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OSI-774

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Brain Tumors


Jakacki RI, Hamilton M, Gilbertson RJ, Blaney SM, Tersak J, Krailo MD, Ingle AM, Voss SD, Dancey JE, Adamson PC
Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study
J Clin Oncol. 2008 Oct 20;26(30):4921-7. Epub 2008 Sep 15
  Abstract


Glioblastoma


Brown PD, Krishnan S, Sarkaria JN, Wu W, Jaeckle KA, Uhm JH, Geoffroy FJ, Arusell R, Kitange G, Jenkins RB, Kugler JW, Morton RF, Rowland KM Jr, Mischel P, Yong WH, Scheithauer BW, Schiff D, Giannini C, Buckner JC
Phase I/II Trial Erlotinib and Temozolomide With Radiation Therapy in the Treatment of Newly Diagnosed Glioblastoma Multiforme: North Central Cancer Treatment Group Study N0177
J Clin Oncol. 2008 Oct 27. [Epub ahead of print]
  Abstract

Halatsch ME, Löw S, Hielscher T, Schmidt U, Unterberg A, Vougioukas VI
Epidermal growth factor receptor pathway gene expressions and biological response of glioblastoma multiforme cell lines to erlotinib
Anticancer Res. 2008 Nov-Dec;28(6A):3725-8
  Abstract

S. Krishnan, P. Brown, K. Ballman, J. Fiveash, J. Uhm, C. Giannini, F. Geoffroy, L. Nabors and J. Buckner
Phase I trial of erlotinib with radiation therapy (RT) in patients with glioblastoma multiforme (GBM)
2005 ASCO Annual Meeting. Orlando, FL. May 13-17. Abstract No. 1513. 
Journal of Clinical Oncology, Vol 23, No 16S (June 1 Supplement), 2005: 1513


Löw S, Vougioukas VI, Hielscher T, Schmidt U, Unterberg A, Halatsch ME
Pathogenetic pathways leading to glioblastoma multiforme: association between gene expressions and resistance to erlotinib
Anticancer Res. 2008 Nov-Dec;28(6A):3729-32
  Abstract

Peereboom DM, Shepard DR, Ahluwalia MS, Brewer CJ, Agarwal N, Stevens GH, Suh JH, Toms SA, Vogelbaum MA, Weil RJ, Elson P, Barnett GH
Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme
J Neurooncol. 2009 Dec 4. [Epub ahead of print]
  Abstract |   Full Text |   Reprint

Prados MD, Chang SM, Butowski N, Deboer R, Parvataneni R, Carliner H, Kabuubi P, Ayers-Ringler J, Rabbitt J, Page M, Fedoroff A, Sneed PK, Berger MS, McDermott MW, Parsa AT, Vandenberg S, James CD, Lamborn KR, Stokoe D, Haas-Kogan DA
Phase II Study of Erlotinib Plus Temozolomide During and After Radiation Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma
J Clin Oncol. 2008 Dec 15. [Epub ahead of print]
  Abstract

Recurrent Tumors


de Groot JF, Gilbert MR, Aldape K, Hess KR, Hanna TA, Ictech S, Groves MD, Conrad C, Colman H, Puduvalli VK, Levin V, Yung WK
Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma
J Neurooncol. 2008 Jun 26; [Epub ahead of print]
 Abstract

T. Cloughesy, A. Yung, J. Vrendenberg, K. Aldape, D. Eberhard, M. Prados, S. Vandenberg, B. Klencke and P. Mischel
Phase II study of erlotinib in recurrent GBM: Molecular predictors of outcome
2005 ASCO Annual Meeting. Orlando, FL. May 13-17. Abstract No. 1507. 
Journal of Clinical Oncology, Vol 23, No 16S (June 1 Supplement), 2005: 1507

Reardon DA, Desjardins A, Vredenburgh JJ, Gururangan S, Friedman AH, Herndon JE 2nd, Marcello J, Norfleet JA, McLendon RE, Sampson JH, Friedman HS
Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma
J Neurooncol. 2009 Jun 28. [Epub ahead of print]
  Abstract

van den Bent MJ, Brandes AA, Rampling R, Kouwenhoven MC, Kros JM, Carpentier AF, Clement PM, Frenay M, Campone M, Baurain JF, Armand JP, Taphoorn MJ, Tosoni A, Kletzl H, Klughammer B, Lacombe D, Gorlia T
Randomized Phase II Trial of Erlotinib Versus Temozolomide or Carmustine in Recurrent Glioblastoma: EORTC Brain Tumor Group Study 26034
J Clin Oncol. 2009 Feb 9. [Epub ahead of print]
  Abstract

M. A. Vogelbaum, D. Peereboom, G. Stevens, G. Barnett, C. Brewer
Phase II trial of the EGFR tyrosine kinase inhibitor erlotinib for single agent therapy of recurrent Glioblastoma Multiforme: Interim results
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1558 

A. Yung, J. Vredenburgh, T. Cloughesy, B. J. Klencke, P. S. Mischel, D. D. Bigner, K. Aldape, S. Vanderburg, M. Prados, The Accelerate Brain Cancer Cure Group
Erlotinib HCL for glioblastoma multiforme in first relapse, a phase II trial
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1555 

Yung WK, Vredenburgh JJ, Cloughesy TF, Nghiemphu P, Klencke B, Gilbert MR, Reardon DA, Prados MD.
Safety and efficacy of erlotinib in first-relapse glioblastoma: a phase II open-label study
Neuro Oncol. 2010 Jul 8;. [Epub ahead of print]
  Abstract


