Treatment > Radiation-Enhancing Agents


Astrocytoma


Prados MD, Scott C, Sandler H, Buckner JC, Phillips T, Schultz C, Urtasun R, Davis R, Gutin P, Cascino TL, Greenberg HS, Curran WJ Jr
A phase 3 randomized study of radiotherapy plus procarbazine, CCNU, and vincristine (PCV) with or without BUdR for the treatment of anaplastic astrocytoma: a preliminary report of RTOG 9404
Int J Radiat Oncol Biol Phys. 1999 Dec 1;45(5):1109-15 


Brain Tumors


Howard Landy, Arnold Markoe, Priscilla Potter, Angela Marini, Niramol Savaraj, Isildinha Reis, Medhi Wangpaichitr, Lynn Feun
Radiosurgery (RS) plus estramustine in the treatment of patients (pts) with malignant primary brain tumors (MBT)
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002. Abstract No.
2093 (Clinical Study)

Prados MD, Larson DA, Lamborn K, McDermott MW, Sneed PK, Wara WM, Chang SM, Mack EE, Krouwer HG, Chandler KL, Warnick RE, Davis RL, Rabbitt JE, Malec M, Levin VA, Gutin PH, Phillips TL, Wilson CB
Radiation therapy and hydroxyurea followed by the combination of 6-thioguanine and BCNU for the treatment of primary malignant brain tumors
Int J Radiat Oncol Biol Phys. 1998 Jan 1;40(1):57-63
 


Glioblastoma


Bhawana S Awasthy, Renita Bhamrah, Omana Nair, Rajvir Singh, Goura K Rath, Chitra Sarkar, Veer S Mehta, Pramod K Julka
Concurrent chemoradiotherapy in chemo- naive operated glioblastoma multiforme: a phase II study
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002. Abstract No.
2092  

Cordes N, Plasswilm L, Bamberg M, Rodemann HP
Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L. protects human fibroblasts but not human tumour cells in vitro against ionizing radiation
Int J Radiat Biol. 2002 Jan;78(1):17-27

J. M. Ford, W. Seiferheld, M. Mehta, S. Phan, W. Curran
Comparison of survival of patients in the phase I study of motexafin gadolinium (MGd) with radiation therapy (RT) for glioblastoma multiforme (GBM), with a matched cohort of patients from the RTOG RPA glioma database
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003. Abstract No. 425 

Heather L. Glanzberg, Kerri Kislin, Chad Stadheim, Aaron A. Ambrad, Ryan R. Falsey, Baldassarre Stea, Jesse D. Martinez, D. L. Kirpatrick, Garth Powis, Emmanuelle J. Meuillet
The anti-tumor compound D-3-deoxy-phosphatidyl-myo-inositol radiosensitizes glioblastoma cells by inhibition of the Akt survival signaling pathway
Proceedings of the AACR, Volume 44, 2nd ed., July 2003, Abstract No. 678

Kleinberg L, Grossman SA, Carson K, Lesser G, O'Neill A, Pearlman J,Phillips P, Herman T, Gerber M.
Survival of Patients With Newly Diagnosed Glioblastoma Multiforme Treated With RSR13 and Radiotherapy: Results of a Phase II New Approaches to Brain Tumor Therapy CNS Consortium Safety and Efficacy Study
J Clin Oncol. 2002 Jul 15;20(14):3149-55
Abstract | Full Text | Reprint | DBLinks | BL 1:1

John Suh, Eric Chang, Robert Timmerman, Mark Leibenhaut, Yoshiya Yamada, Laurie E Gaspar, Aroor Rao, Jennifer Smith, See Phan, W K Alfred Yung, Minesh P Mehta
Phase II trial of motexafin gadolinium (MGd, Xcytrin®) and cranial radiation in newly diagnosed glioblastoma multiforme (GBM)
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002. Abstract No.
2108


Gliomas


Landy H, Markoe A, Potter P, Lasalle G, Marini A, Savaraj N, Reis I, Heros D, Wangpaichitr M, Feun L
Pilot study of estramustine added to radiosurgery and radiotherapy for treatment of high grade glioma
J Neurooncol. 2004 Mar-Apr;67(1-2):215-20.(Abstract+)

Levin VA, Prados MR, Wara WM, Davis RL, Gutin PH, Phillips TL, Lamborn K, Wilson CB
Radiation therapy and bromodeoxyuridine chemotherapy followed by procarbazine, lomustine, and vincristine for the treatment of anaplastic gliomas
Int J Radiat Oncol Biol Phys 1995 Apr 30;32(1):75-83 


Menei P, Jadaud E, Faisant N, Boisdron-Celle M, Michalak S, Fournier D, Delhaye M, Benoit JP
Stereotaxic implantation of 5-fluorouracil-releasing microspheres in malignant glioma
Cancer. 2004 Jan 15;100(2):405-10

