Treatment > PCV


Astrocytic Tumors


Alba A. Brandes, Linda Nicolardi, Alicia Tosoni, Marina Gardiman, Paolo Iuzzolino, Claudio Ghimenton, Michele Reni, Antonino Rotilio, Guido Sotti and Mario Ermani
Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma
Abstract | Full Text | Reprint

Marc Frenay, C Lebrun, D Fontaine, V Bourg, A Ramaioli, PY Marcy, F Peyrade, JF Michiels
First-line chemotherapy in non resectable low-grade astrocytomas in adults

38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002. Abstract No.
2095  

Medical Research Council Brain Tumor Working Party
Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: a Medical Research Council trial

J Clin Oncol 2001 Jan 15;19(2):509-18 (
PDF Full Text)

Prados MD, Scott C, Sandler H, Buckner JC, Phillips T, Schultz C, Urtasun R, Davis R, Gutin P, Cascino TL, Greenberg HS, Curran WJ Jr
A phase 3 randomized study of radiotherapy plus procarbazine, CCNU, and vincristine (PCV) with or without BUdR for the treatment of anaplastic astrocytoma: a preliminary report of RTOG 9404
Int J Radiat Oncol Biol Phys. 1999 Dec 1;45(5):1109-15 

Michael D. Prados, Charles Scott, Walter J. Curran, Jr, Diana F. Nelson, Steve Leibel, Simon Kramer
Procarbazine, Lomustine, and Vincristine (PCV) Chemotherapy for Anaplastic Astrocytoma: A Retrospective Review of Radiation Therapy Oncology Group Protocols Comparing Survival With Carmustine or PCV Adjuvant Chemotherapy
Journal of Clinical Oncology, Vol 17, Issue 11 (November 1), 1999: 3389-3395. (PDF Full Text)


Gliomas


M Brada, DG Thomas, NM Bleehen, JT Roberts, F Senanayake, P Abram, PL Lantos, TH Moss, JW Ironside, JB Whaley, SP Stenning
Medical Research Council (MRC) Randomised Trial of Adjuvant Chemotherapy in High Grade Glioma (HGG)

ASCO Proceedings, 1998 Annual Meeting, Abstract No. 1543 


Chamberlain MC, Jaeckle KA
Medical Research Council adjuvant trial in high-grade gliomas
J Clin Oncol 2001 Oct 1;19(19):3997-9 (
PDF Full Text)

Levin VA, Hess KR, Choucair A, Flynn PJ, Jaeckle KA, Kyritsis AP, Yung WK, Prados MD, Bruner JM, Ictech S, Gleason MJ, Kim HW
Phase III randomized study of postradiotherapy chemotherapy with combination alpha-difluoromethylornithine-PCV versus PCV for anaplastic gliomas
Clin Cancer Res. 2003 Mar;9(3):981-90  (
PDF Full Text)

Levin VA, Prados MR, Wara WM, Davis RL, Gutin PH, Phillips TL, Lamborn K, Wilson CB
Radiation therapy and bromodeoxyuridine chemotherapy followed by procarbazine, lomustine, and vincristine for the treatment of anaplastic gliomas
Int J Radiat Oncol Biol Phys 1995 Apr 30;32(1):75-83 


Levin VA, Silver P, Hannigan J, Wara WM, Gutin PH, Davis RL, Wilson CB
Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report
Int J Radiat Oncol Biol Phys 1990 Feb;18(2):321-4 

A. Pace, A. Pompili, M. Maschio, E. Galie', S. Telera, B. Jandolo, E. Occhipinti, C. M. Carapella
PCV and/or TMZ chemotherapy in 255 gliomas. Analysis of the clinical experience from a neuro-oncology data-base
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1538 


Gliomas (Low Grade)


Buckner JC, Gesme D Jr, O'Fallon JR, Hammack JE, Stafford S, Brown PD, Hawkins R, Scheithauer BW, Erickson BJ, Levitt R, Shaw EG, Jenkins R
Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities
J Clin Oncol 2003 Jan 15;21(2):251-5 (
PDF Full Text)

Stege EM, Kros JM, de Bruin HG, Enting RH, van Heuvel I, Looijenga LH, van der Rijt CD, Smitt PA, van den Bent MJ
Successful treatment of low-grade oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine
Cancer. 2005 Feb 15;103(4):802-9. 



