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•
Astrocytomas
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•
Gliomas
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• Antiangiogenic
Action of the Antiestrogens
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• Metastatic Tumors
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• Brain
Tumors
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• Non-Nervous
System Tumors
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• Glioblastoma
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Astrocytomas
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Chamberlain MC,
Kormanik PA
Salvage
chemotherapy with tamoxifen for recurrent anaplastic astrocytomas
Arch Neurol 1999
Jun;56(6):703-8 (Clinical Study,
Abstract)
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Antiangiogenic
Action of the Antiestrogens
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Gagliardi AR, Hennig B, Collins DC
Antiestrogens
inhibit endothelial cell growth stimulated by angiogenic growth factors
Anticancer Res 1996 May-Jun;16(3A):1101-6 (Cell Culture Study, Abstract)
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Brain
Tumors
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Cheppail Ramachandran, Ziad Khatib,
Athena Pefkarou, John Fort, Hugo B. Fonseca, Steven J. Melnick and Enrique
Escalon
Tamoxifen modulation of etoposide cytotoxicity involves
inhibition of protein kinase C activity and insulin-like growth factor II
expression in brain tumor cells
J Neurooncol. 2004 Mar-Apr;67(1-2):19-28. (Laboratory
Investigation, Abstract+)
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Glioblastoma
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Christian
Hagel, Sung-Ho Park, Maximilian J.A. Puchner and Dimitrios Stavrou
CD44 expression and tumour cell density
correlate with response to tamoxifen/carboplatin chemotherapy in glioblastomas
Journal of Neuro-Oncology 66: 139–146, January
2004. (Laboratory Investigation, Abstract+)
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Mastronardi L, Farah JO, Puzzilli F, Qasho R, Lunardi P
Clinical and radiographic stabilization of
intracranial glioblastoma. Report of a case treated after surgery with tamoxifen
J Neurosurg Sci. 1996 Jun;40(2):129-33. (Case Study, Abstract)
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Robert
Morgan Jr., Timothy Synold, Adam Mamelak, Kim Margolin, Al-Kadhimi Zaid,
Przemyslaw Twardowski, Lucille Leong, Dean Lim, Sandeep Reddy, Isan Chen, Warren
Chow, Stephen Shibata, George Somlo, Yun Yen, Paul Frankel, James H Doroshow
Phase
I trial of tamoxifen (Tam), carboplatin (C), and topotecan (T) in recurrent or
metastatic brain tumors
38th
ASCO Annual Meeting. Orlando, FL. May 18-21, 2002.
Abstract No.
2102
(Clinical Study)
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Napolitano
M, Keime-Guibert F, Monjour A, Lafitte C, Ameri A, Cornu P, Broet
P, Delattre JY
Treatment
of supratentorial glioblastoma multiforme with radiotherapy and a combination of
BCNU and tamoxifen: a phase II study
J Neurooncol 1999;45(3):229-35 (Clinical Study,
Abstract)
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Puchner MJ, Giese A, Lohmann F, Cristante L.
High-dose tamoxifen treatment increases the incidence of multifocal tumor
recurrences in glioblastoma patients
Anticancer Res. 2004
Nov-Dec;24(6):4195-203
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H. Ian Robins, M. Won, Wendy F. Seiferheld,
Christopher J. Schultz, Ali K. Choucair, David G. Brachman, William F. Demas,
and Minesh P. Mehta
Phase
2 trial of radiation plus high-dose tamoxifen for glioblastoma multiforme:
RTOG protocol BR-0021
Neuro-oncol
2006; 8(1): 47-52; DOI:10.1215/S1522851705000311
Abstract
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Full
Text | 
Reprint
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DBLinks
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H. I. Robins,
M. Won, C. Schultz, A. Choucair, D. Brachman, W. Demas, M. Mehta
A phase II trial of conventional radiation
therapy (XRT) plus high dose tamoxifen (TAM) for the treatment of
supratentorial glioblastoma multiforme (GBM): RTOG protocol BR-0021
40th
ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1529 (Clinical
Study)
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Toms SA, Hercbergs A, Liu J, Kondo S,
Haqqi T, Casey G, Iwasaki K, Barnett GH, Barna BP
Antagonist effect of
insulin-like growth factor I on protein kinase inhibitor-mediated
apoptosis in human glioblastoma cells in association with bcl-2 and bcl-xL
J Neurosurg. 1998 May;88(5):884-9 (Cell Culture Study, Abstract)
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Vertosick,
F.T., and Selker, R.G.