P Menei, L Capelle, R Assaker, J Guyotat, P Francois, B Bataille, T Dufour, D Dorwling-Carter, J Sabatier, F Parker, P Paquis, O Chinot, L Bauchet, A Yovine, B Lhote
A randomized phase II trial of early radiotherapy (RT) with or without local fluorouracil-releasing microspheres (FU-M) in patients (pts) with complete surgical resection of high grade glioma (HGG): preliminary results
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002. Abstract No.
313

P. Z. New, S. Grossman, T. Mikkelsen, T. Batchelor, S. Phuphanich, K. Carson, J. Fisher, M. Craig, P. Cagnoni
Evaluation of safety and tolerance of escalating doses of RSR13 administered with a fixed dose of BCNU every six weeks in patients with recurrent malignant glioma: Results of the phase I NABTT 9806 clinical trial
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1533

Sui Shen, M. B. Khazaeli, G. Yancey Gillespie and Vernon L. Alvarez
Radiation dosimetry of 131I-chlorotoxin for targeted radiotherapy in glioma-bearing mice
Journal of Neuro-Oncology, 71(2): 113-119, January 2005. (Abstract+)


Gliomas (High-grade)


Roger Henriksson, Annika Malmström, Per Bergström, Gertrud Bergh, Thomas Trojanowski, Lars  Andreasson, Erik Blomquist, Sonny Jonsborg, Tomas Edekling, Pär Salander, Thomas Brännström and A. Tommy Bergenheim
High-grade astrocytoma treated concomitantly with estramustine and radiotherapy
J Neurooncol. 2006 Jul;78(3):321-6. Epub 2006 Apr 6.
Abstract


Metastatic Tumors


Mehta MP, Shapiro WR, Glantz MJ, Patchell RA, Weitzner MA, Meyers CA, Schultz CJ, Roa WH, Leibenhaut M, Ford J, Curran W, Phan S, Smith JA, Miller RA, Renschler MF
Lead-in phase to randomized trial of motexafin gadolinium and whole-brain radiation for patients with brain metastases: centralized assessment of magnetic resonance imaging, neurocognitive, and neurologic end points
J Clin Oncol. 2002 Aug 15; 20(16): 3445-53.  

M P Mehta, P Rodrigus, C Terhaard, A Rao, J Suh, W Roa, WR Shapiro, M J Glantz, RA Patchell, MA Weitzner, L Souhami, A Bezjak, M Leibenhaut, R Komaki, C Schultz, R Timmerman, T Illidge, C Meyers, W J Curran, S Phan, J Smith, R Miller, M F Renschler
Results from the phase III trial of motexafin gadolinium (MGd) in brain metastases
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002. Abstract No.
286  

J. Sgouros, S. Upadhyay, M. Braun, M. Holmes, A. Maraveyas
A phase I study of chemo-radiotherapy using gemcitabine as a radiosensitiser in patients with metastases to the brain
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No. 1570

Penny K. Sneed
Efaproxiral: Should We Hold Our Breath?
Journal of Clinical Oncology, Vol 24, No 1 (January 1), 2006: pp. 13-15
Originally published as JCO Early Release 10.1200/JCO.2005.03.8281 on November 28 2005
Editorial | Reprint | Abstract

M. A. Spear, A. Mirmiran, E. McClay
Phase I/II trial of IV topotecan (TOPO) in combination with whole brain radiation therapy (WBXRT)
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1553

B Stea, E Shaw, T Pintér, J Hackman, M Craig, J May, R P Steffen and J H Suh
Efaproxiral red blood cell concentration predicts efficacy in patients with brain metastases
British Journal of Cancer, 94:1777-1784 (19 June 2006). doi: 10.1038/sj.bjc.6603169

John H. Suh, Baldassarre Stea, Abdenour Nabid, John J. Kresl, André Fortin, Jean-Philippe Mercier, Neil Senzer, Eric L. Chang, Adam P. Boyd, Pablo J. Cagnoni, Edward 
Phase III Study of Efaproxiral As an Adjunct to Whole-Brain Radiation Therapy for Brain Metastases
Journal of Clinical Oncology, Vol. 24, No 1 (January 1), 2006: pp. 106-114
Originally published as JCO Early Release 10.1200/JCO.2004.00.1768 on November 28 2005
Abstract | BrainLife | Full Text | Reprint | Editorial | News 

J. Suh, B. Stea, A. Nabid, J. Kresl, A. Fortin, J. P. Mercier, N. Senzer, E. Chang, J. B. Holz, E. Shaw
Standard whole brain radiation therapy (WBRT) with supplemental oxygen (O2), with or without RSR13 (efaproxiral) in patients with brain metastases: Results of the randomized REACH (RT-009) study
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1534


Tumors


C. Norman Coleman, James B. Mitchell
Clinical Radiosensitization: Why It Does and Does Not Work 
J Clin Oncol, Vol 17, Issue 1 (January 1), 1999: 1. (PDF Full Text) 

 

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