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Treatment > ZD1839 (Gefitinib, Iressa)


Brain Tumors

Yanli Zhuang, Charles H. Fraga, K. Elaine Hubbard, Nikolaus Hagedorn, John C. Panetta, Christopher M. Waters and Clinton F. Stewart
Topotecan Central Nervous System Penetration Is Altered by a Tyrosine Kinase Inhibitor

Cancer Research 66, 11305-11313, December 1, 2006. doi: 10.1158/0008-5472.CAN-06-0929


Glioblastoma

A. Chakravarti, W. Seiferheld, H. I. Robins, A. Guha, D. Brachman, W. Curran, A. Choucair, M. Mehta
An update of phase I data from RTOG 0211: A phase I/II clinical study of gefitinib+ radiation for newly-diagnosed glioblastoma (GBM) patients
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1571 (Clinical Study)

A. Das, M. Badruddoja, D. Tryciecky, J. Yu and K. Black
Phase I study of gefitinib and rapamycin in patients with recurrent or progressive glioblastoma (Gbm)
2005 ASCO Annual Meeting. Orlando, FL. May 13-17. Abstract No. 1572. (Clinical Study)
Journal of Clinical Oncology, Vol 23, No 16S (June 1 Supplement), 2005: 1572

T. S. Peery, D. A. Reardon, J. Quinn, J. Ochs, C. Wikstrand, T. T. Stenzel, D. D. Bigner, H. S. Friedman, J. N. Rich, J. Dancey
Phase II trial of ZD1839 for patients with first relapse glioblastoma
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003. Abstract No. 396 (Clinical Study)

M. Raphael Pfeffer, Mark L. Levitt, Dan Aderka
Gefitinib in Recurrent Glioblastoma
Journal of Clinical Oncology, Vol 22, No 13 (July 1), 2004: pp. 2755. (Correspondence, HTML & PDF Full Text)

Jeremy N. Rich, Henry S. Friedman, James B. Powell, Jr, Janet E. Dancey
In Reply
Journal of Clinical Oncology, Vol 22, No 13 (July 1), 2004: pp. 2755-a-2756. (Correspondence, HTML & PDF Full Text)

Jeremy N. Rich, David A. Reardon, Terry Peery, Jeannette M. Dowell, Jennifer A. Quinn, Kara L. Penne, Carol J. Wikstrand, Lauren B. Van Duyn, Janet E. Dancey, Roger E. McLendon, James C. Kao, Timothy T. Stenzel, B.K. Ahmed Rasheed, Sandra E. Tourt-Uhlig, James E. Herndon, II, James J. Vredenburgh, John H. Sampson, Allan H. Friedman, Darell D. Bigner, Henry S. Friedman
Phase II Trial of Gefitinib in Recurrent Glioblastoma
Journal of Clinical Oncology, Vol 22, No 1 (January 1), 2004: pp. 133-142 (Clinical Study, Abstract & PDF Full Text)

J. H. Uhm, K. V. Ballman, C. Giannini, J. C. Krauss, J. C. Buckner, D. James, B. W. Scheithauer, J. R. O'Fallon, K. A. Jaeckle
Phase II study of ZD1839 in patients with newly diagnosed grade 4 astrocytoma
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1505 (Clinical Study)


Gliomas

Brandes AA, Franceschi E, Tosoni A, Hegi ME, Stupp R
Epidermal growth factor receptor inhibitors in neuro-oncology: hopes and disappointments
Clin Cancer Res. 2008 Feb 15;14(4):957-60
 Abstract |
Links | BL 7:12

Lassman AB, Rossi MR, Razier JR, Abrey LE, Lieberman FS, Grefe CN, Lamborn K, Pao W, Shih AH, Kuhn JG, Wilson R, Nowak NJ, Cowell JK, Deangelis LM, Wen P, Gilbert MR, Chang S, Yung WA, Prados M, Holland EC
Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from north american brain tumor consortium trials 01-03 and 00-01
Clin Cancer Res. 2005 Nov 1;11(21):7841-50. (Clinical Study, Abstract)