The treatment of newly diagnosed glioblastoma
multiforme using high dose tamoxifen (TMX), radiotherapy and convenzional
chemotherapy
AACR
Proceedings, 1997 Annual Meeting, Abstract No. 2887 (Clinical Study)
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Joy
K. Zartman, Nicholas K. Foreman, Andrew M. Donson, Julie M. Fleitz
Measurement
of Tamoxifen-Induced Apoptosis in Glioblastoma by Cytometric Bead Analysis
of Active Caspase-3
Journal of Neuro-Oncology, Volume 67, Issue
1-2, March - April 2004. (Cell Culture Study, Abstract+)
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Gliomas
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T. Ahmed, B. Chen,
G. Rabbani, M. N. Wallam and D. Benzil
Phase II trial of thalidomide (TD), tamoxifen
(TX), and temozolomide (T) for patients with advanced malignant gliomas (MG)
2005
ASCO Annual Meeting. Orlando, FL. May 13-17. Abstract No. 1575. (Clinical
Study)
Journal of Clinical Oncology, Vol 23, No 16S (June 1 Supplement),
2005: 1575
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Baltuch GH, Couldwell WT, Villemure JG, Yong VW
Protein kinase C inhibitors suppress cell growth in established and low-passage
glioma cell lines. A comparison between staurosporine and tamoxifen
Neurosurgery.
1993 Sep;33(3):495-501; discussion 501. (Cell Culture Study, Abstract)
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Baltuch G, Shenouda G, Langleben A, Villemure JG
High dose tamoxifen in the treatment of recurrent high grade
glioma: a report of clinical stabilization and tumour regression
Can J Neurol Sci. 1993 May;20(2):168-70.(Case Report, Abstract)
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Brandes AA, Ermani M, Turazzi S,
Scelzi E, Berti F, Amista P, Rotilio A, Licata C, Fiorentino MV
Procarbazine and high-dose tamoxifen as a second-line
regimen in recurrent high-grade gliomas: a phase II study
J Clin Oncol 1999
Feb;17(2):645-50 (Clinical Study,
Abstract & Full Text)
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Cloughesy
TF, Woods RP, Black KL, Couldwell WT, Law RE, Hinton DR
Prolonged
treatment with biologic agents for malignant glioma: a case study with high dose
tamoxifen
J Neurooncol. 1997 Oct;35(1):39-45.
(Case Report, Abstract)
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Couldwell
WT, Hinton DR, Surnock AA, DeGiorgio CM, Weiner LP, Apuzzo ML, Masri L, Law
RE, Weiss MH
Treatment
of recurrent malignant gliomas with chronic oral high-dose tamoxifen
Clin Cancer Res 1996 Apr;2(4):619-22 (Clinical Study,
HTML Full
Text)
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Couldwell
WT, Weiss MH, DeGiorgio CM, Weiner LP, Hinton DR, Ehresmann GR, Conti PS,
Apuzzo ML.
Clinical and
radiographic response in a minority of patients with recurrent malignant gliomas
treated with high-dose tamoxifen
Neurosurgery 1993 Mar;32(3):485-9 (Clinical Study,
Abstract)
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Lav
Goyal, Aleck Hercbergs, John Suh, Robert Fine, Bruce Cohen, David Peerboom,
Glen Stevens, Manjula Gupta, Sethu Reddy, Chandana Reddy, Paul Elson, Gene
Barnett
High-Dose
Tamoxifen and Thyroid Suppression in Recurrent Malignant Glioma Patients
ASCO
Proceedings, 2000 Annual Meeting, Abstract No. 655 (Clinical Study)
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Hercbergs AA, Goyal LK, Suh JH, Lee S, Reddy CA, Cohen BH,
Stevens GH, Reddy SK, Peereboom DM, Elson PJ, Gupta MK, Barnett GH
Propylthiouracil-induced chemical hypothyroidism
with high-dose tamoxifen prolongs survival in recurrent high grade glioma: a
phase I/II study
Anticancer Res. 2003 Jan-Feb;23(1B):617-26 (Clinical Study, Abstract)
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Hau P, Fabel K, Baumgart U, Rummele P, Grauer O,
Bock A, Dietmaier C, Dietmaier W, Dietrich J, Dudel C, Hubner F, Jauch T,
Drechsel E, Kleiter I, Wismeth C, Zellner A, Brawanski A, Steinbrecher A,
Marienhagen J, Bogdahn U
Pegylated liposomal
doxorubicin-efficacy in patients with recurrent high-grade glioma
Cancer. 2004 Mar 15;100(6):1199-207. (Clinical Study, Abstract)
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Peter
Hau, Joerg Dietrich, Klaus Fabel, Ulrike Baumgart, Oliver Grauer,
Tanya Jauch, Anton Zellner, Martin Proescholdt, Andreas Steinbrecher,
Alexander Brawanski, Peter Krauseneck, Ulrich Bogdahn
Liposomal
doxorubicin with and without tamoxifen in the salvage treatment of high
grade glioma - a phase-II study
38th
ASCO Annual Meeting. Orlando, FL. May 18-21, 2002.
