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Contents
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Astrocytoma* |
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Prados
MD, Scott C, Sandler H, Buckner JC, Phillips T, Schultz C, Urtasun R,
Davis R, Gutin P, Cascino TL, Greenberg HS, Curran WJ Jr
A
phase 3 randomized study of radiotherapy plus procarbazine, CCNU, and
vincristine (PCV) with or without BUdR for the treatment of anaplastic
astrocytoma: a preliminary report of RTOG 9404
Int J Radiat Oncol Biol Phys. 1999 Dec 1;45(5):1109-15
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Brain Tumors* |
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Howard
Landy, Arnold Markoe, Priscilla Potter, Angela Marini, Niramol Savaraj,
Isildinha Reis, Medhi Wangpaichitr, Lynn Feun
Radiosurgery
(RS) plus estramustine in the treatment of patients (pts) with malignant primary
brain tumors (MBT)
38th
ASCO Annual Meeting. Orlando, FL. May 18-21, 2002.
Abstract No.
2093
(Clinical Study)
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Prados MD,
Larson DA, Lamborn K, McDermott MW, Sneed PK, Wara WM, Chang SM, Mack EE,
Krouwer HG, Chandler KL, Warnick RE, Davis RL, Rabbitt JE, Malec M, Levin VA,
Gutin PH, Phillips TL, Wilson CB
Radiation therapy and
hydroxyurea followed by the combination of 6-thioguanine and BCNU for the
treatment of primary malignant brain tumors
Int J Radiat Oncol Biol Phys. 1998 Jan 1;40(1):57-63
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Glioblastoma* |
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Bhawana
S Awasthy, Renita Bhamrah, Omana Nair, Rajvir Singh, Goura K Rath,
Chitra Sarkar, Veer S Mehta, Pramod K Julka
Concurrent
chemoradiotherapy in chemo- naive operated glioblastoma multiforme: a
phase II study
38th
ASCO Annual Meeting. Orlando, FL. May 18-21, 2002.
Abstract No.
2092
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Bobola MS, Kolstoe DD, Blank A, Silber JR.
Minimally
cytotoxic doses of temozolomide produce radiosensitization in human
glioblastoma cells regardless of MGMT expression.
Mol Cancer Ther.
2010 May;9(5):1208-18.
.JPG) Abstract |
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Chakravarti A, Erkkinen MG, Nestler U, Stupp R, Mehta M, Aldape K, Gilbert
MR, Black PM, Loeffler JS.
Temozolomide-mediated radiation enhancement in glioblastoma: a report on
underlying mechanisms.
Clin
Cancer Res. 2006 Aug 1;12(15):4738-46.
Abstract |
Reprint |
Related articles
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Cordes N,
Plasswilm L, Bamberg M, Rodemann HP
Ukrain,
an alkaloid thiophosphoric acid derivative of Chelidonium majus L. protects
human fibroblasts but not human tumour cells in vitro against ionizing radiation
Int J Radiat Biol. 2002 Jan;78(1):17-27
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J.
M. Ford, W. Seiferheld, M. Mehta, S. Phan, W. Curran
Comparison
of survival of patients in the phase I study of motexafin gadolinium (MGd)
with radiation therapy (RT) for glioblastoma multiforme (GBM), with a
matched cohort of patients from the RTOG RPA glioma database
39th
ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003. Abstract No. 425
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Heather
L. Glanzberg, Kerri Kislin, Chad Stadheim, Aaron A. Ambrad, Ryan R. Falsey,
Baldassarre Stea, Jesse D. Martinez, D. L. Kirpatrick, Garth Powis, Emmanuelle
J. Meuillet
The anti-tumor compound
D-3-deoxy-phosphatidyl-myo-inositol radiosensitizes glioblastoma cells by
inhibition of the Akt survival signaling pathway
Proceedings
of the AACR, Volume 44, 2nd ed., July 2003, Abstract No. 678
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Kleinberg L, Grossman SA, Carson K, Lesser G, O'Neill
A, Pearlman J,Phillips P, Herman T, Gerber M.
Survival of
Patients With Newly Diagnosed Glioblastoma Multiforme Treated
With RSR13 and Radiotherapy: Results of a Phase II New Approaches
to Brain Tumor Therapy CNS Consortium Safety and Efficacy
Study
J Clin Oncol. 2002 Jul 15;20(14):3149-55
Abstract |
Full Text |
Reprint
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Sigmond J, Honeywell RJ, Postma TJ, Dirven CM,
de Lange SM, van der Born K, Laan AC, Baayen JC, Van Groeningen CJ, Bergman
AM, Giaccone G, Peters GJ.
