellani
Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma
Neuro-Oncology,
Volume 7, Number 1, Pages 41 -- 48, January 2005. (Abstract+)


Primary CNS Lymphoma


Igor T. Gavrilovic, Adília Hormigo, Joachim Yahalom, Lisa M. DeAngelis, Lauren E. Abrey
Long-Term Follow-Up of High-Dose Methotrexate-Based Therapy With and Without Whole Brain Irradiation for Newly Diagnosed Primary CNS Lymphoma
J Clin Oncol. 2006 Oct 1;24(28):4570-4. DOI: 10.1200/JCO.2006.06.6910

Herrlinger U, Kuker W, Uhl M, Blaicher HP, Karnath HO, Kanz L, Bamberg M, Weller M; Neuro-Oncology Working Group of the German Society
NOA-03 trial of high-dose methotrexate in primary central nervous system lymphoma: final report
Ann Neurol. 2005 Jun;57(6):843-7. 

Illerhaus G, Marks R, Ihorst G, Guttenberger R, Ostertag C, Derigs G, Frickhofen N, Feuerhake F, Volk B, Finke J.
High-dose chemotherapy with autologous stem-cell transplantation and hyperfractionated radiotherapy as first-line treatment of primary CNS lymphoma.
J Clin Oncol. 2006 Aug 20;24(24):3865-70. Epub 2006 Jul 24.
Abstract

Shah GD, Yahalom J, Correa DD, Lai RK, Raizer JJ, Schiff D, LaRocca R, Grant B, DeAngelis LM, Abrey LE.
Combined immunochemotherapy with reduced whole-brain radiotherapy for newly diagnosed primary CNS lymphoma.
J Clin Oncol. 2007 Oct 20;25(30):4730-5.
Abstract | DBLinks

 

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