Current Neuro-Oncology

Volume 27 Number 29
20 October 2025

Home > Publications > Current Neuro-Oncology > Volume 27, Year 2025 > Number 29, 20 October

Loughan AR, Braun SE, Lanoye A, Davies A, Kleva CS, Fox A, Zarrella GV.
FearLess in Neuro-Oncology: Phase I trial targeting fear of cancer recurrence in patients with primary malignant glioma and their caregivers.
Neurooncol Pract. 2025 Apr 12;12(5):850-862. doi: 10.1093/nop/npaf038. PMID: 410802034. Interventional study˰ ˍ

Misztela-Lisiecka E, Waska G, Strozak A, Miernik-Skrzypczak MA, Nowakowski P.
From Tachycardia to Brain Tumor: An Unusual Evolution of Epilepsy.
Cureus. 2025 Sep 12;17(9):e92152. doi: 10.7759/cureus.92152. PMID: 41084664. Case report. ˍ

Ijare OB, Baskin DS, Powell SZ, Pichumani K.
Case Report: Metabolic alterations and cholesterol esterification in a low-grade diffuse astrocytoma patient who progressed to glioblastoma at recurrence.
Front Oncol. 2025 Sep 19;15:1651974. doi: 10.3389/fonc.2025.1651974. PMID: 41049838. Case report. ˍ

Ma H, Zeng S, Huang Y, Xie D, Mazu L, Zhu N, Zhao J, Yang Z, Chu J.
Predicting glioma histo-molecular diagnosis and prognosis: preoperative dynamic contrast-enhanced magnetic resonance imaging insights.
Quant Imaging Med Surg. 2025 Sep 22;15(10):9855-9870. doi: 10.21037/qims-2025-36. PMID: 41081223. Observational study. ˍ

Imai N, Yano H, Ikegame Y, Yasuda S, Morishima R, Ikuta S, Nakayama N, Maruyama T, Ohe N, Kumagai M, Muragaki Y, Shinoda J, Izumo T.
Evaluation of [¹¹C]-Methionine Positron Emission Tomography and Cerebral Blood Volume Imaging in the Diagnosis of Non-Contrast-Enhanced Gliomas.
J Clin Med. 2025 Sep 25;14(19):6777. doi: 10.3390/jcm14196777. PMID: 41095858. Observational study. ˍ

Wainwright D, Lukas R, Zhai L, Lauing K, Kim M, Koch T, Penco-Campillo M, Bommi P, Dixit K, Kumthekar P, Sharp L, Lezon R, Garcia D, Sonabend A, McCortney K, Castro B, Chandler J, Gondi V, Grimm S, Heimberger A, Dobinda K, Zhang H, Sachdev S, Juhasz C, James CD, Allen J, Horbinski C, Lesniak M, Stupp R, Miska J.
Newly diagnosed glioblastoma IDHwt patients treated with radiation, nivolumab, and BMS-986205.
Res Sq [Preprint]. 2025 Sep 25:rs.3.rs-7567487. doi: 10.21203/rs.3.rs-7567487/v1. PMID: 41041559. Interventional study. ˍ

Tang X, Wei W, Huang Y, Zheng Y, Xu Y, Li F.
A case report on IDH-mutant astrocytoma, CNS WHO grade 4: multi-omic characterization of untreated clinical progression.
Front Oncol. 2025 Sep 26;15:1557245. doi: 10.3389/fonc.2025.1557245. PMID: 41079096. Case report. ˍ

Huang J, Johanns TM, Campian JL, Chicoine M, Zipfel G, Chheda M, Butt O, Ivanov D, Chernyshov K, Salem B, Tkachuk A, Frank A, Klimova D, Tabakov D, Harmanci AS, Chen WC, Patel AJ, Raleigh DR, Kim AH, Chen CK.
A phase I window-of-opportunity study of neoadjuvant avelumab and hypofractionated radiation therapy in radiation-relapsed meningioma.
medRxiv [Preprint]. 2025 Sep 28:2025.09.26.25336740. doi: 10.1101/2025.09.26.25336740. PMID: 41040714. Interventional study. ˍ

Mehta MP, Gondi V, Ahluwalia MS, Roberge D, Sio TTW, Trifiletti DM, Muanza T, Krpan AM, Zhu Z, Ramakrishna NR, Fiveash JB, Metellus P, Yu J, Wang CJ, Jacob J, Freyschlag CF, Csőszi T, Salmaggi A, Taliansky A, Lucas A, Debus J, Brown PD, Harat M; METIS study investigators.
Tumor Treating Fields (TTFields) therapy after stereotactic radiosurgery for brain metastases from non-small cell lung cancer: final results of the phase 3 METIS study.
Int J Radiat Oncol Biol Phys. 2025 Sep 29:S0360-3016(25)06217-0. doi: 10.1016/j.ijrobp.2025.08.066. PMID: 41033612. Interventional study. ˍ