F. S. Lieberman, T. Cloughesy, H. Fine, J. Kuhn, K. Lamborn, M. Malkin, H. I. Robbins, W. A. Yung, P. Wen, M. Prados
NABTC phase I/II trial of ZD-1839 for recurrent malignant gliomas and unresectable meningiomas
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1510 (Clinical Study)

F. S. Lieberman, T. Cloughesy, L. DeAngelis, H. Fine, K. Fink, L. Junck, J. Kuhn, M. Mehta, P. Wen, M. Prados
Phase I-II study of ZD-1839 for recurrent malignant gliomas and meningiomas progressing after radiation therapy
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003. Abstract No. 421 (Clinical Study)

Marie Y, Carpentier AF, Omuro AM, Sanson M, Thillet J, Hoang-Xuan K, Delattre JY
EGFR tyrosine kinase domain mutations in human gliomas
Neurology. 2005 Apr 26;64(8):1444-5. (Laboratory Investigation, Abstract)

M. Prados, W. Yung, P. Wen, L. Junck, K. Fink, T. Cloughesy, I. Robins, S. Chang, J. Kuhn
Phase I study of ZD1839 plus temozolomide in patients with malignant glioma. A study of the North American Brain Tumor Consortium
40th ASCO Annual Meeting. New Orleans, LA. June 5-8, 2004. Abstract No.1504 (Clinical Study)

Schwer AL, Damek DM, Kavanagh BD, Gaspar LE, Lillehei K, Stuhr K, Chen C.
A Phase I Dose-Escalation Study of Fractionated Stereotactic Radiosurgery in Combination with Gefitinib in Patients with Recurrent Malignant Gliomas.
Int J Radiat Oncol Biol Phys. 2007 Oct 29; [Epub ahead of print]
Abstract


Metastatic Tumors

Lung Cancer

E. A. Diaz-Canton, G. Recondo
Non small cell lung cancer (NSCLC) metastatic to the brain: A cohort study
39th ASCO Annual Meeting. Chicago, IL. May 31-June 3, 2003. Abstract No. 462 (Clinical Study)

Cappuzzo F, Calandri C, Bartolini S, Crino L
ZD 1839 in patients with brain metastases from non-small-cell lung cancer (NSCLC): report of four cases
Br J Cancer. 2003 Jul 21;89(2):246-7
(Case Report, Abstract)
H Cortes-Funes and H Soto Parra
Extensive experience of disease control with gefitinib and the role of prognostic markers
British Journal of Cancer (December 2003) 89 (Suppl 2), S3-S8. (Review Article, Abstract)

A Katz and P Zalewski
Quality-of-life benefits and evidence of antitumour activity for patients with brain metastases treated with gefitinib
British Journal of Cancer
(December 2003) 89 (Suppl 2), S15-S18. (Case Report, Abstract)

R Stahel, A Rossi, L Petruzelka, P Kosimidis, F de Braud, M M Bernardo, P-J Souquet, H Soto Parra and C Gridelli
Lessons from the 'Iressa' Expanded Access Programme: gefitinib in special non-small-cell lung cancer patient populations
British Journal of Cancer (December 89 (Suppl 2), S19-S23. (Clinical Study, Abstract)

N van Zandwijk
Tolerability of gefitinib in patients receiving treatment in everyday clinical practice
British Journal of Cancer (December 89 (Suppl 2), S9-S14. (Review Article, Abstract)

Wu C, Li YL, Wang ZM, Li Z, Zhang TX, Wei Z. 
Gefitinib as palliative therapy for lung adenocarcinoma metastatic to the brain.
Lung Cancer. 2007 Apr 12; [Epub ahead of print]
PMID: 17434236 [PubMed - as supplied by publisher]


Wu YL, Yang JJ, Lin JY, Huang YJ, Liao RQ, Huang YS, Zhou Q, Xu CR, Wang Z. 
[Gefitinib target treatment in non-small cell lung cancer.]
Zhonghua Jie He He Hu Xi Za Zhi. 2007 Feb;30(2):98-102. Chinese.
PMID: 17445469 [PubMed - in process]


 

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