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Glioblastoma | Prognosis | Methylation

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Ghimire P, Kamaludin A, Palau BF, Lavrador JP, Gullan R, Vergani F, Bhangoo R, Ashkan K.
MGMT methylation and its prognostic significance in inoperable IDH-wildtype glioblastoma: the MGMT-GBM study.
Acta Neurochir (Wien). 2024 Oct 5;166(1):394. doi: 10.1007/s00701-024-06300-x. PMID: 39367282. Observational study. ˍ

Kiesel B, Borkovec M, Furtner J, Roetzer-Pejrimovsky T, Nenning KH, Greutter L, Miller-Michlits Y, Widhalm G, Woehrer A.
Sex-specific differences in DNA methylation defining prognostically relevant subgroups in glioblastoma.
J Neurosurg. 2025 Feb 14:1-10. doi: 10.3171/2024.9.JNS24665. PMID: 39951709. Laboratory investigation; Observational study˰ ˍ

*Fanizzi C, Bintintan-Socaciu P, Pirola E, Fiore G, Carnicelli I, Tariciotti L, Parlangeli A, Scagliotti E, Tabano SM, Lopez G, Ferrero S, Navone S, Guarnaccia L, Marfia G, Caroli M, Locatelli M.
Optimal MGMT promoter methylation cut-off to predict better survival in glioblastoma patients undergoing gross-total resection.
J Neurosurg Sci. 2025 May 12. doi: 10.23736/S0390-5616.25.06421-5. PMID: 40351039. Observational study˰ ˍ

Hong B, Chaib H, Moros G, Tsoy Y, Ziegler S, Heissler HE, Mawrin C, Shiban E.
Impact of weak MGMT promoter methylation on the prognosis of patients with newly diagnosed glioblastoma.
J Neurosurg Sci. 2026 Jun 23. doi: 10.23736/S0390-5616.26.06772-X. PMID: 42334248˰ ˍ