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Anaplastic
Astrocytomas
|
|
|
|
|
Sadones J, Michotte A, Veld P, Chaskis C, Sciot
R, Menten J, Joossens EJ, Strauven T, D'Hondt LA, Sartenaer D, Califice SF,
Bierau K, Svensson C, De Grève J, Neyns B.
MGMT promoter hypermethylation correlates with a survival benefit from
temozolomide in patients with recurrent anaplastic astrocytoma but not
glioblastoma
Eur J Cancer. 2008 Oct 20; [Epub ahead of print]
Abstract | 
Links |
Issue
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Basic
Science
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Waldeck W, Wiessler M, Ehemann V, Pipkorn R,
Spring H, Debus J, Didinger B, Mueller G, Langowski J, Braun K.
TMZ-BioShuttle--a reformulated temozolomide
Int J Med Sci. 2008 Sep 15;5(5):273-84
Abstract |  Full Text |
Reprint |
Links |
BL 7:19
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Brain
Tumors
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Maschio M, Albani F, Jandolo B, Zarabla A,
Contin M, Dinapoli L, Fabi A, Pace A, Baruzzi A
Temozolomide treatment does not affect topiramate and oxcarbazepine
plasma concentrations in chronically treated patients with brain
tumor-related epilepsy
J Neurooncol. 2008 Jul 9; [Epub ahead of print]
Abstract |
Links |
BL 7:14
|
|
Stupp
R, Gander M, Leyvraz S, Newlands E
Current
and future developments in the use of temozolomide for the treatment of
brain tumours
Lancet Oncol. 2001 Sep; 2(9): 552-60.
|
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Tilleul
P, Brignone M, Hassani Y, Taillandier L, Taillibert S, Cartalat-Carel S,
Borget I, Chinot O.
Prescription guidebook for temozolomide usage in brain tumors
Bull Cancer. 2009 May 1;96(5):579-589. French
Abstract |
Full Text |
Reprint |
Links |
Issue
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Cancer
Research
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Pegg
AE
Mammalian
O6-alkylguanine-DNA alkyltransferase: regulation and importance in
response to alkylating carcinogenic and therapeutic agents
Cancer Res 1990 Oct 1;50(19):6119-29
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Shinoura N, Yamada R, Tabei Y, Saito K, Nakamura
O, Takahashi M.
Temozolomide-temodal
Gan To Kagaku Ryoho. 2008 Mar;35(3):543-7
Abstract |
Links | BL 7:7
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Glioblastoma
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Manish Aghi, Samuel Rabkin,
Robert L. Martuza
Effect of Chemotherapy-Induced DNA Repair on
Oncolytic Herpes Simplex Viral Replication
Journal of the National Cancer Institute, Vol. 98, No. 1, 38-50, January 4, 2006
Abstract
| BrainLife
|
News
|
|
Balana C,
Ramirez JL, Taron M, Roussos Y, Ariza A, Ballester R, Sarries C, Mendez P,
Sanchez JJ, Rosell R
O(6)-methyl-guanine-DNA
methyltransferase Methylation in Serum and Tumor DNA Predicts Response to
1,3-Bis(2-Chloroethyl)-1-Nitrosourea but not to Temozolamide Plus
Cisplatin in Glioblastoma Multiforme
Clin Cancer Res
2003 Apr;9(4):1461-8
|
|
|
Beier D, Röhrl S, Pillai DR, Schwarz S, Kunz-Schughart
LA, Leukel P, Proescholdt M, Brawanski A, Bogdahn U, Trampe-Kieslich A,
Giebel B, Wischhusen J, Reifenberger G, Hau P, Beier CP
Temozolomide preferentially depletes cancer stem cells in glioblastoma
Cancer Res. 2008
Jul 15;68(14):5706-15
Abstract |
Reprint |
Links |
BL 7:15
|
|
Susan E. Jones-Bolin, Hugh
Zhao, Kathryn Hunter, Bruce Ruggeri
Effects of
chronic oral administration of the pan VEGF-R kinase inhibitor,
CEP-7055, alone and in combination with temozolomide (TMZ), on
primary tumor growth, neurological dysfunction, and survival in
an orthotopic model of human glioblastoma in nude mice
Proceedings of the AACR, Volume 44, 2nd ed., July 2003, Abstract
No. 61
|
|
|
Brandes AA, Tosoni A, Franceschi E, Sotti G, Frezza G, Amistà P, Morandi L,
Spagnolli F, Ermani M
Recurrence
Pattern after Temozolomide Concomitant With and Adjuvant to Radiotherapy in
Newly Diagnosed Patients With Glioblastoma: Correlation With MGMT Promoter
Methylation Status
J
Clin Oncol. 2009 Feb 2. [Epub ahead of print]
Abstract |
Links |
Issue
|
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Brandes
AA, Franceschi E, Tosoni A, Blatt V, Pession A, Tallini G, Bertorelle R,
Bartolini S, Calbucci F, Andreoli A, Frezza G, Leonardi M, Spagnolli F,
Ermani M.
