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High-grade gliomas | Treatment | Chemotherapy | Temozolomide






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*Omene E, Abdel-Rahman O, Batuyong E, Patel S, Coppens R, Easaw J, Young K.
Switch to generic formulation of temozolomide results in statistically significant increase in grade 3 and 4 bone marrow toxicity in glioma patients in the province of Alberta.
Neurooncol Pract. 2023 Oct 27;11(2):171-177. doi: 10.1093/nop/npad065. PMID: 38496912. Observational study. ˍ




*Elia A, Roux A, Trancart B, Moiraghi A, Seneca M, Dezamis E, Varlet P, Chretien F, Oppenheim C, Zanello M, Pallud J.
Watch-and-wait approach versus adjuvant treatment after radical awake resection in selected adult-type grade 3 gliomas, isocitrate dehydrogenase mutant: A case-matched cohort.
Neurooncol Adv. 2024 Nov 18;6(1):vdae189. doi: 10.1093/noajnl/vdae189. PMID: 39620200. Observational study. ˍ




Ding X, Chen D, Zhang Z, Qi Y, Chen D, Wen J, Wang Y, Cheng H, Ji C, Chen L, Tang C, Yao Y.
Cisplatin and Alternating Temozolomide in Recurrent High-Grade Gliomas: Efficacy and the Role of Tumor-Infiltrating Lymphocytes in a Phase II Clinical Trial.
Clin Med Insights Oncol. 2025 Jul 13;19:11795549251350188. doi: 10.1177/11795549251350188. PMID: 40661859. Interventional study. ˍ ClinicalTrials.gov ID: NCT02263105.