Current Neuro-Oncology

Volume 28 Number 5
20 February 2026

Home > Publications > Current Neuro-Oncology > Volume 28, Year 2026 > Number 5, 20 February

Gupta T, Dasgupta A, Goswami S, Chatterjee A, Dhingra S, Deodhar J, Sonkusare L, Prasad M, Gollamudi VRM, Kannan S, Vishwakarma K, Menon N, Moiyadi A, Shetty P, Singh V, Epari S, Sahay A, Shah A, Sahu A, Choudhari A, Bhattacharya K, Bano N, Gupta N, Chinnaswamy G.
Memantine to preserve memory and neurocognition following craniospinal irradiation (MEMENTO): a phase 3 randomized controlled trial.
BMC Cancer. 2026 Feb 11;26(1):365. doi: 10.1186/s12885-026-15627-w. PMID: 41673604. Interventional study protocol. ˍ

Meylan M, Tian Y, Wu L, Ling AL, Kovarsky D, Barlow GL, Nguyen LD, Pyrdol J, Marx S, Westphal L, Michel J, Gonzalez Castro LN, Dumont S, Santos A, Tirosh I, Suvà ML, Chiocca EA, Wucherpfennig KW.
Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial.
Cell. 2026 Feb 11;189(5):1287-1304.e18. doi: 10.1016/j.cell.2025.12.055. PMID: 41679299. Interventional study. ˍ

Alhalabi OT, Klein L, Mironov K, Beyl L, Kessler T, Jungk C, Sievers P, Sahm F, Bendszus M, Wick W, Suchorska B, Krieg SM, Ille S.
MGMT promoter methylation modulates the effect of residual tumor on survival after re-resection of recurrent glioblastoma.
Acta Neuropathol Commun. 2026 Feb 12;14(1):47. doi: 10.1186/s40478-026-02234-w. PMID: 41680847. Observational study. ˍ

Esparragosa Vázquez I, López-Díaz de Cerio A, Inoges S, Aristu J, Domínguez P, García-Eulate R, Calvo-Imirizaldu M, Arbizu J, Rodríguez-Ruiz ME, Irimia P, Alonso MM, Prósper F, Díez-Valle R, Gállego Pérez-Larraya J.
Feasibility and Safety of Autologous Dendritic Cell Vaccination Combined with Radio-Chemotherapy in Newly Diagnosed Glioblastoma: A Retrospective Single-Center Series.
Vaccines (Basel). 2026 Feb 12;14(2):172. doi: 10.3390/vaccines14020172. PMID: 41746092. Observational study. ˍ

Mohan AA, Batich K, Wang SJ, López GY, Salacz ME, Peters KB.
Synchronous diagnosis of multicentric glioma with distinct isocitrate dehydrogenase molecular profiles: a case report.
CNS Oncol. 2026 Feb 12;15(1):2626299. doi: 10.1080/20450907.2026.2626299. PMID: 41674328. Case report. ˍ

Dasgupta A, Ghosh S, Chatterjee A, Kannan S, Goswami S, Ranjith CP, Punde R, Meena L, Shinde P, Konthoujam M, Phurailatpam R, Sutar A, Patil D, Sahu A, Sridhar E, Moiyadi A, Menon N, Puranik A, Bano N, Gupta T.
Proton versus photon radiotherapy in adults with primary brain tumors evaluating functional survival: a phase 3 randomized controlled trial study protocol (PRIDE).
Radiat Oncol. 2026 Feb 14;21(1):38. doi: 10.1186/s13014-025-02785-7. PMID: 41689093. Interventional study protocol. ˍ

Lassman AB, Pugh SL, Wang TJC, Aldape K, Gan HK, Preusser M, Vogelbaum MA, Sulman EP, Won M, Zhang P, Moazami G, Macsai MS, Gilbert MR, Bain EE, Blot V, Ansell PJ, Samanta S, Kundu MG, Armstrong TS, Wefel JS, Seidel C, de Vos FY, Hsu S, Cardona AF, Lombardi G, Bentsion D, Peterson RA, Gedye C, Bourg V, Wick A, Curran WJ, Mehta MP.
Depatuxizumab mafodotin in EGFR-amplified newly diagnosed glioblastoma: A phase III randomized clinical trial.
Neuro Oncol. 2023 Feb 14;25(2):339-350. doi: 10.1093/neuonc/noac173. (Erratum in: Neuro Oncol. 2026 Feb 26:noag031. doi: 10.1093/neuonc/noag031). PMID: 35849035. Interventional study. ˍ