MGMT promoter methylation status can predict the incidence and outcome of
pseudoprogression after concomitant radiochemotherapy in newly diagnosed
glioblastoma patients
J
Clin Oncol. 2008 May 1;26(13):2192-7
Abstract |
Links |
BL 7:10
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|
Carlson BL, Grogan PT, Mladek AC, Schroeder MA, Kitange GJ,
Decker PA, Giannini C, Wu W, Ballman KA, James CD, Sarkaria JN
Radiosensitizing effects of temozolomide observed in vivo only in a
subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma
multiforme xenografts
Int
J Radiat Oncol Biol Phys. 2009 Sep 1;75(1):212-9
Abstract |
Links |
CNO 8(10)
|
|
Arabinda Das, Kunal D. Patel, Marc S. Weinberg, Sunil J.
Patel, Naren L. Banik, Swapan K. Ray
Modulatory effect of dexamethasone on temozolomide induced
apoptosis in human glioblastoma U87MG cells
Proceedings of the AACR, Volume 45, March 2004, Abstract
Number: 554.
|
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Fu
J, Liu ZG, Liu XM, Chen FR, Shi HL, Pangjesse CS, Ng HK, Chen ZP
Glioblastoma stem cells resistant to temozolomide-induced autophagy
Chin Med J (Engl). 2009 Jun 5;122(11):1255-9
Abstract |
Full Text |
Reprint |
Links |
Issue
|
|
|
Li S, Zhang W, Chen B, Jiang T, Wang Z
Prognostic and predictive value of p53 in low MGMT expressing
glioblastoma treated with surgery, radiation and adjuvant temozolomide
chemotherapy
Neurol Res.
2009 Aug 21. [Epub ahead of print]
Abstract |
Links |
CNO 8(10)
|
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|
Li S, Jiang T, Li G, Wang Z
Impact of p53 status to response of temozolomide in low MGMT expression
glioblastomas: preliminary results
Neurol Res.
2008 Jul;30(6):567-70
Abstract |
Links |
BL 7:15
|
|
Huan Ren, Alf Giese,
Tingchang Chou, Steven Pelech, Nikolai Rainov
Biological
activity of a novel tyrosine kinase inhibitor of the
2-phenylaminopyrimidine class, Imatinib (STI571, Gleevec), on
human glioblastoma cells
Proceedings of the AACR, Volume 44, 2nd ed., July 2003, Abstract
No. R3776
|
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|
Schaich M, Kestel L, Pfirrmann M, Robel K,
Illmer T, Kramer M, Dill C, Ehninger G, Schackert G, Krex D.
A MDR1 (ABCB1) gene single nucleotide polymorphism predicts outcome of
temozolomide treatment in glioblastoma patients
Ann Oncol. 2008 Aug 7; [Epub ahead of print]
Abstract |
Links |
BL 7:16
|
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Mrugala MM, Chamberlain MC.
Mechanisms of disease: temozolomide and glioblastoma--look to the future
Nat
Clin Pract Oncol. 2008 Aug;5(8):476-86.
Epub 2008 Jun 10
Abstract |
Links | BL 7:18
|
|
|
Park
DM, Shah DD, Egorin MJ, Beumer JH
Disposition
of temozolomide in a patient with glioblastoma multiforme after gastric
bypass surgery
J Neurooncol.
2009 Jan 6. [Epub ahead of print]
Abstract |
Links |
Issue
|
|
|
Antonio Silvani, Elena Lamperti, Paola Gaviani,
Marica Eoli, Anna Fiumani, Andrea Salmaggi, Chiara Falcone,
Graziella Filippini, Andrea Botturi and Amerigo Boiardi
Salvage chemotherapy with procarbazine and fotemustine combination in the
treatment of temozolomide treated recurrent glioblastoma patients
Journal of Neuro-Oncology, Epub June 19, 2007, DOI:
10.1007/s11060-007-9427-y
Abstract |
Links | BL 7:4
|
|
|
van
Nifterik KA, van den Berg J, Stalpers LJ, Lafleur MV, Leenstra S, Slotman BJ,
Hulsebos TJ, Sminia P.
