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Glioblastoma | Etiopathogenesis | Methylation

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Deng B, Head R, Draaisma K, Hoeben A, Lukacova S, Lombardi G, Leenstra S, Hanse M, Fleischeuer REM, Watts C, Angelopoulos N, Gorlia T, Bours V, Van Den Bent MJ, Robe PA, Hoogstrate Y, French PJ.
Epigenetic evolution of IDHwt glioblastomas.
Neuro Oncol. 2026 Jan 2:noaf298. doi: 10.1093/neuonc/noaf298. PMID: 41485099. Laboratory investigation˰ ˍ

Cai L, Sun X, Li R, Ping Y, Lv S, Chen J.
Key methylation modifications in glioma stem cells.
Biochim Biophys Acta Rev Cancer. 2025 Dec 31;1881(1):189527. doi: 10.1016/j.bbcan.2025.189527. PMID: 41482238. Review˰ ˍ

Salam SA, Tanoy NM, Sabuj MSS, Rahman MJ, Sadekuzzaman M, Chowdhury S, Jahan E, Siddiqui MSI, Park BY, Akanda MR.
MGMT promoter methylation in glioblastoma: Molecular mechanisms, tumor microenvironment interactions, and therapeutic implications.
Pathol Res Pract. 2026 Jun 8;286:156585. doi: 10.1016/j.prp.2026.156585. PMID: 42263464˰ ˍ

Lehmann U.
Clinical diagnostic utility of MGMT promoter methylation.
Epigenomics. 2026 Jun 17:1-12. doi: 10.1080/17501911.2026.2688974. PMID: 42307140˰ ˍ

Hong B, Chaib H, Moros G, Tsoy Y, Ziegler S, Heissler HE, Mawrin C, Shiban E.
Impact of weak MGMT promoter methylation on the prognosis of patients with newly diagnosed glioblastoma.
J Neurosurg Sci. 2026 Jun 23. doi: 10.23736/S0390-5616.26.06772-X. PMID: 42334248˰ ˍ