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Treatment
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Topotecan and
Camptothecin Analogues |
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Brain
Tumors
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Yanli Zhuang, Charles
H. Fraga, K. Elaine Hubbard, Nikolaus Hagedorn,
John C. Panetta, Christopher M. Waters and Clinton
F. Stewart
Topotecan Central Nervous System
Penetration Is Altered by a Tyrosine Kinase Inhibitor
Cancer Research 66, 11305-11313, December 1, 2006. doi:
10.1158/0008-5472.CAN-06-0929
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Glioblastoma
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Grabenbauer
GG, Anders K, Fietkau RJ, Klautke G, Feldmann HJ, Weiser S, Staab HJ, Krauseneck
P, Sauer R
Prolonged
infusional topotecan and accelerated hyperfractionated 3d-conformal radiation in
patients with newly diagnosed glioblastoma--a phase I study
J Neurooncol 2002 Dec;60(3):269-75
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Lesimple T,
Hassel MB, Gedouin D, Seigneuret E, Carsin B, Hamlat A, Riffaud L, Simon H,
Malhaire JP, Guegan Y
Phase
I study of topotecan in combination with concurrent radiotherapy in adults with
glioblastoma
J Neurooncol. 2003 Nov;65(2):141-8.
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Piroth MD, Gagel B, Pinkawa M, Stanzel S,
Asadpour B, Eble MJ
Postoperative Radiotherapy of Glioblastoma Multiforme : Analysis and
Critical Assessment of Different Treatment Strategies and Predictive Factors
Strahlenther
Onkol. 2007 Dec;183(12):695-702.
Epub 2007 Nov 27
Abstract | 
DBLinks
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Gliomas
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Marco Balzarotti, Emilio Ciusani, Chiara Calatozzolo, Danilo Croci,
Amerigo Boiardi, and Andrea Salmaggi
Effect of Association of Temozolomide With Other
Chemotherapic Agents on Cell Growth Inhibition in Glioma Cell Lines
Oncology Research, 2004, Volume 14, pp. 325-330.
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Emilio Ciusani, Danilo Croci,
Maurizio Gelati, Chiara Calatozzolo,
Francesca Sciacca, Luisa Fumagalli,
Marco Balzarotti, Laura Fariselli,
Amerigo Boiardi and Andrea Salmaggi
In vitro effects of topotecan and ionizing radiation on
TRAIL/Apo2L-mediated apoptosis in malignant glioma
Journal
of Neuro-Oncology, 71(1):
19-25, January 2005. (Abstract+)
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Pinel
S, Chastagner
P, Merlin
JL, Marchal
C, Taghian
A, Barberi-Heyob
M
Topotecan can compensate for protracted radiation
treatment time effects in high grade glioma xenografts (bigstar)
J
Neurooncol. 2005 Nov 16; [Epub ahead of print].
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J. G. Supko, L. Alderson, P. Wen, K. Cassidy, S.
Pace, M. Obrocea, F. Hochberg
Pharmacokinetics of gimatecan, and orally administered camptothecin analogue, in
patients with malignant gliomas
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.2039
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Medulloblastoma |
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Stewart CF, Iacono LC, Chintagumpala M, Kellie SJ, Ashley D, Zamboni WC,
Kirstein MN, Fouladi M, Seele LG, Wallace D, Houghton PJ, Gajjar A
Results of a phase II upfront window of pharmacokinetically
guided topotecan in high-risk medulloblastoma and supratentorial primitive
neuroectodermal tumor
J Clin Oncol. 2004 Aug 15;22(16):3357-65.
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Antonio Pérez-Martínez,
Alvaro Lassaletta, Marta González-Vicent, Julián Sevilla,
Miguel Angel Díaz and Luis Madero
High-dose chemotherapy with autologous
stem cell rescue for children with high risk and recurrent
medulloblastoma and supratentorial primitive neuroectodermal tumors
Journal
of Neuro-Oncology, 71(1):
33-38, January 2005. (Abstract+)
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Metastatic
Tumors
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J.-P.
Hedde,
Y. Ko, U. Metzler, H. Vetter, I. G. Schmidt-Wolff, C. Grohe, O.
Lange, S. Kaubitzsch, H. Schueller
A
phase I/II trial of topotecan and radiation therapy for CNS-metastases of
patients with solid tumors
39th
ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003.
Abstract No. 444
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Robert
Morgan Jr., Timothy Synold, Adam Mamelak, Kim Margolin, Al-Kadhimi Zaid,
Przemyslaw Twardowski, Lucille Leong, Dean Lim, Sandeep Reddy, Isan Chen, Warren
Chow, Stephen Shibata, George Somlo, Yun Yen, Paul Frankel, James H Doroshow
Phase
I trial of tamoxifen (Tam), carboplatin (C), and topotecan (T) in recurrent or
metastatic brain tumors
38th
ASCO Annual Meeting. Orlando, FL. May 18-21, 2002.
Abstract No.
2102
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M. A. Spear, A. Mirmiran, E. McClay
Phase I/II trial of IV topotecan (TOPO) in combination
with whole brain radiation therapy (WBXRT)
40th
ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1553
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Malignant
Lymphoma
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A.
Korfel, L. Fischer, E. Thiel
Response
of relapsed or refractory primary central nervous system lymphoma (PCNSL) to
topotecan
39th ASCO Annual
Meeting. Chicago, IL. May 31-June 3, 2003. Abstract No. 429
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Neuroblastoma
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A. Donfrancesco, A. Jenkner, A.
Castellano, I. Ilari, G. M. Milano, C. Dominici, L. De Sio, P. Fidani
Front-line topotecan and
high-dose cyclophosphamide followed by ICE in high-risk neuroblastoma
40th
ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.8536
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C. N. Frantz, W. B. London, L.
Diller, R. Seeger, K. Sawyer
Recurrent neuroblastoma: Randomized treatment with
topotecan + cyclophosphamide (T+C) vs. topotecan alone(T). A POG/CCG
Intergroup Study
40th
ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.8512
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Pediatric
Brain Tumors
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Perez Martinez A, Contra T, Scaglione C, Diaz Perez MA,
Madero Lopez L
Topotecan for pediatric patients with
resistant and recurrent solid tumors
An Pediatr (Barc). 2003 Aug;59(2):143-8. (PDF Full
Text)
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PCNS
Lymphoma
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Voloschin AD, Betensky R, Wen PY, Hochberg F,
Batchelor T.
Topotecan as salvage therapy for relapsed or refractory primary central
nervous system lymphoma
J Neurooncol.
2008 Jan;86(2):211-5.
Epub 2007 Sep 21
Abstract |
DBLinks | BL 7:6
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