Gemcitabine uptake in glioblastoma multiforme: potential as a
radiosensitizer
Ann Oncol. 2008 Aug 12; [Epub ahead of print]
Abstract
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John
Suh, Eric Chang, Robert Timmerman, Mark Leibenhaut, Yoshiya Yamada, Laurie E
Gaspar, Aroor Rao, Jennifer Smith, See Phan, W K Alfred Yung, Minesh P Mehta
Phase
II trial of motexafin gadolinium (MGd, Xcytrin®) and cranial radiation in newly
diagnosed glioblastoma multiforme (GBM)
38th
ASCO Annual Meeting. Orlando, FL. May 18-21, 2002.
Abstract No.
2108
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van Nifterik KA, van den Berg J, Stalpers LJ, Lafleur MV, Leenstra S,
Slotman BJ, Hulsebos TJ, Sminia P.
Differential
radiosensitizing potential of temozolomide in MGMT promoter methylated
glioblastoma multiforme cell lines.
Int
J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1246-53.
Abstract |
Related articles
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Gliomas* |
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Geiger GA, Fu W, Kao GD.
Temozolomide-mediated
radiosensitization of human glioma cells in a zebrafish embryonic system.
Cancer Res. 2008 May
1;68(9):3396-404.
Abstract |
Reprint |
Related articles
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Kil WJ, Cerna D, Burgan WE, Beam K, Carter D, Steeg PS, Tofilon PJ,
Camphausen K.
In
vitro and in vivo radiosensitization induced by the DNA methylating agent
temozolomide.
Clin
Cancer Res. 2008 Feb 1;14(3):931-8.
Abstract |
Reprint |
Related articles
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Landy H, Markoe A, Potter
P, Lasalle G, Marini A, Savaraj N, Reis I, Heros D, Wangpaichitr M, Feun L
Pilot study of estramustine added to radiosurgery
and radiotherapy for treatment of high grade glioma
J Neurooncol. 2004 Mar-Apr;67(1-2):215-20.(Abstract+)
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Levin
VA, Prados MR, Wara WM, Davis RL, Gutin PH, Phillips TL, Lamborn K, Wilson
CB
Radiation
therapy and bromodeoxyuridine chemotherapy followed by procarbazine, lomustine,
and vincristine for the treatment of anaplastic gliomas
Int J Radiat Oncol Biol Phys 1995 Apr 30;32(1):75-83
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Menei P,
Jadaud E, Faisant N, Boisdron-Celle M, Michalak S, Fournier D, Delhaye M, Benoit
JP
Stereotaxic
implantation of 5-fluorouracil-releasing microspheres in malignant glioma
Cancer.
2004 Jan 15;100(2):405-10
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P
Menei, L Capelle, R Assaker, J Guyotat, P Francois, B Bataille, T Dufour, D
Dorwling-Carter, J Sabatier, F Parker, P Paquis, O Chinot, L Bauchet, A Yovine,
B Lhote
A
randomized phase II trial of early radiotherapy (RT) with or without local
fluorouracil-releasing microspheres (FU-M) in patients (pts) with complete
surgical resection of high grade glioma (HGG): preliminary results
38th
ASCO Annual Meeting. Orlando, FL. May 18-21, 2002.
Abstract No.
313
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P. Z. New, S. Grossman, T.
Mikkelsen, T. Batchelor, S. Phuphanich, K. Carson, J. Fisher, M. Craig, P.
Cagnoni
Evaluation of safety and tolerance of escalating doses of
RSR13 administered with a fixed dose of BCNU every six weeks in patients with
recurrent malignant glioma: Results of the phase I NABTT 9806 clinical trial
40th
ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1533
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Sui Shen, M. B. Khazaeli,
G. Yancey Gillespie and Vernon L. Alvarez
Radiation dosimetry of 131I-chlorotoxin
for targeted radiotherapy in glioma-bearing mice
Journal
of Neuro-Oncology, 71(2):
113-119, January 2005. (Abstract+)
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Gliomas
(High-grade)*
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Roger Henriksson, Annika Malmström, Per Bergström,
Gertrud Bergh, Thomas Trojanowski, Lars Andreasson, Erik Blomquist,
Sonny Jonsborg, Tomas Edekling, Pär Salander, Thomas Brännström
and A. Tommy Bergenheim
High-grade astrocytoma treated concomitantly with estramustine and
radiotherapy
J Neurooncol. 2006
Jul;78(3):321-6. Epub 2006 Apr 6.
