Current Neuro-Oncology




Volume 27 Number 21
31 July 2025




Home > Publications > Current Neuro-Oncology > Volume 27, Year 2025 > Number 21, 31 July






Zeyen T, Treiber A, Schneider M, Potthoff AL, Schaub C, Roever L, Layer JP, Gkika E, Vatter H, Paech D, Radbruch A, Schaefer N, Herrlinger U, Weller J.
Second-line temozolomide in first recurrent MGMT-methylated glioblastoma after lomustine/temozolomide: Efficacy and safety.
Neurooncol Adv. 2025 Apr 28;7(1):vdaf084. doi: 10.1093/noajnl/vdaf084. PMID: 40575419. Observational study. ˍ




Ying YZ, Cai XH, Yang H, Huang HW, Zheng D, Li HY, Dong GH, Wang YG, Jiang ZL, An ZL, Zhang GB.
Development and validation of a deep learning algorithm for discriminating glioma recurrence from radiation necrosis on MRI.
Front Oncol. 2025 Jun 6;15:1573700. doi: 10.3389/fonc.2025.1573700. PMID: 40548110. Observational study. ˍ




Campian JL, Grossman SA, Kask AS, Kosydar S, Strowd R, Piotrowski A, Tang J, Chheda MG, DiPersio JF, Schullery D, D'Amico L, Desideri S, Danda N, Ferrando-Martinez S, Lee BH, Fling SP, Ye X.
Phase I study of NT-I7, a long-acting interleukin-7, in severe treatment-related lymphopenia following standard radiation and temozolomide for high-grade glioma.
Neurooncol Adv. 2025 Jun 7;7(1):vdaf117. doi: 10.1093/noajnl/vdaf117. PMID: 40703805. Interventional study. ˍ AI Overview




*Bonucci M, Fuggetta MP, Anelli L, Giannarelli D, Fiorentini C, Ravagnan G.
New Approach for Enhancing Survival in Glioblastoma Patients: A Longitudinal Pilot Study on Integrative Oncology.
Cancers (Basel). 2025 Jul 12;17(14):2321. doi: 10.3390/cancers17142321. PMID: 40723205. Observational study. ˍ




Segura Arderiu MM, Momin SMB, Pohl U, Chan H.
Dexamethasone-associated regression of glioblastoma.
Surg Neurol Int. 2025 Jun 13;16:245. doi: 10.25259/SNI_818_2024. PMID: 40656499. Case report. ˍ




Vankan B, Var V, Rommers N, Psychogios MN, Todea RA.
Treatment response assessment in glioblastoma with GRASP DCE-MRI.
Eur J Radiol. 2025 Jun 13;190:112234. doi: 10.1016/j.ejrad.2025.112234. PMID: 40543285. Observational study. ˍ AI Overview




Henssen D, Rullmann M, Schildan A, Striepe S, Schürer M, Feraco P, Scherlach C, Jähne K, Stassart R, Sabri O, Seidel C, Hesse S.
Retrospective Evaluation of Baseline Amino Acid PET for Identifying Future Regions of Tumor Recurrence in High-Grade Glioma Patients.
Cancers (Basel). 2025 Jun 14;17(12):1986. doi: 10.3390/cancers17121986. PMID: 40563636. Observational study. ˍ




Arvaniti CK, Brotis AG, Young JS, Sivanrupan S, Menna G, Nishide M, Schucht P, Berger M, Fountas KN.
The role of Lobectomy in Glioblastoma management: A Retrospective series.
Brain Spine. 2025 Jun 18;5:104305. doi: 10.1016/j.bas.2025.104305. PMID: 40678087. Observational study. ˍ AI Overview




Fu FX, Li G, Hong L, Chen WS.
Preliminary investigation on predicting postoperative glioma recurrences based on a multiparametric radiomics model.
Front Oncol. 2025 Jun 19;15:1592881. doi: 10.3389/fonc.2025.1592881. PMID: 40612337. Observational study˰ ˍ




He L, Luo M, Yin L, Feng J, Xu R, Fei F.
Preoperative Nomogram-Based Assessment to Identify GBM Patients Who Do not Derive Survival Benefit From GTR Compared to STR.
Acad Radiol. 2025 Jun 20:S1076-6332(25)00552-5. doi: 10.1016/j.acra.2025.06.003. PMID: 40541548. Observational study˰ ˍ AI Overview