Abstract No.
312
(Clinical Study)
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Yong-Jung Kim, Chang-Joong Lee,
Uhn Lee and Young-Mi Yoo
Tamoxifen-induced cell death and expression of neurotrophic factors in
cultured C6 glioma cells
Journal
of Neuro-Oncology, 71(2):
121-125, January 2005. (Laboratory Investigation, Abstract+)
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Mastronardi
L, Puzzilli F, Couldwell WT, Farah JO, Lunardi P.
Tamoxifen
and carboplatin combinational treatment of high-grade gliomas. Results of a
clinical trial on newly diagnosed patients
J
Neurooncol 1998 May;38(1):59-68 (Clinical Study, Abstract)
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Preul
MC, Caramanos Z, Villemure JG, Shenouda G, LeBlanc R, Langleben A, Arnold DL
Using
proton magnetic resonance spectroscopic imaging to predict in vivo the response
of recurrent malignant gliomas to tamoxifen chemotherapy
Neurosurgery 2000 Feb;46(2):306-18 (Clinical Study, Abstract)
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Alexander
M. Spence, Richard A. Peterson, Jeffrey D. Scharnhorst, Daniel L. Silbergeld,
Robert C. Rostomily
Phase
II Study of Concurrent Continuous Temozolomide (TMZ) and Tamoxifen (TMX) for
Recurrent Malignant Astrocytic Gliomas
J Neurooncol,
70(1):91-95, Oct 2004. (Clinical Study, Abstract+)
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P. Tang, G. Roldan,
P.M.A Brasher, D. Fulton, W. Roa, A. Murtha, J.G. Cairncross
and P.A. Forsyth
A phase II study of carboplatin and chronic high-dose tamoxifen in
patients with recurrent malignant glioma
J Neurooncol. 2006 May 19;
[Epub ahead of print]; DOI: 10.1007/s11060-005-9104-y
Abstract
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Tseng SH, Wang CH, Lin SM, Chen CK,
Huang HY, Chen Y
Activation of c-Jun N-terminal kinase 1 and
caspase 3 in the tamoxifen-induced apoptosis of rat glioma cells
J Cancer Res Clin Oncol. 2004 Mar 2 [Epub ahead of print] (Cell Culture Study, Abstract)
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Vertosick FT Jr, Selker RG, Randall MS, Kristofik MP, Rehn
T
A comparison of the relative chemosensitivity of
human gliomas to tamoxifen and n-desmethyltamoxifen in vitro
J Neurooncol 1994;19(2):97-103 (Cell Culture Study, Abstract)
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Vertosick
FT Jr, Selker RG, Pollack IF, Arena V
The treatment of intracranial malignant gliomas
using orally administered tamoxifen therapy: preliminary results in a series of
"failed" patients
Neurosurgery
1992 Jun;30(6):897-902 (Clinical Study, Abstract)
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Yaz G, Kabadere S, Oztopcu P, Durmaz R, Uyar
R
Comparison of the antiproliferative properties of
antiestrogenic drugs (nafoxidine and clomiphene) on glioma cells in vitro
Am J Clin Oncol. 2004 Aug;27(4):384-8. (Laboratory Investigation,
Abstract)
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Zhang
W, Yamada H, Sakai N, Niikawa S, Nozawa Y.