Differential Radiosensitizing Potential of
Temozolomide in MGMT Promoter Methylated Glioblastoma Multiforme Cell Lines.
Int
J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1246-53.
Abstract
|
|
|
Vinjamuri M, Adumala RR, Altaha R, Hobbs GR,
Crowell EB Jr.
Comparative analysis of temozolomide (TMZ) versus 1,3-bis
(2-chloroethyl)-1 nitrosourea (BCNU) in newly diagnosed glioblastoma
multiforme (GBM) patients
J Neurooncol. 2008 Sep 24; [Epub ahead of print]
Abstract |
Links |
BL 7:19
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Gliomas
|
|
|
|
|
Akbar U, Jones T, Winestone J, Michael M, Shukla A, Sun Y, Duntsch C
Delivery
of temozolomide to the tumor bed via biodegradable gel matrices in a novel
model of intracranial glioma with resection
J Neurooncol.
2009 Apr 1. [Epub ahead of print]
Abstract |
Links |
Issue
|
|
Marco Balzarotti, Emilio Ciusani, Chiara Calatozzolo, Danilo Croci,
Amerigo Boiardi, and Andrea Salmaggi
Effect of Association of Temozolomide With Other
Chemotherapic Agents on Cell Growth Inhibition in Glioma Cell Lines
Oncology Research, 2004, Volume 14, pp. 325-330.
|
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Banissi C, Ghiringhelli F, Chen L, Carpentier AF
Treg depletion with a low-dose metronomic temozolomide regimen in a rat
glioma model
Cancer Immunol Immunother. 2009 Feb 17; [Epub ahead of print]
Abstract |
Links |
Issue
|
|
|
Dora
B. Bocangel, Sydney Finkelstein, S. Clifford Schold, Kishor K. Bhakat, Sankar
Mitra and Demetrius M. Kokkinakis
Multifaceted Resistance of Gliomas to Temozolomide
Clinical Cancer Research Vol. 8, 2725-2734, 1 August 2002
Abstract |
Full Text |
Reprint |
Links | BL
1:3
|
|
|
Brem S, Tyler B, Li K, Pradilla G, Legnani F, Caplan J, Brem H
Local
delivery of temozolomide by biodegradable polymers is superior to oral
administration in a rodent glioma model
Cancer
Chemother Pharmacol. 2007 Oct;60(5):643-50. Epub 2007 Jan 26.
Abstract |
Links |
Issue
|
|
|
Chalmers
AJ, Ruff EM, Martindale C, Lovegrove N, Short SC
Cytotoxic effects of temozolomide and radiation are additive- and
schedule-dependent
Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1511-9
Abstract |
Links |
CNO 8(12)
|
|
M.J.M.
Darkes, G.L. Plosker, B. Jarvis
Temozolomide: A Review of its Use in the
Treatment of Malignant Gliomas, Malignant Melanoma and Other Advanced
Cancers
American Journal of Cancer,
Volume 1, Number 1, Pages: 55 -- 80 [2002]
|
|
Dinnes
J, Cave C, Huang S, Milne R
A rapid
and systematic review of the effectiveness of temozolomide for the
treatment of recurrent malignant glioma
Br J Cancer. 2002 Feb 12;86(4):501-5
|
|
Friedman HS, Keir S, Pegg AE, Houghton PJ, Colvin OM, Moschel RC,
Bigner DD, Dolan ME
O6-benzylguanine-mediated
enhancement of chemotherapy
Mol Cancer Ther 2002
Sep;1(11):943-8
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|
Hassouna I, Sperling S, Kim E, Schulz-Schaeffer W, Rave-Fränk M,
Hasselblatt M, Jelkmann W, Giese A, Ehrenreich H
Erythropoietin
augments survival of glioma cells after radiation and temozolomide
Int
J Radiat Oncol Biol Phys. 2008 Nov 1;72(3):927-34
Abstract |
Links |
Issue
|
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Hingtgen
S, Ren X, Terwilliger E, Classon M, Weissleder R, Shah K.
Targeting multiple pathways in gliomas with stem cell and viral delivered
S-TRAIL and Temozolomide
Mol Cancer Ther. 2008 Nov 1;7(11):3575-85
Abstract |
Links |
Issue
|
|
Takao Kanzawa, Hideaki Ito, Yasuko Kondo, Seiji Kondo
Role of autophagy in temozolomide-induced cytotoxicity for
malignant glioma cells
Proceedings of the AACR, Volume 45, March 2004, Abstract
Number: 579.
|
|
Kanzawa T,
Germano IM, Kondo Y, Ito H, Kyo S, Kondo S
Inhibition
of telomerase activity in malignant glioma cells correlates with their
sensitivity to temozolomide
Br J Cancer.
