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Glioblastoma | Treatment | Immunotherapy | Nivolumab (Anti-programmed cell death protein 1)

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*Hendriksen JD, Locallo A, Maarup S, Debnath O, Ishaque N, Hasselbach B, Skjøth-Rasmussen J, Yde CW, Poulsen HS, Lassen U, Weischenfeldt J.
Immunotherapy drives mesenchymal tumour cell state shift and TME immune response in glioblastoma patients.
Neuro Oncol. 2024 May 2:noae085. doi: 10.1093/neuonc/noae085. PMID: 38695342. Observational study˰ ˍ

Alan O, Bulbul MC, Enlice MA, Mandel NM.
Immunotherapy-related secondary hemophagocytosis in a glioblastoma patient: response to cytokine-directed therapy.
Immunotherapy. 2025 Jan 15:1-7. doi: 10.1080/1750743X.2025.2451604. PMID: 39812468. Case report˰ ˍ

Neuro-Oncology Clinical Research Program; Camphausen K.
Phase II Trial Evaluating the Association of Peripheral Blood Immunologic Response to Therapeutic Response After Adjuvant Treatment with Immune Checkpoint Inhibition (ICI) in Patients with Newly Diagnosed Glioblastoma or Gliosarcoma.
medRxiv [Preprint]. 2025 Dec 30:2025.12.23.25342908. doi: 10.64898/2025.12.23.25342908. PMID: 41607658. Trial registration ID: NCT04817254. ˍ

Lukas RV, Zhai L, Lauing KL, Kim M, Koch T, Penco-Campillo M, Bommi P, Dixit K, Kumthekar P, Sharp L, Lezon R, Garcia D, Sonabend AM, McCortney K, Castro BA, Chandler JP, Gondi V, Grimm SA, Miska JM, Heimberger AB, Dobinda K, Zhang H, Sachdev S, Juhasz C, James CD, Allen JM, Horbinski C, Lesniak MS, Stupp R, Wainwright DA.
Phase 1 evaluation of patients with newly diagnosed glioblastoma treated with radiation, nivolumab, and IDO1 enzyme inhibitor BMS-986205.
Clin Cancer Res. 2026 May 26. doi: 10.1158/1078-0432.CCR-26-1124. PMID: 42189896. Trial registration ID: NCT04047706. ˍ

Lim M, Ye X, Piotrowski AF, Desai A, Ahluwalia MS, Walbert T, Lesser G, Ellingson BM, Peereboom DM, Fisher JD, Desideri S, Jackson C, Pant A, Jain A, Verma R, Oberlton B, Piyadasa H, Bettegowda C, Engle L, Taube J, Bendall SC, Choi J, Drappatz J, Lieberman FS, Kleinberg LR, Pardoll DM, Nabors LB, Wen PY, Grossman SA.
Anti-LAG-3 with or without anti-PD-1 in recurrent glioblastoma: a phase 1 trial.
Nat Med. 2026 Jul 10;32(7):2449-2460. doi: 10.1038/s41591-026-04475-7. PMID: 42432293. Trial registration ID: NCT02658981. ˍ