Treatment > Temozolomide Investigations


Brain Tumors


Stupp R, Gander M, Leyvraz S, Newlands E
Current and future developments in the use of temozolomide for the treatment of brain tumours
Lancet Oncol. 2001 Sep; 2(9): 552-60.  


Cancer Research


Pegg AE
Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents
Cancer Res 1990 Oct 1;50(19):6119-29 

Shinoura N, Yamada R, Tabei Y, Saito K, Nakamura O, Takahashi M.
Temozolomide-temodal
Gan To Kagaku Ryoho. 2008 Mar;35(3):543-7
 Abstract |
DBLinks | BL 7:7


Glioblastoma


Manish Aghi, Samuel Rabkin, Robert L. Martuza
Effect of Chemotherapy-Induced DNA Repair on Oncolytic Herpes Simplex Viral Replication
Journal of the National Cancer Institute, Vol. 98, No. 1, 38-50, January 4, 2006
Abstract | BrainLife | News

Balana C, Ramirez JL, Taron M, Roussos Y, Ariza A, Ballester R, Sarries C, Mendez P, Sanchez JJ, Rosell R
O(6)-methyl-guanine-DNA methyltransferase Methylation in Serum and Tumor DNA Predicts Response to 1,3-Bis(2-Chloroethyl)-1-Nitrosourea but not to Temozolamide Plus Cisplatin in Glioblastoma Multiforme
Clin Cancer Res 2003 Apr;9(4):1461-8 

Susan E. Jones-Bolin, Hugh Zhao, Kathryn Hunter, Bruce Ruggeri
Effects of chronic oral administration of the pan VEGF-R kinase inhibitor, CEP-7055, alone and in combination with temozolomide (TMZ), on primary tumor growth, neurological dysfunction, and survival in an orthotopic model of human glioblastoma in nude mice
Proceedings of the AACR, Volume 44, 2nd ed., July 2003, Abstract No. 61 

Arabinda Das, Kunal D. Patel, Marc S. Weinberg, Sunil J. Patel, Naren L. Banik, Swapan K. Ray
Modulatory effect of dexamethasone on temozolomide induced apoptosis in human glioblastoma U87MG cells
Proceedings of the AACR, Volume 45, March 2004, Abstract Number: 554.

Huan Ren, Alf Giese, Tingchang Chou, Steven Pelech, Nikolai Rainov
Biological activity of a novel tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class, Imatinib (STI571, Gleevec), on human glioblastoma cells
Proceedings of the AACR, Volume 44, 2nd ed., July 2003, Abstract No. R3776 

Antonio Silvani, Elena Lamperti, Paola Gaviani, Marica Eoli, Anna Fiumani, Andrea Salmaggi, Chiara Falcone, Graziella Filippini, Andrea Botturi and Amerigo Boiardi
Salvage chemotherapy with procarbazine and fotemustine combination in the treatment of temozolomide treated recurrent glioblastoma patients
Journal of Neuro-Oncology, Epub June 19, 2007, DOI: 10.1007/s11060-007-9427-y
Abstract | DBLinks | BL 7:4

van Nifterik KA, van den Berg J, Stalpers LJ, Lafleur MV, Leenstra S, Slotman BJ, Hulsebos TJ, Sminia P.
Differential Radiosensitizing Potential of Temozolomide in MGMT Promoter Methylated Glioblastoma Multiforme Cell Lines.
Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1246-53.
Abstract


Gliomas


Marco Balzarotti, Emilio Ciusani, Chiara Calatozzolo, Danilo Croci, Amerigo Boiardi, and Andrea Salmaggi
Effect of Association of Temozolomide With Other Chemotherapic Agents on Cell Growth Inhibition in Glioma Cell Lines
Oncology Research, 2004, Volume 14, pp. 325-330. 

Dora B. Bocangel, Sydney Finkelstein, S. Clifford Schold, Kishor K. Bhakat, Sankar Mitra and Demetrius M. Kokkinakis
Multifaceted Resistance of Gliomas to Temozolomide
Clinical Cancer Research Vol. 8, 2725-2734, 1 August 2002

 Abstract |  Full Text |  Reprint |  DBLinks | BL 1:3

M.J.M. Darkes, G.L. Plosker, B. Jarvis
Temozolomide: A Review of its Use in the Treatment of Malignant Gliomas, Malignant Melanoma and Other Advanced Cancers

American Journal of Cancer, Volume 1, Number 1, Pages: 55 -- 80 [2002] 


Dinnes J, Cave C, Huang S, Milne R
A rapid and systematic review of the effectiveness of temozolomide for the treatment of recurrent malignant glioma
Br J Cancer. 2002 Feb 12;86(4):501-5
 

Friedman HS, Keir S, Pegg AE, Houghton PJ, Colvin OM, Moschel RC, Bigner DD, Dolan ME
O6-benzylguanine-mediated enhancement of chemotherapy
Mol Cancer Ther 2002 Sep;1(11):943-8 

Takao Kanzawa, Hideaki Ito, Yasuko Kondo, Seiji Kondo
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells
Proceedings of the AACR, Volume 45, March 2004, Abstract Number: 579. 

