Treatment > Tamoxifen


Contents

Astrocytomas Gliomas
Antiangiogenic Action of the Antiestrogens Metastatic Tumors
Brain Tumors Non-Nervous System Tumors
Glioblastoma


Astrocytomas

Chamberlain MC, Kormanik PA
Salvage chemotherapy with tamoxifen for recurrent anaplastic astrocytomas
Arch Neurol 1999 Jun;56(6):703-8 (Clinical Study, Abstract)


Antiangiogenic Action of the Antiestrogens

Gagliardi AR, Hennig B, Collins DC
Antiestrogens inhibit endothelial cell growth stimulated by angiogenic growth factors

Anticancer Res 1996 May-Jun;16(3A):1101-6 (
Cell Culture Study, Abstract)


Brain Tumors

Cheppail Ramachandran, Ziad Khatib, Athena Pefkarou, John Fort, Hugo B. Fonseca, Steven J. Melnick and Enrique Escalon
Tamoxifen modulation of etoposide cytotoxicity involves inhibition of protein kinase C activity and insulin-like growth factor II expression in brain tumor cells
J Neurooncol. 2004 Mar-Apr;67(1-2):19-28. (Laboratory Investigation, Abstract+)


Glioblastoma

Christian Hagel, Sung-Ho Park, Maximilian J.A. Puchner and Dimitrios Stavrou
CD44 expression and tumour cell density correlate with response to tamoxifen/carboplatin chemotherapy in glioblastomas
Journal of Neuro-Oncology 66: 139–146, January 2004. (Laboratory Investigation, Abstract+)

Mastronardi L, Farah JO, Puzzilli F, Qasho R, Lunardi P
Clinical and radiographic stabilization of intracranial glioblastoma. Report of a case treated after surgery with tamoxifen
J Neurosurg Sci. 1996 Jun;40(2):129-33. (Case Study, Abstract)

Robert Morgan Jr., Timothy Synold, Adam Mamelak, Kim Margolin, Al-Kadhimi Zaid, Przemyslaw Twardowski, Lucille Leong, Dean Lim, Sandeep Reddy, Isan Chen, Warren Chow, Stephen Shibata, George Somlo, Yun Yen, Paul Frankel, James H Doroshow
Phase I trial of tamoxifen (Tam), carboplatin (C), and topotecan (T) in recurrent or metastatic brain tumors
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002.
Abstract No. 2102 (Clinical Study)

Napolitano M, Keime-Guibert F, Monjour A, Lafitte C, Ameri A, Cornu P, Broet P, Delattre JY
Treatment of supratentorial glioblastoma multiforme with radiotherapy and a combination of BCNU and tamoxifen: a phase II study
J Neurooncol 1999;45(3):229-35 (Clinical Study, Abstract)

Puchner MJ, Giese A, Lohmann F, Cristante L.
High-dose tamoxifen treatment increases the incidence of multifocal tumor recurrences in glioblastoma patients
Anticancer Res. 2004 Nov-Dec;24(6):4195-203

H. Ian Robins, M. Won, Wendy F. Seiferheld, Christopher J. Schultz, Ali K. Choucair, David G. Brachman, William F. Demas, and Minesh P. Mehta
Phase 2 trial of radiation plus high-dose tamoxifen for glioblastoma multiforme: RTOG protocol BR-0021
Neuro-oncol 2006; 8(1): 47-52; DOI:10.1215/S1522851705000311
Abstract | Full Text | Reprint | DBLinks

H. I. Robins, M. Won, C. Schultz, A. Choucair, D. Brachman, W. Demas, M. Mehta
A phase II trial of conventional radiation therapy (XRT) plus high dose tamoxifen (TAM) for the treatment of supratentorial glioblastoma multiforme (GBM): RTOG protocol BR-0021
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1529 (Clinical Study)

Toms SA, Hercbergs A, Liu J, Kondo S, Haqqi T, Casey G, Iwasaki K, Barnett GH, Barna BP
Antagonist effect of insulin-like growth factor I on protein kinase inhibitor-mediated apoptosis in human glioblastoma cells in association with bcl-2 and bcl-xL
J Neurosurg. 1998 May;88(5):884-9 (Cell Culture Study, Abstract)