Sucuoğlu İşleyen Z, Seçmeler Ş, Sakin A, Cihan Ş, Beşiroğlu M, Kahraman S, Karakurt Eryılmaz M, Zeynelgil E, Çalışkan Yıldırım E, Kut E, Şengül N, Paksoy Türköz F, Alan Ö, Özkul Ö, Işık S, Yılmaz F, Gülmez A, Türker S, Karakaya G, Günaldı M, Özer L, Aksoy A, Karataş F, Sakalar T, Demirtaş Esmer D, Teker F, Demir N, Dülgar Ö, Turhal S, Türk HM, Ertürk K, Çelik E, Atcı MM.
Evaluation of the efficacy and tolerability of bevacizumab-based treatments in recurrent primary brain tumors: a multicenter real-world Turkish Oncology Group (TOG) study.
BMC Cancer. 2026 Feb 14;26(1):347. doi: 10.1186/s12885-026-15725-9. PMID: 41691201. Observational study. ˍ

Adjei BO, Renterghem JP, Hayes Meizoso C, Daci R, Mietus CJ, Amenta PS, Johnson MD, Cachia D.
Ivosidenib treatment in IDH-mutant WHO grade 4 astrocytomas: illustrative case.
J Neurosurg Case Lessons. 2026 Feb 16;11(7):CASE25572. doi: 10.3171/CASE25572. PMID: 41698198. Case report. ˍ

Aizer AA, Shin KY, Catalano PJ, Ricca I, Johnson M, Benham G, Roper K, Spicer B, Mann E, Nosker J, Parsons MW, Mendu ML, Hepel J, Chipidza F, Krishnan M, Shi DD, Lamba N, Pashtan I, Peng L, Alexander B, Brown PD, Wen PY, Haas-Kogan DA, Rahman R, Tanguturi S.
Treatment for Brain Metastases With Stereotactic Radiation vs Hippocampal-Avoidance Whole Brain Radiation: A Randomized Clinical Trial.
JAMA. 2026 Feb 19:e260076. doi: 10.1001/jama.2026.0076. PMID: 41712219. Interventional study˰ ˍ

Chen N, Yang M, Li R, Ye C, Wang L, Liu X, Wu J, Sessler DI, Wang E.
Cardiac output-guided vs. mean arterial pressure-guided hemodynamic management in craniotomy patients with cardiovascular disease: a randomized trial.
Sci Rep. 2026 Feb 19;16(1):9789. doi: 10.1038/s41598-026-40615-2. PMID: 41708779. Interventional study. ˍ

Lerman BJ, Doyle OM, Costello JF.
The cellular and mutational origins of IDH mutant glioma.
Neuro Oncol. 2026 Feb 19:noag034. doi: 10.1093/neuonc/noag034. PMID: 41707677. Editorial. ˍ
REFERS TO
Park JW, Kwak J, Kim KW, Jung S, Nam CH, Kim HJ, Lee SM, Choi C, Ahn Y, Park JH, Yoo J, Shim JK, Cho HJ, Kim EH, Kim C, Ahn S, Pusch S, von Deimling A, Chang JH, Kim SH, Kim H, Ju YS, Kang SG, Lee JH.
IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation.
Science. 2026 Jan 8;391(6781):eadt0559. doi: 10.1126/science.adt0559. PMID: 41505555. Laboratory investigation˰ ˍ
COMMENT
Mount CW, Suvà ML. The source of IDH-mutant gliomas. Science. 2026 Jan 8;391(6781):125-126. doi: 10.1126/science.aed6843. PMID: 41505560. Comment˰ ˍ

Malhotra R, Moitra P, Chatterjee A, Kota PK, Dasgupta A, Epari S, Menon N, Kowtal P, Sarin R, Gupta T.
Clinical and genetic predictors of temozolomide-induced severe myelotoxicity in adult diffuse glioma: a case-control study.
J Neurooncol. 2026 Feb 20;177(1):9. doi: 10.1007/s11060-026-05474-x. PMID: 41718852. Observational study˰ ˍ