Kanzawa T, Germano IM, Kondo Y, Ito H, Kyo S, Kondo S
Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide
Br J Cancer. 2003 Sep 1;89(5):922-929 (Cell Culture Study, Abstract)


Murphy PS, Viviers L, Abson C, Rowland IJ, Brada M, Leach MO, Dzik-Jurasz AS
Monitoring temozolomide treatment of low-grade glioma with proton magnetic resonance spectroscopy
Br J Cancer. 2004 Feb 23;90(4):781-6. 

Panetta JC, Kirstein MN, Gajjar AJ, Nair G, Fouladi M, Stewart CF
A mechanistic mathematical model of temozolomide myelosuppression in children with high-grade gliomas
Math Biosci. 2003 Nov;186(1):29-41

Susan Pannullo, D. C Shungu, R. L DeLaPaz, M. Odaimi, J. Serventi, L. Heller, C. M Balmaceda
Use of magnetic resonance spectroscopy (MRS) in malignant gliomas treated with temozolomide (TMZ)
38th ASCO Annual Meeting. Orlando, FL. May 18-21, 2002. Abstract No.
2101.  

Patel VJ, Elion GB, Houghton PJ, Keir S, Pegg AE, Johnson SP, Dolan ME, Bigner DD, Friedman HS
Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft
Clin Cancer Res 2000 Oct;6(10):4154-7 

Paz MF, Yaya-Tur R, Rojas-Marcos I, Reynes G, Pollan M, Aguirre-Cruz L, Garcia-Lopez JL, Piquer J, Safont MJ, Balana C, Sanchez-Cespedes M, Garcia-Villanueva M, Arribas L, Esteller M
CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas
Clin Cancer Res. 2004 Aug 1;10(15):4933-8. 

Plowman J, Waud WR, Koutsoukos AD, Rubinstein LV, Moore TD, Grever MR
Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea
Cancer Res 1994 Jul 15;54(14):3793-9 

Lucio Tentori, Carlo Leonetti, Marco Scarsella, Giulia d'Amati, Weizheng Xu, Vincent Kalish, Jie Zhang, Gabriella Zupi, Grazia Graziani
Systemic administration of the PARP inhibitor GPI 15427 increases the anti-tumor activity of temozolomide in melanoma, glioma and lymphoma preclinical models in vivo
Proceedings of the AACR, Volume 44, 2nd ed., July 2003, Abstract No. 5466 

van Rijn J, Heimans JJ, van den Berg J, van der Valk P, Slotman BJ
Survival of human glioma cells treated with various combination of temozolomide and X-rays
Int J Radiat Oncol Biol Phys. 2000 Jun 1; 47(3): 779-84

Meg Verrees, Lili Liu, Stanton L. Gerson
Interruption of base excision repair selectively enhances temozolamide and 1,3-bis(2-chloroethyl)-nitrosurea cytotoxicity in treatment of adult human malignant glioma cell lines
Proceedings of the AACR, Volume 45, March 2004, Abstract Number: 1548. 

F. S. Viola, F. Morrone, J. Stella, F. Spiller, A. Battastini, C. H. Barrios
Combination of STI571 and temozolamide on inhibition of rat and human glioma cell lines proliferation
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003. Abstract No. 469

Yamini B, Yu X, Pytel P, Galanopoulos N, Rawlani V, Veerapong J, Bickenbach K, Weichselbaum RR
Adenovirally delivered tumor necrosis factor-alpha improves the antiglioma efficacy of concomitant radiation and temozolomide therapy
Clin Cancer Res. 2007 Oct 15;13(20):6217-23

Abstract | DBLinks | BL 7:2


Hum. lymphoblastoid cell lines


D'Atri S, Tentori L, Lacal PM, Graziani G, Pagani E, Benincasa E, Zambruno G, Bonmassar E, Jiricny J
Involvement of the mismatch repair system in temozolomide-induced apoptosis
Mol Pharmacol 1998 Aug;54(2):334-41 (PDF Full Text)


Metastatic Tumors


Islam R, Isaacson BJ, Zickerman PM, Ratanawong C, Tipping SJ
Hemorrhagic cystitis as an unexpected adverse reaction to temozolomide: case report
Am J Clin Oncol 2002 Oct;25(5):513-4 


Lucio Tentori, Carlo Leonetti, Marco Scarsella, Weizheng Xu, David C. Calvin, Lisa Morgan, Zhaocheng Tang, Krystyna M. Wozniak, Christina Alemu, Randall Hoover, Rena G. Lapidus, Gabriella Zupi, Jie Zhang, Grazia Graziani
Oral administration of the PARP-1 inhibitor GPI 15427 increases the anti-tumor activity of temozolomide against melanoma growing at the CNS site
Proceedings of the AACR, Volume 45, March 2004, Abstract Number: 2007. 


Anaplastic Oligoastrocytoma


Alfredo D. Voloschin, David N. Louis, Garth R. Cosgrove, and Tracy T. Batchelor
Neoadjuvant temozolomide followed by complete resection of a 1p- and 19q-deleted anaplastic oligoastrocytoma: Case study
Neuro-Oncology, Volume 7, Number 1, Pages 97 -- 100, January 2005. (Abstract+)


Pediatric Brain Tumors


Michael S. Bobola, Richard Ellenbogen, Ryan Goff, John Silber
Ablation of O6-methylguanine-DNA methyltransferase with O6-benzylguanine reduces the resistance of pediatric primary brain tumor cell lines to temozolomide and BCNU
Proceedings of the AACR, Volume 45, March 2004, Abstract Number: 2143. 

 

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