Vertosick, F.T., and Selker, R.G.
The treatment of newly diagnosed glioblastoma multiforme using high dose tamoxifen (TMX), radiotherapy and convenzional chemotherapy

AACR Proceedings, 1997 Annual Meeting, Abstract No. 2887 (Clinical Study)

Joy K. Zartman, Nicholas K. Foreman, Andrew M. Donson, Julie M. Fleitz
Measurement of Tamoxifen-Induced Apoptosis in Glioblastoma by Cytometric Bead Analysis of Active Caspase-3
Journal of Neuro-Oncology, Volume 67, Issue 1-2, March - April 2004. (Cell Culture Study, Abstract+)


Gliomas

T. Ahmed, B. Chen, G. Rabbani, M. N. Wallam and D. Benzil
Phase II trial of thalidomide (TD), tamoxifen (TX), and temozolomide (T) for patients with advanced malignant gliomas (MG)
2005 ASCO Annual Meeting. Orlando, FL. May 13-17. Abstract No. 1575. (Clinical Study)
Journal of Clinical Oncology, Vol 23, No 16S (June 1 Supplement), 2005: 1575

Baltuch GH, Couldwell WT, Villemure JG, Yong VW
Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. A comparison between staurosporine and tamoxifen
Neurosurgery. 1993 Sep;33(3):495-501; discussion 501. (Cell Culture Study, Abstract)

Baltuch G, Shenouda G, Langleben A, Villemure JG
High dose tamoxifen in the treatment of recurrent high grade glioma: a report of clinical stabilization and tumour regression
Can J Neurol Sci. 1993 May;20(2):168-70.(Case Report, Abstract)

Brandes AA, Ermani M, Turazzi S, Scelzi E, Berti F, Amista P, Rotilio A, Licata C, Fiorentino MV
Procarbazine and high-dose tamoxifen as a second-line regimen in recurrent high-grade gliomas: a phase II study

J Clin Oncol 1999 Feb;17(2):645-50 (Clinical Study, Abstract & Full Text)

Cloughesy TF, Woods RP, Black KL, Couldwell WT, Law RE, Hinton DR
Prolonged treatment with biologic agents for malignant glioma: a case study with high dose tamoxifen
J Neurooncol. 1997 Oct;35(1):39-45. (Case Report, Abstract)

Couldwell WT, Hinton DR, Surnock AA, DeGiorgio CM, Weiner LP, Apuzzo ML, Masri L, Law RE, Weiss MH
Treatment of recurrent malignant gliomas with chronic oral high-dose tamoxifen
Clin Cancer Res 1996 Apr;2(4):619-22 (Clinical Study, HTML Full Text)

Couldwell WT, Weiss MH, DeGiorgio CM, Weiner LP, Hinton DR, Ehresmann GR, Conti PS, Apuzzo ML.
Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen
Neurosurgery 1993 Mar;32(3):485-9 (
Clinical Study, Abstract)

Lav Goyal, Aleck Hercbergs, John Suh, Robert Fine, Bruce Cohen, David Peerboom, Glen Stevens, Manjula Gupta, Sethu Reddy, Chandana Reddy, Paul Elson, Gene Barnett
High-Dose Tamoxifen and Thyroid Suppression in Recurrent Malignant Glioma Patients
ASCO Proceedings, 2000 Annual Meeting, Abstract No. 655 (Clinical Study)

Hercbergs AA, Goyal LK, Suh JH, Lee S, Reddy CA, Cohen BH, Stevens GH, Reddy SK, Peereboom DM, Elson PJ, Gupta MK, Barnett GH
Propylthiouracil-induced chemical hypothyroidism with high-dose tamoxifen prolongs survival in recurrent high grade glioma: a phase I/II study
Anticancer Res. 2003 Jan-Feb;23(1B):617-26 (Clinical Study, Abstract)

