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Temozolomide Laboratory Investigations

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Basic Science


Blough MD, Westgate MR, Beauchamp D, Kelly JJ, Stechishin O, Ramirez AL, Weiss S, Cairncross JG.
Sensitivity to temozolomide in brain tumor initiating cells
Neuro Oncol. 2010 Apr 13;. [Epub ahead of print]
  Abstract

Waldeck W, Wiessler M, Ehemann V, Pipkorn R, Spring H, Debus J, Didinger B, Mueller G, Langowski J, Braun K.
TMZ-BioShuttle--a reformulated temozolomide
Int J Med Sci. 2008 Sep 15;5(5):273-84
  Abstract |  Full text |   Reprint


Brain Tumors


Maschio M, Albani F, Jandolo B, Zarabla A, Contin M, Dinapoli L, Fabi A, Pace A, Baruzzi A
Temozolomide treatment does not affect topiramate and oxcarbazepine plasma concentrations in chronically treated patients with brain tumor-related epilepsy
J Neurooncol. 2008 Jul 9; [Epub ahead of print]
 Abstract

Stupp R, Gander M, Leyvraz S, Newlands E
Current and future developments in the use of temozolomide for the treatment of brain tumours
Lancet Oncol. 2001 Sep; 2(9): 552-60.  

Tilleul P, Brignone M, Hassani Y, Taillandier L, Taillibert S, Cartalat-Carel S, Borget I, Chinot O.
Prescription guidebook for temozolomide usage in brain tumors
Bull Cancer. 2009 May 1;96(5):579-589. French
  Abstract |   Full text |   Reprint


Cancer Research


Pegg AE
Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents
Cancer Res 1990 Oct 1;50(19):6119-29 

Shinoura N, Yamada R, Tabei Y, Saito K, Nakamura O, Takahashi M.
Temozolomide-temodal
Gan To Kagaku Ryoho. 2008 Mar;35(3):543-7
 Abstract


Hum. lymphobl. cell lines


D'Atri S, Tentori L, Lacal PM, Graziani G, Pagani E, Benincasa E, Zambruno G, Bonmassar E, Jiricny J
Involvement of the mismatch repair system in temozolomide-induced apoptosis
Mol Pharmacol 1998 Aug;54(2):334-41 (PDF Full text)


Metastatic Tumors


Islam R, Isaacson BJ, Zickerman PM, Ratanawong C, Tipping SJ
Hemorrhagic cystitis as an unexpected adverse reaction to temozolomide: case report
Am J Clin Oncol 2002 Oct;25(5):513-4 


Lucio Tentori, Carlo Leonetti, Marco Scarsella, Weizheng Xu, David C. Calvin, Lisa Morgan, Zhaocheng Tang, Krystyna M. Wozniak, Christina Alemu, Randall Hoover, Rena G. Lapidus, Gabriella Zupi, Jie Zhang, Grazia Graziani
Oral administration of the PARP-1 inhibitor GPI 15427 increases the anti-tumor activity of temozolomide against melanoma growing at the CNS site
Proceedings of the AACR, Volume 45, March 2004, Abstract Number: 2007. 


Anapl. Oligoastrocytoma


Alfredo D. Voloschin, David N. Louis, Garth R. Cosgrove, and Tracy T. Batchelor
Neoadjuvant temozolomide followed by complete resection of a 1p- and 19q-deleted anaplastic oligoastrocytoma: Case study
Neuro-Oncology, Volume 7, Number 1, Pages 97 -- 100, January 2005. (Abstract+)

 

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