2003 Sep 1;89(5):922-929 (Cell Culture Study, Abstract)
|
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Koukourakis GV, Kouloulias V, Zacharias G, Papadimitriou C, Pantelakos P, Maravelis G,
Fotineas A, Beli I, Chaldeopoulos D, Kouvaris J
Temozolomide with radiation therapy in high grade brain gliomas:
pharmaceuticals considerations and efficacy; a review article
Molecules. 2009 Apr 16;14(4):1561-77
Abstract |
Links |
Issue
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|
La Rocca RV, Mehdorn HM.
Localized BCNU chemotherapy and the multimodal management of malignant
glioma
Curr Med Res Opin. 2009 Jan;25(1):149-60
Abstract |
Links |
Issue
|
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Maurer GD, Tritschler I, Adams B,
Tabatabai G, Wick W, Stupp R, Weller M.
Cilengitide modulates attachment and viability of human glioma cells, but
not sensitivity to irradiation or temozolomide in vitro
Neuro Oncol. 2009 Feb 16; [Epub ahead of print]
Abstract |
Links |
Issue
|
|
Murphy PS, Viviers L, Abson C, Rowland IJ, Brada M, Leach
MO, Dzik-Jurasz AS
Monitoring temozolomide treatment of low-grade glioma
with proton magnetic resonance spectroscopy
Br J Cancer. 2004 Feb 23;90(4):781-6.
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Panetta
JC, Kirstein MN, Gajjar AJ, Nair G, Fouladi M, Stewart CF
A
mechanistic mathematical model of temozolomide myelosuppression in children with
high-grade gliomas
Math
Biosci. 2003 Nov;186(1):29-41
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| |
Susan
Pannullo, D. C
Shungu, R. L DeLaPaz, M. Odaimi, J. Serventi, L. Heller, C. M Balmaceda
Use
of magnetic resonance spectroscopy (MRS) in malignant gliomas treated with
temozolomide (TMZ)
38th
ASCO Annual Meeting. Orlando, FL. May 18-21, 2002.
Abstract No.
2101.
|
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Patel
VJ, Elion GB, Houghton PJ, Keir S, Pegg AE, Johnson SP, Dolan ME,
Bigner DD, Friedman HS
Schedule-dependent
activity of temozolomide plus CPT-11 against a human central nervous
system tumor-derived xenograft
Clin Cancer Res 2000
Oct;6(10):4154-7
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Paz MF, Yaya-Tur R, Rojas-Marcos I, Reynes G, Pollan M, Aguirre-Cruz L,
Garcia-Lopez JL, Piquer J, Safont MJ, Balana C, Sanchez-Cespedes M,
Garcia-Villanueva M, Arribas L, Esteller M
CpG island hypermethylation of the DNA repair enzyme
methyltransferase predicts response to temozolomide in primary gliomas
Clin Cancer Res. 2004 Aug 1;10(15):4933-8.
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Plowman
J, Waud WR, Koutsoukos AD, Rubinstein LV, Moore TD, Grever MR
Preclinical
antitumor activity of temozolomide in mice: efficacy against human brain tumor
xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea
Cancer
Res 1994 Jul 15;54(14):3793-9
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Quinn JA, Jiang SX, Reardon DA, Desjardins A, Vredenburgh JJ, Rich JN,
Gururangan S, Friedman AH, Bigner DD, Sampson JH, McLendon RE, Herndon JE
2nd, Walker A, Friedman HS
Phase
II Trial of Temozolomide Plus O6-Benzylguanine in Adults With Recurrent,
Temozolomide-Resistant Malignant Glioma
J
Clin Oncol. 2009 Feb 9. [Epub ahead of print]
Abstract |
Links |
Issue
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|
Lucio Tentori, Carlo
Leonetti, Marco Scarsella, Giulia d'Amati, Weizheng Xu, Vincent
Kalish, Jie Zhang, Gabriella Zupi, Grazia Graziani
Systemic
administration of the PARP inhibitor GPI 15427 increases the
anti-tumor activity of temozolomide in melanoma, glioma and
lymphoma preclinical models in vivo
Proceedings of the AACR, Volume 44, 2nd ed., July 2003, Abstract
No. 5466
|
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|
Rosso
L, Brock CS, Gallo JM, Saleem A, Price PM, Turkheimer FE, Aboagye EO
A
new model for prediction of drug distribution in tumor and normal tissues:
pharmacokinetics of temozolomide in glioma patients
Cancer Res. 2009
Jan 1;69(1):120-7
Abstract |
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Issue
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van
Rijn J, Heimans JJ, van den Berg J, van der Valk P, Slotman BJ
Survival
of human glioma cells treated with various combination of temozolomide and
X-rays
Int J Radiat Oncol Biol Phys. 2000 Jun 1; 47(3): 779-84
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Meg Verrees, Lili Liu, Stanton L. Gerson
Interruption of base excision repair selectively enhances
temozolamide and 1,3-bis(2-chloroethyl)-nitrosurea cytotoxicity in treatment of
adult human malignant glioma cell lines
Proceedings of the AACR, Volume 45, March 2004, Abstract
Number: 1548.