Balasubramanian K, Fung KM, McNall-Knapp RY, Balsara K.
Sustained response to larotrectinib in a pediatric patient with recurrent STRN3::NTRK2 fusion-positive pilocytic astrocytoma.
CNS Oncol. 2025 Oct 3;14(1):2558455. doi: 10.1080/20450907.2025.2558455. PMID: 41042836. Case report. ˍ

Kaewborisutsakul A, Kitsiripant C, Churuangsuk C, Puttarak P, Suntornlohanakul O, Khanungwanitkul K, Rattanaburi A, Uppanisakorn S, Sungkaro K, Taweesomboonyat C, Tunthanathip T, Oearsakul T, Sae-Heng S.
Does adding ginger extract to a preoperative carbohydrate drink improve outcomes in enhanced recovery after elective neuro-oncologic craniotomy? A randomized controlled trial.
Front Nutr. 2025 Oct 3;12:1624176. doi: 10.3389/fnut.2025.1624176. PMID: 41112738. Interventional study. ˍ

Giantini-Larsen AM, Garton ALA, Rivera M, Han R, Pisapia DJ, Sait SF, Karajannis MA, Greenfield JP, Bilsky MH, Newman WC, Souweidane MM.
Diffuse midline glioma with extra central nervous system metastases in the pediatric, adolescent, and young adult population.
Childs Nerv Syst. 2025 Oct 7;41(1):306. doi: 10.1007/s00381-025-06903-4. PMID: 41055765. Case report. ˍ

Li T, Wang H, Wang Y, Mai Y, Wang P, Zhang M, Jiang Z, Xie L, Zhou H, Wang Y, Li X, Xiao D, Geng J, Wu W, Zhang P, Wang L, Wu Z, Zhang J, Cao D, Pan C, Zhang L.
Co-detection of mutations and methylations in cerebrospinal fluid ctdna for minimally-invasive diagnosis of brainstem glioma.
J Exp Clin Cancer Res. 2025 Oct 7;44(1):283. doi: 10.1186/s13046-025-03455-y. PMID: 41057970. Observational study. ˍ

Golla H, Nettekoven C, Hellmich M, Appelmann I, Bausewein C, Becker G, Boehlke C, Brumbarova T, Civello D, Clusmann H, Haberland B, Henrik Heiland D, Herrlinger U, Jaspers B, Joshi M, Mülller D, Müller W, Na CH, Neukirchen M, Radbruch L, Rapp M, Rolke R, Ruge M, Sabel M, Schnell O, Schwartz J, Thon N, Vatter H, Baumgarten LV, Voltz R, Goldbrunner R; EPCOG Study Group.
Early Palliative Care for Patients with Glioblastoma: A randomized phase lll clinical trial (EPCOG).
Neuro Oncol. 2025 Oct 9:noaf230. doi: 10.1093/neuonc/noaf230. PMID: 41071052. Interventional study. ˍ

Kim SE, Kim Y, Moon HH, Nam SJ, Park KS, Hong CK, Lee HS, Yoon S, Park JE.
Vabametkib Treatment in Refractory Glioblastoma: A Case Report.
JCO Precis Oncol. 2025 Oct 9;9:e2500108. doi: 10.1200/PO-25-00108. PMID: 41066728. Case report. ˍ

Tsao AS, Song Z, Ho AL, Mehnert JM, Ivy P, Gray RJ, Wang V, McShane LM, Rubinstein LV, Patton DR, Williams PM, Hamilton SR, Takebe N, Ajumally R, Silhavy J, Rahmanian S, Das B, Chen L, Karlovich C, Lococo JS, Tricoli JV, Conley BA, Arteaga CL, Harris LN, O'Dwyer PJ, Chen AP, Flaherty KT.
Phase II Study of Vismodegib in Patients With SMO- or PTCH1-Mutated Tumors: Results From the National Cancer Institute Molecular Analysis for Therapy Choice Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Trial (EAY131) Subprotocol T.
JCO Precis Oncol. 2025 Oct 9;9:e2500119. doi: 10.1200/PO-25-00119. PMID: 41066729. Interventional study˰ ˍ

