Treatment > Valproic Acid


Basic Science


Blaheta RA, Cinatl J Jr
Anti-tumor mechanisms of valproate: a novel role for an old drug
Med Res Rev 2002 Sep;22(5):492-511

Jihong Chen, Feras M Ghazawi, Wafae Bakkar and Qiao Li
Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B
Molecular Cancer 2006, 5:71, doi:10.1186/1476-4598-5-71, Published 11 December 2006


Brain Tumors


Charles J. Vecht, MD, PhD and Melanie van Breemen, MD
Optimizing therapy of seizures in patients with brain tumors
Neurology. 2006 Dec 26;67(12 Suppl 4):S10-3

Tremont-Lukats IW, Ratilal B, Armstrong T, Gilbert M
Antiepileptic drugs for preventing seizures in people with brain tumors
Cochrane Database Syst Rev. 2008 Apr 16;(2):CD004424
 Abstract |
DBLinks | BL 7:9


Gliomas


A.M. Admirant, J. A. Hendricks, P.C. De Witt Hamer, S. Leenstra, W.P. Vandertop, C.J.F. van Noorden, and J.P. Medema
Valproic Acid is toxic to malignant glioma cells and increases sensitivity to irradiation and chemotherapy
Abstracts for the Seventh Congress of the European Association for Neuro-Oncology (EANO). Abstract No. P80.
Neuro-Oncology, October 2006, Page 334.

Driever PH, Knupfer MM, Cinatl J, Wolff JE
Valproic acid for the treatment of pediatric malignant glioma
Klin Padiatr 1999 Jul-Aug;211(4):323-8

Rincon Castro LM, Gallant M, Niles LP
Novel targets for valproic acid: up-regulation of melatonin receptors and neurotrophic factors in C6 glioma cells
J Neurochem. 2005 Dec;95(5):1227-36

Wang AD, Ji XY, Huang Q, Wang CR, Dong J, Lan Q.
[Studies on the target cells and molecules with sodium valproate induced differential of human glioma cells.]
Zhonghua Wai Ke Za Zhi. 2007 Aug;45(16):1121-1124. Chinese.
Abstract | DBLinks

 

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