|
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F.
S. Viola, F. Morrone, J. Stella, F. Spiller, A. Battastini, C. H. Barrios
Combination
of STI571 and temozolamide on inhibition of rat and human glioma cell lines
proliferation
39th
ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003. Abstract No. 469
|
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Yamini B, Yu X, Pytel P, Galanopoulos N, Rawlani
V, Veerapong J, Bickenbach K, Weichselbaum RR
Adenovirally delivered tumor necrosis
factor-alpha improves the antiglioma efficacy of concomitant radiation and
temozolomide therapy
Clin
Cancer Res. 2007 Oct 15;13(20):6217-23
Abstract |
Links | BL 7:2
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Hum.
lymphoblastoid cell lines
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D'Atri S, Tentori L, Lacal PM,
Graziani G, Pagani E, Benincasa E, Zambruno G, Bonmassar E, Jiricny J
Involvement
of the mismatch repair system in temozolomide-induced apoptosis
Mol Pharmacol 1998 Aug;54(2):334-41 (PDF Full Text)
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Metastatic Tumors
|
|
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Islam
R, Isaacson BJ, Zickerman PM, Ratanawong C, Tipping SJ
Hemorrhagic
cystitis as an unexpected adverse reaction to temozolomide: case report
Am J Clin Oncol 2002
Oct;25(5):513-4
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|
Lucio Tentori, Carlo Leonetti, Marco Scarsella, Weizheng Xu,
David C. Calvin, Lisa Morgan, Zhaocheng Tang, Krystyna M. Wozniak, Christina
Alemu, Randall Hoover, Rena G. Lapidus, Gabriella Zupi, Jie Zhang, Grazia
Graziani
Oral administration of the PARP-1 inhibitor GPI 15427 increases
the anti-tumor activity of temozolomide against melanoma growing at the CNS site
Proceedings of the AACR, Volume 45, March 2004, Abstract
Number: 2007.
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Microenvironment
|
|
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Virrey JJ, Golden EB, Sivakumar W, Wang W, Pen L, Schönthal AH, Hofman FM, Chen TC
Glioma-associated
endothelial cells are chemoresistant to temozolomide
J Neurooncol.
2009 Apr 18. [Epub ahead of print]
Abstract |
Links |
Issue
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Anaplastic
Oligoastrocytoma
|
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|
|
Alfredo D. Voloschin,
David N. Louis, Garth R. Cosgrove, and Tracy T. Batchelor
Neoadjuvant temozolomide followed by complete resection of a 1p- and
19q-deleted anaplastic oligoastrocytoma: Case study
Neuro-Oncology, Volume
7, Number 1, Pages 97 -- 100, January 2005. (Abstract+)
|
|
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Pediatric
Brain Tumors
|
|
|
|
Michael S. Bobola, Richard Ellenbogen, Ryan Goff, John Silber
Ablation of O6-methylguanine-DNA methyltransferase
with O6-benzylguanine reduces the resistance of pediatric primary
brain tumor cell lines to temozolomide and BCNU
Proceedings of the AACR, Volume 45, March 2004, Abstract
Number: 2143.
|
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Pseudo-progression
|
|
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Taal
W, Brandsma D, de Bruin HG, Bromberg JE, Swaak-Kragten AT, Sillevis Smitt
PA, van Es CA, van den Bent MJ.
Incidence of early pseudo-progression in a cohort of malignant glioma
patients treated with chemoirradiation with temozolomide
Cancer. 2008 May 16. [Epub
ahead of print]
Abstract |
Links | BL 7:11
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