Bagley SJ, Umemura Y, Mendez JS, Arrillaga-Romany I, Bielamowicz KJ, Butowski N, Hutchins K, Kong XT, Odia Y, Sharma A, Weintraub L, Koschmann C, Wen PY, Saratsis AM, Brundage T, Ramage SC, Tarapore RS, Knowles T, Yang D, Allen JE, Cloughesy T.
Prognostic Features of Recurrent Midline and H3 K27M-Mutant Glioma.
Cancers (Basel). 2025 Jun 23;17(13):2107. doi: 10.3390/cancers17132107. PMID: 40647406. Observational study. ˍ AI Overview




Meulendijks TFC, Kaspers GJL, Ramaswamy V, Tsang DS, Laughlin S, Bennett J, Nathan PC.
How long should survivors of pediatric medulloblastoma and ependymoma be screened for recurrence? A retrospective cohort study.
Int J Cancer. 2025 Jun 23. doi: 10.1002/ijc.70016. PMID: 40548641. Observational study˰ ˍ AI Overview




Al-Mistarehi AH, Zaitoun KJ, Javed S, Xia Y, Hersh A, Ghaith AK, Weber-Levine C, Jiang K, Khan M, Mendelson B, Ksabi N, Sciubba DM, Gokaslan ZL, Jallo GI, Wolinsky JP, Theodore N, Lubelski D.
Survival and Functional Outcomes Following Surgical Resection of Intramedullary Spinal Cord Tumors: A Series of 253 Patients over 22 Years.
Cancers (Basel). 2025 Jun 24;17(13):2112. doi: 10.3390/cancers17132112. PMID: 40647411. Observational study. ˍ AI Overview




Chen W, Wu D, Chen X.
Drug adverse events associated with temozolomide administration: A real-world pharmacovigilance study using the FAERS database from 2014 to 2024.
J Oncol Pharm Pract. 2025 Jun 25:10781552251350618. doi: 10.1177/10781552251350618. PMID: 40566845. Observational study˰ ˍ AI Overview




Li J, Chang T, Zeng Y, Ma W, Liu J, Ren T, Niu X.
Clinical Characteristics and Prognostic Outcomes of Spinal Cord Gliomas with Intracranial Metastasis: An Integrated Analysis Based on Individual Cases.
World Neurosurg. 2025 Jun 25;200:124205. doi: 10.1016/j.wneu.2025.124205. PMID: 40578429. Observational study. ˍ AI Overview




Vishnu AR, Damle NA, Haresh KP, Tripathi M, Priyanka GB.
68Ga-PSMA PET/CT in a case of recurrent Glioblastoma.
Indian J Nucl Med. 2025 Jun 27;40(2):115-116. doi: 10.4103/ijnm.ijnm_126_24. PMID: 40735748. Case report. ˍ




Breen WG, Dixon JG, Anderson SK, Sarkaria JN, Brown PD, Yan ES, Kizilbash S, Galanis E, Anderson D, Tran D, Mazurczak M, Johnson DR, Geoffroy FJ, Leinweber C, Laack NN.
Final Report on NCCTG N0877 (Alliance): A Phase II Randomized, Placebo-Controlled Trial of Chemoradiotherapy with or without Dasatinib for Glioblastoma.
Neuro Oncol. 2025 Jun 28:noaf156. doi: 10.1093/neuonc/noaf156. PMID: 40579995. Interventional study. ˍ




Sferruzza G, Desingu K, Cubero Cruz A, Finocchiaro G.
Assessing time-trend bias in glioblastoma prognosis over two decades of clinical trials.
Neuro Oncol. 2025 Jun 28:noaf158. doi: 10.1093/neuonc/noaf158. PMID: 40580109. Observational study˰ ˍ AI Overview






Amaral LJ, Gresham G, Kim S, Tighiouart M, Nelson TA, Welborn A, Lockshon L, Noorvash B, Rudnick JD, Irwin SA, Freedland SJ, Hu J.
A phase 1 safety and feasibility trial of a ketogenic diet plus standard of care for patients with recently diagnosed glioblastoma.
Sci Rep. 2025 Jul 1;15(1):21064. doi: 10.1038/s41598-025-06675-6. PMID: 40595067. Interventional study. ˍ