Gliomas


Brandes AA, Franceschi E, Tosoni A, Hegi ME, Stupp R
Epidermal growth factor receptor inhibitors in neuro-oncology: hopes and disappointments
Clin Cancer Res. 2008 Feb 15;14(4):957-60
 Abstract

Broniscer A, Baker SJ, Stewart CF, Merchant TE, Laningham FH, Schaiquevich P, Kocak M, Morris EB, Endersby R, Ellison DW, Gajjar A
Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma
Clin Cancer Res. 2009 Jan 15;15(2):701-7
  Abstract

Lassman AB, Rossi MR, Razier JR, Abrey LE, Lieberman FS, Grefe CN, Lamborn K, Pao W, Shih AH, Kuhn JG, Wilson R, Nowak NJ, Cowell JK, Deangelis LM, Wen P, Gilbert MR, Chang S, Yung WA, Prados M, Holland EC
Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from north american brain tumor consortium trials 01-03 and 00-01
Clin Cancer Res. 2005 Nov 1;11(21):7841-50

M. Prados, S. Chang, E. Burton, A. Kapadia, J. Rabbitt, M. Page, A. Federoff, S. Kelly, G. Fyfe
Phase I study of OSI-774 alone or with temozolomide in patients with malignant glioma
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003. Abstract No. 394 

Recurrent Tumors


Geoerger B, Hargrave D, Thomas F, Ndiaye A, Frappaz D, Andreiuolo F, Varlet P, Aerts I, Riccardi R, Jaspan T, Chatelut E, Le Deley MC, Paoletti X, Saint-Rose C, Leblond P, Morland B, Gentet JC, Méresse V, Vassal G.
Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors.
Neuro Oncol. 2010 Oct 25;. [Epub ahead of print]
  Abstract |   Related articles

J. J. Raizer, L. E. Abrey, P. Wen, T. Cloughesy, I. A. Robins, H. A. Fine, F. Lieberman, V. K. Puduvalli, K. L. Fink, M. Prados
A phase II trial of erlotinib (OSI-774) in patients (pts) with recurrent malignant gliomas (MG) not on EIAEDs
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1502 

Sathornsumetee S, Desjardins A, Vredenburgh JJ, McLendon RE, Marcello J, Herndon JE, Mathe A, Hamilton M, Rich JN, Norfleet JA, Gururangan S, Friedman HS, Reardon DA.
Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma
Neuro Oncol. 2010 Aug 17;. [Epub ahead of print]
  Abstract


Hemangioblastoma


Lisa R Rogers, William Kaelin, Paul Nadler, Anthony F Shields, Patricia LoRusso
Response of cerebellar hemangioblastomas associated with von Hippel-Lindau disease to OSI-774 (TarcevaTM)
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002. Abstract No. 2111


Meningioma


Norden AD, Raizer JJ, Abrey LE, Lamborn KR, Lassman AB, Chang SM, Yung WK, Gilbert MR, Fine HA, Mehta M, Deangelis LM, Cloughesy TF, Robins HI, Aldape K, Dancey J, Prados MD, Lieberman F, Wen PY
Phase II trials of erlotinib or gefitinib in patients with recurrent meningioma
J Neurooncol. 2009 Jun 28. [Epub ahead of print]
  Abstract


Metastatic Tumors


Altavilla G, Arrigo C, Santarpia MC, Galletti G, Picone G, Marabello G, Tomasello C, Pitini VV
Erlotinib therapy in a patient with non-small-cell lung cancer and brain metastases
J Neurooncol. 2008 Jun 20. [Epub ahead of print]
 Abstract

Costa DB, Kobayashi S
Response of intracranial metastases to epidermal growth factor receptor tyrosine kinase inhibitors: it may all depend on EGFR mutations
J Clin Oncol. 2008 Feb 1;26(4):686.
 Abstract |  Full Text |  Reprint

Fekrazad MH, Ravindranathan M, Jones DV Jr.
Response of intracranial metastases to erlotinib therapy
J Clin Oncol. 2007 Nov 1;25(31):5024-6
 Abstract |  Full Text |  Reprint

Lind JS, Lagerwaard FJ, Smit EF, Senan S
Phase I Study of Concurrent Whole Brain Radiotherapy and Erlotinib for Multiple Brain Metastases from Non-Small-Cell Lung Cancer
Int J Radiat Oncol Biol Phys. 2009 Mar 14. [Epub ahead of print]
  Abstract

Olmez I, Donahue BR, Butler JS, Huang Y, Rubin P, Xu Y.
Clinical outcomes in extracranial tumor sites and unusual toxicities with concurrent whole brain radiation (WBRT) and Erlotinib treatment in patients with non-small cell lung cancer (NSCLC) with brain metastasis
Lung Cancer. 2010 Mar 5;. [Epub ahead of print]
  Abstract

Lung Cancer


Zhao J, Fu Q, Zhang L.
A Clinical Observation of Concomitant Therapy of Erlotinib and Whole Brain Radiotherapy in Patients of NSCLC Combined with Brain Metastases
Zhongguo Fei Ai Za Zhi (Chinese Journal of Lung Cancer). 2009 Dec 20;12(12):1291-4. Chinese
  Abstract |   Full Text |   Reprint

 

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