Abstract
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Metastatic
Tumors |
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Mehta MP, Shapiro WR, Phan SC, Gervais R, Carrie
C, Chabot P, Patchell RA, Glantz MJ, Recht L, Langer C, Sur RK, Roa WH, Mahe
MA, Fortin A, Nieder C, Meyers CA, Smith JA, Miller RA, Renschler MF.
Motexafin Gadolinium Combined with Prompt Whole Brain Radiotherapy
Prolongs Time to Neurologic Progression in Non-Small-Cell Lung Cancer
Patients with Brain Metastases: Results of a Phase III Trial
Int
J Radiat Oncol Biol Phys. 2008 Oct 31. [Epub ahead of print]
Abstract
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Mehta MP,
Shapiro WR, Glantz MJ, Patchell RA, Weitzner MA, Meyers CA, Schultz CJ, Roa WH,
Leibenhaut M, Ford J, Curran W, Phan S, Smith JA, Miller RA, Renschler MF
Lead-in
phase to randomized trial of motexafin gadolinium and whole-brain radiation for
patients with brain metastases: centralized assessment of magnetic resonance
imaging, neurocognitive, and neurologic end points
J Clin Oncol. 2002 Aug 15; 20(16): 3445-53.
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M
P Mehta, P Rodrigus, C Terhaard, A Rao, J Suh, W Roa, WR Shapiro, M J
Glantz, RA Patchell, MA Weitzner, L Souhami, A Bezjak, M Leibenhaut, R Komaki, C
Schultz, R Timmerman, T Illidge, C Meyers, W J Curran, S Phan, J Smith, R
Miller, M F Renschler
Results
from the phase III trial of motexafin gadolinium (MGd) in brain metastases
38th
ASCO Annual Meeting. Orlando, FL. May 18-21, 2002.
Abstract No.
286
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J. Sgouros, S.
Upadhyay, M. Braun, M. Holmes, A. Maraveyas
A phase I study of chemo-radiotherapy using
gemcitabine as a radiosensitiser in patients with metastases to the brain
40th
ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No. 1570
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Penny K. Sneed
Efaproxiral: Should We Hold Our Breath?
Journal of Clinical Oncology, Vol 24, No 1 (January 1),
2006: pp. 13-15
Originally published as JCO Early Release 10.1200/JCO.2005.03.8281 on
November 28 2005
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Comment
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M. A. Spear, A. Mirmiran, E. McClay
Phase I/II trial of IV topotecan (TOPO) in
combination with whole brain radiation therapy (WBXRT)
40th
ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1553
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B Stea, E Shaw,
T Pintér, J Hackman, M Craig, J May, R P Steffen and J H Suh
Efaproxiral
red blood cell concentration predicts efficacy in patients with brain
metastases
British Journal of Cancer, 94:1777-1784 (19 June 2006). doi:
10.1038/sj.bjc.6603169
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John H. Suh, Baldassarre
Stea, Abdenour Nabid, John J. Kresl, André
Fortin, Jean-Philippe Mercier, Neil Senzer,
Eric L. Chang, Adam P. Boyd, Pablo J.
Cagnoni, Edward
Phase III Study of Efaproxiral As an
Adjunct to Whole-Brain Radiation Therapy for Brain Metastases
Journal of Clinical Oncology, Vol. 24, No 1 (January 1), 2006: pp. 106-114
Originally published as JCO Early Release 10.1200/JCO.2004.00.1768 on
November 28 2005
Abstract
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Editorial | .gif)
News
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J. Suh, B. Stea, A. Nabid, J.
Kresl, A. Fortin, J. P. Mercier, N. Senzer, E. Chang, J. B. Holz, E. Shaw
Standard whole brain radiation therapy (WBRT) with
supplemental oxygen (O2), with or without RSR13 (efaproxiral) in
patients with brain metastases: Results of the randomized REACH (RT-009)
study
40th
ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1534
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Viani
GA, Borges GM, Fonseca EC, De Fendi LI, Afonso SL, Stefano EJ
Whole brain radiotherapy with radiosensitizer for brain metastases: a
meta-analysis of randomized controlled trials
J Exp Clin Cancer Res. 2009 Jan 6;28(1):1. [Epub ahead of print]
Abstract |
Reprint
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Tumors* |
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C. Norman Coleman, James B. Mitchell
Clinical Radiosensitization: Why It Does and Does Not Work
J Clin Oncol, Vol 17, CNO 1 (January 1), 1999: 1.
(PDF Full Text)
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