Nör C, Kharas K, Rasnitsyn A, Vladoiu MC, Cho NW, Young JS, Nör F, Mankahla N, Haapasalo J, Nordfors K, Rapic S, Skowron P, Suárez RA, Bahcheli AT, Ocsenas O, Chen X, Bahrampour S, Momin A, Sundaresan L, Ong W, Hendrikse LD, Abeysundara N, Juraschka K, Ly M, Pallota JG, Douglas T, Huang N, Wang H, Mak E, Qin L, Liu J, Shen L, Luu B, Manno A, Kumar SA, Donovan LK, Fong V, Richman C, Daniels C, Garzia L, Rich JN, Hawkins C, Wu X, DaCosta R, Reimand J, Huang X, Ramaswamy V, Raleigh DR, Taylor MD.
Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process.
Dev Cell. 2025 Jul 2:S1534-5807(25)00371-5. doi: 10.1016/j.devcel.2025.06.016. PMID: 40609543. Lab investigation˰ ˍ




*Kim HJ, Kim KW, Cha DH, Yoo J, Kim EH, Chang JH, Kang SG, Park JW, Kim JH, Lee Y, Lim E, Kim Y, Kim MH, Li X, Lee JH, Lee JH.
Precancerous Cells Initiate Glioblastoma Evolution and Contribute to Intratumoral Heterogeneity.
Cancer Discov. 2025 Jul 3;15(7):1377-1391. doi: 10.1158/2159-8290.CD-24-0234. PMID: 40233712. Lab investigation˰ ˍ
RELATED ARTICLE
Lee JJY, Suvà ML. Malignant Transformation of Glioblastoma: One Step at a Time. Cancer Discov. 2025 Jul 3;15(7):1312-1314. doi: 10.1158/2159-8290.CD-25-0698. PMID: 40605506. Comment˰ ˍ AI Overview




Kawaguchi Y, Hana T, Hasegawa H, Murakami C, Higashi M, Hanakita S.
Rapid response to BRAF/MEK inhibitor therapy within 2 weeks for high-grade glioma with leptomeningeal metastasis: illustrative case.
J Neurosurg Case Lessons. 2025 Jul 7;10(1):CASE25247. doi: 10.3171/CASE25247. PMID: 40623326. Case report. ˍ




Shankar J, Patil N, Ayroso M, Marin R, Del Bigio M, Pitz M, Beiko J, Silvaggio J, Essig M, Kakumanu S, Sinha N.
Isolated restricted diffusion in glioblastoma: incidence, progression, and survival impact.
Neuroradiology. 2025 Jul 8. doi: 10.1007/s00234-025-03672-4. PMID: 40627192. Observational study. ˍ AI Overview




Piccioni D, Juarez TM, Kesari SL, Rose L, Nomura N, Kesari S.
Phase II trial of nilotinib in PDGFR-alpha-enriched recurrent high-grade gliomas.
Neurooncol Adv. 2025 Jul 10;7(1):vdaf150. doi: 10.1093/noajnl/vdaf150. PMID: 40709015. Interventional study. ˍ




*Bonucci M, Fuggetta MP, Anelli L, Giannarelli D, Fiorentini C, Ravagnan G.
New Approach for Enhancing Survival in Glioblastoma Patients: A Longitudinal Pilot Study on Integrative Oncology.
Cancers (Basel). 2025 Jul 12;17(14):2321. doi: 10.3390/cancers17142321. PMID: 40723205. Observational study. ˍ




Ding X, Chen D, Zhang Z, Qi Y, Chen D, Wen J, Wang Y, Cheng H, Ji C, Chen L, Tang C, Yao Y.
Cisplatin and Alternating Temozolomide in Recurrent High-Grade Gliomas: Efficacy and the Role of Tumor-Infiltrating Lymphocytes in a Phase II Clinical Trial.
Clin Med Insights Oncol. 2025 Jul 13;19:11795549251350188. doi: 10.1177/11795549251350188. PMID: 40661859. Interventional study. ˍ




Jung Y, Dirks J, Hawkins C, Tabori U, Das A, Bennett J, Dirks P, Quon JL.
A role for early surgical intervention in childhood low-grade glioma? Illustrative case.
J Neurosurg Case Lessons. 2025 Jul 14;10(2):CASE2584. doi: 10.3171/CASE2584. PMID: 40658996. Case report. ˍ AI Overview




