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Glioblastoma | Treatment | Radiotherapy | Boron Neutron Capture Therapy

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Kawabata S, Goto H, Narita Y, Furuse M, Nonoguchi N, Shidoh-Kazuki R, Eza K, Hirose K, Ohno M, Kondo N, Suzuki M, Tanaka H, Ono K, Nihei K, Wanibuchi M, Miyatake SI.
Extended follow-up of recurrent glioblastoma patients treated with boron neutron capture therapy (BNCT): Long-term survival from a Phase II trial (JG002) using Cyclotron Neutron Source and Boronophenylalanine.
Appl Radiat Isot. 2025 Aug 22;226:112118. doi: 10.1016/j.apradiso.2025.112118. PMID: 40865370. Interventional study˰ ˍ

Nakai K, Kumada H, Matsumoto Y, Baba K, Murakami M, Ishida T, Saito T, Nakamura M, Numajiri H, Mizumoto M, Sugii N, Miki S, Ishikawa E, Maruo K, Takemura M, Hashimoto K, Takahashi T, Hayashi T, Sakurai H.
Boron neutron capture therapy (BNCT) phase I clinical trial for newly diagnosed glioblastoma by newly developed accelerator at University of Tsukuba.
Appl Radiat Isot. 2025 Sep 3;226:112152. doi: 10.1016/j.apradiso.2025.112152. PMID: 40945116.Interventional study protocol. ˍ

Li X, Liu Z, Liu K, Wang C, Liu Z, Xu X.
Advances in Clinical Trials of Boron Neutron Capture Therapy.
Research (Wash D C). 2026 Jan 8;9:0988. doi: 10.34133/research.0988. PMID: 41522606. Review. ˍ

Kutuk T, Atak E, Harrell M, Raval RR, Fekrmandi F, Zhu S, Beyer S, Singh PK, Giglio P, Mohtashami H, Wu KC, Elder JB, Mahase SS, Singh R, Chakravarti A, Palmer JD.
Boron Neutron Capture Therapy for High-Grade CNS Tumors: Mechanisms, Carriers, and Clinical Progress: A Narrative Review.
Int J Mol Sci. 2026 Mar 18;27(6):2765. doi: 10.3390/ijms27062765. PMID: 41898626. ˍ