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Glioblastoma | Treatment | Radiotherapy | Hypofractionation




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*Beckham TH, Rooney MK, McAleer MF, Ghia AJ, Tom MC, Perni S, McGovern S, Grosshans D, Chung C, Wang C, De B, Swanson T, Paulino A, Jiang W, Ferguson S, Patel CB, Li J, Yeboa DN.
Hypofractionated radiotherapy for glioblastoma: A large institutional retrospective assessment of 2 approaches.
Neurooncol Pract. 2024 Jan 18;11(3):266-274. doi: 10.1093/nop/npae004. PMID: 38737610. Observational study˰ ˍ




Almeida ND, Rupp J, Gulzar B, Schrand TV, Madhugiri V, Fang M, Shekher R, Goulenko V, Goyal D, Prasad S, Milano MT, Prasad D.
Evaluating the impact of performance status in elderly patients with glioblastoma.
J Clin Neurosci. 2025 Jan 3;133:111028. doi: 10.1016/j.jocn.2024.111028. PMID: 39755030. Observational study. ˍ




Di Guglielmo FC, Bonaparte I, Davì V, Guida P, Ciliberti MP, Gregucci F, Surgo A, Caliandro M, Carbonara R, Giraldi D, Fanelli V, Surico G, Gentile MA, Calbi R, Internò V, Laera L, Talienti T, Signorelli F, Lombardi G, Fiorentino A.
Are conventional and hypofractionated chemoradiotherapy comparable in glioblastoma patients?
Clin Transl Oncol. 2025 Nov 2. doi: 10.1007/s12094-025-04107-5. PMID: 41176740. Observational study˰ ˍ




Chien DL, Hardy SJ, Serventi JN, Behr JM, Mohile NA, Hemminger LE.
Impact of radiation fractionation on pseudoprogression in older patients with glioblastoma: a retrospective cohort study.
CNS Oncol. 2025 Nov 6;14(1):2584958. doi: 10.1080/20450907.2025.2584958. PMID: 41196722. Observational study. ˍ




Di Muzio N, Torrisi M, Barzaghi R, Pocaterra A, Mori M, Folchini F, Giannini L, Valle M, Bailo M, Deantoni CL, Snider S, Gagliardi F, Ruggiero E, Broggi S, Ruffino L, Di Franco R, Mercogliano S, Fiorino C, Del Vecchio A, Muto M, Muto P, Mortini P, Mondino A, Fodor A.
Neoadjuvant ultrahypofractionated radiotherapy with simultaneous integrated boost for glioblastoma: study protocol for a phase I multicenter clinical trial.
BMC Cancer. 2026 Apr 6;26(1):633. doi: 10.1186/s12885-026-15950-2. PMID: 41942944. Trial registration ID: NCT06551909. ˍ




de Jong AM, van der Boog ATJ, Wester G, Eekers DBP, Budiharto TCG, Rozema T, Lagerwaard FJ, Bruynzeel AME, de Groot C, van der Meulen M, Cialdella F, Dankbaar JW, Hendrikse J, Kleynen KE, Claes A, Philippens MEP, Smid EJ, de Vos FYFL, van Rossum PSN, Robe PA, David S, Snijders TJ, Verhoeff JJC.
Ultra-hypofractionated versus conventional chemoradiation for newly diagnosed glioblastoma: Survival and toxicity results of a multicenter randomized trial.
Radiother Oncol. 2026 Aug 8;223:111726. doi: 10.1016/j.radonc.2026.111726. PMID: 42570798. Trial registration ID: NL72953.041.20. ˍ