Hau P, Fabel K, Baumgart U, Rummele P, Grauer O, Bock A, Dietmaier C, Dietmaier W, Dietrich J, Dudel C, Hubner F, Jauch T, Drechsel E, Kleiter I, Wismeth C, Zellner A, Brawanski A, Steinbrecher A, Marienhagen J, Bogdahn U
Pegylated liposomal doxorubicin-efficacy in patients with recurrent high-grade glioma
Cancer. 2004 Mar 15;100(6):1199-207. (Clinical Study, Abstract)

Peter Hau, Joerg Dietrich, Klaus Fabel, Ulrike Baumgart, Oliver Grauer, Tanya Jauch, Anton Zellner, Martin Proescholdt, Andreas Steinbrecher, Alexander Brawanski, Peter Krauseneck, Ulrich Bogdahn
Liposomal doxorubicin with and without tamoxifen in the salvage treatment of high grade glioma - a phase-II study
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002. Abstract No.
312 (Clinical Study)

Yong-Jung Kim, Chang-Joong Lee, Uhn Lee and Young-Mi Yoo
Tamoxifen-induced cell death and expression of neurotrophic factors in cultured C6 glioma cells
Journal of Neuro-Oncology, 71(2): 121-125, January 2005. (Laboratory Investigation, Abstract+)

Mastronardi L, Puzzilli F, Couldwell WT, Farah JO, Lunardi P.
Tamoxifen and carboplatin combinational treatment of high-grade gliomas. Results of a clinical trial on newly diagnosed patients
J Neurooncol 1998 May;38(1):59-68 (Clinical Study, Abstract)

Preul MC, Caramanos Z, Villemure JG, Shenouda G, LeBlanc R, Langleben A, Arnold DL
Using proton magnetic resonance spectroscopic imaging to predict in vivo the response of recurrent malignant gliomas to tamoxifen chemotherapy

Neurosurgery 2000 Feb;46(2):306-18 (
Clinical Study, Abstract)

Alexander M. Spence, Richard A. Peterson, Jeffrey D. Scharnhorst, Daniel L. Silbergeld, Robert C. Rostomily
Phase II Study of Concurrent Continuous Temozolomide (TMZ) and Tamoxifen (TMX) for Recurrent Malignant Astrocytic Gliomas
J Neurooncol,
70(1):91-95, Oct 2004. (Clinical Study, Abstract+)

P. Tang, G. Roldan, P.M.A Brasher, D. Fulton, W. Roa, A. Murtha, J.G. Cairncross and P.A. Forsyth
A phase II study of carboplatin and chronic high-dose tamoxifen in patients with recurrent malignant glioma
J Neurooncol. 2006 May 19; [Epub ahead of print]; DOI: 10.1007/s11060-005-9104-y
Abstract

Tseng SH, Wang CH, Lin SM, Chen CK, Huang HY, Chen Y
Activation of c-Jun N-terminal kinase 1 and caspase 3 in the tamoxifen-induced apoptosis of rat glioma cells
J Cancer Res Clin Oncol. 2004 Mar 2 [Epub ahead of print] (Cell Culture Study, Abstract)

Vertosick FT Jr, Selker RG, Randall MS, Kristofik MP, Rehn T
A comparison of the relative chemosensitivity of human gliomas to tamoxifen and n-desmethyltamoxifen in vitro
J Neurooncol 1994;19(2):97-103 (Cell Culture Study, Abstract)

Vertosick FT Jr, Selker RG, Pollack IF, Arena V
The treatment of intracranial malignant gliomas using orally administered tamoxifen therapy: preliminary results in a series of "failed" patients
Neurosurgery 1992 Jun;30(6):897-902 (Clinical Study, Abstract)

Yaz G, Kabadere S, Oztopcu P, Durmaz R, Uyar R
Comparison of the antiproliferative properties of antiestrogenic drugs (nafoxidine and clomiphene) on glioma cells in vitro
Am J Clin Oncol. 2004 Aug;27(4):384-8. (Laboratory Investigation, Abstract)

Zhang W, Yamada H, Sakai N, Niikawa S, Nozawa Y.
Enhancement of radiosensitivity by tamoxifen in C6 glioma cells