Enhancement
of radiosensitivity by tamoxifen in C6 glioma cells
Neurosurgery 1992
Oct;31(4):725-9 (Cell Culture Study, Abstract)
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Metastatic
Tumors
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Treatment
> Paclitaxel / Tamoxifen
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Robert L. Fine, Johnson Chen,
Casilda Balmaceda, Jeffrey N. Bruce, May
Huang, Manisha Desai, Michael B. Sisti, Guy
M. McKhann, Robert R. Goodman, Joseph S. Bertino,
Jr., Anne N. Nafziger and Michael R. Fetell
Randomized Study of Paclitaxel and Tamoxifen Deposition into Human Brain
Tumors: Implications for the Treatment of Metastatic Brain Tumors
Clin
Cancer Res. 2006 Oct 1;12(19):5770-6.
Abstract
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Myriam
W Ben Arush, Sergey Postovsky, Ronit Elhasid, A Ben-Barak, C Levine,
Joseph F Guilburd
Antiangiogenic therapy
in pediatric malignancies: experience of the Northern Israel Pediatric Cancer
Center
ASCO Proceedings, 2002
Annual Meeting, Abstract No. 2926 (Clinical Study)
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Non-Nervous
System Tumors
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Figueredo A, Arnold A, Goodyear M, Findlay B, Neville A,
Normandeau R, Jones A
Addition
of verapamil and tamoxifen to the initial chemotherapy of small cell lung
cancer. A phase I/II study
Cancer
1990 May 1;65(9):1895-902 (Clinical Study, Abstract)
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Kazanci
N, Severcan F.
Concentration Dependent Different Action of Tamoxifen on Membrane Fluidity.
Biosci Rep. 2007 Jun
28; [Epub ahead of print]
PMID: 17597395 [PubMed - as supplied by publisher]
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Kenny
FS, Gee JM, Nicholson RI, Ellis IO, Morris TM, Watson SA, Bryce RP,
Robertson JF
Effect
of dietary GLA+/-tamoxifen on the growth, ER expression and fatty acid profile
of ER positive human breast cancer xenografts
Int J Cancer 2001 May 1;92(3):342-7 (Animal Study, Abstract)
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Kenny
FS, Pinder SE, Ellis IO, Gee JM, Nicholson RI, Bryce RP, Robertson JF
Gamma
linolenic acid with tamoxifen as primary therapy in breast cancer
Int J Cancer 2000 Mar 1;85(5):643-8 (Clinical Study,
Abstract)
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Iino
Y, Takai Y, Sugamata N, Morishita Y
PSK (krestin)
potentiates chemotherapeutic effects of tamoxifen on rat mammary carcinomas
Anticancer Res 1992 Nov-Dec;12(6B):2101-3 (Animal Study,
Abstract)
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Rowlands
MG, Budworth J, Jarman M, Hardcastle IR, McCague R, Gescher A
Comparison between inhibition of protein kinase C
and antagonism of calmodulin by tamoxifen analogues
Biochem Pharmacol 1995 Aug 25;50(5):723-6 (Cell Culture Study, Abstract)
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Figueredo A, Arnold A, Goodyear M, Findlay B, Neville A,
Normandeau R, Jones A
Addition
of verapamil and tamoxifen to the initial chemotherapy of small cell lung
cancer. A phase I/II study
Cancer
1990 May 1;65(9):1895-902 (Clinical Study, Abstract)
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Li Hua Wang, Xiao Yi Yang, Xiaohu Zhang,
Ping An, Han-Jong Kim,
Jiaqiang Huang, Robert Clarke,
C. Kent Osborne, John K. Inman,
Ettore Appella and William L. Farrar
Disruption of estrogen receptor
DNA-binding domain and related intramolecular communication restores
tamoxifen sensitivity in resistant breast cancer
Cancer Cell. 2006 Dec;10(6):487-99; doi:10.1016/j.ccr.2006.09.015; Available
online 11 December 2006.
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Yimin Zhu, Qihan
Dong, Bee Jen Tan, Wee Guan Lim, Shufeng
Zhou and Wei Duan
The PKCα-D294G Mutant Found in
Pituitary and Thyroid Tumors Fails to Transduce Extracellular Signals
Cancer Research, 65, 4520-4524, June 1,
2005. (Laboratory Investigation, Abstract+)
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