Glioblastoma


Boiardi A
PCV chemotherapy for recurrent glioblastoma multiforme

Neurology 2001 Jun 26;56(12):1782 

Alba A. Brandes, Mario Ermani, Umberto Basso, Myriam K. Paris, Franco Lumachi, Franco Berti, Pietro Amistą, Marina Gardiman, Paolo Iuzzolino, Sergio Turazzi, Silvio Monfardini
Temozolomide in Patients with Glioblastoma at Second Relapse after First Line Nitrosourea-Procarbazine Failure: A Phase II Study
Oncology, Vol. 63, No. 1, 38-41, August 2002
 Abstract |   DBLinks | BL 1:3

Kappelle AC, Postma TJ, Taphoorn MJ, Groeneveld GJ, van den Bent MJ, van Groeningen CJ, Zonnenberg BA, Sneeuw KC, Heimans JJ
PCV chemotherapy for recurrent glioblastoma multiforme
Neurology 2001 Jan 9;56(1):118-20 (
PDF Full Text)

Levin VA, Maor MH, Thall PF, Yung WK, Bruner J, Sawaya R, Kyritsis AP, Leeds N, Woo S, Rodriguez L, et al
Phase II study of accelerated fractionation radiation therapy with carboplatin followed by vincristine chemotherapy for the treatment of glioblastoma multiforme
Int J Radiat Oncol Biol Phys. 1995 Sep 30;33(2):357-64  

Nieder C
Treatment of newly diagnosed glioblastoma multiforme
J Clin Oncol. 2002 Jul 15;20(14):3179-80; author reply 3181-2. (PDF Full Text)

R. Soffietti, A. Costanza, E. Laguzzi, M. Nobile, R. Rudą; 
A phase II study of first-line temozolomide and second-line PCV in recurrent/progressive malignant gliomas
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1574 


Oligo Tumors & Mixed Gliomas


Martin J. van den Bent, Antoine F. Carpentier, Alba A. Brandes, Marc Sanson, Martin J.B. Taphoorn, Hans J.J.A. Bernsen, Marc Frenay, Cees C. Tijssen, Wolfgang Grisold, Laslo Sipos, Hanny Haaxma-Reiche, Johannes M. Kros, Mathilde C.M. van Kouwenhoven, Charles J. Vecht, Anouk Allgeier, Denis Lacombe, Thierry Gorlia
Adjuvant Procarbazine, Lomustine, and Vincristine Improves Progression-Free Survival but Not Overall Survival in Newly Diagnosed Anaplastic Oligodendrogliomas and Oligoastrocytomas: A Randomized European Organisation for Research and Treatment of Cancer Phase III Trial
Journal of Clinical Oncology, Vol 24, No 18 (June 20), 2006: pp. 2715-2722. DOI: 10.1200/JCO.2005.04.6078

M. J. van den Bent, J. Delattre, A. A. Brandes, M. J. Taphoorn, K. Hoang Xuan, H. Bernsen, M. Frenay, W. Grisold, T. Gorlia, D. Lacombe 
First analysis of EORTC trial 26951, a randomized phase III study of adjuvant PCV chemotherapy in patients with highly anaplastic oligodendroglioma
2005 ASCO Annual Meeting. Orlando, FL. May 13-17. Abstract No. 1503. 
Journal of Clinical Oncology, Vol 23, No 16S (June 1 Supplement), 2005: 1503

M J van den Bent, O Chinot, W Boogerd, J Bravo-Marques, MJB Taphoorn, JM Kros, CDD van de Rijt, N de Beule, B Baron, On Behalf of the EORTC Brain Tumor Group.
EORTC Study 26972: Second Line Temozolomide Chemotherapy in Recurrent Oligodendroglial Tumors After PCV Chemotherapy: a Phase II Study
ASCO Proceedings, 2001 Annual Meeting, Abstract No. 203 


Gregory Cairncross, Brian Berkey, Edward Shaw, Robert Jenkins, Bernd Scheithauer, David Brachman, Jan Buckner, Karen Fink, Luis Souhami, Normand Laperierre, Minesh Mehta, Walter Curran
Phase III Trial of Chemotherapy Plus Radiotherapy Compared With Radiotherapy Alone for Pure and Mixed Anaplastic Oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402
Journal of Clinical Oncology, Vol 24, No 18 (June 20), 2006: pp. 2707-2714. DOI: 10.1200/JCO.2005.04.3414

G. Cairncross, W. Seiferheld, E. Shaw, R. Jenkins, B. Scheithauer, D. Brachman, J. Buckner, K. Fink, L. Souhami, W. Curran
An intergroup randomized controlled clinical trial (RCT) of chemotherapy plus radiation (RT) versus RT alone for pure and mixed anaplastic oligodendrogliomas: Initial report of RTOG 94-02
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1500 

Mark R. Gilbert, Frederick F. Lang
Anaplastic Oligodendroglial Tumors: A Tale of Two Trials
Journal of Clinical Oncology, Vol 24, No 18 (June 20), 2006: pp. 2689-2690. DOI: 10.1200/JCO.2006.05.8594

Jeremic B, Milicic B, Grujicic D, Samardzic M, Antunovic V, Dagovic A, Aleksandrovic J
Combined treatment modality for anaplastic oligodendroglioma and oligoastrocytoma: a 10-year update of a phase II study
Int J Radiat Oncol Biol Phys. 2004 Jun 1;59(2):509-14. 

Ozyigit G, Onal C, Gurkaynak M, Soylemezoglu F, Zorlu F
Postoperative radiotherapy and chemotherapy in the management of oligodendroglioma: single institutional review of 88 patients
J Neurooncol. 2005 Nov;75(2):189-93. 

 

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