Neurosurgery 1992 Oct;31(4):725-9 (
Cell Culture Study, Abstract)


Metastatic Tumors

Treatment > Paclitaxel / Tamoxifen
Robert L. Fine, Johnson Chen, Casilda Balmaceda, Jeffrey N. Bruce, May Huang, Manisha Desai, Michael B. Sisti, Guy M. McKhann, Robert R. Goodman, Joseph S. Bertino, Jr., Anne N. Nafziger and Michael R. Fetell
Randomized Study of Paclitaxel and Tamoxifen Deposition into Human Brain Tumors: Implications for the Treatment of Metastatic Brain Tumors
Clin Cancer Res. 2006 Oct 1;12(19):5770-6.
Abstract

Myriam W Ben Arush, Sergey Postovsky, Ronit Elhasid, A Ben-Barak, C Levine, Joseph F Guilburd
Antiangiogenic therapy in pediatric malignancies: experience of the Northern Israel Pediatric Cancer Center

ASCO Proceedings, 2002 Annual Meeting, Abstract No. 2926 (Clinical Study)


Non-Nervous System Tumors

Figueredo A, Arnold A, Goodyear M, Findlay B, Neville A, Normandeau R, Jones A
Addition of verapamil and tamoxifen to the initial chemotherapy of small cell lung cancer. A phase I/II study
Cancer 1990 May 1;65(9):1895-902 (Clinical Study, Abstract)

Kazanci N, Severcan F.
Concentration Dependent Different Action of Tamoxifen on Membrane Fluidity.
Biosci Rep. 2007 Jun 28; [Epub ahead of print]
PMID: 17597395 [PubMed - as supplied by publisher]

Kenny FS, Gee JM, Nicholson RI, Ellis IO, Morris TM, Watson SA, Bryce RP, Robertson JF
Effect of dietary GLA+/-tamoxifen on the growth, ER expression and fatty acid profile of ER positive human breast cancer xenografts

Int J Cancer 2001 May 1;92(3):342-7 (Animal Study, Abstract)

Kenny FS, Pinder SE, Ellis IO, Gee JM, Nicholson RI, Bryce RP, Robertson JF
Gamma linolenic acid with tamoxifen as primary therapy in breast cancer
Int J Cancer 2000 Mar 1;85(5):643-8 (Clinical Study, Abstract)

Iino Y, Takai Y, Sugamata N, Morishita Y
PSK (krestin) potentiates chemotherapeutic effects of tamoxifen on rat mammary carcinomas
Anticancer Res 1992 Nov-Dec;12(6B):2101-3
(Animal Study, Abstract)

Rowlands MG, Budworth J, Jarman M, Hardcastle IR, McCague R, Gescher A
Comparison between inhibition of protein kinase C and antagonism of calmodulin by tamoxifen analogues

Biochem Pharmacol 1995 Aug 25;50(5):723-6
(Cell Culture Study, Abstract)

Figueredo A, Arnold A, Goodyear M, Findlay B, Neville A, Normandeau R, Jones A
Addition of verapamil and tamoxifen to the initial chemotherapy of small cell lung cancer. A phase I/II study
Cancer 1990 May 1;65(9):1895-902 (Clinical Study, Abstract)

Li Hua Wang, Xiao Yi Yang, Xiaohu Zhang, Ping An, Han-Jong Kim, Jiaqiang Huang, Robert Clarke, C. Kent Osborne, John K. Inman, Ettore Appella and William L. Farrar
Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer
Cancer Cell. 2006 Dec;10(6):487-99; doi:10.1016/j.ccr.2006.09.015; Available online 11 December 2006.

Yimin Zhu, Qihan Dong, Bee Jen Tan, Wee Guan Lim, Shufeng Zhou and Wei Duan
The PKCα-D294G Mutant Found in Pituitary and Thyroid Tumors Fails to Transduce Extracellular Signals
Cancer Research, 65, 4520-4524, June 1, 2005. (Laboratory Investigation, Abstract+)

 

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