Sarkaria JN, Donner WH Professor.
A precision medicine umbrella trial to nominate promising therapies for glioblastoma.
Neuro Oncol. 2025 Oct 10:noaf243. doi: 10.1093/neuonc/noaf243. PMID: 41071634. Interventional study. ˍ

Almeida ND, Schrand TV, Madhugiri V, Fang M, Cheruvu H, Shekher R, Goulenko V, Snyder KV, Lipinski L, Fabiano AJ, Fenstermaker RA, Prasad D.
Early Initiation of Radiation Therapy Improves Survival in Elderly Patients With Glioblastoma.
Neurosurgery. 2025 Oct 13. doi: 10.1227/neu.0000000000003768. PMID: 41081517. Observational study. ˍ

Anghileri E, Miele E, Patrizi S, Barresi S, Lazzarini E, Maddaloni L, Patanè M, Pedace L, Paterra R, Silvani A, Locatelli F, Indraccolo S, Pollo B.
Unique Genetic and Epigenetic Alterations in Glioblastoma Long-Term Survivors: Insights From Two Clinical Cases.
J Cell Mol Med. 2025 Oct 14;29(20):e70771. doi: 10.1111/jcmm.70771. PMID: 41085137. Case report. ˍ

Koay JM, Dion C, Michaelides L, Chaichana K, Gruenbaum BF, Middlebrooks EH, Quinones-Hinojosa A, Sabsevitz DS.
Cognitive impact of repeated surgical resections for the management of high-grade glioma.
J Neurooncol. 2025 Oct 14;176(1):4. doi: 10.1007/s11060-025-05283-8. PMID: 41085575. Observational study˰ ˍ

Harlay V, Bequet C, Appay R, Bertucci A, Petrirena G, Campello C, Barrié M, Autran D, Graillon T, Dufour H, Figarella-Branger D, Padovani L, Barlier A, Nanni I, Tabouret E, Chinot O.
Autonomy duration in patients with biopsy-only unresectable IDH wild-type glioblastomas.
J Neurooncol. 2025 Oct 16;176(1):20. doi: 10.1007/s11060-025-05250-3. PMID: 41099970. Observational study˰ ˍ

Roux A, Tauziede-Espariat A, Simboli GA, Elia A, Moiraghi A, Hudelist B, Defrance G, Gehanno A, Dezamis E, Blauwblomme T, Dangouloff-Ros V, Boddaert N, Dufour C, Grill J, Muto J, Metais A, Saffroy R, Varlet P, Chretien F, Oppenheim C, Zanello M, Pallud J.
High-grade glioma, IDH- and H3-wildtype in young adults: a rare condition with a distinct epigenetic landscape.
J Neurooncol. 2025 Oct 16;176(1):22. doi: 10.1007/s11060-025-05246-z. PMID: 41099772. Observational study. ˍ

Schiff D, Ye X, Li J, Ellingson BM, Wen PY, Walbert T, Campian J, Burt Nabors L, Ozer BH, Desai A, Omuro A, Desideri S, Danda N, Grossman S, Bindra RS.
Phase I/II and Window-of-Opportunity Study of Pamiparib and Metronomic Temozolomide for Recurrent IDH Mutant Gliomas.
Neuro Oncol. 2025 Oct 16:noaf246. doi: 10.1093/neuonc/noaf246. PMID: 41099363. Interventional study˰ ˍ

Spanggaard I, Matrana M, Lima CR, Mahipal A, Vieito M, Hervieu A, Goyal L, Rodón J, Veronese ML, Oliveira N, Li X, Schaffer M, Kesari S.
Pemigatinib for Previously Treated Metastatic or Unresectable Central Nervous System Tumors with FGFR Mutations or Rearrangements: FIGHT-207 Results.
Oncologist. 2025 Oct 16:oyaf272. doi: 10.1093/oncolo/oyaf272. PMID: 41100064. Interventional study. ˍ

Tolboom N, Albert NL, Braat AJAT, Snijders TJ, Tabouret E, Taillandier L, Brendel M, Cecchin D, Aguiar-Fernandez P, Fraioli F, Guedj E, Traub-Weidinger T, Yakushev I, Van Weehaeghe D, Preusser M, Verger A.
From Compassionate Use Toward High-Level Evidence for Radiopharmaceutical Therapy in Recurrent Meningioma: The LUMEN-1 and MOMENTUM-1 Trials.
J Nucl Med. 2025 Oct 16:jnumed.125.270820. doi: 10.2967/jnumed.125.270820. PMID: 41101976. Editorial. ˍ