Prosperetti C, Yenigün M, Pagnamenta A, Tabaee Damavandi P, Disanto G, Marchi F, Espeli V, Muoio B, Spina P, Pesce G, Agazzi P.
Sex-Related Differences in Glioblastoma: A Single-Center Retrospective Cohort Study.
Biomedicines. 2025 Jul 14;13(7):1715. doi: 10.3390/biomedicines13071715. PMID: 40722784. Observational study. ˍ




Sumita K, Sawada M, Hattori EY, Sano N, Takada S, Tanji M, Mineharu Y, Kikuchi T, Arakawa Y.
Diffuse midline glioma H3K27-altered with thoracic epidural metastasis: illustrative case.
J Neurosurg Case Lessons. 2025 Jul 14;10(2):CASE25249. doi: 10.3171/CASE25249. PMID: 40658994. Case report. ˍ




Haisraely O, Vedala S, Al-Sharfeen A, Manzar GS, Perni S, Tom MC, Beckham TH, Wang C, Yeboa DN, Chung C, McAleer MF, Ghia AJ, Ene CI, Weathers SP, McGovern SL, Wogan CF, Roth M, Li J, De B.
Glioblastoma in young adult patients: contemporary patterns of care and survival in the United States.
J Neurooncol. 2025 Jul 15. doi: 10.1007/s11060-025-05135-5. PMID: 40663309. Observational study˰ ˍ




Comer C, Cotton K, Edwards C, Dai X, Badodi S, Buccafusca R, Bennett C, Peet A, Williams A, Michod D, Bochukova E, Niklison-Chirou MV.
Simvastatin suppresses spinal cord metastasis of medulloblastoma at clinically significant doses.
Cell Death Dis. 2025 Jul 15;16(1):527. doi: 10.1038/s41419-025-07829-0. PMID: 40664675. Lab investigation. ˍ




Lü MJS, Michaelsen SR, Locallo A, Eickhart-Dalbøge CS, Scheie D, Melchior LC, Weischenfeldt J, Lassen U, Poulsen HS, Urup T.
Repeated responders to bevacizumab combination treatment in recurrent glioblastoma: a retrospective case study.
J Neurooncol. 2025 Jul 16. doi: 10.1007/s11060-025-05162-2. PMID: 40668315. Observational study. ˍ AI Overview




Oster C, Matyar A, Schmidt T, Hummel T, Hattingen E, Jokisch M, Jokisch D, Grieger J, Cappello G, Kizina K, Lazaridis L, Ahmadipour Y, Rauschenbach L, Stuschke M, Pöttgen C, Guberina N, Tertel T, Giebel B, Dreizner GL, Barbato F, Skoda EM, Scheffler B, Müther M, Herrmann K, Kleinschnitz C, Sure U, Deuschl C, Glas M, Kebir S.
Decoding glioblastoma survival: unraveling the prognostic potential of olfactory function in a prospective observational study.
Neurol Res Pract. 2025 Jul 24;7(1):51. doi: 10.1186/s42466-025-00410-2. PMID: 40708059. Clinical trial protocol. ˍ




Tang LY, Botros D, Kim AA, Khalafallah AM, Dux H, Fox K, Hussain N, Mao Y, Pellegrino R, Sharma P, Lucas CG, Ahmed AK, Jackson CM, Gallia G, Bettegowda C, Weingart J, Brem H, Mukherjee D.
Impact of peri-tumoral resection on survival in primary glioblastoma.
Cancer. 2025 Jul 24;131(15):e70016. doi: 10.1002/cncr.70016. PMID: 40704606. Observational study˰ ˍ AI Overview




Qian X, Ning W, Yang J, Dunmall LC, Pandha HS, Shang G, Guo Y, Zhang D, Qu Y, Wang H, Gu C, Zhang M, Wang Y, Wang S, Zhang H.
The oncolytic adenovirus Ad-TD-nsIL12 in primary or progressive pediatric IDH wild-type diffuse intrinsic pontine glioma results of two phase I clinical trials.
Nat Commun. 2025 Jul 28;16(1):6934. doi: 10.1038/s41467-025-62260-5. PMID: 40721414. Interventional study. ˍ AI Overview




Faison SL, Batonga J, Arumugham T, Bartkus A, Morrison ME, Mullin MJ, Tippin T, Naderer O.
Effect of Severe Renal Impairment on Dordaviprone (ONC201) Pharmacokinetics.
Drugs R D. 2025 Jul 30. doi: 10.1007/s40268-025-00520-x. PMID: 40742663. Interventional study. ˍ